비타민B5 (판토텐산)

Revealing VNN1: An Emerging and Promising Target for Inflammation and Redox Balance.

1. Immun Inflamm Dis. 2025 Oct;13(10):e70274. doi: 10.1002/iid3.70274. Revealing VNN1: An Emerging and Promising Target for Inflammation and Redox Balance. Lv L(1), Wang T(1), Xie W(1), Wei J(1), Zhou L(1), Qiu X(1), Feng H(1), Gu W(1). Author information: (1)Center of Smart Laboratory and Molec

Vitamins B(9) and B(12) in children with attention deficit hyperactivity disorder (ADHD).

2. Int J Vitam Nutr Res. 2024 Jun;94(5-6):476-484. doi: 10.1024/0300-9831/a000809. Vitamins B(9) and B(12) in children with attention deficit hyperactivity disorder (ADHD). Razavinia F(1), Ebrahimiyan A(1), Faal Siahkal S(2), Ghazinezhad N(3), Abedi P(4). Author information: (1)Midwifery Depart

Unmasking the Metabolite Signature of Bladder Cancer: A Systematic Review.

3. Int J Mol Sci. 2024 Mar 15;25(6):3347. doi: 10.3390/ijms25063347. Unmasking the Metabolite Signature of Bladder Cancer: A Systematic Review. Pereira F(1)(2), Domingues MR(3), Vitorino R(4), Guerra IMS(1)(3), Santos LL(2), Ferreira JA(2), Ferreira R(1). Author information: (1)LAQV-REQUIMTE, Ma

Demand for Water-Soluble Vitamins in a Group of Patients with CKD versus Interventions and Supplementation-A Systematic Review.

4. Nutrients. 2023 Feb 8;15(4):860. doi: 10.3390/nu15040860. Demand for Water-Soluble Vitamins in a Group of Patients with CKD versus Interventions and Supplementation-A Systematic Review. Kędzierska-Kapuza K(1)(2), Szczuko U(3), Stolińska H(4), Bakaloudi DR(5)(6), Wierzba W(1), Szczuko M(3). A

ESPEN micronutrient guideline.

5. Clin Nutr. 2022 Jun;41(6):1357-1424. doi: 10.1016/j.clnu.2022.02.015. Epub 2022 Feb 26. ESPEN micronutrient guideline. Berger MM(1), Shenkin A(2), Schweinlin A(3), Amrein K(4), Augsburger M(5), Biesalski HK(6), Bischoff SC(7), Casaer MP(8), Gundogan K(9), Lepp HL(10), de Man AME(11), Muscogi

Clinical efficacy of vitamin B in the treatment of mouth ulcer: a systematic review and meta-analysis.

6. Ann Palliat Med. 2021 Jun;10(6):6588-6596. doi: 10.21037/apm-21-1064. Epub 2021 Jun 16. Clinical efficacy of vitamin B in the treatment of mouth ulcer: a systematic review and meta-analysis. Shi J(1), Wang L(2), Zhang Y(1), Zhi D(1). Author information: (1)Department of Oral and Maxillofacia

Association between B-group vitamins and venous thrombosis: systematic review and meta-analysis of epidemiological studies.

7. J Thromb Thrombolysis. 2012 Nov;34(4):459-67. doi: 10.1007/s11239-012-0759-x. Association between B-group vitamins and venous thrombosis: systematic review and meta-analysis of epidemiological studies. Zhou K(1), Zhao R, Geng Z, Jiang L, Cao Y, Xu D, Liu Y, Huang L, Zhou J. Author information

Prevention of and therapies for nipple pain: a systematic review.

8. J Obstet Gynecol Neonatal Nurs. 2005 Jul-Aug;34(4):428-37. doi: 10.1177/0884217505276056. Prevention of and therapies for nipple pain: a systematic review. Morland-Schultz K(1), Hill PD. Author information: (1)Pediatric Intensive Care Unit at OSF - Saint Francis Medical Center, Children's Ho

Safety, Pharmacokinetics, and Pharmacodynamics of BI 1595043, a Selective Vanin Inhibitor, in Phase 1 Clinical Trials Involving Healthy Volunteers.

9. Clin Transl Sci. 2025 Sep;18(9):e70285. doi: 10.1111/cts.70285. Safety, Pharmacokinetics, and Pharmacodynamics of BI 1595043, a Selective Vanin Inhibitor, in Phase 1 Clinical Trials Involving Healthy Volunteers. Kukreja A(1), Keller S(2), Shatillo Y(3), Bauer A(1), Sharma A(1), Wojciekowski S

Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study.

10. J Cosmet Dermatol. 2025 Jul;24(7):e70223. doi: 10.1111/jocd.70223. Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study. Gao M(1), Gao N(1), Wang L(1), Yao T(1), Jing H

Randomized-Controlled Trial Comparing Safety and Efficacy of Repairing Balm vs Topical Antimicrobial for Post-Procedural Wounds.

11. J Drugs Dermatol. 2025 May 1;24(5):507-515. doi: 10.36849/JDD.8746. Randomized-Controlled Trial Comparing Safety and Efficacy of Repairing Balm vs Topical Antimicrobial for Post-Procedural Wounds. Lynde CW, Andriessen A, Guenther L, Dayeh N, Skotnicki S, Nigen S, Sibbald GR. BACKGROUND: Acti

Prebiotic and panthenol-containing dermocosmetic improves tolerance from artificial daylight photodynamic therapy: A randomized controlled trial in patients with actinic keratosis.

12. Photodiagnosis Photodyn Ther. 2024 Dec;50:104394. doi: 10.1016/j.pdpdt.2024.104394. Epub 2024 Nov 9. Prebiotic and panthenol-containing dermocosmetic improves tolerance from artificial daylight photodynamic therapy: A randomized controlled trial in patients with actinic keratosis. Fredman G

Randomized Trial to Assess the Safety and Tolerability of Daily Intake of an Allulose Amino Acid-Based Hydration Beverage in Men and Women.

13. Nutrients. 2024 Jun 5;16(11):1766. doi: 10.3390/nu16111766. Randomized Trial to Assess the Safety and Tolerability of Daily Intake of an Allulose Amino Acid-Based Hydration Beverage in Men and Women. Bloomer RJ(1), Pence J(1), Hellenbrand J(1), Davis A(1), Davis S(1), Stockton M(1), Martin K

Cream versus ointment: Randomized single-blinded study on the adherence to treatment with topical methylprednisolone aceponate.

14. Contact Dermatitis. 2024 Feb;90(2):161-168. doi: 10.1111/cod.14447. Epub 2023 Nov 13. Cream versus ointment: Randomized single-blinded study on the adherence to treatment with topical methylprednisolone aceponate. Gregersen DM(1), Peckruhn M(1), Breternitz-Gruhne M(2), Schiller I(2), Schuma

Topical Ectoin Versus Topical Dexpanthenol for Managing Acute Radiodermatitis Associated With Breast Cancer Radiotherapy: A Randomized Double-Blind Study.

15. Dermatitis. 2023 Nov-Dec;34(6):516-524. doi: 10.1089/derm.2023.0055. Epub 2023 Oct 4. Topical Ectoin Versus Topical Dexpanthenol for Managing Acute Radiodermatitis Associated With Breast Cancer Radiotherapy: A Randomized Double-Blind Study. Abd Elazim NE(1), Awad SM(1), El-Naggar MS(2), Moha

Effects of supplementation with low-dose group B vitamins on clinical and biochemical parameters in critically ill patients with COVID-19: a randomized clinical trial.

39. Expert Rev Anti Infect Ther. 2024 Jul;22(7):579-585. doi: 10.1080/14787210.2022.2125867. Epub 2022 Sep 28. Effects of supplementation with low-dose group B vitamins on clinical and biochemical parameters in critically ill patients with COVID-19: a randomized clinical trial. Majidi N(1), Bah

Efficacy of intramuscular injections of biotin and dexpanthenol in the treatment of diffuse hair loss: A randomized, double-blind controlled study comparing two brands.

36. Dermatol Ther. 2022 Sep;35(9):e15695. doi: 10.1111/dth.15695. Epub 2022 Jul 15. Efficacy of intramuscular injections of biotin and dexpanthenol in the treatment of diffuse hair loss: A randomized, double-blind controlled study comparing two brands. Samadi A(1), Ketabi Y(2), Firooz R(1), Firo

Postoperative Vitamin Profile after Receiving a Novel Peripheral Parenteral Nutrition Solution: Multicenter Randomized Controlled Phase III Trial.

1. Ann Nutr Metab. 2022;78(4):222-235. doi: 10.1159/000524625. Epub 2022 Apr 19. Postoperative Vitamin Profile after Receiving a Novel Peripheral Parenteral Nutrition Solution: Multicenter Randomized Controlled Phase III Trial. Fukatsu K(1), Shineha R(2), Kawauchi Y(3), Katayose S(3), Nakayama M(

Determination of Dietary Pantothenic Acid Requirement for Olive Flounder (Paralichthys olivaceus): Growth and Physiological Responses.

31. Mar Biotechnol (NY). 2026 Apr 22;28(3):70. doi: 10.1007/s10126-026-10619-0. Determination of Dietary Pantothenic Acid Requirement for Olive Flounder (Paralichthys olivaceus): Growth and Physiological Responses. Kim S(#)(1), Lim J(#)(1), Lee Y(1), Kim W(1), Kim S(1), Song S(1), Lee Y(1), Lee

Heart-Cutting Two-Dimensional Liquid Chromatography-Isotope Ratio Mass Spectrometry for Compound-Specific δ(13)C Analysis of Water-Soluble B Vitamins in Complex Supplement Matrices.

38. J Sep Sci. 2026 Apr;49(4):e70419. doi: 10.1002/jssc.70419. Heart-Cutting Two-Dimensional Liquid Chromatography-Isotope Ratio Mass Spectrometry for Compound-Specific δ(13)C Analysis of Water-Soluble B Vitamins in Complex Supplement Matrices. Rockel SP(1)(2), Martiny J(1)(3), Jochmann MA(1), S

HPLC-Orbitrap-MS for the Determination of B-Vitamins in Fruit Juices and Food Supplements.

2. J Mass Spectrom. 2026 Apr;61(4):e70050. doi: 10.1002/jms.70050. HPLC-Orbitrap-MS for the Determination of B-Vitamins in Fruit Juices and Food Supplements. Bartella L(1)(2), Mazzotti F(1)(2), Santoro I(1)(2), Di Donna L(1)(2). Author information: (1)Dipartimento di Chimica e Tecnologie Chimich

Structure-function relationship of Konjac glucomannan with varying acetylation degrees in modulating gut microbiota and alleviating prediabetes.

8. Carbohydr Polym. 2026 May 15;380:125103. doi: 10.1016/j.carbpol.2026.125103. Epub 2026 Feb 16. Structure-function relationship of Konjac glucomannan with varying acetylation degrees in modulating gut microbiota and alleviating prediabetes. Wang H(1), Zhao Y(1), Dang D(1), Huang L(1), Pei Z(1)

The Plasmodium falciparum PPCS is a unique heteromeric complex with prokaryote-like activity and is a target of pantothenate analogs.

41. Sci Adv. 2026 Mar 13;12(11):eadx5265. doi: 10.1126/sciadv.adx5265. Epub 2026 Mar 13. The Plasmodium falciparum PPCS is a unique heteromeric complex with prokaryote-like activity and is a target of pantothenate analogs. Liu X(1), Jin R(1), Domingo R(2), Kotzé TJ(2), Guan J(3), Hamann AR(2), C

[Analysis of urine biomarkers in urothelial carcinoma based on untargeted metabolomics].

47. Se Pu. 2026 Mar;44(3):329-337. doi: 10.3724/SP.J.1123.2025.05018. [Analysis of urine biomarkers in urothelial carcinoma based on untargeted metabolomics]. [Article in Chinese] Liu S(1), Wang M(2)(3), Wang W(1). Author information: (1)Department of Urology，Beijing Chao-Yang Hospital，Capital

Optimization of Indole- and Pyrazole-fused Glycyrrhetinic Acid Derivatives as Potent PTP1B Inhibitors: In Silico, In Vitro, In Vivo, and Metabolomic Studies.

33. ACS Bio Med Chem Au. 2025 Oct 31;6(1):15-35. doi: 10.1021/acsbiomedchemau.5c00164. eCollection 2026 Feb 18. Optimization of Indole- and Pyrazole-fused Glycyrrhetinic Acid Derivatives as Potent PTP1B Inhibitors: In Silico, In Vitro, In Vivo, and Metabolomic Studies. López-Sánchez M(1)(2)(3)(4

Pantothenic Acid and Parkinson Disease: A Systematic Review of Metabolomics Analysis Studies.

29. Nutr Rev. 2026 Feb 19:nuaf232. doi: 10.1093/nutrit/nuaf232. Online ahead of print. Pantothenic Acid and Parkinson Disease: A Systematic Review of Metabolomics Analysis Studies. Kheirouri S(1), Alizadeh M(1)(2). Author information: (1)Department of Nutrition, Faculty of Nutrition and Food Sc

Effects of Dietary Supplementation with Dihydromyricetin on Hindgut Microbiota and Metabolite Profiles in Dairy Cows.

1. Microorganisms. 2025 Dec 21;14(1):20. doi: 10.3390/microorganisms14010020. Effects of Dietary Supplementation with Dihydromyricetin on Hindgut Microbiota and Metabolite Profiles in Dairy Cows. Yu J(1), Ao Y(1), Chen H(2), Liu C(1), Deng T(2), Wang D(1), Xiang M(1), Wan P(1), Cheng L(1). Auth

Evaluating the Effect of Random Multi-Donor Pooling on the Nutritional Variability in Donor Human Milk Using Computer Modeling.

13. Matern Child Nutr. 2026 Mar;22(1):e70158. doi: 10.1111/mcn.70158. Evaluating the Effect of Random Multi-Donor Pooling on the Nutritional Variability in Donor Human Milk Using Computer Modeling. Smith RM(1), Richter S(1)(2), Iwayemi EF(3), Mansen K(4), Israel-Ballard K(4), Hampel D(5)(6), Sha

Functional Expansion of the Skin Microbiome: A Pantothenate-Producing Rothia Strain Confers Anti-Inflammatory and Photoaging-Protective Effects.

4. Int J Mol Sci. 2025 Dec 15;26(24):12058. doi: 10.3390/ijms262412058. Functional Expansion of the Skin Microbiome: A Pantothenate-Producing Rothia Strain Confers Anti-Inflammatory and Photoaging-Protective Effects. Kim HB(1), Kim G(2), Park E(1), Kim H(1), Yu BS(3), Lee DG(1), Park CH(1), Jo H

Dietary resveratrol modulates rumen microbiota and metabolic function in Tibetan sheep: an integrated 16S rRNA sequencing and metabolomics analysis.

24. Front Microbiol. 2025 Dec 12;16:1679856. doi: 10.3389/fmicb.2025.1679856. eCollection 2025. Dietary resveratrol modulates rumen microbiota and metabolic function in Tibetan sheep: an integrated 16S rRNA sequencing and metabolomics analysis. Xie W(1), Zhang Y(1), Feng Y(2), Li Y(2), Gui L(1),

Pantothenic Acid Derivatives Modulate Oxidative Stress and Hepatic Fibrosis in Bile Duct Ligation-Induced Cholestatic Liver Injury.

1. Pathophysiology. 2026 May 13;33(2):32. doi: 10.3390/pathophysiology33020032. Pantothenic Acid Derivatives Modulate Oxidative Stress and Hepatic Fibrosis in Bile Duct Ligation-Induced Cholestatic Liver Injury. Semenovich DS(1)(2), Abramicheva PA(1), Zorova LD(1)(2), Elchaninov AV(3), Kozlova MA(3), Areshidze DA(3), Andrianova NV(1), Kanunnikova NP(4)(5), Moiseenok AG(5), Pevzner IB(1)(2), Plotnikov EY(1)(2), Zorov DB(1)(2). Author information: (1)A.N. Belozersky Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, 119992 Moscow, Russia. (2)V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, 117997 Moscow, Russia. (3)Avtsyn Research Institute of Human Morphology, Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", 117418 Moscow, Russia. (4)Department of Technology, Physiology and Food Hygiene, Yanka Kupala State University of Grodno, 230022 Grodno, Belarus. (5)Institute of Biochemistry of Biologically Active Compounds, 230030 Grodno, Belarus. BACKGROUND/OBJECTIVES: Inflammation and oxidative stress are key factors contributing to the initiation and progression of liver fibrosis in chronic obstructive cholestasis. Pantothenic acid (PA) and some of its derivatives have been reported to exhibit moderate anti-inflammatory, antioxidant, and regenerative effects. This study aimed to evaluate the redox-modulating effects of PA derivatives-panthenol (PL), pa

Correlation between oxidative stress and inflammation with metabolomics profile in skeletal muscle of ageing animal model and its modulation by tocotrienol-rich fraction.

2. Br J Biomed Sci. 2026 May 8;83:16208. doi: 10.3389/bjbs.2026.16208. eCollection 2026. Correlation between oxidative stress and inflammation with metabolomics profile in skeletal muscle of ageing animal model and its modulation by tocotrienol-rich fraction. Saud Gany SL(1), Mohd Sahardi NFN(2), Tan JK(1)(3), Makpol S(1)(3). Author information: (1)Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. (2)Secretariat of Research & Innovation, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. (3)Ageing and Degenerative Diseases Research Group, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia. INTRODUCTION: Sarcopenia, characterised by age-associated decline in skeletal muscle mass and function, is driven by multifactorial mechanisms including oxidative stress, chronic inflammation, and genomic instability. The imbalance between reactive oxygen species (ROS) and antioxidant defence contributes to mitochondrial dysfunction and DNA damage, thereby affecting cellular metabolism and promoting muscle degeneration. Tocotrienol-rich fraction (TRF), a potent antioxidant form of vitamin E, has shown potential in modulating oxidative and inflammatory pathways. However, in vivo evidence exploring TRF's multifaceted role in ageing muscle remains limited. This study investigates the correlation between oxidative stress and inflammation with the metabolomics profile in ageing skeletal mu

Ammonia stress induces hepatotoxicity in hybrid grouper: histological, oxidative, inflammatory, and metabolomic responses.

3. Fish Physiol Biochem. 2026 May 19;52(3):77. doi: 10.1007/s10695-026-01698-w. Ammonia stress induces hepatotoxicity in hybrid grouper: histological, oxidative, inflammatory, and metabolomic responses. Fang Z(1), Wang Y(1), Zhu R(2), Duan Y(3). Author information: (1)Guangdong Eco - Engineering Polytechnic, School of Ocean and Fisheries, Guangzhou, 510520, People's Republic of China. (2)State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture and Rural Affairs, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, 510300, People's Republic of China. (3)State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture and Rural Affairs, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, 510300, People's Republic of China. duanyafei89@163.com. Ammonia acts as a key environmental pollutant in fish farming. Elevated ammonia concentrations can induce stress responses in fish, threatening their survival and growth. As a vital metabolic organ, the fish liver plays key roles in detoxification and immune defense. In the present study, juvenile hybrid groupers (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂) were subjected to ammonia stress at 4 mg/L (A

Dexpanthenol reduces IL 6 and VEGF gene expression in a rat model of acetic acid induced ulcerative colitis.

4. Mol Biol Rep. 2026 May 5;53(1):715. doi: 10.1007/s11033-026-11890-z. Dexpanthenol reduces IL 6 and VEGF gene expression in a rat model of acetic acid induced ulcerative colitis. Shahrooei M(1), Rahimi K(2), Givi ME(1), Rezaie A(3). Author information: (1)Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran. (2)Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran. k.rahimi@scu.ac.ir. (3)Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran. BACKGROUND: Ulcerative colitis is a chronic inflammatory bowel disease characterized by inflammation of the colonic mucosa. This study aimed to evaluate the effects of dexpanthenol in an acetic acid-induced model of colitis in rats. METHODS: Thirty-two adult male Wistar rats were randomly assigned to four groups: Control (intracolonic saline), dexpanthenol, acetic acid (A.A; 4% acetic acid-induced colitis), and treatment (A.A + dexpanthenol 500). Colitis was induced by intracolonic administration of 4% acetic acid. After 7 days, macroscopic and histopathological evaluations of the colon were performed. The mRNA expression levels of IL-6 and VEGF were assessed using real-time PCR. Stool consistency, colon length, and colon weight-to-length ratio were also measured. RESULTS: Dexpanthenol administration significantly ameliorated acetic acid-induced colitis.

Assessment of oxidative and inflammatory biomarkers in denture-related traumatic ulcers treated with different topical agents.

5. Arch Oral Biol. 2026 Jul;187:106599. doi: 10.1016/j.archoralbio.2026.106599. Epub 2026 Apr 17. Assessment of oxidative and inflammatory biomarkers in denture-related traumatic ulcers treated with different topical agents. Okicic N(1), Milojevic Samanovic A(2), Jovanovic M(3), Jakovljevic V(4), Zivkovic V(5), Kocovic A(6), Nikolic M(7), Andjic M(8), Lazarevic N(9), Petrovic A(10), Stanisic D(11), Mladenovic R(12), Milosavljevic M(13). Author information: (1)Department of Dental Prosthetics, Military Medical Academy, 17 Crnotravska St., Belgrade 11000, Serbia. Electronic address: nemanjaokicic@gmail.com. (2)Department of Dentistry, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica St., Kragujevac 34000, Serbia; Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, 69 Svetozara Markovica St., Kragujevac 34000, Serbia. Electronic address: andjela-kg@hotmail.com. (3)Department of Dentistry, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica St., Kragujevac 34000, Serbia. Electronic address: micamonro@gmail.com. (4)Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, 69 Svetozara Markovica St., Kragujevac 34000, Serbia; Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica St., Kragujevac 34000, Serbia; Department of Human Pathology, I.M. Sechenov First Moscow State Medical University

Dexpanthenol Attenuates Methotrexate-Induced Nephrotoxicity Through Modulation of NF-κB-Mediated Inflammation and SIRT1/PGC-1α-NRF2/HO-1-Associated Oxidative Stress Pathways.

1. J Biochem Mol Toxicol. 2026 Aug;40(8):e71055. doi: 10.1002/jbt.71055. Dexpanthenol Attenuates Methotrexate-Induced Nephrotoxicity Through Modulation of NF-κB-Mediated Inflammation and SIRT1/PGC-1α-NRF2/HO-1-Associated Oxidative Stress Pathways. Altuntas A(1), Asci H(2), Selcuk E(3), Karaosman H(4), Aydin O(5), Ilhan I(6), Ozturk SA(7), Ozmen O(8). Author information: (1)Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Suleyman Demirel University, Isparta, Türkiye. (2)Department of Medical Pharmacology, Faculty of Medicine, Suleyman Demirel University, Isparta, Türkiye. (3)Department of Medical Biology, Faculty of Medicine, Institute of Health Sciences, Isparta, Türkiye. (4)Department of Internal Medicine, Faculty of Medicine, Suleyman Demirel University, Isparta, Türkiye. (5)Department of Internal Medicine, Konya State Hospital, Konya, Türkiye. (6)Department of Biochemistry, Faculty of Medicine, Suleyman Demirel University, Isparta, Türkiye. (7)Department of Urology, Faculty of Medicine, Suleyman Demirel University, Isparta, Türkiye. (8)Department of Pathology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur, Türkiye. Methotrexate (MTX)-induced nephrotoxicity remains a clinically relevant limitation associated with oxidative stress, inflammation, and apoptosis. Dexpanthenol (DEX), a pantothenic acid derivative, has demonstrated cytoprotective properties; however, its effects on MTX-induced renal inju

Immune regulatory mechanisms and potential microbiota-associated targets in Kawasaki disease: an integrative multi-omics and network pharmacology study.

2. Artif Cells Nanomed Biotechnol. 2026 Dec;54(1):305-320. doi: 10.1080/21691401.2026.2700919. Epub 2026 Jul 9. Immune regulatory mechanisms and potential microbiota-associated targets in Kawasaki disease: an integrative multi-omics and network pharmacology study. Mei Z(1), Xiong X(2)(3). Author information: (1)Department of Pediatrics, Luzhou Maternal and Child Health Hospital, Luzhou Second People's Hospital, Luzhou Women and Children's Hospital, Luzhou, Sichuan, China. (2)Department of Pediatrics, Children's Medical Center, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. (3)Sichuan Clinical Research Center for Birth Defects, Luzhou, Sichuan, China. Kawasaki disease (KD) is a systemic vasculitis in children primarily affecting the coronary arteries, and studies suggest that the gut microbiota may be involved in KD pathogenesis, inflammatory responses, and immune regulation. This study employed an integrative multi-omics strategy to systematically investigate gut microbiota-metabolite interactions in KD. Key molecular targets were identified using network-based analyses and machine learning models, with Mendelian randomization providing causal validation. Single-cell transcriptomics and molecular docking further elucidated immune cell interactions and metabolite-protein binding, highlighting critical regulatory pathways. We identified SELP as a core molecular target in KD, predominantly expressed in platelets and involved i

Ultrasound-assisted pectin extraction from 'Lane Late' navel orange: RSM optimization, structural identification and anti-alcoholic liver injury potential.

3. Int J Biol Macromol. 2026 Jul 10;375:153381. doi: 10.1016/j.ijbiomac.2026.153381. Online ahead of print. Ultrasound-assisted pectin extraction from 'Lane Late' navel orange: RSM optimization, structural identification and anti-alcoholic liver injury potential. Gao R(1), Han B(2), Ma J(1), Fu H(1), Liu Y(1), Liu Y(1), Pang Y(1), Liao M(1), Yang G(1), Huang X(3), Li Q(4), Liu S(5), Li J(6). Author information: (1)School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, 430074, China. (2)College of Life Sciences, South-Central Minzu University, Wuhan, 430074, China. (3)School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, 430074, China; Science and Technology Cooperation Base for Evaluation and Utilization of Traditional Medical Resources, South-Central Minzu University, Wuhan, 430074, China. (4)Tibetan Medical College, Qinghai University, Xining, 810016, China. (5)Hubei Shizhen Laboratory, Wuhan, 430061, China. Electronic address: newforest@163.com. (6)School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, 430074, China; Science and Technology Cooperation Base for Evaluation and Utilization of Traditional Medical Resources, South-Central Minzu University, Wuhan, 430074, China. Electronic address: lijun-pharm@hotmail.com. 'Lane Late' (LL) is a late-ripening navel orange consumed in spring and summer. Increased orange production and consumption generate peel waste. To utilize the pectin resource from LL

Protective effects of dexpanthenol on experimental colitis in young rats: modulation of p53/BAX/BCL2 and RIPK1/RIPK3/MLKL signaling with anti-inflammatory activity.

4. Pediatr Res. 2026 Jul 1. doi: 10.1038/s41390-026-05253-4. Online ahead of print. Protective effects of dexpanthenol on experimental colitis in young rats: modulation of p53/BAX/BCL2 and RIPK1/RIPK3/MLKL signaling with anti-inflammatory activity. Elmas A(1), Asci H(2), Tepebasi MY(3), Imeci OB(2), Gulal A(2), Selver MB(4), Akcam M(5), Ozmen O(6). Author information: (1)Division of Pediatric Gastroenterology, Hepatology and Nutrition; Department of Pediatrics, Faculty of Medicine, Suleyman Demirel University, Isparta, Türkiye. akelmas@gmail.com. (2)Department of Pharmacology, Faculty of Medicine, Suleyman Demirel University, Isparta, Türkiye. (3)Department of Genetics, Faculty of Medicine, Suleyman Demirel University, Isparta, Türkiye. (4)Department of Pediatrics, Faculty of Medicine, Suleyman Demirel University, Isparta, Türkiye. (5)Division of Pediatric Gastroenterology, Hepatology and Nutrition; Department of Pediatrics, Faculty of Medicine, Suleyman Demirel University, Isparta, Türkiye. (6)Department of Pathology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur, Türkiye. BACKGROUND: Inflammatory bowel disease features chronic inflammation and epithelial barrier loss, driven by apoptosis, necroptosis, and oxidative stress. Dexpanthenol (DEX), a pantothenic acid derivative and CoA precursor, has antioxidant and tissue-protective properties, but its efficacy in colitis is unclear. METHODS: Thirty-two 8-week-old female Wistar al

Dexpanthenol Attenuates Doxorubicin-Induced Cardiotoxicity by Modulating Oxidative Stress, Inflammation, and Apoptosis.

1. Cardiovasc Toxicol. 2026 Sep 30;26(10):120. doi: 10.1007/s12012-026-10194-9. Dexpanthenol Attenuates Doxorubicin-Induced Cardiotoxicity by Modulating Oxidative Stress, Inflammation, and Apoptosis. Aslanlar DA(1)(2), Çelik M(3), Öz M(4), Kökbudak N(5). Author information: (1)Department of Medical Pharmacology, Faculty of Medicine, Necmettin Erbakan University, Konya, Türkiye. daliaslanlar@gmail.com. (2)Department of Medical Pharmacology, Faculty of Medicine, Necmettin Erbakan University, Türkiye Yaka Neighborhood, Beyşehir Street, No: 281, Meram, 42090, Konya, Türkiye. daliaslanlar@gmail.com. (3)Department of Cardiology, Faculty of Medicine, Necmettin Erbakan University, Konya, Türkiye. (4)Department of Physiology, Faculty of Medicine, Aksaray University, Aksaray, Türkiye. (5)Department of Medical Pathology, Faculty of Medicine, Necmettin Erbakan University, Konya, Türkiye. Doxorubicin (DOX)-induced cardiotoxicity converges on oxidative-nitrosative stress, TLR4/NF-κB-driven inflammation, and caspase-3-mediated apoptosis, and remains a major dose-limiting complication of anthracycline therapy. Dexpanthenol (DEX), a coenzyme A precursor, has shown anti-oxidative, anti-inflammatory, and anti-apoptotic activity in diverse organ-injury models, but its cardioprotective potential against DOX has not been systematically evaluated. The present study aimed to investigate the protective effects of DEX against DOX-induced cardiotoxicity in Wistar rats. Twenty-eight ma