비타민B1 (티아민)
Vitamin B1 (Thiamine)
📖 핵심 요약
📖 64편 · 32분 읽기비타민B1 (티아민)은(는) 비타민 계열 보충제입니다. PubMed에 64편의 관련 논문이 있습니다.
📊 효과 크기 분포 (Forest plot)
각 연구의 효과 추정치와 95% 신뢰구간. 개별 연구를 통합(pooling)하지 않고 그대로 표시합니다.
📚 관련 논문 (64편) · 📊 정량 근거 4건
1. J Glob Antimicrob Resist. 2018 Jun;13:231-236. doi: 10.1016/j.jgar.2018.01.005. Epub 2018 Feb 3. Evaluation of synergistic antimicrobial effect of vitamins (A, B1, B2, B6, B12, C, D, E and K) with antibiotics against resistant bacterial strains. Shahzad S(1), Ashraf MA(2), Sajid M(2), Shahzad
2. Anticancer Res. 2002 Mar-Apr;22(2A):927-9. Influence of vitamin B1 on sanazole activity under irradiation. A study in vitro. Heinrich E(1), Getoff N. Author information: (1)Ludwig Boltzmann Institute for Radiation Chemistry and Radiation Biology, The University of Vienna, Austria. The effec
3. Cochrane Database Syst Rev. 2001;(2):CD001498. doi: 10.1002/14651858.CD001498. Thiamine for Alzheimer's disease. Rodríguez-Martín JL(1), Qizilbash N, López-Arrieta JM. Author information: (1)Iberoamerican Cochrane Centre, Department of Epidemiology, Hospital de la Santa Creu i Sant Pau, Sant
4. Cochrane Database Syst Rev. 2000;(2):CD001498. doi: 10.1002/14651858.CD001498. Thiamine for Alzheimer's disease. Rodríguez-Martín JL(1), López-Arrieta JM, Qizilbash N. Author information: (1)Departamento de Psicobiología, Universidad Nacional de Educación a Distancia, Ciudad Universitaria s/n
1. Nutr Clin Pract. 2026 Apr;41(2):498-505. doi: 10.1002/ncp.70073. Epub 2025 Nov 24. Thiamin supplementation on mitigating kidney injury and mortality in patients with septic shock: A systematic review and meta-analysis of randomized controlled trials. Wang G(1), Liao X(2), Liao Y(3), Han D(1). Author information: (1)Department of Respiratory and Critical Care Medicine, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China. (2)Neurocritical Rehabilitation Unit, Care Alliance Jinchen Rehabilitation Hospital of Chengdu, Chengdu, Sichuan, China. (3)Department of Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. BACKGROUND: The effectiveness of thiamin supplementation in mitigating renal injury and mortality outcomes in patients with septic shock remains uncertain. This systematic review and meta-analysis aimed to determine the efficacy of thiamin in patients with septic shock. MATERIALS AND METHODS: A systematic search was made of PubMed, Embase, Cochrane Library, and clinicaltrials.gov, without language restrictions. Randomized controlled trials (RCTs) on treatment of septic shock with thiamin, compared with placebo or blank, were reviewed. Studies were pooled to risk ratios (RRs) and weighted mean differences, with 95% confidence intervals (CIs). Six RCTs (enrolling 438 patients) met the inclusion criteria. RESULTS: Thiamin showed significant effects on in-hospital mortality (RR 0.80, 95% CI 0.65-0.99; P = 0.04) and renal replacement therapy (RR 0.48, 95% CI 0.31-0.74; P = 0.0009). CONCLUSION: Thiamin was associated with a reduction in in-hospital mortality and the use of renal replacement therapy in patients with septic shock. Thiamin should be considered for patients with septic shock. © 2025 American Society for Parenteral and Enteral Nutrition. DOI: 10.1002/ncp.70073 PMID: 41277404 [Indexed for MEDLINE]
2. J Pharm Health Care Sci. 2025 Oct 21;11(1):88. doi: 10.1186/s40780-025-00495-6. Natural relief for premenstrual syndrome (PMS): a double-blind clinical trial on the efficacy and safety of PMSoff. Saghafi F(1), Zare P(2), Hatamizadeh N(3), Malmir M(4), Sahebnasagh A(5). Author information: (1)Department of Clinical Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. (2)Student Research Committee, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. (3)Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. (4)Department of Chemistry, College of Science, University of Tehran, Tehran, Iran. (5)Clinical Research Center, Department of Internal Medicine , Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, North Khorasan Province, Iran. masoomehsahebnasagh@gmail.com. BACKGROUND: Premenstrual syndrome (PMS) is a prevalent and often debilitating health conditions affecting women of reproductive age. The natural PMSoff supplement contains several active ingredients, including spirulina, whey protein, calcium citrate, vitamin B1, chamomile, turmeric, marigold, lavender, saffron, valerian, and aftimoon. This clinical trial aimed to assess the efficacy and safety of PMSoff, a natural supplement, in alleviating the symptoms of PMS. METHODS: In this double-blind, randomized trial, women diagnosed with PMS were randomly assigned to receive either PMSoff or placebo. The primary objective of the study was to evaluate the impact of PMSoff on symptom severity, with secondary objectives focusing on safety and adherence. The primary outcome of this study was the severity of PMS symptoms, evaluated using the Daily Record of Severity of Problems (DRSP) questionnaire. The secondary outcome focused on the presence of premenstrual dysphoric disorder (PMDD), a more severe and debilitating form of PMS. Symptom severity was assessed at multiple time points: pre-intervention, one month post-intervention, and two months post-intervention. RESULTS: Of the 255 randomized participants, 218 (85.4%) patients aged 14 to 30 years were enrolled and completed the clinical trial. No significant difference was observed between groups at baseline characteristics. Medication adherence in the first and second month of treatment was reported 72%. Following one month of treatment, the intervention group showed a significant reduction in DRSP scores compared to the control group (P-value = 0.043). This reduction became even more pronounced after two months of taking the supplement (P-value = 0.001). In patients with PMDD, a more severe form of PMS, a statistically significant difference emerged two months after the intervention (P-value = 0.04), indicating that the PMSoff was effective in alleviating PMDD-related symptoms, particularly during the second month of treatment. CONCLUSION: The results of this randomized placebo-controlled clinical trial were suggestive of the use of PMSoff in patients with PMS and PMDD to ameliorate its unpleasant symptoms, with sustained improvements observed over two months of treatment. Our findings suggest that PMSoff could be a viable alternative or adjunct to conventional pharmacological treatments for PMS and PMDD. Further studies are still demanded to explore the long-term effects, mechanisms of action, and broader applicability of this supplement. TRIAL REGISTRATION: Trial Registry Date: 2025-03-02, Trial Registry number: IRCT20190810044500N30. © 2025. The Author(s). DOI: 10.1186/s40780-025-00495-6 PMCID: PMC12538989 PMID: 41121435 Conflict of interest statement: Declarations. Ethics approval and consent to participate: Study protocols were approved by the local Ethics Committee of Shahid Sadoughi University of Medical Sciences (Ethics ID: IR.SSU.MEDICINE.REC.1402.179). Following a health-screening questionnaire, all volunteers provided a written informed consent. Before the intervention, study protocol, benefits, and possible side effects were described for patients. Understandable written informed consent was obtained for all patients prior to participation in the study. This trial was performed in accordance with the Declaration of Helsinki and Good Clinical Practice Guidelines. Consent for publication: Consent for publication was agreed upon in the written consent forms signed by all subjects for publication of identifying information/images in a publication. Competing interests: The authors declare no competing interests.
3. Nutrients. 2025 Jul 4;17(13):2227. doi: 10.3390/nu17132227. l-Carnitine and Alpha-Lipoic Acid Fail to Improve Anaerobic and Aerobic Performance in Trained Cyclists Despite a Reduction in Blood Lactate Concentration. de Rozas A(1), Pérez-Díaz JJ(1), Muros JJ(2), Sánchez-Muñoz C(1), Rufían-Henares JÁ(3), Zabala M(1), Salas-Montoro JA(1). Author information: (1)Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, 18071 Granada, Spain. (2)Department of Didactics of Body Expression, University of Granada, 18071 Granada, Spain. (3)Department of Nutrition and Food Sciences, Institute of Nutrition and Food Sciences, Biomedical Research Center, University of Granada, 18071 Granada, Spain. Background/Objectives: This study aimed to evaluate the effects of four weeks of combined Acetyl-l-Carnitine and alpha-lipoic acid (ALA) supplementation on anaerobic and aerobic performance and fatigue resistance in trained cyclists, hypothesizing improvements in maximal aerobic power (MAP), Wingate test performance, and reduced lactate accumulation. Methods: In a double-blind, randomized trial, 41 male trained cyclists (age: 36 ± 12 years; MAP: 4.35 ± 0.60 W·kg-1) were assigned to a supplement group (SUP, n = 19; 1200 mg/day Acetyl-l-Carnitine, 300 mg/day ALA, 1.1 mg Vitamin B1, 2.5 µg Vitamin B12) or placebo group (PLA, n = 22) for four weeks. Performance was assessed pre- and post-intervention via counter-movement jumps (CMJs), Wingate tests (WG1, WG2), and a graded exercise test (GXT). Blood lactate ([La-]) was measured post-Wingate. A three-way mixed ANOVA analyzed Wingate performance (session, order, and group), and a two-way ANOVA assessed MAP and fatigue effects. Results: MAP increased by 3.4% (314 ± 32 W to 324 ± 37 W; p = 0.005) with no group interaction (p = 0.457). Wingate peak power showed main effects for order (p < 0.001) and session (p = 0.011) but no group interaction (p = 0.676). SUP reduced [La-] by 1.5 mmol·L-1 post-WG2 in POST (p = 0.049). No significant group differences were found for CMJ or fatigue metrics. Conclusions: Four weeks of Acetyl-l-Carnitine and ALA supplementation did not enhance aerobic or anaerobic performance in trained cyclists, despite reducing blood lactate after high-intensity exercise, suggesting no ergogenic benefits. DOI: 10.3390/nu17132227 PMCID: PMC12252364 PMID: 40647331 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflicts of interest.
4. Nutrients. 2025 May 27;17(11):1821. doi: 10.3390/nu17111821. Impact of Vitamin B1 and Vitamin B2 Supplementation on Anxiety, Stress, and Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Trial. Tao Y(1), Wu M(1), Su B(1), Lin H(1), Li Q(1), Zhong T(1), Xiao Y(1), Yu X(1). Author information: (1)Faculty of Medicine, Macau University of Science and Technology, Avenida Wai Long Taipa, Macau. Background: Anxiety, stress, and sleep disturbances significantly affect overall health. Research suggests that vitamins B1 and B2 may play a role in mood regulation and neuroprotection. This study aimed to investigate the effects of vitamin B1 and B2 supplementation in alleviating anxiety and stress and improving sleep quality. Methods: This study was a parallel randomized, double-blind, placebo-controlled clinical trial. Participants (n = 43) were randomized to receive one of the following two interventions: 100 mg of vitamin B1 and 100 mg of vitamin B2 or placebo. Intervention outcomes were assessed at baseline and week four, including SAS (Self-Rating Anxiety Scale), PSS (Perceived Stress Scale), PSQI (Sleep Quality Index), ESS (Sleepiness Scale), and measurement of urinary vitamin B1 and B2 levels. Results: After four weeks, urinary vitamin B1 levels increased from 158 ± 108.9 ng to 1333.1 ± 1204.5 ng (p < 0.01), and urinary vitamin B2 levels increased from 308.0 ± 198.3 ng to 6123.2 ± 4847.2 ng in the supplement group (p < 0.01). The PSS scores decreased significantly in the supplement group from 21.5 ± 4.1 to 15.5 ± 4.5 (p < 0.05), while the placebo group showed a change from 20.3 ± 4.3 to 19.8 ± 5.5. Vitamins B1 and B2 did not have a significant effect on anxiety improvement (p > 0.05). The PSQI scores decreased in the supplement group from 8.0 ± 3.12 to 6.3 ± 2.0 (p < 0.05), while the placebo group worsened from 5.7 ± 2.7 to 7.4 ± 2.9. Meanwhile, the ESS scores in the supplement group decreased from 13.0 ± 3.4 to 9.1 ± 3.9 (p < 0.05), demonstrating a significant improvement compared to the placebo group. Conclusions: The clinical trial findings demonstrated that while vitamin B1 and B2 supplements helped reduce stress, enhance sleep, and reduce sleepiness, they had no discernible impact on reducing anxiety. Future studies should focus on the long-term effects of vitamin B1 and B2 supplements, exploring the combined effects of combined vitamin B1 and B2 medications for the treatment of stress and sleep disorders. DOI: 10.3390/nu17111821 PMCID: PMC12157762 PMID: 40507089 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflicts of interest.
5. J Nutr Sci. 2025 May 8;14:e34. doi: 10.1017/jns.2025.22. eCollection 2025. Effect of vitamin B1 supplementation on bone turnover markers in adults: an exploratory single-arm pilot study. Hara A(1), Takazawa C(1), Tsujiguchi H(1), Zhao J(1), Nakamura M(1), Kasahara T(1), Shimizu Y(2), Nakamura H(1). Author information: (1)Department of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan. (2)Department of Nursing, Faculty of Health Sciences, Komatsu University, Komatsu, Ishikawa, Japan. Although B vitamins have been shown to play beneficial roles in bone health, the effects of vitamin B1 in humans are still unclear. This study aimed to investigate the effects of vitamin B1 supplementation on middle-aged and older adults. This single-armed trial study included community-dwelling adults in Japan and used a pre- and post-test design. The participants were given 28.0 mg of vitamin B1 supplementation per day for 1 month in addition to their daily usual diet. The effect of this treatment on bone turnover markers and metabolism was evaluated at baseline and after 1 month. Forty-two participants were enrolled (mean age, 58.6 ± 10.4 years; 36 women). The vitamin B1 levels in whole blood increased significantly from baseline after vitamin B1 supplementation. The level of serum tartrate-resistant acid phosphatase 5b (TRACP 5b), a bone resorption marker, reduced significantly (378 ± 135 vs. 335 ± 120 mU/dL, p < 0.001), while the level of N-terminal propeptide of type I procollagen (P1NP), a marker specific to bone formation, did not change. Moreover, the serum phosphorus and parathyroid hormone (PTH) concentrations did not change, whereas the corrected serum calcium concentrations increased and vitamin D concentrations decreased. The serum TRACP 5b levels decreased after vitamin B1 supplementation in the middle-aged and older adults. Further definitive trials are needed to determine the efficacy of vitamin B1 in improving bone health. © The Author(s) 2025. DOI: 10.1017/jns.2025.22 PMCID: PMC12075007 PMID: 40371216 [Indexed for MEDLINE] Conflict of interest statement: The authors have no conflicts of interest to declare.
6. Int J Mol Sci. 2025 Mar 27;26(7):3090. doi: 10.3390/ijms26073090. The Pivotal Role of Thiamine Supplementation in Counteracting Cardiometabolic Dysfunctions Associated with Thiamine Deficiency. Ritorto G(1), Ussia S(1), Mollace R(1)(2), Serra M(1), Tavernese A(3), Palma E(4), Muscoli C(1), Mollace V(1)(5), Macrì R(1). Author information: (1)Pharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy. (2)Department of Experimental Medicine, University "Tor Vergata" of Rome, 00133 Rome, Italy. (3)Department of Medicine and Surgery, University Campus Bio-Medico of Rome, 00128 Rome, Italy. (4)Veterinary Pharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy. (5)Renato Dulbecco Institute, Lamezia Terme, 88046 Catanzaro, Italy. The isolation, structural elucidation, and synthesis of pure thiamin were achieved in 1936, marking a milestone in vitamin research. As an organic compound soluble in water, thiamin is essential for carbohydrate metabolism in plants and animals, and in its active form-as part of the thiamin pyrophosphate coenzyme-performs these functions. Thereby, thiamin represents an essential vitamin to human health and is involved in several pathways that regulate several pathophysiological mechanisms. Cardiovascular disease is significantly impacted by thiamine imbalance and its supplementation offers substantial improvements to the associated conditions. In this comprehensive review, we aimed to examine the dual role of thiamine deficiency and accumulation, focusing on an analysis of the causes of thiamine deficiency. We detailed the effects of thiamine deficiency on metabolism and on cardiovascular risk and heart failure, explaining the molecular mechanisms involved in metabolic dysfunction, and highlighting the role of B1 vitamin supplementation in diabetes mellitus management and atherosclerosis development and progression. Indeed, B1 supplementation counteracts oxidative stress and inflammation, significantly ameliorating glycemic and lipemic profiles. Additionally, we reported the beneficial effects of thiamine in counteracting cardiotoxicity induced by cancer therapy. Although preclinical data strongly support the benefits of thiamine, clinical trial findings are in contrast and contradictory, hampered by limitations such as small sample sizes and inadequate follow-up. Further research is needed to investigate thiamine's potential benefits, overcoming current study limitations and evaluating its use as a supplemental therapy alongside standard treatments in different high-cardiovascular-risk conditions. DOI: 10.3390/ijms26073090 PMCID: PMC11988323 PMID: 40243711 [Indexed for MEDLINE] Conflict of interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest.
7. Dev Psychol. 2025 Aug;61(8):1427-1440. doi: 10.1037/dev0001829. Epub 2024 Dec 19. Language processing in breastfed infants at risk of thiamine deficiency benefits from maternal thiamine supplementation. Baldwin DA(1), Measelle J(1), Gallivan L(1), Sanchirico A(1), Weinstein N(1), Bala A(1), Chan K(2), Gallant J(2), Borath M(3), Kroeun H(4), Wieringa FT(5), Green TJ(6), Whitfield KC(2). Author information: (1)Department of Psychology, University of Oregon. (2)Department of Applied Human Nutrition, Mount Saint Vincent University. (3)Cambodian Ministry of Planning. (4)Helen Keller International. (5)Institut de recherche pour le developpement. (6)South Australian Health and Medical Research Institute. In a double-blind, randomized controlled trial, we investigated relationships between infants' exposure to thiamine and their language-processing ability. Three hundred thirty-five lactating Cambodian mothers of 161 female/174 male infants received either 0, 1.2, 2.4, or 10 mg of thiamine daily, from 2 to 24 weeks postpartum. We assessed infants' language processing at 24 weeks via the infant-directed speech (IDS) task, measuring attentional enhancement to IDS versus adult-directed speech. Maternal thiamine supplementation displayed a small but statistically significant dose-response relationship to the magnitude of infants' IDS-elicited attentional enhancement (adjusted R² = 0.022, p = .011). As well, only infants whose mothers received a daily thiamine supplement of 10 mg showed fully robust IDS-related attentional enhancement. These findings showcase the IDS Task for monitoring the integrity of infants' language processing and underscore the importance of adequate thiamine early in life for ensuring optimal language development. (PsycInfo Database Record (c) 2025 APA, all rights reserved). DOI: 10.1037/dev0001829 PMID: 39699595 [Indexed for MEDLINE]
8. Nutrients. 2024 Dec 4;16(23):4187. doi: 10.3390/nu16234187. Evaluation of the Efficacy of the Addition of a Combination of Pyrimidine Nucleotides and Vitamin B1 and B12 to Standard Treatment in the Management of Painful Radiculopathy and in the Quality of Life of Patients. Monfort J(1)(2), Carrión-Barberà I(1)(2), Tío L(2), Marante J(3), López Vázquez A(4), Bas T(5), Fernandez-Fuente-Burson L(6), Caracuel MA(7), Oliveros-Cid A(8), Gallart V(9), Romera-López C(10), Román JA(11), Abejón D(12), Roca Ruíz LJ(13), Gurt A(14), Ojeda F(1)(2), Grima P(15), Aldonza R(16). Author information: (1)Departament of Rheumatology, Hospital del Mar, 08003 Barcelona, Spain. (2)Hospital del Mar Research Institute, 08003 Barcelona, Spain. (3)Hospital Universitario Jerez de la Frontera, 11407 Cádiz, Spain. (4)Hospital de Orense, 32005 Ourense, Spain. (5)Department of Traumatology and Orthopaedic Surgery, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain. (6)Hospital Quirónsalud Infanta Luisa, 41010 Sevilla, Spain. (7)Hospital Universitario Reina Sofía, 14004 Córdoba, Spain. (8)Hospital Viamed Montecanal, 50012 Zaragoza, Spain. (9)Hospital Universitario Doctor Peset, 46017 Valencia, Spain. (10)Hospital General Universitario de Elche, 03203 Elche, Spain. (11)Department of Rheumatology, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain. (12)Hospital Universitario Quirónsalud Madrid, 28223 Madrid, Spain. (13)Hospital Universitario Virgen Macarena, 41009 Sevilla, Spain. (14)CAP Vila Olímpica, 08005 Barcelona, Spain. (15)Affinity Petcare, 08902 Barcelona, Spain. (16)Ferrer Internacional, S.A., 08029 Barcelona, Spain. Background/Objectives: Radiculopathy leads to pain, consequently reducing patient's quality of life (QoL). Research indicates that certain nucleotides, such as cytidine and uridine, along with vitamins B1 and B12, may help alleviate pain and enhance QoL. This study assessed the impact of adding a supplement containing cytidine and uridine nucleotides and vitamins B1 and B12, alongside standard treatment, on radiculopathy-associated pain. Methods: A multicenter, prospective, two-cohort, randomized, open-label study was conducted. The control group received standard treatment, while the experimental group received standard treatment plus the supplement. The primary endpoint was pain reduction measured by a Visual Analog Scale (VAS). Secondary endpoints included functional improvement (Roland Morris questionnaire), clinical improvement (Clinical Global Impression [CGI] scale), and QoL improvement (EQ-5D-5L questionnaire). Results: A total of 122 patients were included from 17 centers across Spain. Both groups showed pain improvement, but the VAS reduction (control: 24.58 vs. experimental: 31.35) was not statistically significant. The Roland Morris score decreased significantly in the experimental group (estimate: -1.70, 95% CI -3.29 to -0.10; p = 0.038), and these patients were 5 times more likely to progress to a better CGI category (OR = 0.20, 95% CI 0.07 to 0.57; p = 0.003). No significant differences were observed in EQ-5D-5L scores or analgesic consumption. Conclusions: The addition of supplemental pyrimidine nucleotides and vitamins B1 and B12 to standard of care treatment improved radiculopathy functional and clinical outcomes. Regarding pain, however, although there was a numerical improvement, it did not reach statistical significance. DOI: 10.3390/nu16234187 PMCID: PMC11644542 PMID: 39683579 [Indexed for MEDLINE] Conflict of interest statement: Author Pedro Grima was an employer of Ferrer Internacional S.A. at the beginning of the study and was employed by the company Affinity Petcare. Rebeca Aldonza is full-time employee of Ferrer Internacional S.A. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declare that this study received funding from Ferrer Internacional, S.A. The funder was not involved in the collection, analysis and interpretation of data.
9. Nutrients. 2024 Sep 10;16(18):3045. doi: 10.3390/nu16183045. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Didangelos T(1), Karlafti E(1), Kotzakioulafi E(1), Giannoulaki P(2), Kontoninas Z(1), Kontana A(1), Evripidou P(1), Savopoulos C(1), Birkenfeld AL(3)(4)(5), Kantartzis K(3)(4)(5). Author information: (1)Diabetes Center, 1st Propaedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 54636 Thessaloniki, Greece. (2)Department of Clinical Nutrition and Dietetics, AHEPA Hospital, 54636 Thessaloniki, Greece. (3)Department of Internal Medicine IV, Division of Endocrinology, Diabetology and Nephrology, University of Tübingen, 72076 Tübingen, Germany. (4)Institute for Diabetes Research and Metabolic Diseases (IDM), Helmholtz Centre Munich, University of Tübingen, 72076 Tübingen, Germany. (5)German Center for Diabetes Research (DZD), 85764 München-Neuherberg, Germany. AIM: To investigate the efficacy of Palmitoylethanolamide (PEA, 300 mg), Superoxide Dismutase (SOD, 70 UI), Alpha Lipoic Acid (ALA, 300 mg), vitamins B6 (1.5 mg), B1 (1.1 mg), B12 (2.5 mcg), E (7.5 mg), nicotinamide (9 mg), and minerals (Mg 30 mg, Zn 2.5 mg) in one tablet in people with Diabetic Neuropathy (DN). PATIENTS-METHODS: In the present pilot study, 73 people (age 63.0 ± 9.9 years, 37 women) with type 2 Diabetes Mellitus (DMT2) (duration 17.5 ± 7.3 years) and DN were randomly assigned to receive either the combination of ten elements (2 tablets/24 h) in the active group (n = 36) or the placebo (n = 37) for 6 months. We used the Michigan Neuropathy Screening Instrument Questionnaire and Examination (MNSIQ and MNSIE), measured vibration perception threshold (VPT) with biothesiometer, and Cardiovascular Autonomic Reflex Tests (CARTs). Nerve function was assessed by DPN Check [sural nerve conduction velocity (SNCV) and amplitude (SNAP)]. Sudomotor function was assessed with SUDOSCAN, which measures electrochemical skin conductance in hands and feet (ESCH and ESCF). Pain score (PS) was assessed with Pain DETECT questionnaire. Quality of life was assessed by questionnaire. RESULTS: In the active group, there was a large improvement of pain (PS from 20.9 to 13.9, p < 0.001). There was also a significant improvement of vitamin B12 (B12) levels, MNSIQ, SNCV, VPT, and ESCF (222.1 vs. 576.3 pg/ mL, p < 0.001; 6.1 vs. 5.9, p = 0.017; 28.8 vs. 30.4, p = 0.001; 32.1 vs. 26.7, p = 0.001; and 72.2 vs. 74.8, p < 0.001 respectively). In the placebo group, neither pain (21.6 vs. 21.7, p = 0.870) or any other aforementioned parameters changed significantly, and MNSIE worsened (2.9 vs. 3.4, p < 0.001). As a result, changes from baseline to follow-up in pain, B12 levels, VPT, and MNSIQ differed significantly between the two groups (p < 0.001, 0.025, 0.009, and <0.001, respectively). CARTs, SNAP, ESCH did not significantly change in either of the two groups. CONCLUSIONS: The combination of the ten elements in one tablet for 6 months at a daily dose of two tablets in people with DN significantly improves pain, vibration perception threshold, and B12 levels. DOI: 10.3390/nu16183045 PMCID: PMC11434759 PMID: 39339645 [Indexed for MEDLINE] Conflict of interest statement: E.Kot. is currently an employee at Nestlé Research, Lausanne, Switzerland. The study was conducted prior to her employment. The other authors declare no conflicts of interest.
10. J Affect Disord. 2025 Jan 15;369:35-42. doi: 10.1016/j.jad.2024.09.131. Epub 2024 Sep 22. Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial. Duan H(1), Xu N(1), Yang T(2), Wang M(3), Zhang C(3), Zhao J(3), Li Z(1), Chen Y(2), Yan J(4), Zhang M(1), Li W(1), Yue Z(5), Ma F(2), He R(6), Huang G(7). Author information: (1)Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China; Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, Tianjin, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China. (2)Department of Epidemiology & Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China; Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, Tianjin, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China. (3)Community Health Service Center, Sanhuailu Street, Binhai New District, Tianjin, China. (4)Department of Social Medicine and Health Management, School of Public Health, Tianjin Medical University, Tianjin, China; Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, Tianjin, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China. (5)BYHEALTH Institute of Nutrition & Health, Guangzhou, China. (6)BYHEALTH Institute of Nutrition & Health, Guangzhou, China. Electronic address: herk@by-health.com. (7)Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China; Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, Tianjin, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China; The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin, China. Electronic address: huangguowei@tmu.edu.cn. BACKGROUND: Phosphatidylserine (PS) and α-Linolenic acid (ALA), are positively associated with cognitive function, but their combination effects and possible mechanisms remain unclear. We aimed to explore the effects on cognition and potential mechanism of the supplements. METHODS: This randomized, double-blind, placebo-controlled trial recruited 190 MCI patients in Tianjin, China, and randomly assigned in intervention group and placebo group. Each group consumed two capsules every day for 12 months. Each capsule for intervention group contains 144 mg ALA, 31.5 mg PS and 3.6 mg Ginkgo total flavonoids as main functional components, with 0.48 mg Vitamin B1 (as thiamine hydrochloride), 0.48 mg Vitamin B6 (as pyridoxine hydrochloride) and 90 μg folic acid as supplement. Capsules for placebo group were identical but contain no active ingredients. Cognitive function, serum n-3 polyunsaturated fatty acids (PUFAs) and neurotransmitters were assessed at baseline and 12 months. Linear mixed effects model and causal mediation analysis were conducted to explore the effects and potential mechanism of the intervention. RESULTS: A total of 190 participants (mean [SD] age, 67.95 [5.62] years; 70 (36.8 %) male and 120 (63.2 %) female) were randomized to the placebo group (n = 95) and intervention group (n = 95). Compared with placebo group, the intervention group had statistically significant improvements in arithmetic testing (β, 0.688; 95 % CI, 0.103-1.274), the similarity test (β, 1.070; 95 % CI, 0.472-1.667) and short-term memory (β, 0.600; 95 % CI, 0.399-0.800). Besides, the intervention group had statistically significant increases in serum ALA (β, 1.620; 95 % CI, 0.967-2.265), DHA (β, 2.797; 95 % CI, 1.075-4.532), EPA (β, 1.472; 95 % CI, 0.296-2.643), acetylcholine (β, 0.441; 95 % CI, 0.415-0.468), GABA (β, 0.009; 95 % CI, 0.001-0.016) and 5-HT (β, 0.160; 95 % CI, 0.081-0.238) compared to the placebo group. And the intervention may improve short-term memory by increasing serum ALA levels (average causal mediation effect = 0.132, 95 % CI, 0.053-0.225) with 19.7 % mediation proportion. CONCLUSIONS: This food supplement containing phosphatidylserine could improve different cognitive functions of MCI patients, especially short-term memory, and increase serum n-3 PUFAs and neurotransmitters levels. Serum ALA level might play a mediation role. Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved. DOI: 10.1016/j.jad.2024.09.131 PMID: 39317299 [Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest The authors declare no conflict of interest, financial or otherwise.
11. Clin Cardiol. 2024 Jul;47(7):e24309. doi: 10.1002/clc.24309. Role of Thiamine Supplementation in the Treatment of Chronic Heart Failure: An Updated Meta-Analysis of Randomized Controlled Trials. He S(1), Wang S(2), Xu T(2), Wang S(2), Qi M(2), Chen Q(2), Lin L(2), Wu H(2), Gan P(2). Author information: (1)Department of Hand and Foot Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China. (2)Department of Intensive Care Rehabilitation, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China. BACKGROUND: Chronic heart failure (CHF) has always posed a significant threat to human survival and health. The efficacy of thiamine supplementation in CHF patients remains uncertain. HYPOTHESIS: Receiving supplementary thiamine may not confer benefits to patients with CHF. METHODS: A comprehensive search was conducted across the Cochrane Library, PubMed, EMBASE, ClinicalTrials.gov, and Web of Science databases up until May 2023 to identify articles investigating the effects of thiamine supplementation in CHF patients. Predefined criteria were utilized for selecting data on study characteristics and results. RESULTS: Seven randomized, double-blind, controlled trials (five parallel trials and two crossover trials) involving a total of 274 patients were enrolled. The results of the meta-analysis pooling these studies did not reveal any significant effect of thiamine treatment compared with placebo on left ventricular ejection fraction (WMD = 1.653%, 95% CI: -1.098 to 4.405, p = 0.239, I2 = 61.8%), left ventricular end-diastolic volume (WMD = -6.831 mL, 95% CI: -26.367 to 12.704, p = 0.493, I2 = 0.0%), 6-min walking test (WMD = 16.526 m, 95% CI: -36.582 to 69.634, p = 0.542, I2 = 66.3%), N-terminal pro-B type natriuretic peptide (WMD = 258.150 pg/mL, 95% CI: -236.406 to 752.707, p = 0.306, I2 = 21.6%), or New York Heart Association class (WMD = -0.223, 95% CI: -0.781 to 0.335, p = 0.434, I2 = 87.1%). However, it effectively improved the status of thiamine deficiency (TD). CONCLUSIONS: Our meta-analysis indicates that thiamine supplementation does not have a direct therapeutic effect on CHF, except for correcting TD. © 2024 The Author(s). Clinical Cardiology published by Wiley Periodicals LLC. DOI: 10.1002/clc.24309 PMCID: PMC11212003 PMID: 38940395 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflicts of interest.
12. Nutr Rev. 2025 Feb 1;83(2):280-306. doi: 10.1093/nutrit/nuae043. Effect of nutritional interventions on the psychological symptoms of premenstrual syndrome in women of reproductive age: a systematic review of randomized controlled trials. Robinson J(1), Ferreira A(1), Iacovou M(2), Kellow NJ(1)(2). Author information: (1)Department of Nutrition, Dietetics and Food, Monash University, Notting Hill, Victoria, Australia. (2)Department of Molecular and Translational Science, Centre of Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia. CONTEXT: Premenstrual syndrome (PMS) affects approximately 48% of women of reproductive age worldwide. It can lead to functional impairment, lower quality of life, and decreased work productivity. Despite the availability of medical treatment options, women are seeking alternative interventions because of concerns of harmful side effects and limited evidence of efficacy associated with pharmacological treatments. To date, high-quality research investigating the effects of dietary and nutrient intervention on PMS is limited. OBJECTIVE: This systematic review investigated the effect of nutritional interventions on the psychological symptoms of PMS. DATA SOURCES: Five electronic databases were searched for randomized controlled trials (RCTs) published in English from inception to October 2022. Trials eligible for inclusion were nutritional intervention studies involving women of reproductive age that measured PMS-associated psychological outcomes. DATA EXTRACTION: Articles were selected using prespecified inclusion criteria. Data screening and extraction and risk-of-bias assessments were conducted by 3 independent reviewers using article screening software and the Cochrane Risk of Bias 2 tool. DATA ANALYSIS: Thirty-two articles reporting on 31 RCTs involving 3254 participants, ranging in age from 15 to 50 years were included and narratively reviewed. Only 1 of the included studies had a low risk of bias. Treatment with vitamin B6, calcium, and zinc consistently had significant positive effects on the psychological symptoms of PMS. There was insufficient evidence to support the effects of vitamin B1, vitamin D, whole-grain carbohydrates, soy isoflavones, dietary fatty acids, magnesium, multivitamin supplementation, or PMS-specific diets. CONCLUSIONS: There is some evidence to support the use of nutritional interventions for improving psychological symptoms of PMS. However, more research using consistent protocols, procedures to minimize risk of bias, intention-to-treat analysis, and clearer reporting is required to provide conclusive nutritional recommendations for improving PMS-related psychological outcomes. PROSPERO REGISTRATION NO: CRD42022369999. © The Author(s) 2024. Published by Oxford University Press on behalf of the International Life Sciences Institute. DOI: 10.1093/nutrit/nuae043 PMCID: PMC11723155 PMID: 38684926 [Indexed for MEDLINE]
13. Clin Nutr. 2023 Dec;42(12):2443-2456. doi: 10.1016/j.clnu.2023.09.009. Epub 2023 Oct 5. A nutritional supplement during preconception and pregnancy increases human milk vitamin D but not B-vitamin concentrations. Han SM(1), Huang F(2), Derraik JGB(3), Vickers MH(1), Devaraj S(4), Redeuil K(5), Campos-Giménez E(5), Pang WW(6), Godfrey KM(7), Chan SY(8), Thakkar SK(4), Cutfield WS(9); NiPPeR Study Group. Collaborators: Albert BB, Barton SJ, Binia A, Cavanagh M, Chang HF, Chong YS, Chong MF, Conlon C, Cooper C, Costello P, Cox V, Creagh C, Depczynski M, El-Heis S, Hammond J, Harvey NC, Jagtap M, Kenealy T, Nield H, O'Sullivan JM, Satianegara G, Silva-Zolezz I, Soh SE, Tay V, Taylor R, Tham E, Titcombe P, Wall C, Wong R, Woon G, Han Z. Author information: (1)Liggins Institute, The University of Auckland, Auckland, New Zealand. (2)Nestlé Research, Société des Produits Nestlé SA, Beijing, China. (3)Liggins Institute, The University of Auckland, Auckland, New Zealand; Department of Paediatrics: Child and Youth Health, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand. (4)Nestlé Research, Société des Produits Nestlé SA, Singapore. (5)Nestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland. (6)Global Centre for Asian Women's Health, Dean's Office, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore. (7)MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK. (8)Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore. (9)Liggins Institute, The University of Auckland, Auckland, New Zealand; A Better Start - National Science Challenge, The University of Auckland, Auckland, New Zealand. Electronic address: w.cutfield@auckland.ac.nz. BACKGROUND & AIMS: Optimal maternal vitamin status during pregnancy and lactation is essential to support maternal and infant health. For instance, vitamin D3 is involved in infant bone development, and B-vitamins are involved in various metabolic processes, including energy production. Through a double-blind randomised controlled trial, we investigated the effects of maternal supplementation from preconception throughout pregnancy until birth on human milk (HM) concentrations of vitamin D3 and B-vitamins. In addition, we aimed to characterise longitudinal changes in milk concentrations of these vitamins. METHODS: Both control and intervention supplements contained calcium, iodine, iron, β-carotene, and folic acid, while the intervention also contained zinc, vitamins B2, B6, B12, and D3, probiotics, and myo-inositol. HM samples were collected across 4 time points from 1 week to 3 months post-delivery from 158 mothers in Singapore, and 7 time points from 1 week to 12 months from 180 mothers in New Zealand. HM vitamin D was quantified using supercritical fluid chromatography and B-vitamins with mass spectrometry. Potential intervention effects on HM vitamins D3, B2, B6, and B9, as well as other B-vitamin (B1 and B3) concentrations were assessed using linear mixed models with a repeated measures design. RESULTS: Over the first 3 months of lactation, HM 25-hydroxyvitamin D3 concentrations were 20% (95% CI 8%, 33%, P = 0.001) higher in the intervention group, with more marked effects in New Zealand. There were no observed intervention effects on HM concentrations of vitamins B1, B2, B3, B6, and B9. In New Zealand mothers, longitudinally, vitamin D3 concentrations gradually increased from early lactation up to 12 months, while vitamins B1 and B2 peaked at 6 weeks, B3 at 3 weeks, and B6 and B9 at 3 months. CONCLUSIONS: Maternal supplementation during preconception and pregnancy increased HM vitamin D, but not B-vitamin concentrations in lactation. Further studies are required to examine the discrete benefits of vitamin D supplementation starting preconception vs during pregnancy, and to further characterise the effects of supplementation on later offspring health outcomes. CLINICAL TRIAL REGISTRATION: Registered at ClinicalTrials.gov on the 16 July 2015 (identifier NCT02509988); Universal Trial Number U1111-1171-8056. This study was academic-led by the EpiGen Global Research Consortium. Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved. DOI: 10.1016/j.clnu.2023.09.009 PMID: 38411017 [Indexed for MEDLINE]
14. BMC Nephrol. 2023 Dec 14;24(1):372. doi: 10.1186/s12882-023-03423-8. Effects of a low-protein nutritional formula with dietary counseling in older adults with chronic kidney disease stages 3-5: a randomized controlled trial. Yang WC(1), Hsieh HM(1), Chen JP(2), Liu LC(1), Chen CH(3)(4)(5)(6). Author information: (1)Department of Food and Nutrition, Taichung Veterans General Hospital, Taichung, Taiwan. (2)Biostatistics Group, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan. (3)Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, No. 1650, Sect. 4, Taiwan Boulevard, Taichung, Taiwan. cschen920@yahoo.com. (4)Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University School of Medicine, Taichung, Taiwan. cschen920@yahoo.com. (5)Department of Life Science, Tunghai University, Taichung, Taiwan. cschen920@yahoo.com. (6)Program in Tissue Engineering and Regenerative Medicine, College of Medicine, National Chung-Hsing University, Taichung, Taiwan. cschen920@yahoo.com. BACKGROUND: Although combining a low-protein diet (LPD) with oral nutritional supplements increases treatment adherence and nutritional status in patients with chronic kidney disease (CKD), the effect of this combination approach in older adults remains unclear. This study examined the impact of a 6% low-protein formula (6% LPF) with diet counseling in older adults with stage 3-5 CKD. METHODS: In this three-month randomized controlled study, 66 patients (eGFR < 60 mL/min/1.73 m2, non-dialysis, over 65 years of age) were randomly assigned to an intervention group (LPD plus a 6% LPF) or control group (LPD alone). The 6% LPF comprised 400 kcal, 6 g of protein, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and various micronutrients. All data were collected at baseline and after three months, including physical performance based on hand grip strength (HGS) and gait speed, nutritional status using Mini Nutritional Assessment-Short Form (MNA-SF) scores, body composition through bioelectrical impedance analysis, and dietary intake from 24-h dietary records. RESULTS: This study incorporated 47 participants (median age, 73; median eGFR, 36 ml/min/1.73 m2; intervention group: 24; control group: 23). The intervention group exhibited significant differences in HGS and gait speed, and micronutrient analysis revealed significantly higher monounsaturated fatty acids (MUFA), EPA, DHA, calcium, iron, zinc, copper, thiamine, riboflavin, niacin, B6, B12, and folic acid intake than the control group. MNA-SF scores, macronutrient intake, and body composition did not differ significantly between the two groups. CONCLUSIONS: Compared to LPD counseling alone, an LPD prescription with 6% LPF in older adults with CKD stages 3-5 helped relieve physical deterioration and increased micronutrient intake after three months. TRIAL REGISTRATION: ClinicalTrials.gov NCT05318014 (retrospectively registered on 08/04/2022). © 2023. The Author(s). DOI: 10.1186/s12882-023-03423-8 PMCID: PMC10720150 PMID: 38097963 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no competing interests.
15. Int J Med Sci. 2023 Aug 15;20(10):1272-1281. doi: 10.7150/ijms.86738. eCollection 2023. A functional evaluation of anti-fatigue and exercise performance improvement following vitamin B complex supplementation in healthy humans, a randomized double-blind trial. Lee MC(1), Hsu YJ(1), Shen SY(2), Ho CS(1), Huang CC(1)(3). Author information: (1)Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan City 333325, Taiwan. (2)Graduate Institute of Applied Science and Engineering, Fu-Jen Catholic University, New Taipei City, 242062, Taiwan. (3)Tajen University, Pingtung 907101, Taiwan. B vitamins play a crucial role in maintaining fundamental cellular functions and various essential metabolic pathways in the body. Although they do not directly provide energy, each B vitamin acts as a cofactor in energy metabolism processes. Based on the evidence presented above, we hypothesized that a 28-day supplementation of vitamin B would enhance physical performance and reduce physical fatigue. The objective of this study was to evaluate the anti-fatigue effect of vitamin B supplementation, specifically vitamin B1, B2, B6, and B12, and its potential to improve exercise performance. We employed a randomized double-blind crossover design with a 28-day supplementation period. Sixteen male and sixteen female subjects, aged 20-30 years, were divided into two groups: the placebo group (n=16, equal gender distribution) and the Ex PLUS® group (n=16, equal gender distribution). The participants received either placebo or Ex PLUS® (one tablet per day) for 28 consecutive days. Following the intervention, there was a 14-day wash-out period during which the subjects did not receive any further interventions. After supplementation with Ex PLUS®, we found a significant increase in the running time by 1.26-fold (p < 0.05) to exhaustion compared to that before supplementation and that in the placebo group. In addition, the Ex PLUS® supplementation group presented significantly reduced blood lactate and blood ammonia concentrations during exercise and at rest after exercise compared with placebo (p < 0.05). In conclusion, 28 consecutive days of vitamin B complex (Ex PLUS®) supplementation significantly improved exercise endurance performance and reduced exercise fatigue biochemical metabolites in not athletes. In addition, it does not cause adverse effects in humans when taken at appropriate doses. © The author(s). DOI: 10.7150/ijms.86738 PMCID: PMC10542023 PMID: 37786445 [Indexed for MEDLINE] Conflict of interest statement: Competing interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
1. Org Biomol Chem. 2026 Jun 5. doi: 10.1039/d6ob00705h. Online ahead of print. Efficient and metal-free synthesis of functionalized unsymmetrical pyrrolyl-pyridine boron difluoride fluorophores. Aryamueang S(1), Ranuman P(1), Suwanwong N(2)(3), Srimontree W(1), Lai RY(1), Kamkaew A(1). Author information: (1)School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, 30000, Thailand. aryamueang.siri@gmail.com. (2)Program in Chemical Sciences, Chulabhorn Graduate Institute, Bangkok 10210, Thailand. (3)Center of Excellence on Environmental Health and Toxicology (EHT), OPS, Ministry of Higher Education, Science, Research and Innovation, Bangkok 10400, Thailand. The rapid and sustainable construction of highly functionalized fluorophores remains a key challenge in organic synthesis. We detail a concise, metal-free synthetic platform for the preparation of unsymmetrical pyrrolyl-pyridine boron difluoride (BOPP) complexes from simple chalcone precursors. Central to this methodology is the optimization of a thiamine-mediated Stetter reaction under mild sonication, which efficiently generates key 1,4-diketone intermediates. Subsequent Paal-Knorr cyclization and BF3 complexation afford the desired BOPP dyes in good to excellent overall yields. This modular synthetic approach enabled facile expansion of the BOPP library, overcoming the inherent limitations of conventional cross-coupling methods. The synthesized BOPP fluorophore
2. Medicine (Baltimore). 2026 Jun 12;105(24):e49149. doi: 10.1097/MD.0000000000049149. Association between dietary thiamin, riboflavin and niacin intake and hypertension and increased pulse pressure: A cross-sectional study of the National Health and Nutrition Examination Survey 1999-2023. Ma S(1), Jin Q(2), Yu K(2), Dong H(1), Lu Y(1), Chang L(2). Author information: (1)Department of Cardiology, Changchun University of Traditional Chinese Medicine, Changchun, China. (2)Cardiology Department, Changchun University of Traditional Chinese Medicine Affiliated Hospital, Changchun, China. This cross-sectional study aimed to examine the associations between total intake of 3 B vitamins (thiamin, riboflavin, niacin) and hypertension and increased pulse pressure in U.S. adults, and to explore potential nonlinear relationships.Data from the U.S. National Health and Nutrition Examination Survey (NHANES) 1999-2023 were analyzed. A total of 17,484 participants aged ≥ 20 years were included. Total vitamin intake (diet plus supplements) was categorized into quartiles. Hypertension was defined as SBP ≥ 140 mm Hg or DBP ≥ 90 mm Hg; increased pulse pressure as PP ≥ 60 mm Hg. Multivariable logistic regression and restricted cubic spline (RCS) models were used, adjusting for demographic, socioeconomic, and clinical factors.In fully adjusted models, the highest quartile of total thiamin (OR 1.17, 95% CI 1.04-1.31), riboflavin (OR 1.23, 95% CI 1.10-1.39), and niacin (OR 1.16, 9
3. Conserv Physiol. 2026 Jun 10;14(1):coag037. doi: 10.1093/conphys/coag037. eCollection 2026. Fatty acid profiles recorded in ocean prey and California salmonine eggs reveal maternal ocean diets linked to thiamine deficiency. Ludwig JM(1), Mantua NJ(2), Johnson RC(2)(3), Field J(2), Ward AE(3), Rowland FE(4), Williams TH(2), Lipscomb T(5), Jeffres C(3), Rinchard J(1). Author information: (1)Department of Environmental Science and Ecology, State University of New York-Brockport, 350 New Campus Drive, Brockport, NY 14420, USA. (2)Fish Ecology Division, Southwest Fisheries Science Center, NOAA Fisheries, 110 McAllister Way, Santa Cruz, CA 95060, USA. (3)Center for Watershed Science, University of California, Davis, 1 Shields Avenue, Davis, CA 95616, USA. (4)Columbia Environmental Research Center, U.S. Geological Survey, 4200 New Haven Road, Columbia, MO 65201, USA. (5)Department of the Interior, U.S. Fish and Wildlife Service-Headquarters, 5275 Leesburg Pike, Falls Church, VA 22041, USA. Following the principle 'you are what you eat', fatty acid signatures (FASs) of adult fish tissues, when compared with those of potential prey, can link diet to nutritional status. In 2020, thiamine (vitamin B1) deficiency was diagnosed for the first time in multiple anadromous salmon populations in California. However, direct information linking ocean diet to thiamine status in marine-feeding salmonines is typically unavailable. This research aimed to link diet composition an
4. Int J Crit Illn Inj Sci. 2026 May 18;16(2):53-56. doi: 10.4103/ijciis.ijciis_124_25. eCollection 2026 Apr-Jun. Evaluating the role of high-dose intravenous thiamine supplementation for lactate clearance in patients with cirrhosis and sepsis. Ali R(1), Yazdi A(2), Collins K(2), Guffey D(3), Wu TD(2), Kessinger R(1), Omranian A(2), Vallabh M(1). Author information: (1)Department of Pharmacy, Baylor St. Luke's Medical Center, Houston, TX, USA. (2)Section of Pulmonary, Critical Care, and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA. (3)Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA. BACKGROUND: Thiamine is a vitamin that plays a role in lactate clearance. Patients with sepsis may present with elevated lactate, and also in cirrhosis, as lactate is hepatically metabolized. Prior studies showed mixed results regarding the role of thiamine for lactate clearance with limited inclusion of cirrhosis patients. The purpose of this study was to determine the association of high-dose intravenous thiamine on time to lactate clearance among patients with cirrhosis and sepsis. METHODS: We performed a single-center retrospective cohort study of critically ill patients with cirrhosis with a diagnosis of sepsis with lactate >4 mmol/L between January 1, 2020, and December 31, 2024. Patients who received ≥400 mg were classified as receiving high-dose thiamine. Fine-Gray competing risks models adjusted for demogra
5. Foods. 2026 Jun 5;15(11):2028. doi: 10.3390/foods15112028. Impact of Boiling on Cyanogenic Detoxification and Nutrient Retention in Cnidoscolus aconitifolius (Chaya) Leaves. Praditukrit C(1), Muangnoi C(2), Panritdum P(2), Sirivarasai J(3). Author information: (1)Master of Science Program in Nutrition, Faculty of Medicine Ramathibodi Hospital and Institute of Nutrition, Mahidol University, Bangkok 10400, Thailand. (2)Biological Science and Animal Model Unit, Institute of Nutrition, Mahidol University, Nakhon Pathom 73170, Thailand. (3)Nutrition Unit, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand. Cyanogenic glycosides in leafy vegetables pose significant food safety concerns because they release hydrogen cyanide (HCN) when plant tissue is disrupted. Although boiling is widely used for detoxification, its effects on nutritional quality and bioactive compounds remain insufficiently characterized. This study evaluated the effects of boiling on HCN, carotenoids, antioxidant capacity, and nutrient retention in Cnidoscolus aconitifolius (chaya) leaves. Antioxidant capacity was determined using the oxygen radical absorbance capacity, ferric reducing antioxidant power, and 2,2-diphenyl-1-picrylhydrazyl assays. An integrative nutrient retention index (NRI) was used to assess overall nutrient preservation. Boiling reduced HCN by 99.94%, confirming effective detoxification through hydrolysis, volatilization, and leaching. β-c
6. Int J Mol Sci. 2026 Jun 2;27(11):5022. doi: 10.3390/ijms27115022. Hippocampal, Microglial, Morphological, and Amyloid Profiles Following Thiamine Pyrophosphate Treatment in 3xTg-AD Mice. Pastén-Castrejón NJ(1)(2), Martínez-Orozco H(2), Gutiérrez-Silerio GY(1), Hernández-Montiel HL(3), Maya-Arteaga JP(2), Poblano-Paez I(2), García-Solís P(1), Díaz-Miranda SY(2). Author information: (1)Laboratorio de Endocrinología y Nutrición, Facultad de Medicina, Centro de Investigación Biomédica Avanzada de la Universidad Autónoma de Querétaro, Santiago de Querétaro 76140, Mexico. (2)Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología-UNAM Campus Juriquilla, Boulevard Juriquilla 3001, Querétaro 76230, Mexico. (3)Laboratorio de Neurobiología y Bioingeniería Celular, Facultad de Ciencias Naturales de la Universidad Autónoma de Querétaro, Querétaro 76230, Mexico. Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ) and chronic neuroinflammation, with microglia playing a central role in its pathogenesis. Alterations in microglial metabolism have been proposed to contribute to AD-related inflammatory responses and reduced Aβ clearance, suggesting that thiamine-dependent pathways may be relevant in this context. Thiamine pyrophosphate (TPP), the active form of vitamin B1, is essential for glucose metabolism and mitochondrial function; however, its association with microglial changes in AD remains unclear. In t
7. Sci Rep. 2026 Jun 11. doi: 10.1038/s41598-026-56764-3. Online ahead of print. Modulation of grape must vitamin content by oenological treatments affects Saccharomyces cerevisiae fermentation performance and wine volatile composition. Garces F(1)(2), Picart J(3), Bosaro M(4), Riviere E(5), Morge C(6), Alexandre H(3), Roullier-Gall C(3). Author information: (1)Université Bourgogne Europe, Institut Agro, INRAE, UMR PAM, 21000, Dijon, France. fabien_garces@etu.ube.fr. (2)Sofralab SAS, 79 Avenue Alfred Anatole Thévenet, 51530, Magenta, France. fabien_garces@etu.ube.fr. (3)Université Bourgogne Europe, Institut Agro, INRAE, UMR PAM, 21000, Dijon, France. (4)Italiana Biotecnologie, Via Vigazzolo 112, 36054, Montebello Vicentino, Italy. (5)Laboratoire Océania, 1 Rue des Tonneliers, 44330, Vallet, France. (6)Sofralab SAS, 79 Avenue Alfred Anatole Thévenet, 51530, Magenta, France. This study explores the impact of oenological treatments with fining agents or yeast-based nutrients on the vitamin content of grape musts, and thus on the fermentative performance of Saccharomyces cerevisiae yeasts and the volatile composition of wine. Products such as bentonites and oenological carbons were shown to deplete several B-group vitamins from the must, while yeast derivatives were able to release significant amounts. Bentonite was used to modulate the vitamin B1 (thiamine) content of a real must and different yeast inoculation procedures were evaluated: active dry yeast and cel
8. Curr Opin Crit Care. 2026 Jun 4. doi: 10.1097/MCC.0000000000001396. Online ahead of print. Micronutrient trials in critical illness - new evidence since 2023. Blaauw R(1), Berger MM(2). Author information: (1)Division Human Nutrition, Stellenbosch University, Cape Town, South Africa. (2)Faculty of Biology & Medicine, Lausanne University, Lausanne, Switzerland. PURPOSE: Numerous trials have tested the impact on outcome of single high to very high doses of micronutrients as adjuvant therapy in severe critical illness and particularly in septic shock. The present review will address the recent knowledge acquired since 2023 including mainly randomized controlled trials (RCTs), but also some quality observational studies. RECENT FINDINGS: Eighteen RCTs and nine meta-analyses were reviewed and globally confirm previous findings. Very high MN dose interventions delivered independent of a predisease deficiency in the early phase are not successful. The most frequently used outcomes are duration on vasopressors, length of mechanical ventilation, kidney injury, neurological outcome, biomarkers of inflammation, and mortality. Nosocomial infections are rarely reported, and immunity is rarely addressed while being dependent on micronutrients for optimization. Potential factors impacting study outcomes are discussed, such as the heterogeneity of doses, durations of therapy, primary endpoints, and absence of consideration of the level of inflammation and physiological r
9. J Am Chem Soc. 2026 Jun 10. doi: 10.1021/jacs.6c07454. Online ahead of print. Discovery of Pyranoquinolone Diterpenoids Biosynthesized through Oxidative Indole Rearrangement and Atypical Terpene Cyclization. Kakumu Y(1), Helfrich EJN(1)(2). Author information: (1)Institute of Molecular Biosciences, Goethe University Frankfurt, Max-von-Laue Strasse 9, Frankfurt am Main 60438, Germany. (2)Senckenberg Research Institute and Natural History Museum Frankfurt, Senckenberganlage 25, Frankfurt am Main 60325, Germany. Pyr4-like transmembrane terpene cyclases (TCs) are key enzymes in the biosynthesis of diverse fungal meroterpenoids. However, their roles in bacterial meroterpenoid biosynthesis remain largely unexplored. Here, we charted the biosynthetic space of bacterial Pyr4-like TCs and discovered zigralone A, a quinolone diterpenoid. Functional characterization of the gene cluster established a multienzymatic assembly of its 6/6/6/5/6/6/6-heptacyclic scaffold. Key transformations include an oxidative indole rearrangement catalyzed by a thiamine pyrophosphate-dependent enzyme to form a 4-quinolone. Subsequent cytochrome P450-mediated epoxidation and hydroxylation direct carbo/oxacyclizations catalyzed by a Pyr4-like TC, generating a bilobed architecture of a pyranoquinolone and a 6/6/6-tricyclic ring system. Further P450-mediated oxidations and nonenzymatic hemiketalization furnish a spiro-fused tetrahydrofuran, completing the heptacyclic framework. Notably, zi
10. Case Rep Gastrointest Med. 2026 Jun 8;2026:3195006. doi: 10.1155/crgm/3195006. eCollection 2026. Gastrointestinal Beriberi Secondary to Intermittent Hemodialysis With Rapid Improvement Following Thiamine Administration. Day BD(1), Lever JEP(2), Vickers K(1), Centor R(1). Author information: (1)Department of Internal Medicine, Tinsley Harrison Internal Medicine Residency Program, University of Alabama at Birmingham, Birmingham, Alabama, USA, uab.edu. (2)Department of Anesthesiology and Perioperative Medicine, Anesthesiology Residency Program, University of Alabama at Birmingham, Birmingham, Alabama, USA, uab.edu. Thiamine deficiency is classically linked to malnutrition and chronic alcohol use, but emerging evidence indicates that patients on intermittent hemodialysis (iHD) are also at significant risk. While cardiovascular and neurologic syndromes are well characterized, gastrointestinal (GI) beriberi remains an underrecognized presentation. We describe a 67-year-old man on iHD with chronic abdominal pain, nausea, vomiting, and anorexia refractory to conventional therapy. Workup revealed elevated lactate and a low plasma thiamine level prior to supplementation. Symptoms and elevated lactate resolved rapidly following intravenous thiamine. This case underscores GI beriberi as a treatable cause of chronic GI symptoms in dialysis patients. Copyright © 2026 Benjamin Dale Day et al. Case Reports in Gastrointestinal Medicine published by John Wiley & Sons Lt
11. Respir Med. 2026 Jun 6:108943. doi: 10.1016/j.rmed.2026.108943. Online ahead of print. The Association Between Thiamine Use and Mortality in Critically Ill Patients with Sepsis-Associated Acute Respiratory Failure: A Retrospective Analysis of the MIMIC-IV Database. Yin M(1), Suo X(1), Li M(1), He Q(2), Xu D(3). Author information: (1)Department of Respiratory and Critical Care Medicine, Xishan People's Hospital Of Wuxi City, Wuxi, China. (2)Department of Respiratory and Critical Care Medicine, Third Affiliated Hospital of Soochow University, Changzhou, China. Electronic address: 532031383@qq.com. (3)Department of Respiratory and Critical Care Medicine, Xishan People's Hospital Of Wuxi City, Wuxi, China. Electronic address: 361706332@qq.com. BACKGROUND: Thiamine (vitamin B1) is a crucial cofactor in energy metabolism and antioxidant defense, yet its specific impact on patients with sepsis-associated acute respiratory failure remains unclear. METHODS: We conducted a retrospective cohort study of 6248 sepsis-associated acute respiratory failure patients in the MIMIC-IV database (2008-2019). Patients were categorized based on thiamine supplementation. The primary endpoints were in-hospital and ICU mortality, analyzed using Kaplan-Meier curves, multivariable Cox regression, propensity score matching (PSM), and subgroup analyses. RESULTS: The thiamine group comprised 1576 patients and the no-thiamine group 4672. After adjustment, the no thiamine group had a h
12. Front Neurol. 2026 May 20;17:1837183. doi: 10.3389/fneur.2026.1837183. eCollection 2026. Periodic alternating nystagmus as a diagnostic clue in MRI-negative Wernicke encephalopathy mimicking multiple system atrophy: a case with complex heterogeneous dizziness. Zhou H(1), Zhang R(1), Wang W(1). Author information: (1)Department of Neurology, Civil Aviation General Hospital, Beijing, China. Dizziness in elderly patients is heterogeneous and nonspecific, leading to frequent misdiagnosis. Wernicke encephalopathy (WE) is a severe but reversible nutritional disorder responsive to timely thiamine supplementation; it often lacks typical MRI changes and may mimic neurodegenerative diseases such as multiple system atrophy (MSA). A 62-year-old male with chronic heavy alcohol use presented with 1 year of recurrent heterogeneous dizziness, vertigo, unsteadiness, presyncope, falls, and nocturnal visual hallucinations. Severe orthostatic hypotension and pyramidal signs initially suggested MSA. Peripheral neuropathy was attributed to chronic alcohol intake. Brain MRI was normal without typical WE lesions. Videonystagmography revealed periodic alternating nystagmus (PAN), saccadic intrusions, and impaired smooth pursuit, indicating central vestibular dysfunction. These ocular abnormalities resolved rapidly after thiamine replacement, excluding MSA, confirming MRI-negative WE. With high-dose thiamine, cobalamin, and alcohol cessation, PAN disappeared, dizziness and hyp
13. Environ Pollut. 2026 Jun 3;405:128503. doi: 10.1016/j.envpol.2026.128503. Online ahead of print. Environmental molybdenum exposure remodels pulmonary metabolic networks and disrupts oxidative stress-inflammation homeostasis, leading to lung injury and respiratory rhythm disturbances. Ren H(1), Khan A(2), Shen X(3). Author information: (1)College of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, 621010, China; North Sichuan Medical College, Nanchong, 637100, China. (2)College of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, 621010, China. (3)College of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, 621010, China; Rural Revitalization Project Center, Guizhou Department of Agriculture and Rural Affairs, Guiyang, 550000, China. Electronic address: shenxy@swust.edu.cn. Environmental molybdenum (Mo) exposure is increasing worldwide. Notably, the lung has been recognized as a key target organ for heavy metal toxicity, yet the mechanisms underlying Mo-induced lung injury remain poorly understood. In this study, we systematically explored the mechanisms underlying Mo-induced lung injury through a multi-omics strategy integrating respiratory function evaluation, histopathology, biochemical analyses, proteomics, and metabolomics. Our results showed that Mo exposure led to significant accumulation of Mo in lung tissue, accompanied by in
14. Physiother Theory Pract. 2026 Jun 3:1-11. doi: 10.1080/09593985.2026.2683239. Online ahead of print. Physical therapy for a patient with polyneuropathy and cognitive deficits from dry beriberi: case report. Thomas C(1)(2), Massad R(1). Author information: (1)Department of Physical Therapy, Nova Southeastern University, Davie, USA. (2)Memorial Rehabilitation Institute, Rehabilitation Services, Hollywood, Florida, USA. INTRODUCTION: Dry beriberi presents with peripheral polyneuropathy, cognitive deficits, and functional decline that warrant physical therapy. OBJECTIVE: The purpose of this report is to describe the clinical presentation and physical therapy management of a patient with dry beriberi, highlighting the role of neuroplasticity and motor learning strategies. CASE DESCRIPTION: A 36-year-old female transferred to inpatient rehabilitation. Evaluation revealed cognitive deficits inconsistent with the admitting diagnosis, Guillain-Barré. A medical workup identified thiamine deficiency, suggesting dry beriberi, consistent with her sensorimotor polyneuropathy and impairments in attention, memory, and executive function. Her history of alcohol abuse further supported the dry beriberi diagnosis. She received physical therapy across 26 days in inpatient rehabilitation. Motor learning was promoted through the manipulation of practice conditions, feedback, and implicit processes to maximize mobility gains despite cognitive deficits. Repetition and salience
15. Yeast. 2026 Jun 3. doi: 10.1002/yea.70029. Online ahead of print. Genetic Tools in the Nakaseomyces clade for Evolutionary Comparisons of Signal Transduction Pathways. Abraham M(1), Iosue CL(1), Wykoff DD(1). Author information: (1)Department of Biology, Villanova University, Villanova, Pennsylvania, USA. The genus Nakaseomyces provides four species that are closely related but have different characteristics. For example, N. glabratus (formerly known as Candida glabrata) is a common human pathogen, whereas N. bracarensis and N. nivariensis have been isolated in clinical settings but are not common human pathogens. N. delphensis was isolated from fruit and there is no evidence it is pathogenic. Given the differences, we developed the clade as a molecular genetic system where we could introduce plasmids and assess transcriptional output from cloned promoters. We engineered a CRISPR/Cas9 plasmid that allows for rapid Gibson cloning of gRNAs, generated auxotrophic strains for amino acids and nucleotides, and introduced plasmids into each species. We used promoter-YFP plasmids to determine that while there are differences between the species, each species likely has intact thiamine and phosphate (THI and PHO) signal transduction pathways, and that gene expression in N. glabratus and N. bracarensis is more similar to one another than to the other two species. Finally, we determine that N. glabratus, N. bracarensis, and N. nivariensis persist in a murine macro
1. Electrophoresis. 2026 Aug 17. doi: 10.1002/elps.70143. Online ahead of print. Spacer-Enhanced Resolution of Thiamine and Pyridoxine in Hydrodynamically Closed Two-Dimensional Capillary Isotachophoresis Coupled With Tandem Mass Spectrometry. Cermakova P(1), Jackuliakova P(1), Spaglova M(1), Parrak V(1)(2), Piestansky J(1)(3). Author information: (1)Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University Bratislava, Bratislava, Slovak Republic. (2)Clinic of Hematology and Transfusiology, St. Cyril and Methodius Hospital, Bratislava, Slovak Republic. (3)Toxicological and Antidoping Center, Faculty of Pharmacy, Comenius University Bratislava, Bratislava, Slovak Republic. The effect of specific spacers added to the separation environment of capillary isotachophoresis in a hydrodynamically closed two-dimensional device hyphenated with tandem mass spectrometry is reported in this short communication. Combination of two spacers, here, 2-amino-2-hydroxymethyl-propane-1,3-diol and histidine, led to enhanced resolution of two model analytes (thiamine and pyridoxine) in model and real pharmaceutical samples (tablet drug dosage form). The addition of the spacers at relatively high concentration level (i.e., 20 µg/mL) caused no significant interference and suppression of the analytical signal in the mass spectrometry detection step. Eco-friendliness, practicality, and performance of the method were confirmed using the metric tools of the "White Analy
2. J Food Sci Technol. 2026 Sep;63(9):1682-1690. doi: 10.1007/s13197-025-06337-5. Epub 2025 May 26. Development of Vitamin-fortified rice analogs with a focus on extrusion and cooking stability and retention. Ganachari A(1), Nidoni U(2), Hiregoudar S(2), Ganachari S(3), K T R(2), Naik N(2), S V(4), Mathad PF(2). Author information: (1)Zonal Agricultural Research Station, Kalaburagi-03, (UAS Raichur), Raichur, Karnataka India. (2)Department of Processing & Food Engg., College of Agril. Engg., UAS Raichur, Raichur, Karnataka India. (3)School of Advanced Sciences, KLE Technological University, B. V. Bhoomaraddi Campus, Vidyanagar, Hubballi, Karnataka India. (4)Home Science, AEEC Lingasugur, UAS Raichur, Raichur, Karnataka India. Rice, a global staple, often lacks essential nutrients due to milling, leading to micronutrient deficiencies or "hidden hunger." This study aimed to optimize the fortification of rice analogues with essential vitamins, focusing on nutrient retention during cooking. Using cold extrusion technology, rice analogues were produced from a mixture of rice flour, sodium alginate (1%), water (30%), and a nutrient ready mix (NRM) in varying proportions: low-dose (100%), intermediate-dose (125%), and High-dose (150%) of recommended levels. The fortification level was statistically optimized using Design Expert software, with high-dose fortification (150% NRM) yielding the highest cooking retention, achieving a desirability value of 0.961. Post-co
3. J Fish Dis. 2026 Aug 14:e70253. doi: 10.1111/jfd.70253. Online ahead of print. Mortality in Salmon (Salmo salar) Fry Related to Lipoid Liver Disease Induced by Unbalanced Fatty Acid Composition of the Diet. Ek C(1), Persson L(2), Axén C(3). Author information: (1)Department of Aquatic Resources, Institute of Freshwater Research, Swedish University of Agricultural Sciences, Stockholm, Sweden. (2)Department for Wildlife, Fish and Environmental Research, Swedish University of Agricultural Sciences, Umeå, Sweden. (3)Section for Fish, Department of Animal Health and Antimicrobial Strategies, Swedish Veterinary Agency, Uppsala, Sweden. In 2023, all but one Swedish restocking farm rearing Baltic salmon and sea trout fry experienced massive mortality caused by lipoid liver disease (LLD). The struck farms used the same feed, and this was suspected to be the cause of the outbreak. We performed two parallel feed trials in three salmon populations as well as fatty acid and antioxidant analyses of feed and fish to investigate the causal relationship between the feed and the LLD mortality. Significant mortality was induced in one population and LLD histopathology was induced in all three populations in groups fed the suspected feed (test feed) but not in the control groups, linking the test feed to the outbreak in 2023. Fatty acid analysis revealed a difference in bound fatty acid composition between the suspected feed and the control feeds, including higher amounts of
4. Zhonghua Yu Fang Yi Xue Za Zhi. 2026 Aug 6;60(8):1350-1356. doi: 10.3760/cma.j.cn112150-20250814-00793. [Integrated analysis of molecular docking and metabolomics on the anti-candida albicans biofilm mechanism of proanthocyanidins]. [Article in Chinese; Abstract available in Chinese from the publisher] Ding WJ(1), Zhou AQ(2), Qu W(1). Author information: (1)Department of Clinical Laboratory, Guiyang Maternity and Child Health Hospital, Guiyang 550003, China. (2)School of Medical Laboratory, Guizhou Medical University, Guiyang 550000, China. To screen out potential ligands of Agglutinin-like sequence protein 3 (ALS3) with anti-adhesion from the candidate drug library. To clarify the antibacterial and anti-biofilm activities of proanthocyanidins (PAC) and conduct a preliminary exploration of their metabolomics mechanisms. From January to December in 2023, at the Laboratory Department of Guiyang Maternal and Child Health Hospital,using ALS3 as the target protein, the molecular docking virtual screening method was adopted to screen out ALS3 inhibitors with potential resistance to biofilm formation. The minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) of PAC for Candida albicans were determined by the micro-liquid-based dilution method, and the time-growth curve was plotted to explore the antibacterial activity of PAC for Candida albicans. The XTT[2, 3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide] stain
5. Nutrients. 2026 Aug 5;18(15):2555. doi: 10.3390/nu18152555. The Effects of Neurotropic B Vitamins, Vitamin D3, and Alpha-Lipoic Acid in In Vitro Models of Neurodegeneration. Viel C(1), Shi Y(2)(3), Trueman RP(2), Ruiz AJ(2), Rayner MLD(2)(3). Author information: (1)German Innovation Center, P&G Health Germany GmbH, Sulzbacher Straße 40, 65824 Schwalbach am Taunus, Germany. (2)Department of Pharmacology, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK. (3)UCL Centre for Nerve Engineering, UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK. BACKGROUND: Peripheral neuropathy (PN) is one of the most common disorders of the peripheral nervous system, affecting around 10% of the general adult population. PN results in pain, paraesthesia, and sensory loss, negatively impacting patients' quality of life. The condition is characterised by damage to peripheral nerves and is often linked to risk factors, among which diabetes is the most common cause. The incidence rate of patients suffering from PN has significantly increased in the last three decades, yet there are currently no pharmacological treatments to reverse or prevent the development of PN. Therefore, neurotropic B vitamins, specifically vitamins B1, B6, and B12, which are essential for protecting nerves from damage, nerve regeneration, and maintaining nerve health, are promising treatment options. Other biofactors with therapeutic potential a
6. Ecol Evol. 2026 Aug 7;16(8):e74122. doi: 10.1002/ece3.74122. eCollection 2026 Aug. Development and Genetic Monitoring of a Putatively Thiamine Deficiency Complex Tolerant Atlantic Salmon Broodstock. Heim KC(1), Harder AM(2), Earley LA(1), Boynton P(3), Hanlon S(4), Rinchard J(5), Kelsey K(6), Nerkowski SA(7), Campbell NR(8), Ardren WR(1)(9). Author information: (1)U.S. Fish and Wildlife Service, Lake Champlain Fish and Wildlife Conservation Office Essex Junction Vermont USA. (2)College of Forestry, Wildlife and Environment Auburn University Auburn Alabama USA. (3)U.S. Fish and Wildlife Service White River National Fish Hatchery Bethel Vermont USA. (4)U.S. Fish and Wildlife Service Dwight D. Eisenhower National Fish Hatchery North Chittenden Vermont USA. (5)Department of Environmental Science and Ecology State University of New York Brockport Brockport New York USA. (6)Vermont Fish and Wildlife Department Ed Weed Fish Culture Station Grand Isle Vermont USA. (7)U.S. Fish and Wildlife Service Northeast Fishery Center Lamar Pennsylvania USA. (8)GTseek LLC Twin Falls Idaho USA. (9)U.S. Fish and Wildlife Service Silvio O. Conte National Fish and Wildlife Refuge Complex Hadley Massachusetts USA. The concept of assisted evolution suggests that hurdles to species restoration in modified environments might be overcome by selective breeding of individuals better-suited to the contemporary evolutionary landscape. Here, we introduce an experimental program aimed at de
7. Curr Opin Clin Nutr Metab Care. 2026 Sep 1;29(5):469-474. doi: 10.1097/MCO.0000000000001236. Epub 2026 Jun 3. Risk, management and future directions for refeeding syndrome and enteral nutrition, an adult and paediatric perspective. Matthews-Rensch K(1)(2)(3)(4), Leake J(5). Author information: (1)Queensland Centre for Mental Health Research, The Park Centre for Mental Health Treatment, Research and Education, Wacol. (2)School of Public Health, The University of Queensland, St Lucia. (3)Eating disorders and Nutrition Research Group, Western Sydney University, New South Wales. (4)Nutrition Research Collaborative, Royal Brisbane and Women's Hospital, Herston. (5)Queensland Children's Hospital, Children's Health Queensland Hospital and Health Service, Brisbane, Australia. PURPOSE OF REVIEW: The purpose of this review was to summarise recent relevant studies examining refeeding syndrome risk and related outcomes in patients provided with enteral nutrition and discuss considerations for clinical practice and future research. RECENT FINDINGS: Recent studies investigating enteral nutrition and refeeding syndrome were heterogeneous. With the exception of physical indicators of nutritional status, there was no agreement across studies regarding commonly agreed upon risk factors including periods of fasting, feeding rates, or specific medical conditions. Comparisons of three different recommended risk criteria had highly variable results in one study. Confounding fa
8. Clin Obes. 2026 Oct;16(5):e70102. doi: 10.1111/cob.70102. The Neurological Impact of Metabolic and Bariatric Surgery: A Systematic Review of Post-Operative Neuropathic and Non-Neuropathic Complications. Thirumalai S(1), Balamurugan G(2), Jagdale S(3), Hussain K(4), Sayyadi L(5), Vasu SKA(2), Turner C(6), Abuawwad M(7). Author information: (1)University College London Medical School, London, UK. (2)Department of General Surgery, South Tyneside and Sunderland NHS Foundation Trust, South Shields, UK. (3)Department of Surgical Gastroenterology, GEM Hospital and Research Institute, Coimbatore, Tamil Nadu, India. (4)Department of General Surgery, The Royal Wolverhampton NHS Trust, Wolverhampton, UK. (5)South Tyneside and Sunderland NHS Foundation Trust, Sunderland, UK. (6)University Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK. (7)Department of Upper Gastrointestinal and Bariatric Surgery, South Tyneside and Sunderland NHS Foundation Trust, Sunderland, UK. Metabolic and bariatric surgery achieves durable weight loss and meaningful improvement in obesity-related comorbidities yet carries a risk of neurological complications that remains under-recognised in routine clinical practice. This systematic review, registered with PROSPERO (CRD42024591611) and conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines, searched MEDLINE, Embase, Emcare, CINAHL and Cochrane databases through September
9. Adv Sci (Weinh). 2026 Aug 5:e76937. doi: 10.1002/advs.76937. Online ahead of print. Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi-Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin. Yao Y(1), Jiang P(1), Zhou X(1), Yin M(1), Luo Q(1), Wang H(1)(2). Author information: (1)Department of Pharmacology, Wuhan University Taikang School of Medicine (School of Basic Medical Sciences), Wuhan, China. (2)Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, China. Amoxicillin is widely used in human and veterinary medicine and is increasingly detected in aquatic systems, raising concerns regarding its potential adverse effects on sensitive developmental stages. Here, a zebrafish embryonic amoxicillin exposure (EAE) model was used to quantify dose- and time-dependent developmental outcomes and to elucidate underlying metabolic-epigenetic mechanisms. EAE induced dose- and time-dependent increases in mortality and malformation rates, and significantly impaired differentiation of liver, interrenal gland, heart and brain, accompanied by mitochondrial structural damage and reduction in ATP levels. Multi-omics integration identified a previously uncharacterized long noncoding RNA, PCALRx, which was associated with pyruvate carboxylase (PC) and negatively regulated PC protein stability. PCALRx promoted ubiquitination-mediated degradation of PC, resulting in impaired mitochondrial metabolic functi
10. Rheumatol Int. 2026 Aug 4;46(8):226. doi: 10.1007/s00296-026-06246-6. Wernicke's encephalopathy in mixed connective tissue disease triggered by persistent vomiting: a case report and literature review. Memon SMA(1), Prabhu NR(1), Muniraju T(1), Tejaswi KL(1), Sankaralingam R(2). Author information: (1)Department of Rheumatology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, Tamil Nadu, India. (2)Department of Rheumatology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, Tamil Nadu, India. calling_raji@yahoo.com. Wernicke's encephalopathy (WE) is an acute, reversible but potentially disabling neurological syndrome caused by thiamine deficiency. It is increasingly recognized in non-alcoholic settings, particularly when persistent vomiting, poor intake, malabsorption, or systemic illness rapidly depletes limited thiamine stores. Patients with mixed connective tissue disease (MCTD) may be vulnerable because esophageal/gastrointestinal dysmotility, gastroesophageal reflux, chronic inflammation, and reduced oral intake can overlap and obscure nutritional complications. A 38-year-old woman with a 4-year history of anti-U1 RNP-positive MCTD, interstitial lung disease, Raynaud's phenomenon, sclerodactyly, polyarthritis, GERD, and pre-existing sensory axonal neuropathy presented with two weeks of recurrent postprandial vomiting followed by excessive daytime somnolence, bilateral horizontal nystagmus, lo
11. Case Rep Neurol. 2026 Jun 16;18(1):402-412. doi: 10.1159/000552961. eCollection 2026 Jan-Dec. Acute Nutritional Axonal Neuropathy in the Setting of Semaglutide-Associated Gastrointestinal Intolerance: A Case Report. Cohan CJ(1), Townley L(2), Ortega E(2). Author information: (1)Creighton University School of Medicine, Phoenix, AZ, USA. (2)Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA. OBJECTIVES: The aim of the study was to report a unique case of severe sensorimotor polyneuropathy due to acute nutritional axonal neuropathy (ANAN) associated with thiamine and other vitamin deficiencies in the setting of semaglutide-related malnutrition, emphasizing early recognition and intervention to prevent permanent neurologic injury. METHODS: A 65-year-old woman with type 2 diabetes and obesity presented with profound weakness, cranial nerve deficits, dysphagia, and a 120-pound weight loss after months of semaglutide therapy with persistent nausea and vomiting. Neurologic examination was performed, and cerebrospinal fluid analysis and serum vitamin levels were obtained. Electromyography demonstrated absent sensory responses and mild motor slowing, consistent with severe sensory-predominant polyneuropathy. Serum levels of thiamine, folate, and vitamin B12 were below normal, and supplementation was administered. RESULTS: Within 5 days of thiamine, folate, and vitamin B12 supplementation, the patient showed improvement in cognition and bulbar
12. ISME Commun. 2026 May 22;6(1):ycag142. doi: 10.1093/ismeco/ycag142. eCollection 2026 Jan. Multi-omics uncovers nutrient stress-driven interactions in a synthetic Prymnesium parvum holobiont, with vitamin B(12)-limitation revealing mutualism. Patron L(1), Petrilli F(1), Bout A(2), Gaudin M(1), Gouhier L(3), Hubert C(2), Réveillon D(2), Chaffron S(4), Briand E(1), Garnier M(1). Author information: (1)IFREMER, PHYTOX, GENALG, Nantes 44300, France. (2)IFREMER, PHYTOX, METALG, Nantes 44300, France. (3)IFREMER, PHYTOX, PHYSALG, Nantes 44300, France. (4)CNRS, LS2N, Nantes Université, UMR 6004, Nantes 44000, France. Microalgal-bacterial interactions are central to nutrient cycling and ecosystem functioning in marine habitats, yet the mechanisms structuring these associations under defined nutrient constraints remain poorly resolved. Using a synthetic 15-member bacterial community (SynCom) and controlled nitrogen (N), phosphorus (P), and vitamin B12-limitation, we investigated how nutrient scarcity shapes the physiology, metabolism, and transcriptional activity of the harmful alga Prymnesium parvum and its associated microbiota. Under N- and P-limitation, the SynCom had minimal impact on algal growth despite nutrient-dependent shifts in toxin production and metabolite profiles. In contrast, B12-limitation triggered a strong mutualistic interaction in which the SynCom enabled a three-fold increase in algal biomass and drove restructuring of intracellular and extra
13. Front Cell Dev Biol. 2026 Jul 20;14:1880883. doi: 10.3389/fcell.2026.1880883. eCollection 2026. HAT regimen attenuates NF-κb-driven megakaryocyte apoptosis and neuronal cell death in sepsis: convergent mechanisms protecting thrombocytopenia and cognitive function. Hui Z(#)(1)(2), Shen N(#)(3), Zhang H(4), Yu M(5), Li Z(6), Ping J(1), Fu Q(1)(4)(7). Author information: (1)The Fourth Central Clinical School, Tianjin Medical University, Tianjin, China. (2)Department of Critical Care Medicine, Cangzhou Central Hospital, Cangzhou, China. (3)Central Laboratory, Tianjin Fourth Central Hospital, Tianjin, China. (4)Department of Critical Care Medicine, Tianjin Fourth Central Hospital, Tianjin, China. (5)Department of Emergency Medicine, Rizhao People's Hospital, Rizhao, China. (6)Department of Cardiovascular Prevention and Rehabilitation, Cangzhou Central Hospital, Cangzhou, China. (7)Department of Critical Care Medicine, Tianjin Haihe Hospital, Tianjin, China. (#)Contributed equally BACKGROUND: Sepsis-induced NF-κB hyperactivation drives two devastating cell death cascades: megakaryocyte apoptosis causing thrombocytopenia (incidence 35%-59%), and neuronal apoptosis with microglial-mediated neuroinflammation causing cognitive dysfunction in up to 70% of survivors. Mechanistically, NF-κB-driven upregulation of pro-apoptotic mediators (cleaved caspase-3, cytochrome c release) impairs megakaryopoiesis while simultaneously inducing hippocampal neuronal death and syna
14. Cell Rep. 2026 Jul 31;45(8):117727. doi: 10.1016/j.celrep.2026.117727. Online ahead of print. Architecture of distal tips of motile cilia is shaped by the pseudoenzyme Jhc1 in non-mammalian vertebrates. Hong J(1), Nair SR(2), Atayeter E(3), Jo EL(1), Gray RS(3), Young RL(2), Wallingford JB(4). Author information: (1)Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA. (2)Department of Integrative Biology, University of Texas at Austin, Austin, TX, USA. (3)Department of Pediatrics Dell Pediatric Research Institute, University of Texas at Austin Dell Medical School, Austin, TX, USA. (4)Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA. Electronic address: wallingford@austin.utexas.edu. Motile cilia are evolutionarily conserved organelles performing essential roles in development and tissue homeostasis. Unlike the core scaffold, the distal regions remain relatively less explored and display great diversity across species. Here, we describe a previously uncharacterized ciliary protein Jhc1 (just the head of cilia 1, Loc108698169), localizing at the extreme distal tip of multiciliated cell (MCC) cilia and encoded only in the genomes of non-mammalian vertebrates. Jhc1 is essential for normal cilia structure and function in Xenopus, and this activity is conserved in Jhc1 from reptiles and fish. Phylogenetic analysis and structure modeling suggest that Jhc1 arose by duplication and neofunctional
15. Water Res. 2026 Jul 16;306:126515. doi: 10.1016/j.watres.2026.126515. Online ahead of print. Cyanobacterium Microcoleus in toxic benthic mats on different streambed substrates: Ecophysiology and important metabolic pathways. Sohrab A(1), Stancheva R(2), Mansoor F(1), Wei B(3), Stubler S(2), Boyer GL(3), Shriver R(4), Blaszczak J(4), Goel R(5). Author information: (1)University of Utah, Department of Civil & Environmental Engineering, 110 S Central Campus, Salt Lake City, UT, 84112, USA. (2)George Mason University, Department of Environmental Science and Policy, Fairfax, VA, 22030, USA. (3)SUNY-College of Environmental Science and Forestry, Syracuse, NY, 13210, USA. (4)University of Nevada, Reno Department of Natural Resources and Environmental Science, Reno, NV, 89557, USA. (5)University of Utah, Department of Civil & Environmental Engineering, 110 S Central Campus, Salt Lake City, UT, 84112, USA. Electronic address: ram.goel@utah.edu. Benthic cyanobacteria, notably the genus Microcoleus, are a common contributor to benthic harmful algal blooms globally and can produce neurotoxins. Microcoleus can thrive in nutrient-limited freshwater environments, which present significant environmental and public health challenges. In May 2023, we observed Microcoleus mat growing in a small tributary of the Virgin River in Zion National Park near the Temple of Sinawava and collected benthic mats from three rock and three sandy substrate (strata) sites in the Virgin Riv
1. Nat Microbiol. 2026 Oct 5. doi: 10.1038/s41564-026-02499-w. Online ahead of print. Thiamine cross-feeding drives microbial coexistence in the leaf microbiome. Hu Y(1), Bode J(2), Gómez-Pérez D(2)(3), Guerreiro MA(4)(5), Mari A(6), Wang K(2), Niemann S(2), Mahmoudi M(2), Kemen A(2), Duran P(6)(7)(8), Wacker O(9), Straub D(9)(10), Nahnsen S(9)(10)(11), Schwessinger B(12), Roux F(8), Alonso-Blanco C(13), Ågren J(14), Hacquard S(6)(7), Stukenbrock EH(4)(5), Kemen E(15)(16)(17). Author information: (1)Department of Microbial Interactions, Centre of Plant Molecular Biology (ZMBP), Eberhard-Karls-University of Tübingen, Tübingen, Germany. yiheng.hu@zmbp.uni-tuebingen.de. (2)Department of Microbial Interactions, Centre of Plant Molecular Biology (ZMBP), Eberhard-Karls-University of Tübingen, Tübingen, Germany. (3)Dentistry, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK. (4)Environmental Genomics Group, Botanical Institute, Christian-Albrechts University of Kiel, Kiel, Germany. (5)Max Planck Institute for Evolutionary Biology, Plön, Germany. (6)Department of Plant Microbe Interactions, Max Planck Institute for Plant Breeding Research, Cologne, Germany. (7)Cluster of Excellence on Plant Sciences (CEPLAS), Max Planck Institute for Plant Breeding Research, Cologne, Germany. (8)LIPME, INRAE, CNRS, Université de Toulouse, Castanet-Tolosan, France. (9)Quantitative Biology Center (QBiC), University of Tübingen, Tübingen,
2. Clin Biochem. 2026 Oct 5;146:111215. doi: 10.1016/j.clinbiochem.2026.111215. Online ahead of print. Hemoglobin-normalized thiamine diphosphate (vitamin B1) in whole blood: Reference intervals and clinical implications for status assessment. Guihaire S(1), Denimal D(2). Author information: (1)CHU Dijon Bourgogne, Service Biochimie, 2 Bd Maréchal de Lattre de Tassigny, 21000 Dijon, France. Electronic address: sybille.guihaire@chu-dijon.fr. (2)Université Bourgogne Europe, CHU Dijon Bourgogne, Service Biochimie, INSERM, CTM UMR 1231, PADYS Team, 2 Bd Maréchal de Lattre de Tassigny, 21000 Dijon, France. Electronic address: damien.denimal@u-bourgogne.fr. OBJECTIVES: Vitamin B1 status is typically assessed by measuring whole blood thiamine diphosphate (TDP). However, volumetric expression (nmol/L) may be misleading in anemia or polycythemia, as TDP is primarily carried within erythrocytes. While hemoglobin-normalized TDP (ng/g Hb) may provide a more robust biomarker-less influenced by hematological variations-reference interval (RI) data are scarce. Thus, we aimed to establish RIs for Hb-normalized TDP and evaluate the impact of its expression (ng/g Hb vs. nmol/L) on thiamine status classification. DESIGN AND METHODS: RIs for Hb-normalized TDP were established using 130 healthy adults (18-65 years) per CLSI EP28-A3c. Exclusion criteria included vitamin B1 supplementation, denutrition, hepatic disease, and other conditions affecting thiamine metabolism. TDP was
3. Drug Des Devel Ther. 2026 Sep 26;20:634516. doi: 10.2147/DDDT.S634516. eCollection 2026. Comparative Protective Effects of ATP and TPP Against Olaparib-Induced Ovarian Injury in Rats: Insights from Biochemical Parameters, Histopathology, and IRE1α, Cleaved Caspase-3, LC3B, and NF-κB p65 Double Immunofluorescence. Paltaci SI(1), Yilmaz N(1), Kozali Uzun S(1), Yavuzer B(2), Coban TA(3), Ozkaraca M(4), Gungor A(5), Yaqubov K(6), Suleyman H(2)(7). Author information: (1)Department of Obstetrics and Gynecology, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan, Turkey. (2)Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan, Turkey. (3)Department of Medical Biochemistry, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan, Turkey. (4)Department of Pathology, Faculty of Veterinary Medicine, Sivas Cumhuriyet University, Sivas, Turkey. (5)Laboratory and Veterinary Health Program, Vocational School of Health Services, Osmaniye Korkut Ata University, Osmaniye, Turkey. (6)Department of Pharmacology, Azerbaijan Medical University, Baku, Azerbaijan. (7)Department of Pharmacology, Faculty of Medicine, Ataturk University, Erzurum, Turkey. BACKGROUND: Olaparib is a poly(ADP-ribose) polymerase (PARP) inhibitor used to treat several malignancies. Previous studies have reported that olaparib may induce ovarian injury by elevating reactive oxygen species and impairing cellular energy homeostasis. ATP is
4. Cureus. 2026 Aug 31;18(8):e115540. doi: 10.7759/cureus.115540. eCollection 2026 Aug. Acute Bilateral Visual Loss as an Atypical Manifestation of Wernicke Encephalopathy Secondary to Hyperemesis Gravidarum: A Case Report and Narrative Literature Review. Ngee Ling L(1)(2), Abu Kassim SNA(1), Jalaluddin J(2), Mohd Zain A(1). Author information: (1)Ophthalmology, University Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MYS. (2)Ophthalmology, Hospital Melaka, Melaka, MYS. Wernicke encephalopathy (WE) is a severe neurological condition caused by thiamine deficiency that remains underreported in pregnancy. We report a clinical diagnosis of WE in a 41-year-old woman, gravida 2, para 1, at 16 weeks of gestation. She presented with acute, painless visual impairment, severe dietary restriction, and marked weight loss secondary to severe hyperemesis gravidarum (HG). Examination revealed reduced visual acuity, horizontal nystagmus, psychomotor retardation, and an ataxic gait. The initial diagnosis was delayed due to her atypical presentation and the absence of MRI or blood thiamine level confirmation. However, empirical treatment with IV thiamine was followed by rapid visual and cognitive recovery within 24 hours. The pregnancy was subsequently complicated by fetal growth restriction and preterm delivery. This case illustrates the necessity of empirical treatment for WE based on clinical criteria in pregnant patients with HG. Recognizing atypical presentations
5. Chem Biodivers. 2026 Oct;23(10):e71747. doi: 10.1002/cbdv.71747. Environmental Drivers of Metabolic Plasticity in Rubia cordifolia From the Western Himalaya: Implications for Phytochemical Diversity and Antioxidant Potential. Tiwari D(1), Rawat S(2), Pandey V(3), Joshi VC(4), Bhatt ID(1), Sundriyal RC(5)(6). Author information: (1)Centre For Biodiversity Conservation and Management, G. B. Pant National Institute of Himalayan Environment, Kosi-Katarmal, Almora, Uttarakhand, India. (2)G. B. Pant National Institute of Himalayan Environment, Sikkim Regional Centre, Gangtok, Sikkim, India. (3)Division of Environment Science, Indian Agriculture Research Institute, New Delhi, India. (4)Wildlife Institute of India, Chandrabani, Dehradun, Uttarakhand, India. (5)Department of Forestry and Natural Resources, HNB Garhwal University, Srinagar, Garhwal, Uttarakhand, India. (6)Sparsh Himalaya University, Dehradun, Uttarakhand, India. Rubia cordifolia L. is an important Himalayan medicinal plant valued for its diverse therapeutic properties. The present study investigated the influence of altitude, habitat conditions, and edaphic factors on nutritional composition, phytochemicals, and antioxidant activity of R. cordifolia populations collected from different habitats (open grassy, shady, and moist shady) in the western Himalaya. Significant variations (p ≤ 0.05) were observed in edaphic factors, nutritional components and phytochemicals, antinutritional factors and antio
6. Infect Dis Poverty. 2026 Sep 30;15(1):105. doi: 10.1186/s40249-026-01509-7. Comprehensive metabolomic profiling of Angiostrongylus cantonensis across its life cycle reveals developmental and host-associated metabolic signatures. Hu Y(#)(1)(2), Yu B(#)(3), Zhan R(4), Zhang T(5), Zhang Y(6), Zhou Y(7), Wei H(8)(9), Lv Z(10)(11). Author information: (1)Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, Guangdong, China. hu_yue01@gzlab.ac.cn. (2)Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, Guangdong, China. hu_yue01@gzlab.ac.cn. (3)Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. (4)Department of Otorhinolaryngology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China. (5)Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China. (6)Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. (7)National Health Commission of the People's Republic of China (NHC) Key Laboratory of Tropical Disease Control, Hainan Medical University, Haikou, Hainan, China. (8)Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, Guangdong, China. (9)Provincial Engineering Technology Research Center for Biological Vector
7. J Gen Virol. 2026 Sep;107(9):002316. doi: 10.1099/jgv.0.002316. A naturally occurring feline leukaemia virus subgroup A variant exhibits broad mammalian cellular tropism and utilizes canine thiamine transporter 1. Kanemura Y(1)(2), Nakagawa S(3), Miyazawa T(1)(4). Author information: (1)Laboratory of Virus-Host Coevolution, Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan. (2)Present address: AstraZeneca K.K., Grand Front Osaka Tower B, 3-1 Ofukacho, Kita-ku, Osaka 530-0011, Japan. (3)Department of Molecular Life Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. (4)Kyoto Animal-Human-Organism Research Institute (Kyoto AHOI), c/o QUESTION, 390-2 Shimomaruyacho, Nakagyo-ku, Kyoto 604-8006, Japan. Feline leukaemia virus subgroup A (FeLV-A) has generally been regarded as having a narrow, predominantly feline host range. Here, we characterize a naturally occurring FeLV-A isolate, strain F8701, that exhibits unexpectedly broad mammalian cell tropism. Using an infectious molecular clone of F8701, we show that F8701 infects canine cells efficiently and can utilize the canine orthologue of thiamine transporter 1, the canonical FeLV-A receptor. Compared with reference FeLV-A strains, F8701 displayed markedly higher infectivity in multiple non-feline cell lines, including canine and human cells. Sequence analysis of the envelope glycoprotein rev
8. Spectrochim Acta A Mol Biomol Spectrosc. 2026 Sep 19;366:128770. doi: 10.1016/j.saa.2026.128770. Online ahead of print. AChE and CoFe NPs-initiated cascade amplification for sensitive detection of organophosphorus pesticides. Wang Y(1), Wang C(2), Zeng C(3), Wang W(4), Liu Y(5). Author information: (1)Hubei Key Laboratory of Embryonic Stem Cell Rescarch, Hubei University of Medicine, Shiyan 442000, PR China; Department of Psychiatry, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, PR China; Institute of Brain Science and Brain-Inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250000, PR China. (2)Hubei Key Laboratory of Embryonic Stem Cell Rescarch, Hubei University of Medicine, Shiyan 442000, PR China; Department of Psychiatry, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, PR China. (3)School of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming 650000, PR China. (4)Institute of Brain Science and Brain-Inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250000, PR China. Electronic address: wswang@sdfmu.edu.cn. (5)Institute of selenium science and industry, Hubei Minzu University, Xueyuan Road 39, Enshi 445000, PR China. Electronic address: Liuyu199177@163.com. Traditional methods for pesticide residue detection often rely on expensive instruments, are time-consuming, and lack cost efficiency. This investigation
9. Biology (Basel). 2026 Sep 16;15(18):1637. doi: 10.3390/biology15181637. Cyclodextrin Interactions with Water-Soluble Vitamins: Biological Relevance, Stability, Delivery, and Translational Implications-A Critical Review. Stolarek Z(1), Gackowski M(2), Szeleszczuk Ł(1). Author information: (1)Department of Organic and Physical Chemistry, Medical University of Warsaw, 1 Banacha Str., 02-097 Warsaw, Poland. (2)Department of Toxicology and Bromatology, Faculty of Pharmacy, L. Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 2 Jurasza Str., 85-089 Bydgoszcz, Poland. Water-soluble vitamins participate in essential metabolic, redox, and coenzyme-dependent processes, yet their effective delivery can be limited by chemical instability, degradation during processing or storage, restricted membrane transport, and formulation-dependent loss of biological availability. Cyclodextrins have been widely investigated as molecular hosts and functional components of delivery systems capable of modifying these properties. This critical narrative review evaluates cyclodextrin systems involving thiamine, riboflavin, nicotinic acid and nicotinamide, pantothenate, vitamin B6 vitamers, biotin, folates, cobalamins, and vitamin C, with particular emphasis on the relationship between molecular interaction mechanisms and functional or biological outcomes. The available evidence demonstrates that cyclodextrins can protect selected vitamins against photo
10. PLoS One. 2026 Sep 25;21(9):e0358747. doi: 10.1371/journal.pone.0358747. eCollection 2026. Comparative transcriptomics reveals stage-specific regulatory pathways of ear thickening in Auricularia polytricha. Huang YN(1), Ke LN(2), Yuan B(2), Lin Y(1). Author information: (1)Zhangzhou Institute of Technology, Zhangzhou, Fujian, China. (2)Zhangzhou Institute of Agricultural Science, Zhangzhou, Fujian, China. Auricularia polytricha is an economically important edible and medicinal mushroom widely cultivated in China. Ear thickness, as a core commercial trait of this mushroom, directly determines its product quality and economic value. To explore the potential molecular regulatory mechanisms governing ear thickness, we performed comparative transcriptome sequencing on fruiting bodies of the main cultivar 'Zhang'er 4328' and its stable thick-ear mutant 'B2872' at three key developmental stages: primordium stage (PD), young ear stage (IF), and mature stage (MF). Differentially expressed genes (DEGs) were screened, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. GO enrichment results showed that DEGs were mainly enriched in biological processes associated with metabolic activity, cellular component formation, and catalytic function. KEGG enrichment analysis revealed a distinct stage-specific pattern: DEGs at the PD stage were primarily enriched in energy and substance synthesis pathways (e.g., thiamine meta
11. Genetica. 2026 Sep 25;154(1):43. doi: 10.1007/s10709-026-00292-5. Molecular phylogenetics, distribution and evolution of the TPP riboswitch. Kaloudas D(1), Pavlova N(1), Traykovska M(1), Penchovsky R(2). Author information: (1)Laboratory of Synthetic Biology and Bioinformatics, Faculty of Biology, Sofia University 'Saint Kliment Ohridski', 8, Dragan Tzankov Blvd, 1164, Sofia, Bulgaria. (2)Laboratory of Synthetic Biology and Bioinformatics, Faculty of Biology, Sofia University 'Saint Kliment Ohridski', 8, Dragan Tzankov Blvd, 1164, Sofia, Bulgaria. robert.penchovsky@hotmail.com. Thiamine pyrophosphate (TPP) riboswitches are the only riboswitch class identified in eukaryotes. They therefore provide a unique model for reconstructing the evolution of RNA-based gene regulation across life's domains. We investigated the molecular evolution, structural diversification, and genomic-context reassignment of the TPP riboswitch across archaea, bacteria, cyanobacteria, fungi, algae, and land plants using phylogenetic reconstruction, covariance-model-guided sequence analysis, comparative secondary-structure analysis, genomic-context annotation, and covariation-based inference. Our analyses establish an early prokaryotic origin of the TPP riboswitch as a 5'- UTR-associated regulatory element. Archaea retain the most compact ancestral scaffold. The transition to bacteria is characterized by extensive compensatory evolution. Bacteria preserve the canonical fold but exhi
12. Reports (MDPI). 2026 Sep 1;9(3):290. doi: 10.3390/reports9030290. Non-Alcoholic Wernicke-Korsakoff Syndrome After a Whipple Procedure: Delayed Recognition, Neuropsychological Findings, and Rehabilitation Follow-Up: A Case Report. Demir ÜF(1), Karakuş Dilbaz F(1), Memur NB(2), Keskinkılıç C(3), Hasanefendioğlu Bayrak A(4), Battal M(5). Author information: (1)Department of Neurology, Faculty of Medicine, Istanbul Yeni Yüzyıl University, 34010 Istanbul, Türkiye. (2)Department of Internal Medicine, Faculty of Medicine, Istanbul Medeniyet University, 34700 Istanbul, Türkiye. (3)Department of Neuropsychology, Istinye University, 34250 Istanbul, Türkiye. (4)Department of Radiology, Faculty of Medicine, Istinye University, 34250 Istanbul, Türkiye. (5)Independent Practice, General Surgery, 34000 Istanbul, Türkiye. Background and Clinical Significance: Wernicke encephalopathy (WE) is a potentially reversible neurological emergency caused by thiamine deficiency. Although classically associated with alcohol use, it may also occur after gastrointestinal surgery and prolonged nutritional compromise, where diagnosis can be obscured by postoperative delirium or metabolic encephalopathy. Case Presentation: A 58-year-old woman with no history of alcohol use underwent a Whipple procedure for pancreatic head adenocarcinoma. Her postoperative course included an anastomotic leak, prolonged open-abdomen management, severely restricted oral intake, and long-term total parentera
13. Med Sci (Basel). 2026 Sep 17;14(5):577. doi: 10.3390/medsci14050577. The Possible Hematological Cost of Metabolic Success: Do Incretin-Based Therapies Silently Trigger Anemia? Mizdrak M(1), Batistić D(2), Mizdrak I(3). Author information: (1)Department of Internal Medicine, University Hospital of Split, Split School of Medicine, 21000 Split, Croatia. (2)Department of Ophthalmology, University Hospital of Split, Split School of Medicine, 21000 Split, Croatia. (3)Department of ENT, University Hospital of Split, Split School of Medicine, 21000 Split, Croatia. Diabetes mellitus and obesity represent a growing global health burden with high morbidity and mortality. In the last several years, novel incretin-based therapies have been developed, and their use has risen dramatically. Beyond their proven metabolic, glycemic, cardiovascular, renal, and many other benefits, there are some observational data linking anemia development with their use. From the era of gliptins to retatrutide, in this review we tried to explore whether erythroid suppression is the hidden paradigm of advanced incretin-based therapies. Potential pathophysiological explanations include micronutrient vulnerabilities due to reduced food intake, lower dietary diversity, gastrointestinal intolerance, delayed gastric emptying, and weight loss. The most important concerns involve deficiencies in iron, vitamin B12, vitamin B2, vitamin D, calcium, magnesium, and zinc, along with others such as t
14. Eur J Nutr. 2026 Sep 24;65(7):260. doi: 10.1007/s00394-026-04120-6. Integrating HPLC-determined vitamins A, E and B-complex (B(1), B(2), B(3), B(6), B(9)) with population intake estimates: insights from Cuba's inaugural Total Diet Study. Fernández-Guerrero Y(1), Muñoz-Fariña O(2), García O(3), Ravanal MC(4)(5), González L(6). Author information: (1)Doctorado en Ingeniería, Universidad del Bío-Bío, 4051381, Concepción, Chile. (2)Instituto de Ciencia y Tecnología de los Alimentos, Facultad de Ciencias Agrarias y Alimentarias, Universidad Austral de Chile, 5090000, Valdivia, Chile. ocielmunoz@uach.cl. (3)Instituto de Ciencia y Tecnología de los Alimentos, Facultad de Ciencias Agrarias y Alimentarias, Universidad Austral de Chile, 5090000, Valdivia, Chile. (4)Facultad de Agronomía y Sistemas Naturales, Pontificia Universidad Católica de Chile, 7820436, Santiago, Chile. (5)Instituto para el Desarrollo Sustentable, Pontificia Universidad Católica de Chile, 7820436, Santiago, Chile. (6)Instituto de Ciencias Aplicadas, Facultad de Ingeniería, Universidad Autónoma de Chile, 8581151, Santiago, Chile. luisbel.gonzalez@uautonoma.cl. Purpose To quantify seven dietary vitamins and estimate their mean daily intakes and major food sources among Cuban adults through the country's first Total Diet Study.Methods Standardized 24-hour dietary recalls were collected from 450 adults across Western, Central, and Eastern Cuba between October 2020 and March 2021. Foods were classi
15. Cureus. 2026 Aug 24;18(8):e115093. doi: 10.7759/cureus.115093. eCollection 2026 Aug. Wernicke Encephalopathy Secondary to Cannabinoid Hyperemesis Syndrome in a 15-Year-Old Male Patient: A Case Report. Abes J(1), Bou Jaoude M(1), Landrum T(1), McGill J(1). Author information: (1)Pediatrics, Medical College of Georgia at Augusta University, Augusta, USA. The use of cannabis and high-potency tetrahydrocannabinol (THC) products has risen substantially among adolescents, and cannabinoid hyperemesis syndrome (CHS) is now an increasingly recognized complication of chronic use. CHS is characterized by recurrent episodes of intractable nausea, vomiting, and abdominal pain that resolve with cannabis cessation. Wernicke encephalopathy (WE), a neurologic syndrome caused by thiamine deficiency, is classically associated with chronic alcohol use but is increasingly reported in nonalcoholic and pediatric patients, in whom atypical presentations complicate timely diagnosis. We report the case of a 15-year-old male patient with no significant past medical history and chronic cannabis use who developed WE in the setting of CHS. He initially presented with several days of intractable nausea, vomiting, and headache and was diagnosed with CHS. Symptoms persisted, and he returned weeks later with a 25- to 30-pound weight loss along with headache and dizziness. Repeat laboratory studies revealed worsening transaminitis and progressive hyponatremia, which was treated with flu
🔗 같은 분류의 보충제
⚠️ 면책 고지
이 정보는 일반 교육 목적이며 의료 진단/처방을 대체하지 않습니다.