비타민B7 (비오틴)

Vitamin supplementation in the treatment of optic neuritis: A systematic review and meta-analysis.

1. Mult Scler Relat Disord. 2025 Dec;104:106797. doi: 10.1016/j.msard.2025.106797. Epub 2025 Oct 13. Vitamin supplementation in the treatment of optic neuritis: A systematic review and meta-analysis. Gaffney PJ(1), Gupta RK(2). Author information: (1)Department of Neurology, The University of T

ESPEN micronutrient guideline.

2. Clin Nutr. 2022 Jun;41(6):1357-1424. doi: 10.1016/j.clnu.2022.02.015. Epub 2022 Feb 26. ESPEN micronutrient guideline. Berger MM(1), Shenkin A(2), Schweinlin A(3), Amrein K(4), Augsburger M(5), Biesalski HK(6), Bischoff SC(7), Casaer MP(8), Gundogan K(9), Lepp HL(10), de Man AME(11), Muscogi

Dietary interventions for multiple sclerosis-related outcomes.

3. Cochrane Database Syst Rev. 2020 May 19;5(5):CD004192. doi: 10.1002/14651858.CD004192.pub4. Dietary interventions for multiple sclerosis-related outcomes. Parks NE(1), Jackson-Tarlton CS(1), Vacchi L(2), Merdad R(3), Johnston BC(4). Author information: (1)Department of Medicine, Division of N

Systematic review and meta-analysis of the efficacy and safety of chromium supplementation in diabetes.

4. J Clin Pharm Ther. 2014 Jun;39(3):292-306. doi: 10.1111/jcpt.12147. Epub 2014 Mar 17. Systematic review and meta-analysis of the efficacy and safety of chromium supplementation in diabetes. Suksomboon N(1), Poolsup N, Yuwanakorn A. Author information: (1)Department of Pharmacy, Faculty of Ph

Effect of biotin on milk performance of dairy cattle: a meta-analysis.

5. J Dairy Sci. 2011 Jul;94(7):3537-46. doi: 10.3168/jds.2010-3764. Effect of biotin on milk performance of dairy cattle: a meta-analysis. Chen B(1), Wang C, Wang YM, Liu JX. Author information: (1)Institute of Dairy Science, College of Animal Science, Zhejiang University, Hangzhou 310029, P. R.

Effect of feeding biotin on milk production and hoof health in lactating dairy cows: a quantitative assessment.

6. J Dairy Sci. 2011 Mar;94(3):1465-76. doi: 10.3168/jds.2010-3682. Effect of feeding biotin on milk production and hoof health in lactating dairy cows: a quantitative assessment. Lean IJ(1), Rabiee AR. Author information: (1)SBScibus, PO Box 660, Camden 2570, New South Wales, Australia. ianl@s

Effects of konjac glucomannan on gastrointestinal symptoms and gut microbiota in athletes with functional constipation: a double-blind randomized controlled trial.

7. Eur J Nutr. 2025 Oct 21;64(8):303. doi: 10.1007/s00394-025-03826-3. Effects of konjac glucomannan on gastrointestinal symptoms and gut microbiota in athletes with functional constipation: a double-blind randomized controlled trial. Zhu Y(1), Chen X(1), Song G(2). Author information: (1)Insti

Beneficial changes in total cholesterol, LDL-C, biomarkers of intestinal inflammation, and vitamin E status in adults with metabolic syndrome consuming almonds as snack foods: a randomized controlled clinical trial.

8. Nutr Res. 2025 Jul;139:50-65. doi: 10.1016/j.nutres.2025.04.011. Epub 2025 Apr 25. Beneficial changes in total cholesterol, LDL-C, biomarkers of intestinal inflammation, and vitamin E status in adults with metabolic syndrome consuming almonds as snack foods: a randomized controlled clinical t

Safety, Tolerability, and Pharmacokinetics of the Neuroprotectant 2-Iminobiotin in Patients With Large-Vessel Occlusion Ischemic Stroke Treated With Endovascular Thrombectomy.

9. Stroke. 2025 Aug;56(8):1991-1999. doi: 10.1161/STROKEAHA.125.050560. Epub 2025 Apr 24. Safety, Tolerability, and Pharmacokinetics of the Neuroprotectant 2-Iminobiotin in Patients With Large-Vessel Occlusion Ischemic Stroke Treated With Endovascular Thrombectomy. Vos EM(1), Peeters-Scholte CM

Efficacy of 5% topical minoxidil versus 5 mg oral biotin versus topical minoxidil and oral biotin on hair growth in men: randomized, crossover, clinical trial.

10. An Bras Dermatol. 2024 Jul-Aug;99(4):581-584. doi: 10.1016/j.abd.2023.07.008. Epub 2024 Apr 30. Efficacy of 5% topical minoxidil versus 5 mg oral biotin versus topical minoxidil and oral biotin on hair growth in men: randomized, crossover, clinical trial. Valentim FO(1), Miola AC(1), Miot H

Effect of probiotic administration during pregnancy on the functional diversity of the gut microbiota in healthy pregnant women.

11. Microbiol Spectr. 2024 Jun 4;12(6):e0041324. doi: 10.1128/spectrum.00413-24. Epub 2024 Apr 30. Effect of probiotic administration during pregnancy on the functional diversity of the gut microbiota in healthy pregnant women. Ma G(#)(1), Yan H(#)(1), Tye KD(2), Tang X(1), Luo H(1), Li Z(3), Xi

The Oral Transglutaminase 2 Inhibitor ZED1227 Accumulates in the Villous Enterocytes in Celiac Disease Patients during Gluten Challenge and Drug Treatment.

12. Int J Mol Sci. 2023 Jun 28;24(13):10815. doi: 10.3390/ijms241310815. The Oral Transglutaminase 2 Inhibitor ZED1227 Accumulates in the Villous Enterocytes in Celiac Disease Patients during Gluten Challenge and Drug Treatment. Isola J(1)(2), Mäki M(2), Hils M(3), Pasternack R(3), Viiri K(2), D

The effect of multivitamins on anxiety and depression in patients undergoing methadone maintenance treatment: A double-blind randomized controlled trial.

13. Int J Psychiatry Med. 2023 Nov;58(6):576-590. doi: 10.1177/00912174231179320. Epub 2023 May 31. The effect of multivitamins on anxiety and depression in patients undergoing methadone maintenance treatment: A double-blind randomized controlled trial. Lagzi N(1), Bateni A(1), Goli R(2), Talebi

Efficacy of intramuscular injections of biotin and dexpanthenol in the treatment of diffuse hair loss: A randomized, double-blind controlled study comparing two brands.

14. Dermatol Ther. 2022 Sep;35(9):e15695. doi: 10.1111/dth.15695. Epub 2022 Jul 15. Efficacy of intramuscular injections of biotin and dexpanthenol in the treatment of diffuse hair loss: A randomized, double-blind controlled study comparing two brands. Samadi A(1), Ketabi Y(2), Firooz R(1), Firo

Postoperative Vitamin Profile after Receiving a Novel Peripheral Parenteral Nutrition Solution: Multicenter Randomized Controlled Phase III Trial.

15. Ann Nutr Metab. 2022;78(4):222-235. doi: 10.1159/000524625. Epub 2022 Apr 19. Postoperative Vitamin Profile after Receiving a Novel Peripheral Parenteral Nutrition Solution: Multicenter Randomized Controlled Phase III Trial. Fukatsu K(1), Shineha R(2), Kawauchi Y(3), Katayose S(3), Nakayama M

Single high-dose peroral caffeine intake inhibits ultraviolet radiation-induced apoptosis in human lens epithelial cells in vitro.

15. Acta Ophthalmol. 2021 Jun;99(4):e587-e593. doi: 10.1111/aos.14641. Epub 2020 Oct 30. Single high-dose peroral caffeine intake inhibits ultraviolet radiation-induced apoptosis in human lens epithelial cells in vitro. Kronschläger M(1), Ruiß M(1), Dechat T(2), Findl O(1). Author information:

MicroRNA-203-mediated inhibition of doublecortin underpins cardioprotection conferred by sevoflurane in rats after myocardial ischaemia-reperfusion injury.

13. J Cell Mol Med. 2020 Sep;24(17):9825-9838. doi: 10.1111/jcmm.15566. Epub 2020 Aug 11. MicroRNA-203-mediated inhibition of doublecortin underpins cardioprotection conferred by sevoflurane in rats after myocardial ischaemia-reperfusion injury. Tan J(1), Wu Z(1), Liu J(2), Zhang W(1), Yuan W(1)

Codelivery of DOX and siRNA by folate-biotin-quaternized starch nanoparticles for promoting synergistic suppression of human lung cancer cells.

18. Drug Deliv. 2019 Dec;26(1):499-508. doi: 10.1080/10717544.2019.1606363. Codelivery of DOX and siRNA by folate-biotin-quaternized starch nanoparticles for promoting synergistic suppression of human lung cancer cells. Li L(1)(2), He S(1), Yu L(1)(3), Elshazly EH(1)(4), Wang H(1), Chen K(1), Zha

Interference of High Dose Biotin Supplementation with Thyroid Parameters in Immunoassays Utilizing the Interaction between Streptavidin and Biotin: a Case Report and Review of Current Literature.

49. Clin Lab. 2019 Jan 1;65(1). doi: 10.7754/Clin.Lab.2018.180637. Interference of High Dose Biotin Supplementation with Thyroid Parameters in Immunoassays Utilizing the Interaction between Streptavidin and Biotin: a Case Report and Review of Current Literature. Mrosewski I, Neumann I, Switkowsk

Targeted and Synergic Glioblastoma Treatment: Multifunctional Nanoparticles Delivering Verteporfin as Adjuvant Therapy for Temozolomide Chemotherapy.

29. Mol Pharm. 2019 Mar 4;16(3):1009-1024. doi: 10.1021/acs.molpharmaceut.8b01001. Epub 2019 Feb 11. Targeted and Synergic Glioblastoma Treatment: Multifunctional Nanoparticles Delivering Verteporfin as Adjuvant Therapy for Temozolomide Chemotherapy. Pellosi DS(1)(2), Paula LB(2), de Melo MT(2),

A Combination of Linalool, Vitamin C, and Copper Synergistically Triggers Reactive Oxygen Species and DNA Damage and Inhibits Salmonella enterica subsp. enterica Serovar Typhi and Vibrio fluvialis.

1. Appl Environ Microbiol. 2019 Feb 6;85(4):e02487-18. doi: 10.1128/AEM.02487-18. Print 2019 Feb 15. A Combination of Linalool, Vitamin C, and Copper Synergistically Triggers Reactive Oxygen Species and DNA Damage and Inhibits Salmonella enterica subsp. enterica Serovar Typhi and Vibrio fluviali

Methionine Antagonizes para-Aminosalicylic Acid Activity via Affecting Folate Precursor Biosynthesis in Mycobacterium tuberculosis.

11. Front Cell Infect Microbiol. 2018 Nov 12;8:399. doi: 10.3389/fcimb.2018.00399. eCollection 2018. Methionine Antagonizes para-Aminosalicylic Acid Activity via Affecting Folate Precursor Biosynthesis in Mycobacterium tuberculosis. Howe MD(1), Kordus SL(1), Cole MS(2), Bauman AA(1), Aldrich CC(

Dual-Targeting Nanoparticles: Codelivery of Curcumin and 5-Fluorouracil for Synergistic Treatment of Hepatocarcinoma.

35. J Pharm Sci. 2019 Mar;108(3):1284-1295. doi: 10.1016/j.xphs.2018.10.042. Epub 2018 Nov 2. Dual-Targeting Nanoparticles: Codelivery of Curcumin and 5-Fluorouracil for Synergistic Treatment of Hepatocarcinoma. Ni W(1), Li Z(1), Liu Z(1), Ji Y(1), Wu L(1), Sun S(1), Jian X(1), Gao X(2). Author

Synergistic effect of rapamycin and metformin against germ cell apoptosis and oxidative stress after testicular torsion/detorsion-induced ischemia/reperfusion in rats.

23. Biomed Pharmacother. 2018 Sep;105:645-651. doi: 10.1016/j.biopha.2018.06.012. Epub 2018 Jun 11. Synergistic effect of rapamycin and metformin against germ cell apoptosis and oxidative stress after testicular torsion/detorsion-induced ischemia/reperfusion in rats. Ghasemnejad-Berenji M(1), G

Effects of a combination of plant bioactive lipid compounds and biotin compared with monensin on body condition, energy metabolism and milk performance in transition dairy cows.

43. PLoS One. 2018 Mar 27;13(3):e0193685. doi: 10.1371/journal.pone.0193685. eCollection 2018. Effects of a combination of plant bioactive lipid compounds and biotin compared with monensin on body condition, energy metabolism and milk performance in transition dairy cows. Hausmann J(1), Deiner

Association of Biotin Ingestion With Performance of Hormone and Nonhormone Assays in Healthy Adults.

41. JAMA. 2017 Sep 26;318(12):1150-1160. doi: 10.1001/jama.2017.13705. Association of Biotin Ingestion With Performance of Hormone and Nonhormone Assays in Healthy Adults. Li D(1), Radulescu A(2), Shrestha RT(2), Root M(3), Karger AB(1), Killeen AA(1), Hodges JS(4), Fan SL(5), Ferguson A(6), Gar

Apoptosis in dilated cardiomyopathy.

6. Korean J Intern Med. 2000 Jan;15(1):56-64. doi: 10.3904/kjim.2000.15.1.56. Apoptosis in dilated cardiomyopathy. Hong BK(1), Kwon HM, Byun KH, Kim D, Choi EY, Kang TS, Kang SM, Chun KJ, Jang Y, Kim HS, Kim M. Author information: (1)Cardiology Division, Yonsei Cardiovascular Center, Yonsei Univ

Systematic review of optimizing brain-targeted vitamin D delivery: Novel approaches to enhance mental illness therapeutics.

15. Brain Res. 2025 Jul 1;1858:149656. doi: 10.1016/j.brainres.2025.149656. Epub 2025 Apr 24. Systematic review of optimizing brain-targeted vitamin D delivery: Novel approaches to enhance mental illness therapeutics. He J(1), Gao Z(2), Li X(3), Zhao L(4), Tian X(5), Gao B(6). Author informatio

Effects of water-soluble vitamins on glycemic control and insulin resistance in adult type 2 diabetes: an umbrella review of meta-analyses.

48. Asia Pac J Clin Nutr. 2025 Feb;34(1):118-130. doi: 10.6133/apjcn.202502_34(1).0012. Effects of water-soluble vitamins on glycemic control and insulin resistance in adult type 2 diabetes: an umbrella review of meta-analyses. Chai Y(1), Chen C(1), Yin X(1), Wang X(1), Yu W(1), Pan H(1), Qin R(

Episodic Ataxias: Primary and Secondary Etiologies, Treatment, and Classification Approaches.

44. Tremor Other Hyperkinet Mov (N Y). 2023 Mar 28;13:9. doi: 10.5334/tohm.747. eCollection 2023. Episodic Ataxias: Primary and Secondary Etiologies, Treatment, and Classification Approaches. Hassan A(1)(2). Author information: (1)Beacon Hospital, Sandyford, Dublin 18, Ireland. (2)Trinity Colle

Associations between Dietary Micronutrient Intake and Serum Urate Concentrations Are Dependent on SLC2A9 Polymorphism rs12498742: A United Kingdom Biobank Cohort Study.

1. J Nutr. 2026 Jun 2;156(7):101627. doi: 10.1016/j.tjnut.2026.101627. Online ahead of print. Associations between Dietary Micronutrient Intake and Serum Urate Concentrations Are Dependent on SLC2A9 Polymorphism rs12498742: A United Kingdom Biobank Cohort Study. Johnson PR(1), Huizinga PA(1), Kim AY(1), Cardona CJ(1), Sigdel R(1), Joyce JM(1), Montgomery MR(2), Lin D(1), Kim Y(1), Emerson SR(1), Chowanadisai W(3). Author information: (1)Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, United States. (2)Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, United States; Department of Nutritional Sciences, Texas Christian University, Fort Worth, TX, United States. (3)Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, United States. Electronic address: winyoo.chowanadisai@okstate.edu. BACKGROUND: Serum urate (SU) concentrations are associated with increased risk of type 2 diabetes, metabolic syndrome, and gout. Both genetic and lifestyle factors can alter SU. The role of genetics in modifying associations between diet and SU is not well understood. OBJECTIVES: We examined if associations between dietary micronutrient intake and SU are modulated by genetic risk for high SU. METHODS: We utilized the United Kingdom Biobank, with 108,992 participants after exclusions. Micronutrient intake was measured by 24-h recall. Polygenic risk scores (PRSs) were generated to estimate genetic ri

Loganin promotes diabetic wound healing and inhibits NLRP3 inflammasomes in diabetic mice via IL17/NF-κB signaling.

2. Int Immunopharmacol. 2026 Jul 15;181:116767. doi: 10.1016/j.intimp.2026.116767. Epub 2026 May 2. Loganin promotes diabetic wound healing and inhibits NLRP3 inflammasomes in diabetic mice via IL17/NF-κB signaling. Zhou J(1), Ma Z(2), Ding Y(3), Yan X(4), Tan Q(5). Author information: (1)Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital, Clinical College, Nanjing University of Chinese Medicine, Nanjing, China. (2)Department of Plastic and Aesthetic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China. (3)Department of Emergency Surgery, The Fourth Affiliated Hospital of Jiangsu University (Zhenjiang Fourth People's Hospital), Zhenjiang, China; Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing, China. (4)Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital, Clinical College, Nanjing University of Chinese Medicine, Nanjing, China; Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. Electronic address: yanxinglyy@163.com. (5)Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital, Clinical College, Nanjing University of Chinese Medicine, Nanjing, China; Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. Electronic address: smmutanqiana@sina

Cardiac fibroblast-derived CCN1 aggravates diabetic cardiomyopathy through ITGAV-ITGB1/integrin αvβ1-mediated autophagy inhibition.

3. Autophagy. 2026 May 7:1-24. doi: 10.1080/15548627.2026.2667721. Online ahead of print. Cardiac fibroblast-derived CCN1 aggravates diabetic cardiomyopathy through ITGAV-ITGB1/integrin αvβ1-mediated autophagy inhibition. Hu BA(1)(2), Zhang L(1), Song M(1), Kong YR(3), Jiao YQ(1)(4), Jia X(1)(2), Zhu P(1), Li YL(1), Ti Y(1), Zhang W(1), Wang ZH(1)(2), Zhong M(1). Author information: (1)State Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research of MOE, NHC, CAMS and Shandong Province; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China. (2)Department of Geriatric Medicine & Laboratory of Gerontology and Anti-Aging Research, Qilu Hospital of Shandong University, Jinan, China. (3)Department of Cardiology, The Second Hospital of Shandong University, Jinan, China. (4)Department of General Practice, Qilu Hospital of Shandong University, Jinan, China. Cardiac fibrosis is a defining pathological feature of diabetic cardiomyopathy (DCM), and excessive activation of cardiac fibroblasts plays a critical role in regulating cardiomyocyte function through paracrine signaling. CCN1 (cellular communication network factor 1), an extracellular matrix protein involved in intercellular communication, has been suggested to influence cardiac remodeling, although its specific impact on cardiomyocytes in DCM has remained unclear. In this study, we found that CCN1 expression wa

Interacting proteins of AMPK studied using TurboID proximity labeling technology.

4. Exp Ther Med. 2026 Apr 2;31(6):149. doi: 10.3892/etm.2026.13144. eCollection 2026 Jun. Interacting proteins of AMPK studied using TurboID proximity labeling technology. Liu X(1), Guo J(1), Wang Q(2), Liu W(3), Xue Y(1), Guo S(1), Li M(4). Author information: (1)School of Pharmacy, Hubei Key Laboratory of Diabetes and Angiopathy, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China. (2)Department of Oncology, Xianning Central Hospital of Hubei Province (The First Affiliated Hospital of Hubei University of Science and Technology), Xianning, Hubei 437100, P.R. China. (3)School of Basic Medical Sciences, Hubei Key Laboratory of Environmental Risks and Related Diseases Precision Control, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China. (4)Department of Nursing, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570102, P.R. China. In living organisms, the change in the adenosine 5'-monophosphate (AMP)/adenosine 5'-triphosphate ratio serves as a key signal regulating AMP-activated protein kinase (AMPK) activity, which is an important molecule for the control of cellular energy metabolism and serves a key role in a number of diseases, such as diabetes and myocardial infarction. To explore novel AMPK-interacting proteins and investigate their biological functions, the present study used TurboID proximity labeling in U251 cells stab

Metabolites and proteins may mediate the relationship between diet quality and insulin sensitivity in young adult cohort.

5. J Diabetes Metab Disord. 2026 Feb 26;25(1):90. doi: 10.1007/s40200-026-01918-3. eCollection 2026 Jun. Metabolites and proteins may mediate the relationship between diet quality and insulin sensitivity in young adult cohort. Costello E(1), Goodrich JA(1), Baumert BO(1), Li S(2), Pan S(1), Patterson WB(3)(4), Walker DI(5), Rock S(1), Gilliland FD(1), Goran MI(6), Aung MT(1), Eckel SP(1), Alderete TL(7), Chen Z(1), Conti DV(8), Chatzi L(1). Author information: (1)Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA USA. (2)Department of Public Health Sciences, Thompson School of Social Work and Public Health, University of Hawaii at Manoa, Honolulu, HI USA. (3)Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO USA. (4)Department of Biomedical Informatics, University of Colorado School of Medicine, Aurora, CO USA. (5)Gangarosa Department of Environmental Health, Emory University, Atlanta, GA USA. (6)Department of Pediatrics, Children's Hospital Los Angeles, The Saban Research Institute, Los Angeles, CA USA. (7)Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA. (8)Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO USA. PURPOSE: Poor diet quality is a known risk factor for type 2 diabetes and related outcomes, including declines in insulin sensitivity. Biological changes tha

Nutritional Adjuvants in Diabetes: Biotin and Chromium Picolinate as Emerging Therapeutic Agents.

1. Curr Pharm Des. 2026 Jul 25. doi: 10.2174/0113816128456434260713163014. Online ahead of print. Nutritional Adjuvants in Diabetes: Biotin and Chromium Picolinate as Emerging Therapeutic Agents. Mehta M(1), Saini A(1), Mehta DK(1), Das R(1). Author information: (1)M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be) University, Mullana, Ambala, HR, India. INTRODUCTION: Insulin resistance and type 2 diabetes mellitus (T2DM) are serious worldwide health issues linked to dyslipidaemia, oxidative stress, impaired glucose metabolism, and persistent inflammation. Although their clinical significance is still unknown, micronutrients like chromium and biotin are thought to affect insulin signalling, glucose homeostasis, and lipid metabolism. The purpose of this review is to compile the preclinical, clinical, and epidemiological data that is currently available regarding the individual and combined effects of chromium and biotin on metabolic outcomes, insulin sensitivity, and glycaemic control. METHODS: Using databases like PubMed, Scopus, and Google Scholar, a thorough search of narrative literature was carried out. Included were pertinent experimental, clinical, and review studies evaluating the use of chromium and/or biotin supplements in diseases like metabolic syndrome, insulin resistance, and type 2 diabetes. With a focus on study design, dosage, duration, mechanistic pathways, and reported metabolic outcomes, the evidence was qualitatively exam

Zinc finger DHHC-type containing 19 promotes retinal pigment epithelium cell proliferation via VEGFA palmitoylation in diabetic macular edema (DME).

2. J Diabetes Metab Disord. 2026 Jul 25;25(2):210. doi: 10.1007/s40200-026-02023-1. eCollection 2026 Dec. Zinc finger DHHC-type containing 19 promotes retinal pigment epithelium cell proliferation via VEGFA palmitoylation in diabetic macular edema (DME). Jiang L(1)(2)(3), Yang MM(1)(2)(3), Liu YR(1)(2)(3), Deng TM(1)(2)(3), Zhang K(1)(2)(3). Author information: (1)Department of Ophthalmology, Shenzhen People's Hospital, Shenzhen, China. (2)Second Clinical Medical College of Jinan University, Shenzhen, China. (3)The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, China. OBJECTIVES: Vascular endothelial growth factor A (VEGFA) plays a critical role in the pathogenesis of diabetic macular edema (DME) in patients with type 2 diabetes mellitus (T2DM). Herein, we sought to determine whether palmitoylation modulates the stability and function of VEGFA in the context of DME. METHODS: VEGFA protein levels were measured by western blotting in retinal pigment epithelial (RPE) tissues from mice and in cultured RPE cell lines. Palmitoylation of VEGFA was assessed using acyl‑biotin exchange (ABE) and Click‑iT pulldown assays. Cell proliferation was evaluated with the Cell Counting Kit‑8 (CCK‑8) assay. The interaction between VEGFA and zinc finger DHHC-type containing 19 (ZDHHC19) was examined by co‑immunoprecipitation. Retinal histopathology in DME mice was evaluated by hematoxylin‑eosin (H&E) staining. RESULTS: VEGFA levels were elevat

A proximity ligation screen identifies SNAT2 as a novel target of the MARCH1 E3 ubiquitin ligase.

3. Biol Open. 2026 Aug 15;15(8):bio061700. doi: 10.1242/bio.061700. Epub 2026 Aug 7. A proximity ligation screen identifies SNAT2 as a novel target of the MARCH1 E3 ubiquitin ligase. Balthazard R(1)(2)(3), Mitchell W(1)(2)(3), Raymond M(1)(2)(3), Ballestero Vidal A(1)(2)(3), Roy DG(2)(4), Palma Zambrano LC(1)(2)(3), Moulefera MA(1)(2)(3), Faubert D(5), Pasquin S(3)(6), Gauchat JF(3)(6), Thibodeau J(1)(2)(3). Author information: (1)Laboratoire d'immunologie moléculaire, Université de Montréal, Montréal H3T 1J4, Canada. (2)Département de microbiologie, infectiologie et immunologie, Université de Montréal, Montréal H3T 1J4, Canada. (3)Institut Courtois d'innovation biomédicale (CI2B), Faculté de médecine, Université de Montréal, Montréal H3T 1J4, Canada. (4)Centre de recherche du Centre hospitalier de l'Université de Montréal (CR-CHUM), Montréal H2X 0A9, Canada. (5)Institut de recherches cliniques de Montréal, Montréal H2W 1R7, Canada. (6)Département de pharmacologie et physiologie, Université de Montréal, Montréal H3T 1J4, Canada. E3 ubiquitin ligases include hundreds of members that can regulate the half-life of other proteins but also modulate their cellular localization and functions. While MARCH1 appears to target principally immune cell components, such as MHC class II molecules and the co-stimulatory molecule CD86, the repertory of its targets remains to be fully documented. Here, we adapted a proximity-dependent biotin identification (BioID)-based scree

Genome-scale metabolic models predict diet- and lifestyle-driven shifts of ecological interactions in the gut microbiome.

4. Gut Microbes. 2026 Dec 31;18(1):2694811. doi: 10.1080/19490976.2026.2694811. Epub 2026 Jul 3. Genome-scale metabolic models predict diet- and lifestyle-driven shifts of ecological interactions in the gut microbiome. Marinos G(1)(2), Moors KA(1), Schlicht K(1), Rühlemann M(3), Waschina S(4), Lieb W(5), Franke A(3), Laudes M(6), Groussin M(3)(7), Poyet M(8), Kaleta C(1), Kadibalban AS(1). Author information: (1)Research Group Medical Systems Biology, Institute of Experimental Medicine, University Hospital Schleswig-Holstein Campus Kiel, Kiel University, Kiel, Schleswig-Holstein, Germany. (2)CAU Innovation GmbH, Kiel University, Kiel, Schleswig-Holstein, Germany. (3)Institute of Clinical Molecular Biology, University Hospital Schleswig-Holstein Campus Kiel, Kiel University, Kiel, Schleswig-Holstein, Germany. (4)Nutriinformatics, Institute of Human Nutrition and Food Science, Kiel University, Kiel, Schleswig-Holstein, Germany. (5)Institute of Epidemiology, Kiel, Kiel University, Kiel, Schleswig-Holstein, Germany. (6)Institute of Diabetes and Clinical Metabolic Research, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Schleswig-Holstein, Germany. (7)Global Microbiome Conservancy, Institute of Clinical Molecular Biology, University Hospital Schleswig-Holstein Campus Kiel, Kiel University, Kiel, Schleswig-Holstein, Germany. (8)Institute of Experimental Medicine, University Hospital Schleswig-Holstein Campus Kiel, Kiel University, Kiel, Schleswig-Holstei

Mitochondrial STING Governs Glycolytic Reprogramming in Diabetic Cardiomyopathy.

5. Circ Res. 2026 Jul 31;139(4):e327867. doi: 10.1161/CIRCRESAHA.125.327867. Epub 2026 Jul 2. Mitochondrial STING Governs Glycolytic Reprogramming in Diabetic Cardiomyopathy. Zhang S(#)(1)(2)(3)(4), Zhao D(#)(5), Wang M(#)(1)(2)(3)(4)(6), Shen X(#)(1)(7)(8), Yang F(#)(1)(2)(3)(4), Tian Z(2), Du H(1)(2)(3)(4), Lu F(1)(2)(3)(4), Zhang X(2), Chen H(2), Kang J(2), Dong M(9), Abramochkin DV(10), Fan H(11)(12)(13), Tian J(1)(3)(4)(6), Yu B(1)(3)(4), Li S(1)(3)(4)(7)(8), Zhang W(1)(2)(3)(4). Author information: (1)State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD) (S.Z., M.W., X.S., F.Y., H.D., F.L., J.T., B.Y., S.L., W.Z.), Harbin Medical University, China. (2)Department of Pathophysiology, School of Basic Medical Sciences (S.Z., M.W., Z.T., H.D., F.L., X.Z., H.C., J.K., W.Z.), Harbin Medical University, China. (3)Department of Cardiology, Second Affiliated Hospital of Harbin Medical University (S.Z., M.W., F.Y., H.D., F.L., J.T., B.Y., S.L., W.Z.), China. (4)The Key Laboratory of Myocardial Ischemia, Ministry of Education (S.Z., M.W., F.Y., H.D., F.L., J.T., B.Y., S.L., W.Z.), Harbin Medical University, China. (5)Department of Cardiology (D.Z.), First Affiliated Hospital of Harbin Medical University, China. (6)Heilongjiang Provincial Key Laboratory of Panvascular Disease, Harbin, China (M.W., J.T.). (7)Department of Biopharmaceutical Sciences, College of Pharmacy (X.S., S.L.), Harbin Medical University, China. (8)Heilongjiang Province Key Laborat

A proximity-labeling map of PI5P4K phosphoinositide kinases interaction networks.

6. J Biol Chem. 2026 Jun;302(6):113071. doi: 10.1016/j.jbc.2026.113071. Epub 2026 Apr 25. A proximity-labeling map of PI5P4K phosphoinositide kinases interaction networks. Llorente A(1), Arora GK(1), Loughran RM(1), Murad R(2), Maurya S(3), Crabtree S(1), Portillo B(4), Chapagain P(5), Huluka H(5), Eron S(6), Goodman K(6), Ye G(6), Blind RD(5), Emerling BM(7). Author information: (1)Cancer Metabolism and Microenvironment Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA. (2)Bioinformatics Core, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA. (3)Proteomics Core, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA. (4)Flow Cytometry Core, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA. (5)Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, USA. (6)Larkspur Biosciences, Cambridge, USA. (7)Cancer Metabolism and Microenvironment Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA. Electronic address: bemerling@sbpdiscovery.org. Phosphatidylinositol-5-phosphate 4-kinases (PI5P4Ks) have emerged as candidate drug targets in cancer, neurological, inflammatory, and infectious diseases. Although their canonical function is to phosphorylate PI(5)P to generate PI(4,5)P2, growing evidence points to additional catalytic-independent roles, but

BAF60A governs beta cell identity to control systemic glucose homeostasis.

1. Diabetologia. 2026 Oct 3. doi: 10.1007/s00125-026-06884-2. Online ahead of print. BAF60A governs beta cell identity to control systemic glucose homeostasis. Zhu S(1)(2)(3)(4), Zhang Z(5)(6), Wang RR(5)(6)(7)(8), Chen W(9), Xu Q(5)(6)(10)(7), Qiu X(11), Ji X(5)(6)(10)(7), Zhang R(5)(6)(10)(7), Wei R(12), Fu H(5), Yan S(13), Meng ZX(14)(15)(16)(17). Author information: (1)Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. zhuss021@gmail.com. (2)Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, China. zhuss021@gmail.com. (3)Department of General Surgery, Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, China. zhuss021@gmail.com. (4)Institute of Cell Biology, Zhejiang University, Hangzhou, China. zhuss021@gmail.com. (5)Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. (6)Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, China. (7)Institute of Cell Biology, Zhejiang University, Hangzhou, China. (8)School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China. (9)Gan & Lee Pharmaceuticals, Beijing, China. (10)Department of General Surgery, Affiliated Huzhou Hospital, Zhejiang Universi

Identification of Gβ5 Interactome Associated with Neuronal Development in Neuro-2a Cells through miniTurbo Proximity Labeling.

2. ACS Omega. 2026 Sep 14;11(38):57183-57196. doi: 10.1021/acsomega.6c05064. eCollection 2026 Sep 29. Identification of Gβ5 Interactome Associated with Neuronal Development in Neuro-2a Cells through miniTurbo Proximity Labeling. McNabb HJ(1), Zhang J(1), Jewell CP(2), Yang W(2), Jenkins LM(2), Simonds WF(1). Author information: (1)Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States. (2)Center for Cancer Research Mass Spectrometry Resource, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-0001, United States. Gβ5 is a member of the Gβ family; however, unlike other heterotrimeric Gβ proteins, which transduce extracellular signals in response to G-protein coupled receptor (GPCR) activation, Gβ5 negatively regulates GPCR signaling by stabilizing the GTPase-activating proteins (GAP) R7 subfamily of Regulator of G-protein Signaling (R7-RGS) proteins. Mutations in Gβ5 have been implicated in a multisystem developmental disorder. While the regulation of GPCR signaling at the plasma membrane is likely important in this process, Gβ5/R7-RGS also localizes to the cytosol and nucleus. Potential protein-protein interactions of Gβ5 in these subcellular compartments are not well studied, so we sought to characterize the interactome of Gβ5 utilizing a live-cell biotin proximity-labeling assay in Neuro-2a cells coupled with mass s

Association between the naturally nutrient rich score and type 2 diabetes mellitus risk: a case-control study.

3. Front Nutr. 2026 Aug 24;13:1889494. doi: 10.3389/fnut.2026.1889494. eCollection 2026. Association between the naturally nutrient rich score and type 2 diabetes mellitus risk: a case-control study. Almohya SM(1), Alqahtani N(2). Author information: (1)Riyadh Health First Cluster, Riyadh, Saudi Arabia. (2)Northern Border University, Arar, Saudi Arabia. BACKGROUND: The Naturally Nutrient Rich (NNR) score is a validated nutrient-density metric that quantifies micronutrient adequacy relative to energy intake, yet its association with type 2 diabetes mellitus (T2DM) risk remains uninvestigated. This study aimed to examine the association between the NNR score and T2DM risk among Saudi adults. METHODS: A hospital-based case-control study was conducted at Prince Abdulaziz bin Musaed Hospital, Saudi Arabia between November 2024 and August 2025, enrolling 140 confirmed T2DM cases and 280 non-diabetic controls (same healthcare facility) matched 1:2 by age and sex. Dietary intake was assessed using a validated 152-item semi-quantitative food frequency questionnaire. The NNR score was calculated as the mean percentage daily value (%DV) of 14 key nutrients per 2,000 kcal (protein, vitamins A, C, D, E, B1, B2, and B12, calcium, zinc, iron, folate, potassium, and unsaturated fatty acids). Logistic regression models were applied to evaluate the association between the NNR score and T2DM risk, with progressive adjustment for age, sex, smoking, physical activity, BMI, and

Noninvasive, Rapid, and Ultrasensitive Detection of Salivary Glycated Hemoglobin for Point-of-Care Testing of Diabetes.

4. Anal Chem. 2026 Aug 25;98(33):24498-24506. doi: 10.1021/acs.analchem.6c04091. Noninvasive, Rapid, and Ultrasensitive Detection of Salivary Glycated Hemoglobin for Point-of-Care Testing of Diabetes. Zhang T(1), Guo Y(1), Wang X(1), Jin J(2), Wen S(2), Chen L(2), Yuan X(2), Gao M(3), Zhang X(1). Author information: (1)Department of Chemistry, Institutes of Biomedical Sciences, Fudan University, Shanghai200438, China. (2)Department of Endocrinology and Metabolic Diseases, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai201399, China. (3)Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai201399, China. The glycated hemoglobin ratio (HbA1c %) serves as the gold standard for diabetes diagnosis, but traditional detection methods require invasive blood testing. Although saliva holds promising noninvasive potential, the complex salivary matrix and the low abundance of salivary hemoglobin (Hb) and glycated hemoglobin (HbA1c) restrict the development of reliable immunoassays. Here, we present an HbA1c/Hb dual-detection lateral flow assay (LFA) platform for rapid and noninvasive quantification of salivary HbA1c %. The assay integrates two distinct capture strategies onto a single LFA strip: a streptavidin (SA)-biotin bridging system for HbA1c (T1 line) and a conventional double-antibody sandwich

Type 2 diabetes mellitus is associated with distinct post-treatment metabolic profiles in pulmonary tuberculosis.

5. Front Cell Infect Microbiol. 2026 Aug 11;16:1887961. doi: 10.3389/fcimb.2026.1887961. eCollection 2026. Type 2 diabetes mellitus is associated with distinct post-treatment metabolic profiles in pulmonary tuberculosis. Li X(#)(1), He Z(#)(2), Gao Q(#)(1), Hou Z(#)(3), Zhang K(#)(3), Qin Z(4), Zheng X(3), Yu H(5), Wu J(3)(5), Chen H(1)(5). Author information: (1)Tianjin Key Laboratory of Lung Regenerative Medicine, Haihe Hospital, Tianjin University, Tianjin, China. (2)Department of Basic Medicine, Haihe Clinical College, Tianjin Medical University, Tianjin, China. (3)Department of Tuberculosis, Haihe Hospital, Tianjin University, Tianjin, China. (4)Center for Accurate Detection of Tuberculosis, Haihe Hospital, Tianjin University, Tianjin, China. (5)Key Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine, Tianjin Institute of Respiratory Diseases, Tianjin, China. (#)Contributed equally BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major risk factor for pulmonary tuberculosis (PTB), exacerbates disease severity and reduces the efficacy of anti-tuberculosis therapy. Previous studies have shown that T2DM is associated with exacerbated metabolic disturbances in patients with PTB. However, metabolic differences between PTB patients with comorbid T2DM (PTB-DM) and those with PTB after anti-TB therapy remain unclear. METHODS: Untargeted metabolomic analysis was conducted on plasma samples collected fro