비타민C (아스코르브산)

Therapeutic Role of HAT Therapy in Sepsis: A Systematic Review and Meta-Analysis.

1. Curr Med Chem. 2025;32(16):3258-3282. doi: 10.2174/0109298673245464231121094448. Therapeutic Role of HAT Therapy in Sepsis: A Systematic Review and Meta-Analysis. Saghafi F(1), Moghadam ZB(2), Salehi-Abargouei A(3)(4), Beigrezaei S(3), Sohrevardi SM(1)(5), Jamialahmadi T(6), Sahebnasagh A(7),

Effects of vitamin C on oxidative stress, inflammation, muscle soreness, and strength following acute exercise: meta-analyses of randomized clinical trials.

2. Eur J Nutr. 2020 Oct;59(7):2827-2839. doi: 10.1007/s00394-020-02215-2. Epub 2020 Mar 11. Effects of vitamin C on oxidative stress, inflammation, muscle soreness, and strength following acute exercise: meta-analyses of randomized clinical trials. Righi NC(1), Schuch FB(1)(2), De Nardi AT(3), P

Vitamin C for preventing and treating the common cold.

3. Cochrane Database Syst Rev. 2013 Jan 31;2013(1):CD000980. doi: 10.1002/14651858.CD000980.pub4. Vitamin C for preventing and treating the common cold. Hemilä H(1), Chalker E. Author information: (1)Department of Public Health, POB 41, University of Helsinki, Helsinki, Finland. harri.hemila@he

Vitamin C for preventing and treating the common cold.

4. Cochrane Database Syst Rev. 2007 Jul 18;(3):CD000980. doi: 10.1002/14651858.CD000980.pub3. Vitamin C for preventing and treating the common cold. Douglas RM, Hemilä H, Chalker E, Treacy B. Update in Cochrane Database Syst Rev. 2013 Jan 31;(1):CD000980. doi: 10.1002/14651858.CD000980.pub4

Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis.

5. JAMA. 2007 Feb 28;297(8):842-57. doi: 10.1001/jama.297.8.842. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. Bjelakovic G(1), Nikolova D, Gluud LL, Simonetti RG, Gluud C. Author information: (1)The Cochrane

Vitamin C and vitamin E for Alzheimer's disease.

6. Ann Pharmacother. 2005 Dec;39(12):2073-80. doi: 10.1345/aph.1E495. Epub 2005 Oct 14. Vitamin C and vitamin E for Alzheimer's disease. Boothby LA(1), Doering PL. Author information: (1)Harrison School of Pharmacy, Auburn University, AL, USA. lisa.boothby@crhs.net OBJECTIVE: To evaluate the l

Vitamin C for preventing and treating the common cold.

7. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD000980. doi: 10.1002/14651858.CD000980.pub2. Vitamin C for preventing and treating the common cold. Douglas RM(1), Hemila H, D'Souza R, Chalker EB, Treacy B. Author information: (1)National Centre for Epidemiology and Population Health, Australian

Randomized Trial to Assess the Safety and Tolerability of Daily Intake of an Allulose Amino Acid-Based Hydration Beverage in Men and Women.

8. Nutrients. 2024 Jun 5;16(11):1766. doi: 10.3390/nu16111766. Randomized Trial to Assess the Safety and Tolerability of Daily Intake of an Allulose Amino Acid-Based Hydration Beverage in Men and Women. Bloomer RJ(1), Pence J(1), Hellenbrand J(1), Davis A(1), Davis S(1), Stockton M(1), Martin KR

Predictive model for vitamin C levels in hyperinsulinemic individuals based on age, sex, waist circumference, low-density lipoprotein, and immune-associated serum proteins.

9. J Nutr Biochem. 2024 Mar;125:109538. doi: 10.1016/j.jnutbio.2023.109538. Epub 2023 Nov 27. Predictive model for vitamin C levels in hyperinsulinemic individuals based on age, sex, waist circumference, low-density lipoprotein, and immune-associated serum proteins. Mahdavi A(1), Leclercq M(1),

Vitamin C mesotherapy versus topical application for gingival hyperpigmentation: a clinical and histopathological study.

10. Clin Oral Investig. 2021 Dec;25(12):6881-6889. doi: 10.1007/s00784-021-03978-6. Epub 2021 May 8. Vitamin C mesotherapy versus topical application for gingival hyperpigmentation: a clinical and histopathological study. El-Mofty M(1)(2), Elkot S(3), Ghoneim A(4), Yossri D(1), Ezzatt OM(5). Au

Ascorbic Acid Enhances the Inhibitory Effect of Theasaponins against Candida albicans.

11. Int J Mol Sci. 2024 Oct 3;25(19):10661. doi: 10.3390/ijms251910661. Ascorbic Acid Enhances the Inhibitory Effect of Theasaponins against Candida albicans. Chen Y(1)(2), Gao Y(1), Yin J(1). Author information: (1)Key Laboratory of Tea Biology and Resources Utilization, Tea Research Institute

Sub-apoptotic dosages of pro-oxidant vitamin cocktails sensitize human melanoma cells to NK cell lysis.

12. Oncotarget. 2015 Oct 13;6(31):31039-49. doi: 10.18632/oncotarget.5024. Sub-apoptotic dosages of pro-oxidant vitamin cocktails sensitize human melanoma cells to NK cell lysis. Tremante E(1), Santarelli L(2), Lo Monaco E(1), Sampaoli C(1), Ingegnere T(1), Guerrieri R(3), Tomasetti M(2), Giacom

Effects of ascorbic acid and α-tocopherol on the therapeutic index of amphotericin B.

13. J Mycol Med. 2014 Dec;24(4):e137-42. doi: 10.1016/j.mycmed.2014.04.003. Epub 2014 Oct 16. Effects of ascorbic acid and α-tocopherol on the therapeutic index of amphotericin B. Belhachemi MH(1), Boucherit K(2), Boucherit-Otmani Z(2), Belmir S(2), Benbekhti Z(2). Author information: (1)Labor

Ascorbic acid partly antagonizes resveratrol mediated heme oxygenase-1 but not paraoxonase-1 induction in cultured hepatocytes - role of the redox-regulated transcription factor Nrf2.

14. BMC Complement Altern Med. 2011 Jan 3;11:1. doi: 10.1186/1472-6882-11-1. Ascorbic acid partly antagonizes resveratrol mediated heme oxygenase-1 but not paraoxonase-1 induction in cultured hepatocytes - role of the redox-regulated transcription factor Nrf2. Wagner AE(1), Boesch-Saadatmandi C,

Luminal antioxidants enhance the effects of mesalamine in the treatment of chemically induced colitis in rats.

15. Exp Biol Med (Maywood). 2008 Oct;233(10):1301-8. doi: 10.3181/0805-RM-140. Epub 2008 Aug 14. Luminal antioxidants enhance the effects of mesalamine in the treatment of chemically induced colitis in rats. Ancha HR(1), Kurella RR, McKimmey CC, Lightfoot S, Harty RF. Author information: (1)Dep

Vitamin C inactivates the proteasome inhibitor PS-341 in human cancer cells.

30. Clin Cancer Res. 2006 Jan 1;12(1):273-80. doi: 10.1158/1078-0432.CCR-05-0503. Vitamin C inactivates the proteasome inhibitor PS-341 in human cancer cells. Zou W(1), Yue P, Lin N, He M, Zhou Z, Lonial S, Khuri FR, Wang B, Sun SY. Author information: (1)Department of Hematology and Oncology, Wi

Biological role of vitamin C in keratinocytes.

29. Nutr Rev. 2005 Mar;63(3):81-90. doi: 10.1111/j.1753-4887.2005.tb00125.x. Biological role of vitamin C in keratinocytes. Catani MV(1), Savini I, Rossi A, Melino G, Avigliano L. Author information: (1)Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata,

Melatonin, xanthurenic acid, resveratrol, EGCG, vitamin C and alpha-lipoic acid differentially reduce oxidative DNA damage induced by Fenton reagents: a study of their individual and synergistic actions.

16. J Pineal Res. 2003 May;34(4):269-77. doi: 10.1034/j.1600-079x.2003.00041.x. Melatonin, xanthurenic acid, resveratrol, EGCG, vitamin C and alpha-lipoic acid differentially reduce oxidative DNA damage induced by Fenton reagents: a study of their individual and synergistic actions. López-Burill

Interaction among vitamin C, vitamin E, and beta-carotene.

23. Am J Clin Nutr. 1995 Dec;62(6 Suppl):1322S-1326S. doi: 10.1093/ajcn/62.6.1322S. Interaction among vitamin C, vitamin E, and beta-carotene. Niki E(1), Noguchi N, Tsuchihashi H, Gotoh N. Author information: (1)Research Center for Advanced Science and Technology, University of Tokyo, Japan. Th

[The effect of elevated amounts of ascorbic acid on the status of the vitamin and lung disorders in guinea pigs inhaling styrene].

11. Probl Khig. 1992;17:137-45. [The effect of elevated amounts of ascorbic acid on the status of the vitamin and lung disorders in guinea pigs inhaling styrene]. [Article in Bulgarian] Petrova S, Mikhaĭlova A, Donchev N. An inhalation intoxication with styrene is performed on guinea pigs--600

Benefits of combination therapy of hydrocortisone, ascorbic acid and thiamine in sepsis and septic shock: A systematic review.

40. Nutr Health. 2022 Mar;28(1):77-93. doi: 10.1177/02601060211018371. Epub 2021 May 26. Benefits of combination therapy of hydrocortisone, ascorbic acid and thiamine in sepsis and septic shock: A systematic review. Lee YR(1), Vo K(1), Varughese JT(1). Author information: (1)Department of Pharm

The effects of surgery on plasma/serum vitamin C concentrations: a systematic review and meta-analysis.

37. Br J Nutr. 2022 Jan 28;127(2):233-247. doi: 10.1017/S0007114520004353. Epub 2020 Nov 4. The effects of surgery on plasma/serum vitamin C concentrations: a systematic review and meta-analysis. Travica N(1)(2), Ried K(2)(3)(4), Hudson I(1)(5)(6), Scholey A(1), Pipingas A(1), Sali A(2). Autho

The Effect of Vitamin C (Ascorbic Acid) in the Treatment of Patients with Cancer: A Systematic Review.

49. Nutrients. 2019 Apr 28;11(5):977. doi: 10.3390/nu11050977. The Effect of Vitamin C (Ascorbic Acid) in the Treatment of Patients with Cancer: A Systematic Review. van Gorkom GNY(1), Lookermans EL(2), Van Elssen CHMJ(3), Bos GMJ(4). Author information: (1)Division of Hematology, Department of

Control of naive T cell reactivity and peripheral tolerance by ascorbate and TET activity.

1. Sci Adv. 2026 Jun 19;12(25):eaeh1439. doi: 10.1126/sciadv.aeh1439. Epub 2026 Jun 17. Control of naive T cell reactivity and peripheral tolerance by ascorbate and TET activity. Hao X(1), Bai L(1), Li J(1), Xu B(2), Janke LJ(3), Palacios G(1), Guy C(1), Crawford JC(4), Fan Y(2), Rosikiewicz W(2), Keith J(1), Le H(3), He M(1), Yang D(3), Steele JA(5), Pruett-Miller SM(5), Cheng Y(6), Hanna JH(7), Geiger T(1)(3), Feng Y(1). Author information: (1)Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. (2)Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. (3)Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. (4)Department of Host Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN 38105. (5)Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. (6)Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. (7)Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel. Peripheral tolerance depends on limiting conventional T cell responses to self-antigens. To define the contribution of nutritional factors and related epigenetic regulation, we perform in vivo CRISPR screening and identify the ascorbate transporter Slc23a2 as a key regulator of naive T cell (Tn) reactivity. T cell-specific loss of Slc23a2 reduces intrace

Total Sanghuangporus vaninii Extract Ameliorates Cisplatin-Induced Glioma Cell Death by Regulating Ferroptosis and Inflammation.

2. Dose Response. 2026 Jun 12;24(2):15593258261454529. doi: 10.1177/15593258261454529. eCollection 2026 Apr-Jun. Total Sanghuangporus vaninii Extract Ameliorates Cisplatin-Induced Glioma Cell Death by Regulating Ferroptosis and Inflammation. Xu Y(1), Zhou J(1), Zhou X(1), Li Y(1), Yang S(1), Xue Z(1). Author information: (1)Department of Neurosurgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China. OBJECTIVES: Ferroptosis is a distinct form of programmed cell death characterized by iron (Fe)-dependent oxidative stress and the accumulation of intracellular reactive oxygen species. Cisplatin (CPT), a chemotherapeutic agent, can induce ferroptosis in glioma cells and act synergistically with erastin (EST). The total extract of the fungus Sanghuangporus vaninii (TSV) has anticancer and antioxidant activities. This investigation aimed to assess the properties of TSV on CPT-induced inflammatory response and ferroptosis-related changes in glioma cells. METHODS: LNZ308 glioma cells were exposed to CPT and EST, followed by treatment with different TSV concentrations. Cell viability was assessed. Intracellular reactive oxygen species (ROS), glutathione peroxidase 4 (GPX4), glutathione (GSH), labile iron pool (LIP), LPO, interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) were examined, and cell migration was assessed using a scratch assay. RESULTS: TSV (25 µg/mL) exhibited limited toxicity to

The janus-faced extracellular matrix remodeling in acute lung injury: a gatekeeper of macrophage localization and phenotype.

3. Sci China Life Sci. 2026 May 22. doi: 10.1007/s11427-025-3274-2. Online ahead of print. The janus-faced extracellular matrix remodeling in acute lung injury: a gatekeeper of macrophage localization and phenotype. Xie F(#)(1), Sun Y(#)(1), Wei X(#)(1), Zhang W(1), Luo W(1), Huang J(1), Fang S(2), Zhang X(3), Qiu H(4), Chao J(5)(6). Author information: (1)Jiangsu Provincial Key Laboratory of Critical Care Medicine, Zhongda Hospital, Department of Physiology, School of Medicine, Southeast University, Nanjing, 210009, China. (2)Department of Respiratory Medicine, Nanjing Chest Hospital, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, 210009, China. (3)Jiangsu Provincial Key Laboratory of Critical Care Medicine, Zhongda Hospital, Department of Physiology, School of Medicine, Southeast University, Nanjing, 210009, China. dky_dl_11@163.com. (4)Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China. haiboq2000@163.com. (5)Jiangsu Provincial Key Laboratory of Critical Care Medicine, Zhongda Hospital, Department of Physiology, School of Medicine, Southeast University, Nanjing, 210009, China. chaojie@seu.edu.cn. (6)Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China. chaojie@seu.edu.cn. (#)Con

Evaluation the reno-protective effect of tadalafil alone and in combination with ascorbic acid in AKI model in rats.

4. J Basic Clin Physiol Pharmacol. 2026 May 18. doi: 10.1515/jbcpp-2026-0077. Online ahead of print. Evaluation the reno-protective effect of tadalafil alone and in combination with ascorbic acid in AKI model in rats. Salih TM(1), Bashara M(1). Author information: (1)Medicine College, Babylon University, Hillah, Iraq. BACKGROUND: Acute kidney injury (AKI) is associated with increased morbidity, prolonged hospitalization, and mortality, particularly in high-risk patients. OBJECTIVES: This study aimed to evaluate the potential reno-protective effects of Tadalafil, a selective phosphodiesterase-5 (PDE-5) inhibitor, alone and in combination with ascorbic acid, in a cisplatin-induced AKI rat model. METHODS: Thirty male albino rats (250-300 g) were randomly divided into five groups: control (A), cisplatin-treated (B), ascorbic acid-treated (100 mg/kg) (C), Tadalafil-treated (5 mg/kg) (D), and combined ascorbic acid + Tadalafil (E). Treatments were administered for 10 days prior to a single intraperitoneal dose of cisplatin (10 mg/kg). After 72 h, blood and kidney tissue samples were collected for biochemical and histopathological analyses. Serum urea and creatinine, as well as renal tissue levels of NGAL, SOD, and TNF-α, were evaluated. RESULTS: Cisplatin significantly increased urea, creatinine, TNF-α, and NGAL levels, while reducing SOD compared to control. Pre-treatment with Tadalafil, alone or in combination with ascorbic acid, significantly ameliorated these

Mesoporous platinum nanoparticles as high-performance antioxidant and anti-inflammatory nanozymes.

5. J Colloid Interface Sci. 2026 Oct 15;720:140695. doi: 10.1016/j.jcis.2026.140695. Epub 2026 May 5. Mesoporous platinum nanoparticles as high-performance antioxidant and anti-inflammatory nanozymes. Migliavacca M(1), Brescia R(2), Pedone D(3), Gatto F(3), Pomili T(2), Bujedo-Saiz E(4), Solla-Gullón J(4), Moglianetti M(5), Pompa PP(6). Author information: (1)College of Optical Science and Engineering, Zhejiang University, Hangzhou 310058, China; Nanobiointeractions & Nanodiagnostics, Istituto Italiano di Tecnologia (IIT), Via Morego 30, Genova 16163, Italy. (2)Electron Microscopy Facility, Istituto Italiano di Tecnologia (IIT), Via Morego 30, Genova 16163, Italy. (3)Nanobiointeractions & Nanodiagnostics, Istituto Italiano di Tecnologia (IIT), Via Morego 30, Genova 16163, Italy. (4)Institute of Electrochemistry, University of Alicante, Apdo. 99, E-03080 Alicante, Spain. (5)Nanobiointeractions & Nanodiagnostics, Istituto Italiano di Tecnologia (IIT), Via Morego 30, Genova 16163, Italy; Center for Cultural Heritage Technology CCHT, Istituto Italiano di Tecnologia (IIT), Via Torino 155, Venezia Mestre 30172, Italy. Electronic address: mauro.moglianetti@iit.it. (6)College of Optical Science and Engineering, Zhejiang University, Hangzhou 310058, China; Nanobiointeractions & Nanodiagnostics, Istituto Italiano di Tecnologia (IIT), Via Morego 30, Genova 16163, Italy. Electronic address: pierpaolo.pompa@iit.it. Mesoporous platinum nanoarchitectures are attractive fun

Insights of traditional Indian anti-aging herbal beverages, network pharmacology, and perspectives.

6. Ageing Res Rev. 2026 Jul;119:103154. doi: 10.1016/j.arr.2026.103154. Epub 2026 Apr 29. Insights of traditional Indian anti-aging herbal beverages, network pharmacology, and perspectives. Joshi DD(1), Thorat SS(2), Deb L(3), Rana VS(4), Kharkwal H(5). Author information: (1)Himalayans Herbs Research and Cultural Welfare Society, D-109, Swarn Jayanti Puram, Ghaziabad, Uttar Pradesh 201013, India. Electronic address: drddjoshi@gmail.com. (2)Institute of Bioresources and Sustainable Development (IBSD), Node Mizoram, A-1, C/o P. Lalthangzauva Building, Chawnga Road, Nursery Veng, Aizawl, Mizoram 796005, India. Electronic address: sunilthorat@gmail.com. (3)Institute of Bioresources and Sustainable Development (IBSD)-Regional Centre, Sikkim, 5th Mile, Tadong, Gangtok, Sikkim 737102, India. Electronic address: lokeshdeb@gmail.com. (4)Division of Agricultural Chemicals, Indian Agricultural Research Institute (ICAR), Pusa Campus, New Delhi 110012, India. Electronic address: ranavs2008@yahoo.com. (5)Ministry of Environment, Forest and Climate Change, Indira Pryavaran Bhawan, Jor Bagh Road, New Delhi 110003, India. Electronic address: h.kharkwal@nic.in. Plants have served as important sources of medicine since prehistoric times, forging a strong connection between humans and their environment. This relationship has yielded valuable insights into the therapeutic use of herbs for various health conditions. The current study aims to gather scientific evidence about tra

Astaxanthin-ascorbyl palmitate co-loaded transfersomes: Targeting oxidative stress and inflammation.

7. Colloids Surf B Biointerfaces. 2026 Sep;265:115739. doi: 10.1016/j.colsurfb.2026.115739. Epub 2026 Apr 20. Astaxanthin-ascorbyl palmitate co-loaded transfersomes: Targeting oxidative stress and inflammation. Srnec A(1), Kašpárková V(2), Vašíček O(3), Urbánková L(4), Kadlečková M(1), Martínková M(1), Humpolíček P(5). Author information: (1)Centre of Polymer Systems, Tomas Bata University in Zlín, tř. Tomáše Bati 5678, Zlín 760 01, Czech Republic. (2)Centre of Polymer Systems, Tomas Bata University in Zlín, tř. Tomáše Bati 5678, Zlín 760 01, Czech Republic; Department of Fat, Surfactant and Cosmetics Technology, Faculty of Technology, Tomas Bata University in Zlín, nám . T. G. Masaryka 5555, Zlín 760 01, Czech Republic. (3)Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, Brno 612 00, Czech Republic. (4)Department of Fat, Surfactant and Cosmetics Technology, Faculty of Technology, Tomas Bata University in Zlín, nám . T. G. Masaryka 5555, Zlín 760 01, Czech Republic. (5)Centre of Polymer Systems, Tomas Bata University in Zlín, tř. Tomáše Bati 5678, Zlín 760 01, Czech Republic; Department of Fat, Surfactant and Cosmetics Technology, Faculty of Technology, Tomas Bata University in Zlín, nám . T. G. Masaryka 5555, Zlín 760 01, Czech Republic. Electronic address: humpolicek@utb.cz. Astaxanthin, a potent antioxidant carotenoid, exhibits significant therapeutic potential, however its broader biomedical application is limited by chemical

Individual oxidative stress and inflammation responses to vitamin C supplementation: Aggregated sets of n-of-1 trials.

8. Free Radic Biol Med. 2026 Jul;250:274-283. doi: 10.1016/j.freeradbiomed.2026.03.073. Epub 2026 Apr 2. Individual oxidative stress and inflammation responses to vitamin C supplementation: Aggregated sets of n-of-1 trials. Nastos GG(1), Lolli L(2), Atkinson G(3), Theodorou AA(4), Paschalis V(5), Kyparos A(1), Nikolaidis MG(1), Margaritelis NV(6). Author information: (1)Department of Physical Education and Sports Science at Serres, Aristotle University of Thessaloniki, Serres, Greece. (2)Department of Sport and Exercise Sciences, Institute of Sport, Manchester Metropolitan University, Manchester, United Kingdom. (3)School of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom. (4)Department of Life Sciences, School of Sciences, European University Cyprus, Nicosia, Cyprus. (5)School of Physical Education and Sport Science, National and Kapodistrian University of Athens, Athens, Greece. (6)Department of Physical Education and Sports Science at Serres, Aristotle University of Thessaloniki, Serres, Greece. Electronic address: nvmargar@auth.gr. BACKGROUND: Personalized antioxidant supplementation is promoted to optimize redox balance and inflammation profile. OBJECTIVE: To quantify the short-term effects of vitamin C supplementation on redox and inflammatory outcome measures and explore the potential for supplement response heterogeneity in participants with vitamin C inadequacy through aggregated sets of multi-cycle n-of-1 tr

Tendon homeostasis and regeneration: Interplay of cells, immune response, and bioactive compounds.

9. Mech Ageing Dev. 2026 Jun;231:112180. doi: 10.1016/j.mad.2026.112180. Epub 2026 Apr 1. Tendon homeostasis and regeneration: Interplay of cells, immune response, and bioactive compounds. Mencarelli N(1), Carradori S(2), Gallorini M(3). Author information: (1)Department of Pharmacy, "G. d'Annunzio" University of Chieti-Pescara, Via dei Vestini 31, Chieti 66100, Italy. Electronic address: noemi.mencarelli@phd.unich.it. (2)Department of Pharmacy, "G. d'Annunzio" University of Chieti-Pescara, Via dei Vestini 31, Chieti 66100, Italy; UdA-TechLab, "G. d'Annunzio", University of Chieti-Pescara, Chieti 66100, Italy. Electronic address: simone.carradori@unich.it. (3)Department of Pharmacy, "G. d'Annunzio" University of Chieti-Pescara, Via dei Vestini 31, Chieti 66100, Italy. Electronic address: marialucia.gallorini@unich.it. Tendons are specialized connective tissues that transmit mechanical forces from muscle to bone, ensuring joint stability and efficient locomotion. Their homeostasis and regenerative capacity depend on the interplay between extracellular matrix (ECM), resident and recruited cell populations, and immune-mediated signaling. This review provides an overview of tendon structure and composition, emphasizing the collagen-based organization and the functional role of non-collagenous matrix components in mechanotransduction and cell signaling. The heterogeneity of tendon-resident cells, including tenocytes, tendon stem/progenitor cells, and vascular-

Targeting cholinergic dysfunction and neuroinflammation through rationally designed Thieno[3,2-d]pyrimidine hybrids.

10. Bioorg Chem. 2026 Jul 5;175:109778. doi: 10.1016/j.bioorg.2026.109778. Epub 2026 Mar 19. Targeting cholinergic dysfunction and neuroinflammation through rationally designed Thieno[3,2-d]pyrimidine hybrids. Tokalı FS(1), Acar OO(2), Demir Y(3), Şenol H(4), Acar B(5), Çakır F(4), Sen A(6). Author information: (1)Department of Material and Material Processing Technologies, Kars Vocational School, Kafkas University, 36100 Kars, Türkiye. Electronic address: feyzitokali@gmail.com. (2)Health Services Vocational School of Higher Education, Pamukkale University, 20070, Denizli, Turkey. (3)Department of Pharmacy Services, Nihat Delibalta Göle Vocational High School, Ardahan University, 75700 Ardahan, Türkiye; Department of Chemistry, Faculty of Science, Ataturk University, 25240 Erzurum, Türkiye. (4)Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bezmialem Vakif University, 34093 Fatih, Istanbul, Türkiye. (5)Department of Molecular Biology & Genetics, Faculty of Life & Natural Sciences, Abdullah Gül University, 38080 Kayseri, Türkiye. (6)Department of Molecular Biology & Genetics, Faculty of Life & Natural Sciences, Abdullah Gül University, 38080 Kayseri, Türkiye; Department of Biology, Faculty of Sciences, Pamukkale University, 20070 Kinikli, Denizli, Türkiye. Electronic address: sena@pau.edu.tr. Neurodegenerative diseases involve the convergence of cholinergic dysfunction, neuronal loss, and sustained neuroinflammatory responses, necessitating the

Effect of vitamin C supplementation on periodontal inflammation and oxidative stress in cigarette-smoke-exposed rats with periodontitis.

11. Eur J Oral Sci. 2026 Jun;134(3):e70080. doi: 10.1111/eos.70080. Epub 2026 Mar 12. Effect of vitamin C supplementation on periodontal inflammation and oxidative stress in cigarette-smoke-exposed rats with periodontitis. Ilday I(1), Olgac NV(2), Bingul I(3), Baser U(1), Aykol-Sahin G(4), Isik G(1). Author information: (1)Department of Periodontology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey. (2)Oncology Institute, Department of Tumor Pathology and Oncological Cytology, Istanbul University, Istanbul, Turkey. (3)Department of Istanbul University Medical Biochemistry Department, Istanbul University, Istanbul, Turkey. (4)Department of Periodontology, Faculty of Dentistry, Istanbul Okan University, Istanbul, Turkey. This study examined the effects of vitamin C on oxidative stress, antioxidant levels, and periodontal inflammation in a rat model of periodontitis exposed to cigarette smoke. Periodontitis was induced in 30 male Wistar albino rats using ligatures on maxillary second molars. All groups underwent 15 days of smoke exposure, which was then continued for another 15 days in the smoking-only (SO) and smoking + vitamin C. The vitamin C group received 200 mg/kg/day of intraperitoneal vitamin C; the saline group received 0.9% NaCl. On Day 28, rats were euthanized for biochemical and immunohistochemical analyses. The SO group showed significantly elevated cotinine and tumor necrotizing factor-α levels. Reactive oxygen species, thiobarbituri

Relationship between Prostate Cancer and Benign Hyperplasia: Role of Inflammation-Induced Oxidative Stress, Vitamin C, and Epigenetics.

12. World J Mens Health. 2026 Jul;44(3):572-581. doi: 10.5534/wjmh.250116. Epub 2025 Aug 6. Relationship between Prostate Cancer and Benign Hyperplasia: Role of Inflammation-Induced Oxidative Stress, Vitamin C, and Epigenetics. Zarakowska E(#)(1), Guz J(#)(1), Gackowski D(1), Olinski R(2). Author information: (1)Department of Clinical Biochemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland. (2)Department of Clinical Biochemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland. ryszardo@cm.umk.pl. (#)Contributed equally Comment in World J Mens Health. 2026 Jul;44(3):749-750. doi: 10.5534/wjmh.250314. Benign prostatic hyperplasia and prostate cancer (PC) frequently affect aging men, both involving irregular cell growth in the prostate. Inflammation is a major contributor to these conditions, whereas DNA methylation and hydroxymethylation are specifically involved in PC development. In this review, we address several potential factors influencing the progression of PC, including DNA epigenetic marks, ascorbate (vitamin C) concentration in the blood plasma, and its intracellular levels in leukocytes and prostate tissues. Moreover, a new aspect concerning the involvement of leukocytes (white blood cells) in PC formation will also be discussed, highlighting their potential utility for assessing early PC development through a m

Hank's Balanced Salt Solution Supplemented With L-Ascorbic Acid Modulates Periodontal Ligament Cell Inflammation and Regenerative Responses: An In Vitro and Ex Vivo Study.

1. Dent Traumatol. 2026 Aug 5. doi: 10.1111/edt.70107. Online ahead of print. Hank's Balanced Salt Solution Supplemented With L-Ascorbic Acid Modulates Periodontal Ligament Cell Inflammation and Regenerative Responses: An In Vitro and Ex Vivo Study. Poh LF(1), Abdullah D(1), Ng SL(2), Soo E(1), Liew AKC(3). Author information: (1)Department of Restorative Dentistry, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. (2)Department of Craniofacial Diagnostic & Biosciences, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. (3)Department of Family Oral Health, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. BACKGROUND: Successful management of an avulsed tooth depends on preserving periodontal ligament viability during the extraoral period. Although Hank's Balanced Salt Solution (HBSS) is recommended for storage of avulsed teeth, it lacks bioactive components that actively support tissue repair. This study evaluated whether supplementation with L-ascorbic acid (L-AA) could enhance biological responses associated with periodontal healing. MATERIAL AND METHODS: Complementary in vitro and ex vivo models were used. Cultured human periodontal ligament cells were exposed to HBSS, HBSS supplemented with L-AA, or Dulbecco's Modified Eagle Medium containing fetal bovine serum. Wound closure, inflammatory cytokine expression, matrix metalloproteinase expression, and collagen type I alpha

Ascorbic acid attenuates obesity induced myogenic impairment in C2C12 cells.

2. Life Sci. 2026 Aug 3;403:124612. doi: 10.1016/j.lfs.2026.124612. Online ahead of print. Ascorbic acid attenuates obesity induced myogenic impairment in C2C12 cells. Pinto JR(1), Bhat K D(1), Bose B(2), Shenoy P S(3). Author information: (1)Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya Deemed to be University, Deralakatte, Mangalore, Karnataka, 575018, India. (2)Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya Deemed to be University, Deralakatte, Mangalore, Karnataka, 575018, India. Electronic address: bipasha.bose@yenepoya.edu.in. (3)Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya Deemed to be University, Deralakatte, Mangalore, Karnataka, 575018, India. Electronic address: shenoy@yenepoya.edu.in. AIM: Obesity is commonly associated with skeletal muscle atrophy and is attributed to chronic inflammation, oxidative stress, and impaired adipose-muscle cross talk. Ascorbic acid, a potent antioxidant and its role in obesity induced muscle atrophy is not clearly understood. Hence, the aim of the study was to rescue obesity induced skeletal muscle atrophy with ascorbic acid in vitro. MATERIALS AND METHODS: C3H10T1/2 mesenchymal stem cells were developed into obesogenic adipocytes by palmitic acid treatment to generate obesogenic adipocyte-conditioned media (ObCM). C2C12 myoblasts and differentiated myotubes were treated with ObCM in the presence or absence of ascor

Vitamin C-Beyond Deficiency: Mechanisms, Clinical Applications, Formulation and Dosing Considerations, and Safety Across Stress-Responsive Conditions.

3. Nutrients. 2026 Jul 15;18(14):2319. doi: 10.3390/nu18142319. Vitamin C-Beyond Deficiency: Mechanisms, Clinical Applications, Formulation and Dosing Considerations, and Safety Across Stress-Responsive Conditions. Yoon Y(1)(2)(3), Hwang J(1), Yang CM(4), Kim S(3)(5), Lee J(3)(6), Lee JJ(7), Moon M(8), Lam KHS(3)(9)(10)(11). Author information: (1)Department of Orthopaedic Surgery, Gangnam Sacred Heart Hospital, Hallym University College of Medicine, 1 Singil-ro, Yeongdeungpo-gu, Seoul 07441, Republic of Korea. (2)Incheon Terminal Orthopedic Surgery Clinic, Inha-ro 489 beon-gil, Namdong-gu, Incheon 21574, Republic of Korea. (3)International Academy of Regenerative Medicine, Inha-ro 489 beon-gil, Namdong-gu, Incheon 21574, Republic of Korea. (4)Department of Psychiatry, Wonkwang University Hospital, Wonkwang University School of Medicine, Iksan 54538, Republic of Korea. (5)Miso Pain Clinic, 1569, Bongyeong-ro, Yeongtong-gu, Suwon-si 16703, Republic of Korea. (6)Bareun Neurosurgery Clinic, 39, Daenong-ro, Heungdeok-gu, Cheongju-si 28402, Republic of Korea. (7)Ceramique Clinic, Seoul 06123, Republic of Korea. (8)Naeuram Clinic, Seoul 06611, Republic of Korea. (9)The Department of Clinical Research, International Academy of Musculoskeletal Medicine, Hong Kong, China. (10)Faculty of Medicine, The University of Hong Kong, Hong Kong, China. (11)Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. Vitamin C (L-ascorbic acid) is an essential micron

Vitamin C as an Adjunctive Therapy in Cancer: A Systematic Review and Meta-Analysis of Outcomes in Solid and Hematologic Malignancies.

4. Am J Clin Oncol. 2026 Jul 24. doi: 10.1097/COC.0000000000001353. Online ahead of print. Vitamin C as an Adjunctive Therapy in Cancer: A Systematic Review and Meta-Analysis of Outcomes in Solid and Hematologic Malignancies. Shahzad M(1), Amin MK(2), Javed HMH(3), Kasaeian A(4), Sattar Z(2), Zeidkilani J(5), Oskouie IM(6), Irfan S(7), Sehar R(8), Warraich SZ(9), Mushtaq MU(2), Jaglal M(1). Author information: (1)H. Lee Moffitt Cancer Center, Tampa, FL. (2)University of Kansas Medical Center, Kansas City, KS. (3)Tidal Health Peninsula Regional, Salisbury, MD. (4)Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute. (5)MercyOne Siouxland Medical Center, Sioux City, IA. (6)Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran. (7)The Aga Khan University, Karachi. (8)Allama Iqbal Medical College, Lahore, Pakistan. (9)Medical University Lleida, Spain. OBJECTIVES: Vitamin C has gained interest as an adjunctive treatment in oncology due to its antioxidant effects, potential to enhance cancer therapy, and ability to improve quality of life. This systematic review and meta-analysis aimed to assess the therapeutic impact of vitamin C in patients with solid and hematologic malignancies. METHODS: A comprehensive search was conducted in PubMed, Cochrane, Embase, ClinicalTrials.gov, and Google Scholar from inception to August 2025, in accordance with PRISMA guidelines. A total of 43 studies were included, with 19

High-Dose Intravenous Vitamin C in Critical Illness: A Translational Exposure-Response Framework for Biomarker-Guided Precision Therapy.

5. Med Sci (Basel). 2026 Jul 17;14(3):400. doi: 10.3390/medsci14030400. High-Dose Intravenous Vitamin C in Critical Illness: A Translational Exposure-Response Framework for Biomarker-Guided Precision Therapy. Bajić D(1), Andrijević L(1), Todorović N(2), Lalić-Popović M(2)(3), Zarić B(4)(5), Dimić S(1), Stojčević Maletić J(1)(6), Lendak D(6)(7), Milijašević B(8), Milošević N(2). Author information: (1)Department of Biochemistry, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia. (2)Department of Pharmacy, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia. (3)Centre for Medical and Pharmaceutical Investigations and Quality Control (CEMPhIC), Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia. (4)Institute for Pulmonary Diseases of Vojvodina, 21204 Sremska Kamenica, Serbia. (5)Department of Internal Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia. (6)Department of Infectious Diseases, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia. (7)Clinic for Infectious Diseases, University Clinical Center of Vojvodina, 21000 Novi Sad, Serbia. (8)Department of Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia. High-dose intravenous vitamin C (HDIVC) has been investigated as a potential adjunctive therapy in critical illness, including sepsis, acute respiratory distress syndrome (ARDS), and COVID-19. Despite a strong me

Topical hyaluronic acid serum, oral vitamin C, and their combined regimen modulate collagen-related repair indices in a sutured primary-intention rat incisional wound model.

6. J Mol Histol. 2026 Jul 25;57(4):245. doi: 10.1007/s10735-026-10911-2. Topical hyaluronic acid serum, oral vitamin C, and their combined regimen modulate collagen-related repair indices in a sutured primary-intention rat incisional wound model. Abdelrazek SMM(1), Ibrahim OY(2), Farrag MS(3), Hemada MS(4). Author information: (1)Department of Histology, Faculty of Medicine, Damietta University, Damietta, Egypt. (2)Department of Histology and Cell Biology, Faculty of Medicine, Zagazig University, Zagazig, Egypt. (3)Department of Pathology, Faculty of Medicine, Port Said University, Port Said, Egypt. m.saad@med.psu.edu.eg. (4)Department of Forensic Medicine & Clinical Toxicology, Faculty of Medicine, Port Said University, Port Said, Egypt. Healing a skin wound is a complex biological process that proceeds through three stages: inflammation, proliferation, and remodeling. Hyaluronic acid (HA) and vitamin C may help tissues heal in different but complementary ways. This study aimed to examine and compare the effects of HA and vitamin C, alone and in combination, on collagen-related histological and immunohistochemical repair indices at day 22 in a rat sutured incisional wound model. Twenty adult male albino rats were divided into four equal groups (n = 5/group) at random: the control, vitamin C-treated, HA-treated, and combined HA + vitamin C-treated groups. Each animal received a standardized sutured full-thickness cutaneous incision to model primary-intentio

Experimental analysis and genome mining for functional validation of genes associated with anti-inflammatory, antioxidant, and antibacterial activities in Kurthia gibsonii VITAM20.

7. Front Pharmacol. 2026 Jul 3;17:1799206. doi: 10.3389/fphar.2026.1799206. eCollection 2026. Experimental analysis and genome mining for functional validation of genes associated with anti-inflammatory, antioxidant, and antibacterial activities in Kurthia gibsonii VITAM20. Ashokan AK(1), Vaithilingam M(1). Author information: (1)School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India. INTRODUCTION: The identification of microbial strains harbouring bioactive genes is important for the discovery of novel therapeutic agents. The study objective was to identify the genes in Kurthia gibsonii VITAM20 that are associated with anti-inflammatory and antioxidant properties and validate these findings with in vitro functional assays. METHODS: Genes associated with anti-inflammatory and antioxidant activities were identified by BLAST analysis against curated databases. The anti-inflammatory, antioxidant, and antibacterial potential of Kurthia gibsonii VITAM20 were subsequently evaluated using in vitro assays. RESULTS: BLAST analysis identified several genes associated with anti-inflammatory properties, including eps (95.455%), NEMO (100%), spa (100%), and spaB (90.625%). Multiple genes associated with antioxidant potential were also detected, including CAT (92.308%), dps (95.238%), gshR3 (91.304%), gshR4 (100%), KATA (100%), oxyR (100%), KatA (88.462%), perR (74.041%, bit score 126), sodA (100%), sodM (76.471%), and trxA (7

Impact of Co-Supplementation of Gallic Acid With Vitamin C on Oxidant Stress, Inflammation, Hepatic and Renal Histology of Type 2 Diabetic Rats Induced With Fructose and Streptozotocin.

8. Physiol Res. 2026 Jul 17;75(3):471-483. Impact of Co-Supplementation of Gallic Acid With Vitamin C on Oxidant Stress, Inflammation, Hepatic and Renal Histology of Type 2 Diabetic Rats Induced With Fructose and Streptozotocin. Yan S(1), Xiang X, Hua W. Author information: (1)Department of Endocrinology, Huaihe Hospital of Henan University, Kaifeng, China, Department of Nephrology, The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing, China. 302728055hw@sina.com. This study assessed the impact of gallic acid plus vitamin C on systemic oxidant stress, inflammation, hepatic and renal histology of rats with type 2 diabetes mellitus. Twenty five albino male rats were allotted into five categories of five rats each and treated hereafter as: control and diabetic group (fed rat diets and water), vitamin C (diabetic treated rats administered vitamin C, 50 mg/kg), gallic acid (diabetic treated rats administered gallic acid at 20 mg/kg), gallic acid plus vitamin C (diabetic treated rats administered 20 mg/kg gallic acid and 50 mg/kg vitamin C). The study duration was forty two days. The diabetic group had significant raise (P<0.05) of fasting glucose, glycated hemoglobin, insulin resistance scores, oxidative stress and inflammatory markers (in the liver, kidney and serum), alteration of relative liver and kidney weights, liver and kidney function indices, significant decrease (P<0.05) in total hemoglobin, serum insulin, insulin s

Hierarchical microtopology and phase-specific delivery functionally restore ultralong nerve continuity across species.

9. Sci Adv. 2026 Jul 3;12(27):eaeb7931. doi: 10.1126/sciadv.aeb7931. Epub 2026 Jul 1. Hierarchical microtopology and phase-specific delivery functionally restore ultralong nerve continuity across species. Dai S(1)(2), Li F(2), Bao Z(1), Yang Z(2), Wang J(3), Liu L(4), Jia M(2), Wang S(2), Zhang Z(1), Wang X(5), Zhao Y(6), Midgley AC(2), Yang Y(7), Fan M(1), Kong D(1)(2)(8), Dong X(2). Author information: (1)Department of Orthopaedics, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China. (2)State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin, China. (3)Outpatient Department, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China. (4)Department of Radiology, Tianjin First Central Hospital, Tianjin Medical Imaging Institute, School of Medicine, Nankai University, Tianjin, China. (5)Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA. (6)Senior Department of Orthopedics, The Fourth Medical Center of the PLA General Hospital, Beijing, China. (7)Jiangsu Key Laboratory of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, China. (8)Nankai Internationa

Monotherapy or combinations? Intravenous vitamin C in sepsis and septic shock: An umbrella review of 31 systematic reviews.

10. PLoS One. 2026 Jul 1;21(7):e0351072. doi: 10.1371/journal.pone.0351072. eCollection 2026. Monotherapy or combinations? Intravenous vitamin C in sepsis and septic shock: An umbrella review of 31 systematic reviews. Vera-Ponce VJ(1), Ballena-Caicedo J(1), Valladolid-Sandoval LAM(1), Zuzunaga-Montoya FE(1), Acosta-Porzoliz R(2)(3), Rivera-Lozada O(4), Valladares-Garrido MJ(4)(5). Author information: (1)Facultad de Medicina (FAMED), Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas (UNTRM), Amazonas, Perú. (2)Facultad de Medicina Humana, Universidad Peruana Cayetano Heredia (UPCH), Lima, Perú. (3)EpiHealth Research Center for Epidemiology and Public Health, Lima, Perú. (4)Vicerrectorado de Investigación, Universidad Señor de Sipán, Chiclayo, Perú. (5)Oficina de Inteligencia Sanitaria, Red Prestacional EsSalud Lambayeque, Chiclayo, Perú. Intravenous (IV) vitamin C has been proposed as an adjuvant therapy in sepsis/septic shock due to its biological plausibility and safety profile, but the proliferation of reviews has not resolved its clinical utility. To synthesize the evidence on IV vitamin C (monotherapy, HAT-hydrocortisone+vitamin C+thiamine-and vitamin C+thiamine) in adults with sepsis/septic shock, prioritizing 28-30-day mortality. Umbrella review of systematic reviews and meta-analyses (MEDLINE/PubMed, Embase, Scopus, and Web of Science, without language restriction). Quality was assessed with AMSTAR 2, overlap with CCA, and when available,

Circulating metabolomic profile and its association with atrial fibrillation and systemic inflammation.

11. Heart Rhythm O2. 2026 Mar 19;7(6):1086-1094. doi: 10.1016/j.hroo.2026.03.009. eCollection 2026 Jun. Circulating metabolomic profile and its association with atrial fibrillation and systemic inflammation. Thakur U(1)(2), Figgett W(3), Deliyanti D(4), Hawson J(1), Anderson R(1)(2), Chieng D(5)(6), Kummerfeld S(3), Kistler PM(2)(5)(6), McLellan A(1), Lee G(1)(2), Mackay F(7), Joseph S(1), Kalman JM(1)(2), Al-Kaisey A(1)(2). Author information: (1)Department of Cardiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia. (2)Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia. (3)Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia. (4)Department of Anatomy and Physiology, University of Melbourne, Victoria, Australia. (5)Heart Centre, Alfred Hospital, Melbourne, Victoria, Australia. (6)Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia. (7)QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. BACKGROUND: Atrial fibrillation (AF) is a prevalent arrhythmia associated with chronic inflammation and metabolic dysregulation. Metabolic and inflammatory pathways may influence atrial electrophysiology and structural remodeling, contributing to AF onset and persistence, yet key circulating signatures remain poorly defined. OBJECTIVE: The purpose of this study was to characterize systemic inflammatory markers and circulating metabolomic profiles in patients with paroxys

Scurvy in Children With Autism Spectrum Disorder: Dental Implications and Clinical Considerations.

12. Spec Care Dentist. 2026 Jul-Aug;46(4):e70202. doi: 10.1111/scd.70202. Scurvy in Children With Autism Spectrum Disorder: Dental Implications and Clinical Considerations. Moskowitz HS(1), Yeroshalmi F(1)(2), Park JH(1)(2), Van Eyndhoven L(1)(2), Ahmed R(2)(3). Author information: (1)Department of Pediatric Dentistry, NYC Health and Hospitals | Jacobi, Bronx, New York, USA. (2)Albert Einstein College of Medicine, Bronx, New York, USA. (3)Department of Pediatrics, NYC Health and Hospitals | Jacobi, Bronx, New York, USA. Vitamin C deficiency also known as scurvy, can present with musculoskeletal pain, gingival bleeding, oral discomfort, and impaired mobility. Children with Autism Spectrum Disorder (ASD) are at increased risk of vitamin C and other nutritional deficiencies due to sensory sensitivity and food selectivity. This report aims to describe two pediatric patients with nonverbal ASD who presented with oral and systemic symptoms. These cases highlight the importance of obtaining a detailed dietary history and complete examination when evaluating unexplained oral bleeding, gingival inflammation, and limb pain in children with ASD. Interdisciplinary collaboration among pediatric medicine, dentistry, and specialists is essential to ensure timely diagnosis and avoid unnecessary interventions. Increased clinical awareness of nutritional deficiencies and their oral manifestations can improve outcomes and reduce diagnostic delays in this vulnerable populatio

Protective Effects of Momordica charantia Extract on Dexamethasone-Induced Sarcopenic Changes in C2C12 Cells: Integrated Network Pharmacology and Experimental Validation.

13. Pharmaceuticals (Basel). 2026 Jun 4;19(6):893. doi: 10.3390/ph19060893. Protective Effects of Momordica charantia Extract on Dexamethasone-Induced Sarcopenic Changes in C2C12 Cells: Integrated Network Pharmacology and Experimental Validation. Park JE(1), Kim KS(1), Jeong M(1), Ann HW(1), Ramachandran R(1), Park IH(2), Kim KH(3), Kang KS(1), Eom DW(4). Author information: (1)College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea. (2)College of Pharmacy, Sahmyook University, Seoul 01795, Republic of Korea. (3)School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea. (4)Department of Pathology, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung 25440, Republic of Korea. Background/Objectives: Sarcopenia is characterized by progressive skeletal muscle loss and impaired myogenic differentiation and is closely associated with inflammation and metabolic dysfunction. Methods: This study investigated the protective effects of Momordica charantia extract against dexamethasone-induced sarcopenia and explored the underlying mechanisms using network pharmacology, C2C12 cell-based assays, Western blotting, and molecular docking. Network pharmacology analysis identified quercetin, ascorbic acid, and tocopherol as major active compounds associated with targets related to inflammation, extracellular remodeling, and metabolic dysfunction. Results: M. charantia extract (MCE) did not markedly reduce cell

Temporal Effects of Cigarette Smoke and Phytochemical-Based E-Liquid Aerosols on Tracheo-Alveolar Histopathology and the IL-6/TNF-α Molecular Signaling Axis.

14. Curr Issues Mol Biol. 2026 Jun 15;48(6):618. doi: 10.3390/cimb48060618. Temporal Effects of Cigarette Smoke and Phytochemical-Based E-Liquid Aerosols on Tracheo-Alveolar Histopathology and the IL-6/TNF-α Molecular Signaling Axis. Prasetyo A(1)(2), Maftikhati D(1), Athaya Anarizta L(1), Setyawan NG(3), Waradita Putri Yuwono A(3), Meutia Saleha M(3), Mukti FRA(3), Istiadi H(2), Sadhana U(2), Nur Kholis F(4). Author information: (1)Department of Biomedical Science, Faculty of Medicine, Universitas Diponegoro, Semarang 50275, Indonesia. (2)Department of Anatomic Pathology, Faculty of Medicine, Universitas Diponegoro, Semarang 50275, Indonesia. (3)Faculty of Medicine, Universitas Diponegoro, Semarang 50275, Indonesia. (4)Division of Pulmonology, Department of Internal Medicine, Kariadi Hospital, Faculty of Medicine, Universitas Diponegoro, Semarang 50275, Indonesia. This study compared the temporal effects of traditional cigarettes and e-cigarettes on lung health in male Rattus norvegicus over 8- and 12-week periods. Thirty rats were evaluated for tracheal/alveolar histopathology and systemic markers (IL-6, TNF-α, SOD-3, MDA). Chronic cigarette exposure (12 weeks) and nicotine aerosol (8 weeks) significantly suppressed weight gain, while ascorbic acid aerosol caused less growth inhibition. At 8 weeks, cigarette exposure (K3) induced adaptive tracheal mucosal thickening (66.88 ± 17.92 µm vs. 52.40 ± 2.63 µm in control K1), increased goblet cells (4.2 ± 2.44 N/m

Effect of acetylsalicylic acid (ASA) pretreatment on white noise-induced stress model in rats.

15. BMC Vet Res. 2026 Jun 24. doi: 10.1186/s12917-026-05658-7. Online ahead of print. Effect of acetylsalicylic acid (ASA) pretreatment on white noise-induced stress model in rats. Bala DA(1), Akyazi I(2), Eraslan E(2), Gursel FE(3), Akyol S(4), Dariyerli N(4). Author information: (1)Food Technology Programme, Food Processing Department, Vocational School of Veterinary Medicine, Istanbul University-Cerrahpasa, Istanbul, Türkiye. deniz.bala@iuc.edu.tr. (2)Faculty of Veterinary Medicine, Department of Physiology, Istanbul University-Cerrahpasa, Istanbul, Türkiye. (3)Faculty of Veterinary Medicine, Department of Biochemistry, Istanbul University-Cerrahpasa, Istanbul, Türkiye. (4)Faculty of Medicine, Department of Physiology, Istanbul University-Cerrahpasa, Istanbul, Türkiye. BACKGROUND: Environmental noise is a non-specific stressor that can activate stress-response pathways and increase the production of reactive oxygen species, contributing to oxidative stress in the brain. Limbic regions such as the amygdala and hippocampus play key roles in stress processing and are particularly vulnerable to oxidative damage. Acetylsalicylic acid (ASA) has been reported to possess antioxidant and anti-inflammatory properties. Therefore, the present study aimed to determine whether ASA pretreatment provides protective effects against white noise-induced oxidative stress and inflammation, both systemically and in brain tissue. In the study, ALT (Alanine aminotransferase),

Exploring the Anti-Inflammatory Potential of Saudi Propolis Through Phytochemical Characterization, Molecular Docking, and Dynamic Simulation.

1. Pharmaceutics. 2026 Aug 24;18(9):1050. doi: 10.3390/pharmaceutics18091050. Exploring the Anti-Inflammatory Potential of Saudi Propolis Through Phytochemical Characterization, Molecular Docking, and Dynamic Simulation. Aati H(1), Alqahtani JH(1), Al-Taweel A(1), Aati SY(2). Author information: (1)Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia. (2)Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh P.O. Box 10219, Saudi Arabia. Background/Objectives: Propolis is a resinous natural product rich in phenolic acids and flavonoids, recognized in ethnopharmacology for its antioxidant and anti-inflammatory properties. This study aimed to identify the most bioactive Saudi propolis extract using a bioassay-guided strategy and investigate its chemical profile and mechanistic anti-inflammatory potential. Methods: Four propolis extracts (P1-P4) collected from different regions of Saudi Arabia were evaluated for their antioxidant (DPPH and ABTS) and anti-inflammatory (COX-1 and COX-2) activities. The most active extract was profiled using liquid chromatography-mass spectrometry (LC-MS), followed by molecular docking and molecular dynamics simulations. Results: Among all samples, P3 demonstrated the strongest antioxidant activity, with IC50 values of 25.84 ± 0.96 µg/mL (DPPH) and 32.30 ± 1.20 µg/mL (ABTS), comparable to ascorbic acid (27.45 ± 1.42 and 21.22 ± 0.79

Protective Effects of Antioxidant Mix Pre-Treatment Against Visible Light-Induced Damage in Dark Skin Phototype.

2. Antioxidants (Basel). 2026 Aug 26;15(9):1072. doi: 10.3390/antiox15091072. Protective Effects of Antioxidant Mix Pre-Treatment Against Visible Light-Induced Damage in Dark Skin Phototype. Guiotto A(1), Alghamdi M(1), Hickerson R(2), Conneely M(2), Choudhary H(3), Brieva P(3), Lim Y(4), Pecorelli A(5)(6), Valacchi G(1)(4)(6). Author information: (1)Plants for Human Health Institute, NC Research Campus, NC State University, Raleigh, NC 27695, USA. (2)Ten Bio Technologies Inc., NC Research Campus, Kannapolis, NC 28081, USA. (3)SkinCeuticals, New York, NY 10021, USA. (4)Department of Food and Nutrition, Kyung Hee University, Seoul 02447, Republic of Korea. (5)Plants for Human Health Institute, Department of Food, Bioprocessing and Nutrition Sciences, NC Research Campus, NC State University, Raleigh, NC 27695, USA. (6)Department of Environment and Prevention Sciences, University of Ferrara, 44121 Ferrara, Italy. Visible light (VL) accounts for approximately 50% of the solar radiation reaching Earth's surface and has emerged as a major contributor to skin photoaging and pigmentation disorders, particularly in individuals with darker Fitzpatrick skin phototypes. Increasing evidence suggests that VL exposure induces oxidative stress, inflammation, and melanogenesis by generating reactive oxygen species. In this study, we investigated the protective effects of a topical antioxidant formulation (AOX Mix) containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocop

Structural and Functional Characteristics of the Liver After Fractionated Local Electron Irradiation and Against the Background of Ascorbic Acid Administration.

3. J Pers Med. 2026 Aug 22;16(9):439. doi: 10.3390/jpm16090439. Structural and Functional Characteristics of the Liver After Fractionated Local Electron Irradiation and Against the Background of Ascorbic Acid Administration. Demyashkin G(1), Buianova A(2), Pyatigorskaya N(1), Filippova O(1), Brkich G(1), Aladysheva Z(1), Belyaev V(1), Shchekin V(2). Author information: (1)Department of Industrial Pharmacy, Institute of Professional Education, I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya St., 8/2, Moscow 119048, Russia. (2)Research and Educational Resource Center for Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis Innovative Technologies, Peoples' Friendship University of Russia, Miklukho-Maklaya, 6, Moscow 117198, Russia. Radiation-induced liver disease (RILD) remains a clinically significant complication of radiotherapy for malignant neoplasms of the liver and upper abdomen, restricting achievable therapeutic doses and adversely affecting patient outcomes. Conventional photon-based radiotherapy (X-rays/γ-rays) exposes substantial volumes of healthy liver parenchyma and adjacent organs to ionizing radiation, increasing the risk of hepatocellular damage, inflammation, and progressive fibrosis. Electron irradiation (β-particles) represents a promising alternative owing to its limited tissue penetration (~2-3 cm) and steep dose fall-off, which significantly reduces exit dose and may reduce exit

Chemical characterization, antioxidant activity, and effects of Moroccan monofloral honeys on ovalbumin induced asthma in rats.

4. Inflammopharmacology. 2026 Sep 22. doi: 10.1007/s10787-026-02395-z. Online ahead of print. Chemical characterization, antioxidant activity, and effects of Moroccan monofloral honeys on ovalbumin induced asthma in rats. El-Yagoubi K(1)(2), Aboulghazi A(1), El Ouassete M(3), Soulo N(1), Nouioura G(4), Aouji M(5), Maache S(1), Touzani S(2), Lyoussi B(6). Author information: (1)Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health, and Quality of Life (SNAMOPEQ), Faculty of Sciences Dhar El Mahraz, University Sidi Mohamed Ben Abdellah, 30000, Fez, Morocco. (2)Laboratory of Mini-Invasive Surgery, Robotic Surgery, Artificial Intelligence and Educational Innovations (MIRIIL), Faculty of Medicine, Pharmacy and Dental Medicine, University Sidi Mohamed Ben Abdellah, Fez, Morocco. (3)Laboratory of Microbial Biotechnology and Bioactive Molecules, Sciences and Technologies Faculty, Sidi Mohamed Ben Abdellah University, P.O. Box 2202, Fez, Morocco. (4)Laboratory of Drug Sciences, Faculty of Medicine, Pharmacy, and Dental Medicine of Fez, Sidi Mohamed Ben Abdellah University, 30000, Fez, Morocco. (5)Laboratory of Natural Ressources and Sustainable Development, Ibn Tofail University, Kenitra, Morocco. (6)Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health, and Quality of Life (SNAMOPEQ), Faculty of Sciences Dhar El Mahraz, University Sidi Mohamed Ben Abdellah, 30000, Fez, Morocco. Lyoussi@gmail.com. Honey has been traditio

Extraction and Isolation of Bioactive Compounds From Malpighia glabra L. Leaves: In Vivo Investigation of the Leaf Extract Against Oxidative Stress and Inflammation Triggered by γ-Radiation.

5. Chem Biodivers. 2026 Sep;23(9):e71636. doi: 10.1002/cbdv.71636. Extraction and Isolation of Bioactive Compounds From Malpighia glabra L. Leaves: In Vivo Investigation of the Leaf Extract Against Oxidative Stress and Inflammation Triggered by γ-Radiation. Fekry AM(1), El-Sabbagh WA(1), Bakr MSA(2), Mohammed AEI(3), El-Ghazaly MA(1). Author information: (1)Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt. (2)Department of Pharmacognosy, Faculty of Pharmacy (Girls), Al Azhar University, Cairo, Egypt. (3)Department of Pharmacognosy, Faculty of Pharmacy (Boys), Al Azhar University, Cairo, Egypt. Malpighia glabra L. (Acerola), belonging to the family Malpighiaceae, is highly rich in phenolics, flavonoids and ascorbic acid content, which are collectively recognized for their potent antioxidant and anti-inflammatory activities. Since ionizing radiation harm is primarily driven by excessive reactive oxygen species generation and persistent inflammation, this study aimed to explore the radioprotective potential of Malpighia glabra leaf extract (MLE) and identify its bioactive constituents. β-isoarborinol, afzelechin, engeletin, and flavonoid glycosides had been isolated from the ethyl acetate fraction, and their structures were assigned based on NMR/MS data. Histopathological examination revealed that MLE treatment attenuated radiation-induced histopathological

Piezo1 in intestinal epithelial cells plays a critical role in the mechanobiological positive feedback underlying intestinal fibrosis.

6. J Crohns Colitis. 2026 Sep 3;20(9):jjag103. doi: 10.1093/ecco-jcc/jjag103. Piezo1 in intestinal epithelial cells plays a critical role in the mechanobiological positive feedback underlying intestinal fibrosis. Liu X(1), He R(1), Xu Z(1), Dong X(2), Wang D(1), Chen J(3), Zhu B(4), Song J(1), Hou X(1), Bai T(1)(5). Author information: (1)Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, PR China. (2)Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, PR China. (3)Department of Gastroenterology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, PR China. (4)Department of Urology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, PR China. (5)School of Medicine, Wuhan University of Science and Technology, Wuhan, 430065, PR China. BACKGROUND AND AIMS: Intestinal fibrosis involves extracellular matrix stiffening. Piezo1, a mechanosensitive ion channel highly expressed in intestinal epithelial cells (IECs), may sense this change. We investigated whether IEC Piezo1 drives fibrosis and explored the underlying mechanobiological mechanism. METHODS: Dextran sulfate sodium (DSS)-induced fibrosis models, inflammatory bowel disease (IBD) patient samples, an

Synthesis, Characterization, and Multifunctional Bioactivity of ZnO/CuO@Amoxicillin Nanocomposites: A Synergistic Nano-Platform With Potent Antioxidant, Anti-Inflammatory, Antidiabetic, and Anti-Cholinesterase Activities.

7. Chem Biodivers. 2026 Sep;23(9):e71658. doi: 10.1002/cbdv.71658. Synthesis, Characterization, and Multifunctional Bioactivity of ZnO/CuO@Amoxicillin Nanocomposites: A Synergistic Nano-Platform With Potent Antioxidant, Anti-Inflammatory, Antidiabetic, and Anti-Cholinesterase Activities. Nesrat HS(1)(2), Aouadi A(2)(3), Laib I(4)(5), Laouini SE(2)(6), Bouafia A(2)(6), Saoud DH(3), Zidane H(7), Terea H(6), Abdullah MMS(8), Trzepieciński T(9), Saidane-Mosbahi D(1). Author information: (1)Laboratory of Analysis, Treatment and Recovery of Environmental Pollutants and Products, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia. (2)Laboratory of Biotechnology Biomaterials and Condensed Matter (LBBCM), Faculty of Technology, University of El Oued, El Oued, Algeria. (3)Process Engineering Laboratory, Applied Sciences Faculty, Kasdi Merbah University, Ouargla, Algeria. (4)Faculty of Biology, Department of Cellular and Molecular Biology, University of El Oued, El Oued, Algeria. (5)Laboratory of Biodiversity and Application of Biotechnology in the Agricultural Field, Faculty of Natural and Life Sciences, University of El Oued, El Oued, Algeria. (6)Department of Process Engineering and Petrochemistry, Faculty of Technology, University of El Oued, El Oued, Algeria. (7)Laboratory Valorization and Technology of Saharan Resources (VTRS), University of El Oued, El Oued, Algeria. (8)Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi A

Micronutrients in adult critically ill patients: lessons learned and the path toward precision.

8. Curr Opin Clin Nutr Metab Care. 2026 Nov 1;29(6):510-518. doi: 10.1097/MCO.0000000000001253. Epub 2026 Sep 1. Micronutrients in adult critically ill patients: lessons learned and the path toward precision. Stoppe C(1)(2), Gundogan K(3)(4), Marelli S(5). Author information: (1)Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Wuerzburg, Wuerzburg. (2)Department of Cardiac Anesthesiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Berlin, Germany. (3)Division of Medical Intensive Care, Department of Internal Medicine, Erciyes University Faculty of Medicine. (4)Department of Clinical Nutrition, Health Sciences Institute, Erciyes University, Kayseri, Turkey. (5)Neurocritical Care Unit, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore, Milan, Italy. PURPOSE OF REVIEW: Despite strong biological plausibility, empiric high-dose micronutrient supplementation has failed to improve outcomes in critically ill patients. This review synthesizes evidence from the past 18 months and outlines the necessary transition toward biomarker-guided precision nutrition. RECENT FINDINGS: Recent evidence has further challenged routine high-dose micronutrient therapy. High-dose intravenous vitamin C failed to improve outcomes and was associated with potential harm in patients with sepsis, COVID-19, severe burns, and post-cardiac arrest syndrome. In contrast, a 2025 meta-analysis reported reduced sho

Atypical Presentation of Scurvy in the Oral Cavity.

9. J Dent Child (Chic). 2026 May 15;93(2):118-121. Atypical Presentation of Scurvy in the Oral Cavity. Porter MD(1), Curry Ii MJ(2), Pierre JR(3), Smith K(4), Taylor L(5), Martin D(5), Price M(6), Khoury ZH(7). Author information: (1)Pediatric Dentist, Private Practice, School of Dentistry, Meharry Medical College, Nashville, TN, USA. (2)Resident, Department of Oral and Maxillofacial Surgery, School of Dentistry, Meharry Medical College, Nashville, TN, USA. (3)Resident, Department of Oral and Maxillofacial Surgery, Texas A&M University College of Dentistry, Dallas, Texas, USA. (4)Resident, Department of Pediatric Dentistry, College of Dentistry, University of Florida, Gainesville, FL, USA. (5)Dental Student, School of Dentistry, Meharry Medical College, Nashville, TN, USA. (6)Assistant Professor, Department of Pediatric Dentistry, School of Dentistry, Meharry Medical College, Nashville, TN, USA. (7)Associate Professor and Chair, Department of Oral Diagnostic Sciences and Research, School of Dentistry, Meharry Medical College, Nashville, TN, USA. Vitamin C is crucial for normal physiology and function. Severely insufficient levels of vitamin C can disrupt these processes, resulting in scurvy, a condition characterized by compromised collagen production and tissue degradation. The purpose of this report is to present a complex case of a pediatric patient with autism spectrum disorder exhibiting nonspecific oral lesions. Histopathological examination of the lesi

From genomics to horticultural innovation: botanical traits, bioactive compounds, and sustainable utilization of kiwifruit (Actinidia spp.).

10. Front Plant Sci. 2026 Aug 17;17:1903424. doi: 10.3389/fpls.2026.1903424. eCollection 2026. From genomics to horticultural innovation: botanical traits, bioactive compounds, and sustainable utilization of kiwifruit (Actinidia spp.). Tian XX(1), Liu X(2), Wang TY(1), Wu PP(1), Morris-Natschke SL(3), Ma GX(4), Xu XD(4), Zhao ZJ(1), Li YX(1), Wu HF(3)(4), Zhao XS(5), Zou QY(1). Author information: (1)Key Laboratory of Research and Utilization of Ethnomedicinal Plant Resources of Hunan Province, Key Laboratory of Hunan Higher Education for Western Hunan Medicinal Plant and Ethnobotany, Hunan Provincial Higher Education Key Laboratory of Intensive Processing Utilization in Wuling Mountain Area, Department of Chemistry and Chemical Engineering, Huaihua University, Huaihua, China. (2)Science and Technology Research Center of Chinese Customs, Beijing, China. (3)Natural Products Research Laboratories, University of North Carolina at Chapel Hill (UNC) Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, United States. (4)Beijing Key Laboratory of New Drug Discovery Based on Classic Chinese Medicine Prescription, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. (5)Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Me

Vitamin C as a Potential Geroprotector: Interactions with Aging Hallmarks and Implications for Healthy Longevity.

11. Nutrients. 2026 Aug 19;18(16):2704. doi: 10.3390/nu18162704. Vitamin C as a Potential Geroprotector: Interactions with Aging Hallmarks and Implications for Healthy Longevity. Bodó D(1), Jójárt F(2), Jójárt R(2), Csupor D(1)(3), Tóth B(1). Author information: (1)Institute of Clinical Pharmacy, Faculty of Pharmacy, University of Szeged, H-6725 Szeged, Hungary. (2)Goodwill Pharma Plc., H-6724 Szeged, Hungary. (3)Institute of Translational Medicine, University of Pécs, H-7622 Pécs, Hungary. Vitamin C (L-ascorbic acid) is an essential micronutrient with established roles in antioxidant defense, epigenetic regulation, collagen synthesis, redox signaling, immune modulation, and cellular stress responses. This narrative review critically evaluates the potential role of vitamin C as a modulator of the hallmarks of aging. Although mechanistic studies suggest that vitamin C influences gene expression, inflammatory regulation, mitochondrial function, and cellular stress adaptation, the available evidence remains heterogeneous and is derived predominantly from in vitro and preclinical models, whereas human data are largely observational with limited interventional confirmation. Accordingly, vitamin C should be regarded as a context-dependent modulator of cellular resilience, with potential relevance under conditions of deficiency, inflammation, or increased oxidative stress rather than as a general anti-aging agent. Future studies integrating biomarkers of biologica

Turmeric nanovesicles loaded with vitamins C and E attenuate oxidative stress and improve cognitive outcomes in rats with memory deficits.

12. Ther Deliv. 2026 Jul;17(7):649-662. doi: 10.1080/20415990.2026.2715894. Epub 2026 Aug 26. Turmeric nanovesicles loaded with vitamins C and E attenuate oxidative stress and improve cognitive outcomes in rats with memory deficits. Jiyah A(1), Bulama I(2), Onu A(1), Gimba AY(1)(3), Abbas AY(1), Saidu Y(1), Bilbis LS(1), Muhammad SA(1). Author information: (1)Department of Biochemistry and Molecular Biology, Usmanu Danfodiyo University, Sokoto, Nigeria. (2)Department of Veterinary Physiology and Biochemistry, University of Maiduguri, Maiduguri, Nigeria. (3)Department of Biological Sciences, Niger State Polytechnic, Zungeru, Nigeria. AIM: Oxidative stress (OS) contributes to Alzheimer's disease (AD) pathology. Vitamins C and E target OS, but their efficacies are limited by poor intracellular delivery. Encapsulation in nanovesicles (NVs) may improve targeted delivery for AD treatment. METHODS: Forty-five rats were randomly assigned to nine groups (n = 5 per group): normal control, scopolamine control, vitamin C, vitamin E, vitamin C + E, turmeric NVs (TNV), TNV-C, TNV-E, and donepezil. Treatment was administered intraperitoneally (IP) for one week before induction of the AD-like model using daily IP administration of scopolamine and continued for two weeks. During this time, behavioral activities were conducted, and brain tissues were collected for analysis. RESULTS: Vitamins C and E showed encapsulation efficiencies of 12.36 ± 1.01% and 55.24 ± 5.82%, with l