비타민B3 (나이아신)

The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis.

1. Nutrients. 2023 Dec 27;16(1):100. doi: 10.3390/nu16010100. The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis. Tosti G(1), Pepe F(1), Gnagnarella P(2), Silvestri F(1), Gaeta A(3)(4), Queirolo P(5), Gandini S(3). Author information: (1)Dermato-O

Effect of maternal dietary niacin intake on congenital anomalies: a systematic review and meta-analysis.

2. Eur J Nutr. 2022 Apr;61(3):1133-1142. doi: 10.1007/s00394-021-02731-9. Epub 2021 Nov 8. Effect of maternal dietary niacin intake on congenital anomalies: a systematic review and meta-analysis. Palawaththa S(#)(1), Islam RM(#)(1), Illic D(1), Rabel K(1), Lee M(1), Romero L(2), Leung XY(1), Ka

Definition of a tolerable upper intake level of niacin: a systematic review and meta-analysis of the dose-dependent effects of nicotinamide and nicotinic acid supplementation.

3. Nutr Rev. 2017 Jun 1;75(6):471-490. doi: 10.1093/nutrit/nux011. Definition of a tolerable upper intake level of niacin: a systematic review and meta-analysis of the dose-dependent effects of nicotinamide and nicotinic acid supplementation. Minto C(1), Vecchio MG(2), Lamprecht M(2), Gregori D(

The differential impact of three different NAD(+) boosters on circulatory NAD and microbial metabolism in humans.

4. Nat Metab. 2026 Jan;8(1):62-73. doi: 10.1038/s42255-025-01421-8. Epub 2026 Jan 15. The differential impact of three different NAD(+) boosters on circulatory NAD and microbial metabolism in humans. Christen S(1), Redeuil K(1), Goulet L(1), Giner MP(1), Breton I(1), Rota R(1), Frézal A(1), Naz

Randomized Trial to Assess the Safety and Tolerability of Daily Intake of an Allulose Amino Acid-Based Hydration Beverage in Men and Women.

5. Nutrients. 2024 Jun 5;16(11):1766. doi: 10.3390/nu16111766. Randomized Trial to Assess the Safety and Tolerability of Daily Intake of an Allulose Amino Acid-Based Hydration Beverage in Men and Women. Bloomer RJ(1), Pence J(1), Hellenbrand J(1), Davis A(1), Davis S(1), Stockton M(1), Martin KR

The Effect of Niacinamide Supplementation on Phosphate Concentrations in Dutch Dialysis Patients: A Randomized Crossover Trial.

6. J Ren Nutr. 2024 Sep;34(5):454-462. doi: 10.1053/j.jrn.2024.02.005. Epub 2024 Mar 15. The Effect of Niacinamide Supplementation on Phosphate Concentrations in Dutch Dialysis Patients: A Randomized Crossover Trial. Schepers L(1), Jans I(2), Pot GK(3), Smilde AJ(4), Hofstra JM(4), de Roos NM(5)

Longitudinal metabolomics analysis reveals the acute effect of cysteine and NAC included in the combined metabolic activators.

7. Free Radic Biol Med. 2023 Aug 1;204:347-358. doi: 10.1016/j.freeradbiomed.2023.05.013. Epub 2023 May 26. Longitudinal metabolomics analysis reveals the acute effect of cysteine and NAC included in the combined metabolic activators. Yang H(1), Li X(2), Jin H(3), Turkez H(4), Ozturk G(5), Dogan

Topical niacinamide (Nicotinamide) treatment for discoid lupus erythematosus (DLE): A prospective pilot study.

8. J Cosmet Dermatol. 2023 May;22(5):1647-1657. doi: 10.1111/jocd.15628. Epub 2023 Jan 22. Topical niacinamide (Nicotinamide) treatment for discoid lupus erythematosus (DLE): A prospective pilot study. Nouh AH(1), Elshahid AR(1), Kadah AS(2), Zeyada YA(1). Author information: (1)Department of D

NAD+-Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults.

9. J Nutr. 2021 Oct 1;151(10):2917-2931. doi: 10.1093/jn/nxab193. NAD+-Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults. Connell NJ(1), Grevendonk L(1), Fealy CE

Reduction of fatty liver in rats by nicotinamide via the regeneration of the methionine cycle and the inhibition of aldehyde oxidase.

10. J Toxicol Sci. 2021;46(1):31-42. doi: 10.2131/jts.46.31. Reduction of fatty liver in rats by nicotinamide via the regeneration of the methionine cycle and the inhibition of aldehyde oxidase. Yokouchi C(1)(2), Nishimura Y(3), Goto H(3), Sato M(3), Hidoh Y(1), Takeuchi K(1), Ishii Y(2). Autho

APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells.

11. Clin Cancer Res. 2015 Sep 1;21(17):3934-45. doi: 10.1158/1078-0432.CCR-14-3023. Epub 2015 May 11. APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells. Cagnetta A(1), Caffa I(2), Acharya C(3), Soncini D(2), Acharya

Pharmacological doses of nicotinic acid and nicotinamide are independently metabolized in rats.

12. J Nutr Sci Vitaminol (Tokyo). 2014;60(2):86-93. doi: 10.3177/jnsv.60.86. Pharmacological doses of nicotinic acid and nicotinamide are independently metabolized in rats. Shibata K(1), Fukuwatari T, Suzuki C. Author information: (1)Department of Nutrition, School of Human Cultures, The Univers

Supplementation of nicotinic acid with NAMPT inhibitors results in loss of in vivo efficacy in NAPRT1-deficient tumor models.

13. Neoplasia. 2013 Dec;15(12):1314-29. doi: 10.1593/neo.131718. Supplementation of nicotinic acid with NAMPT inhibitors results in loss of in vivo efficacy in NAPRT1-deficient tumor models. O'Brien T(1), Oeh J(1), Xiao Y(1), Liang X(2), Vanderbilt A(3), Qin A(2), Yang L(2), Lee LB(1), Ly J(2),

Extended-release niacin (nicotinic acid)/laropiprant.

14. Drugs. 2009 Aug 20;69(12):1665-79. doi: 10.2165/11203730-000000000-00000. Extended-release niacin (nicotinic acid)/laropiprant. Perry CM(1). Author information: (1)Wolters Kluwer Health/Adis, 41 Centorian Drive, Mairangi Bay, North Shore 0754, Auckland, New Zealand. demail@adis.co.nz Extend

Common vitamin B complex agents and folic acid: Part III. Niacin (nicotinic acid) (Niacinamide, Nia-Bid, Niac, Niacels, Nico-400, Nicobid, Nicolar, Nicotinex, Slo-Niacin, Span-Niacin, Tega-Span).

15. Gastroenterol Nurs. 1997 Mar-Apr;20(2):63-4. Common vitamin B complex agents and folic acid: Part III. Niacin (nicotinic acid) (Niacinamide, Nia-Bid, Niac, Niacels, Nico-400, Nicobid, Nicolar, Nicotinex, Slo-Niacin, Span-Niacin, Tega-Span). [No authors listed] PMID: 9223973 [Indexed for MED

Biocidal action of chlorhexidine is annulled by nicotinic acid.

3. Antimicrob Agents Chemother. 1994 Oct;38(10):2458-9. doi: 10.1128/AAC.38.10.2458. Biocidal action of chlorhexidine is annulled by nicotinic acid. Baker H(1), Frank O, DeAngelis B, Baker ER. Author information: (1)Department of Preventive Medicine and Community Health and Medicine, New Jersey

Interaction of niacin and zinc metabolism in patients with alcoholic pellagra.

30. Am J Clin Nutr. 1989 Aug;50(2):364-9. doi: 10.1093/ajcn/50.2.364. Interaction of niacin and zinc metabolism in patients with alcoholic pellagra. Vannucchi H(1), Moreno FS. Author information: (1)Nutrition Division, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil. The

[The effect of nicotinamide and nicotinic and ascorbic acids on the penicillin concentration in the blood serum and tissues of rabbits].

18. Vestn Dermatol Venerol. 1989;(12):20-3. [The effect of nicotinamide and nicotinic and ascorbic acids on the penicillin concentration in the blood serum and tissues of rabbits]. [Article in Russian] Bednova VN, Rotanov SV, Navolotskaia TI, Milonova TI, Orlina EA. Measurements of penicillin c

[Prevention of abnormalities induced by 2 organophosphate insecticides (parathion and bidrin) in quail embryos].

15. Arch Anat Microsc Morphol Exp. 1976;65(1):1-6. [Prevention of abnormalities induced by 2 organophosphate insecticides (parathion and bidrin) in quail embryos]. [Article in French] Meiniel R. When Quail embryos, injected with bidrin at the unincubated stage, are treated with nicotinamide, b

Dietary patterns related to cardiovascular disease based on reduced rank regression analysis of healthy middle-aged Koreans: data from the community-based Korean Genome and Epidemiology Study (KoGES) cohort.

6. Am J Clin Nutr. 2020 Jun 1;111(6):1159-1169. doi: 10.1093/ajcn/nqaa078. Dietary patterns related to cardiovascular disease based on reduced rank regression analysis of healthy middle-aged Koreans: data from the community-based Korean Genome and Epidemiology Study (KoGES) cohort. Lee HA(1), An

NAD⁺ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidence.

43. Ageing Res Rev. 2026 Apr;116:103057. doi: 10.1016/j.arr.2026.103057. Epub 2026 Feb 6. NAD⁺ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidence. Gallagher C(1), Emmanuel OO(2). Author information: (1)Allure Management, 150 Allen

The adverse effects of oral niacin/nicotinamide - an overview of reviews.

41. Eye (Lond). 2025 Nov;39(16):2852-2859. doi: 10.1038/s41433-025-04027-2. Epub 2025 Sep 25. The adverse effects of oral niacin/nicotinamide - an overview of reviews. Young SL(1), Gazzard G(2)(3). Author information: (1)Moorfields Eye Hospital NHS Foundation Trust, London, UK. Drsuyoung@gmail.

Systematic Review and Meta-Analysis on the Association Between Daily Niacin Intake and Glaucoma.

11. Nutrients. 2024 Oct 23;16(21):3604. doi: 10.3390/nu16213604. Systematic Review and Meta-Analysis on the Association Between Daily Niacin Intake and Glaucoma. Nicola CA(1), Marinescu MC(2), Firan AM(3), Naidin MS(4), Ciuluvica RC(5), Rosu MM(6), Meca AD(7), Bogdan M(7), Turcu-Stiolica A(4).

Effect of vitamins on sexual function: A systematic review.

3. Int J Vitam Nutr Res. 2023 Apr;93(2):154-163. doi: 10.1024/0300-9831/a000703. Epub 2021 Mar 29. Effect of vitamins on sexual function: A systematic review. Ghanbari-Homaie S(1), Ataei-Almanghadim K(2), Mirghafourvand M(3). Author information: (1)Department of Midwifery, Faculty of Nursing and

Intake and adequacy of the vegan diet. A systematic review of the evidence.

18. Clin Nutr. 2021 May;40(5):3503-3521. doi: 10.1016/j.clnu.2020.11.035. Epub 2020 Dec 7. Intake and adequacy of the vegan diet. A systematic review of the evidence. Bakaloudi DR(1), Halloran A(2), Rippin HL(3), Oikonomidou AC(4), Dardavesis TI(5), Williams J(6), Wickramasinghe K(7), Breda J(8)

Benefits and harm of niacin and its analog for renal dialysis patients: a systematic review and meta-analysis.

38. Int Urol Nephrol. 2014 Feb;46(2):433-42. doi: 10.1007/s11255-013-0559-z. Epub 2013 Oct 11. Benefits and harm of niacin and its analog for renal dialysis patients: a systematic review and meta-analysis. He YM(1), Feng L, Huo DM, Yang ZH, Liao YH. Author information: (1)Renal Division, Depart

Human Milk Vitamin B3 (Niacin and Vitamer) Concentrations: Secondary Analysis of a Randomized, Placebo-Controlled Trial of Maternal Nicotinamide Supplementation in Rural Tanzania.

1. Am J Clin Nutr. 2026 Jun 17:101397. doi: 10.1016/j.ajcnut.2026.101397. Online ahead of print. Human Milk Vitamin B3 (Niacin and Vitamer) Concentrations: Secondary Analysis of a Randomized, Placebo-Controlled Trial of Maternal Nicotinamide Supplementation in Rural Tanzania. DeBoer MD(1), McDermid JM(2), Hampel D(3), Shahab-Ferdows S(3), Mazzoni G(4), Peerson JM(5), Elwood SE(2), Scharf RJ(6), Jatosh S(7), Platts-Mills JA(2), Mduma E(7), Allen LH(5). Author information: (1)Department of Pediatrics, University of Virginia, Charlottesville, VA, USA. Electronic address: deboer@virginia.edu. (2)Division of Infectious Diseases & International Health, University of Virginia, Charlottesville, VA, USA. (3)Institute for Global Nutrition, University of California, Davis, CA, USA. (4)Department of Pediatrics, University of Virginia, Charlottesville, VA, USA. (5)U.S. Department of Agriculture, Davis, CA, USA. (6)Department of Pediatrics, University of Virginia, Charlottesville, VA, USA; Division of Infectious Diseases & International Health, University of Virginia, Charlottesville, VA, USA. (7)Haydom Global Health Research Centre, Haydom Lutheran Hospital, Haydom, Tanzania. BACKGROUND: The risk of vitamin B3 (niacin) deficiency is increased if maize is consumed without improving bioavailability during food preparation and with limited consumption of niacin-rich foods. OBJECTIVES: We assessed human-milk vitamin B3 concentrations and their relationship to child outcomes a

Intestinal microbial community assessment in patients with different forms of epilepsy and autoimmune encephalitis: An exploratory study.

2. Gut Microbes Rep. 2026 May 28;3(1):2679348. doi: 10.1080/29933935.2026.2679348. eCollection 2026. Intestinal microbial community assessment in patients with different forms of epilepsy and autoimmune encephalitis: An exploratory study. Mejía-Granados DM(1), Kawasaki de Araújo T(1), Malan-Müller S(2)(3), Oliveira Ribeiro de Aguiar Araújo PA(1)(4), Braz Dos Santos LH(1), Yasuda CL(4)(5), Koutsodontis Machado Alvim M(4)(5), Carvalho BS(4)(6), Cendes F(4)(5), Lopes-Cendes I(1)(4). Author information: (1)Department of Medical Genetics and Genomic Medicine, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil. (2)Department of Pharmacology and Toxicology, Faculty of Medicine, University Complutense of Madrid (UCM); Research Institute of Hospital 12 de Octubre (Imas12); Instituto Universitario de Investigación Neuroquímica (IUIN-UCM), Madrid, Spain. (3)Biomedical Research Network Centre in Mental Health, Institute of Health Carlos III (CIBERSAM, ISCIII), Madrid, Spain. (4)Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), Campinas, SP, Brazil. (5)Department of Neurology, School of Medical Sciences, University of Campinas, Campinas, SP, Brazil. (6)Department of Statistics, Institute of Mathematics, Statistics, and Scientific Computing, University of Campinas (UNICAMP), Campinas, SP, Brazil. Despite the availability of antiseizure medications (ASMs), approximately one-third of patients with epilepsy remain refractory to

Nutrition Information Briefs - Niacin.

3. Adv Nutr. 2026 Jun;17(6):100646. doi: 10.1016/j.advnut.2026.100646. Epub 2026 May 8. Nutrition Information Briefs - Niacin. Meyer-Ficca ML(1), Chini CC(2). Author information: (1)Department of Veterinary Clinical and Life Sciences, College of Veterinary Medicine, Utah State University, Logan, UT, United States. Electronic address: mirella.meyer@usu.edu. (2)Department of Anesthesiology and Perioperative Medicine, Metabolism and Molecular Nutrition Laboratory, Kogod Center on Aging, Mayo Clinic College of Medicine, Jacksonville, FL, United States. DOI: 10.1016/j.advnut.2026.100646 PMCID: PMC13233546 PMID: 42107767

Niacin accelerates skeletal muscle regeneration and enhances C2C12 differentiation by activating the PI3K/Akt signaling pathway.

4. Biochem Pharmacol. 2026 Aug;250(Pt 2):118016. doi: 10.1016/j.bcp.2026.118016. Epub 2026 May 2. Niacin accelerates skeletal muscle regeneration and enhances C2C12 differentiation by activating the PI3K/Akt signaling pathway. Dai L(1), Wang J(1), Cao Z(1), Yu T(1), Liu J(1), Li Y(1), Zhang Y(1), Xiao J(2). Author information: (1)Key Laboratory for Prevention and Control of Common Animal Diseases in General Higher Education Institutions of Heilongjiang Province, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China. (2)Key Laboratory for Prevention and Control of Common Animal Diseases in General Higher Education Institutions of Heilongjiang Province, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China. Electronic address: xiaojianhua@neau.edu.cn. Erratum in Biochem Pharmacol. 2026 Aug;250(Pt 1):118070. doi: 10.1016/j.bcp.2026.118070. Skeletal muscle injury is prevalent in clinical practice and sports medicine, and efficient regeneration is crucial for restoring motor function. Niacin (vitamin B3, NIA), a water-soluble essential nutrient and key precursor of nicotinamide adenine dinucleotide (NAD + ), regulates muscle metabolism and mitochondrial function, but its role and underlying mechanisms in skeletal muscle injury repair remain unclear. In this study, a mouse model of acute skeletal muscle injury was established via intramuscular injection of bupivacaine hydrochloride, and C2C

Niacin enhances erythropoiesis and attenuates oxidative stress and ferroptosis through the modulation of Nrf2/HO-1/GPX4 pathway in phenylhydrazine-induced hemolytic anemia in rats.

5. J Nutr Biochem. 2026 Oct;156:110392. doi: 10.1016/j.jnutbio.2026.110392. Epub 2026 May 2. Niacin enhances erythropoiesis and attenuates oxidative stress and ferroptosis through the modulation of Nrf2/HO-1/GPX4 pathway in phenylhydrazine-induced hemolytic anemia in rats. Galal MR(1), Mohamed AS(2), Baiomy AAA(2), Eissa SM(2). Author information: (1)Department of Zoology, Faculty of Science, Cairo University, Giza, Egypt. Electronic address: muhammed.galall3@gmail.com. (2)Department of Zoology, Faculty of Science, Cairo University, Giza, Egypt. Anemia is a public health issue affecting people of all ages worldwide. 43% of children under five in Egypt are suffering from anemia. Hemolytic anemia (HA), characterized by the premature destruction of red blood cells, is often associated with oxidative stress. Phenylhydrazine (PHZ) is a chemical substance frequently used to induce HA in experimental animal models. Studies indicate that niacin (nicotinic acid) activates antioxidant pathways through nuclear factor erythroid 2-related factor 2 (Nrf2). This study aimed to evaluate the antianemic effects of niacin in PHZ-induced hemolytic anemia in rats. Twenty-four rats were divided into four groups (n=6). The control group received saline for two days, then 5% CMC. The anemia group received PHZ (40 mg/kg/day, i.p.) for two days, followed by 5% CMC. The low- and high-dose niacin groups received PHZ for two days, then niacin (100 or 360 mg/kg/day, orally) for six day

Impact of various types of heat treatment on the content of selected B vitamin and their profile in goose breast meat.

6. Poult Sci. 2026 Jun;105(6):106728. doi: 10.1016/j.psj.2026.106728. Epub 2026 Mar 2. Impact of various types of heat treatment on the content of selected B vitamin and their profile in goose breast meat. Goluch Z(1), Haraf G(2), Okruszek A(1), Stryjecka M(3), Wereńska M(1). Author information: (1)Department of Food Technology and Nutrition, Wroclaw University of Economics and Business, Wroclaw 53-345, Poland. (2)Department of Food Technology and Nutrition, Wroclaw University of Economics and Business, Wroclaw 53-345, Poland. Electronic address: gabriela.haraf@ue.wroc.pl. (3)Department of Dietetics, The University College of Applied Sciences in Chełm, Pocztowa 54, 22-100 Chełm, Poland. The objective of this study was to (1) investigate the impact of commonly used heat treatment methods - water bath cooking (WBC), convection oven roasting (OCR), grilling (G), and pan frying (PF) - on the concentrations and retention of various forms of selected B vitamins (B1, B2, B3, B5, B6, and B12) in goose breast muscle, and (2) assess the extent to which a 100 g portion of goose meat, both with and without skin, contributes to meeting the Nutrient Reference Values-Requirements (NRV-R) for these vitamins in the adults. The material used in the study comprised 36 breast muscles of 17-week-old White Koluda® geese. The contents of B vitamins were determined using liquid chromatography. Significantly lower thermal losses were found in skinless meat (P ≤ 0.05). This meat co

NAD Metabolism in Acute Myeloid Leukaemia: Biological Rationale and Therapeutic Opportunities.

1. Nutrients. 2026 Jul 13;18(14):2295. doi: 10.3390/nu18142295. NAD Metabolism in Acute Myeloid Leukaemia: Biological Rationale and Therapeutic Opportunities. Somers K(1)(2), Karsa M(1)(2), Moujalled DM(3)(4)(5). Author information: (1)Children's Cancer Institute, Minderoo Children's Comprehensive Cancer Centre, Sydney, NSW 2031, Australia. (2)School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW 2052, Australia. (3)Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia. (4)Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC 3010, Australia. (5)Australian Centre for Blood Diseases, Monash University, Melbourne, VIC 3044, Australia. Acute myeloid leukaemia (AML) exhibits profound metabolic plasticity that enables leukaemic cells to survive environmental stress, nutrient limitation, and therapeutic pressure, ultimately driving disease persistence and relapse. While genetic and epigenetic alterations have guided risk stratification and therapeutic development, accumulating evidence indicates that nutrient-dependent metabolic rewiring represents a critical and targetable vulnerability in AML. Nicotinamide adenine dinucleotide (NAD) is a central metabolic cofactor whose intracellular availability is tightly linked to dietary intake of its precursors, including tryptophan, niacin (vitamin B3), nicotinamide, and nicotinamide riboside. NAD sup

Niacin alleviates cerebral microvascular endothelial cell apoptosis induced by hypervirulent Klebsiella Pneumoniae by reducing the accumulation of reactive oxygen species.

2. Front Cell Infect Microbiol. 2026 Jul 10;16:1867024. doi: 10.3389/fcimb.2026.1867024. eCollection 2026. Niacin alleviates cerebral microvascular endothelial cell apoptosis induced by hypervirulent Klebsiella Pneumoniae by reducing the accumulation of reactive oxygen species. Zhao Y(1), Wang M(2), Che X(1). Author information: (1)Department of Vascular Surgery, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, Jiangsu, China. (2)Department of General Surgery, Jingjiang People's Hospital Affiliated to Yangzhou University, Jingjiang, Taizhou, Jiangsu, China. INTRODUCTION: Hypervirulent Klebsiella pneumoniae (hvKp) is an important pathogen causing central nervous system infections, including meningitis; however, the mechanisms by which it disrupts the blood-brain barrier remain unclear. Niacin, a vitamin B3 compound related to NAD+ metabolism, has the potential to regulate redox homeostasis. This study aimed to investigate the mechanism of hvKp-induced injury in human cerebral microvascular endothelial cell (HCMEC) and to evaluate the protective effects of niacin. METHODS: A GFP-labeled hvKp ATCC 43816 strain was used to establish an HCMEC infection model, and an hvKp mouse meningitis model was also constructed. Live-cell imaging was performed to monitor infection dynamics. Flow cytometry was used to assess infection rate, reactive oxygen species (ROS) levels, and

NAXD Deficiency: Heterogeneous Phenotypes and Positive Response to Niacin Treatment.

3. J Inherit Metab Dis. 2026 Jul;49(4):e70217. doi: 10.1002/jimd.70217. NAXD Deficiency: Heterogeneous Phenotypes and Positive Response to Niacin Treatment. Seyedkatouli N(1), Semcesen LN(2), Gallucci L(1), Sikora T(3), Conrotte JF(1), Du MRM(3), Kasakin M(1), Seferi G(1), Corona L(1), Jakubec M(1), Nijagal B(4), Lala S(5), Ganetzky RD(6), Barreto AMR(5), Szlago M(7), Wong M(8), Shah M(8)(9), Nurse J(10)(11), Foulds N(10)(11), Sadagopan S(10), Thu HN(12), Chi DV(12), Ngoc KN(12), de Silva MG(3)(13), Ramialison M(3), Rossello F(3); MitoMDT Diagnostic Network for Genomics and Omics; Thorburn DR(3)(13)(14), Lynch M(15), McGrath P(15), Stroud DA(2)(3)(13), Christodoulou J(3)(13)(14), Linster CL(1), Van Bergen NJ(3)(14). Collaborators: Balasubramaniam S, Ball M, Christodoulou J, Coman D, Compton A, Davis R, Dejong L, Elbaum Y, Filipovska A, Formosa L, Ghaoui R, Harris M, Hock D, Lake N, MacArthur D, McGrath P, Martin E, Murray S, Rius R, Ryan M, Samarasinghe A, Semcesen L, Siira S, Stait T, Stojanovski D, Stroud D, Thorburn D, Woods A. Author information: (1)Enzymology and Metabolism Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg. (2)Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, the University of Melbourne, Parkville, Victoria, Australia. (3)Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia. (4)Metabolomics

Impact of carbon and nitrogen source variation on B-vitamin accumulation in Yarrowia lipolytica: Toward microbial fortification of food ingredients.

4. Biochem Biophys Rep. 2026 Jul 4;47:102699. doi: 10.1016/j.bbrep.2026.102699. eCollection 2026 Sep. Impact of carbon and nitrogen source variation on B-vitamin accumulation in Yarrowia lipolytica: Toward microbial fortification of food ingredients. Khunnonkwao P(1)(2), Thitiprasert S(1)(2), Minamino A(3), Matsuno T(3), Yamada K(4), Yang ST(5), Thongchul N(1)(2). Author information: (1)Center of Excellence in Bioconversion and Bioseparation for Platform Chemical Production, Institute of Biotechnology and Genetic Engineering, Chulalongkorn University, Bangkok, Thailand. (2)Institute of Biotechnology and Genetic Engineering, Chulalongkorn University, Bangkok, Thailand. (3)Cellulosic Biomass Technology, Co., Ltd, Kumphawapi, Udon Thani, Thailand. (4)New Frontiers Research Laboratories, Toray Industries, Inc., 10-1, Tebiro 6-chome, Kamakura, Kanagawa, 248-8555, Japan. (5)Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA. Yarrowia lipolytica is a food-compatible yeast with strong potential for sustainable B-vitamin enrichment of functional food ingredients. This study evaluated the effects of glucose, xylose, mixed, and lignocellulosic sugars, as well as diverse nitrogen sources, on yeast growth and B-vitamin yields in controlled fermentations. Glucose with yeast extract led to the highest biomass and intracellular accumulation of thiamine (B1), niacin (B3), and pyridoxine (B6), while mixed sugars supported maximal

Recognizing pellagra with Casal's necklace: a fatal case of anorexia nervosa.

5. Forensic Sci Med Pathol. 2026 Jun 23. doi: 10.1007/s12024-026-01218-5. Online ahead of print. Recognizing pellagra with Casal's necklace: a fatal case of anorexia nervosa. Yamada A(1)(2)(3), Unuma K(4), Arai N(4), Kuroda R(4)(5), Umemoto N(6), Matsumoto T(7), Kitamura O(8). Author information: (1)Department of Forensic Medicine, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo (ST), 1-5-45 Yushima, Bunkyo- ku, Tokyo, 113-8519, Japan. yamada.a.2386@m.isct.ac.jp. (2)Department of Legal Medicine, Kyorin University School of Medicine, Tokyo, Japan. yamada.a.2386@m.isct.ac.jp. (3)Department of Dermatology, Jichi Medical University Saitama Medical Center, Saitama, Japan. yamada.a.2386@m.isct.ac.jp. (4)Department of Forensic Medicine, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo (ST), 1-5-45 Yushima, Bunkyo- ku, Tokyo, 113-8519, Japan. (5)Department of Pathology, The University of Tokyo Hospital, Tokyo, Japan. (6)Department of Dermatology, Jichi Medical University Saitama Medical Center, Saitama, Japan. (7)Matsumoto Dermatology and Plastic Surgery Clinic, Saitama, Japan. (8)Department of Legal Medicine, Kyorin University School of Medicine, Tokyo, Japan. Pellagra is a nutritional deficiency caused by the inadequate intake or metabolism of niacin (vitamin B3) and its precursor tryptophan. While pellagra is now rare in developed countries, individuals with eating disorders such as anorexia nervosa or chronic a

Dual-Acting Vitamin B(3)-Melanostatin Neuropeptide Hybrids as Potent Modulators of the Dopamine D(2) Receptors with Neuroprotective Activity.

6. J Med Chem. 2026 Jul 9;69(13):15597-15613. doi: 10.1021/acs.jmedchem.6c00697. Epub 2026 Jun 18. Dual-Acting Vitamin B(3)-Melanostatin Neuropeptide Hybrids as Potent Modulators of the Dopamine D(2) Receptors with Neuroprotective Activity. Pires-Lima BL(1)(2), Silva-Reis SC(1)(3), Correia XC(1), Costa-Almeida HF(1), Costa VM(3)(4), García-Mera X(5), Brea J(6), Loza MI(6), Contino M(7), Perrone MG(7), Graziano G(7), Vale N(2)(8)(9), Rodríguez-Borges JE(1), Sampaio-Dias IE(1). Author information: (1)LAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto 4169-007, Portugal. (2)PerMed Research Group, RISE-Health, Faculty of Medicine, University of Porto, Porto 4200-319, Portugal. (3)UCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Porto 4050-313, Portugal. (4)Associate Laboratory i4HB - Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Porto 4050-313, Portugal. (5)Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, Santiago de Compostela E-15782, Spain. (6)Innopharma Screening Platform. Biofarma Research Group. Centre of Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, Santiago de Compostela E-15782, Spain. (7)Department of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", Via E. Orabona 4, Bari 70125, Italy. (8)RISE-Health, Department of Comm

Trace-Level Detection of a Niacin Metabolite in Human Blood under Phosphonate Pillar[6]arene-Induced Columnar-Like Aggregation Conditions.

7. Anal Chem. 2026 Jun 23;98(24):17764-17776. doi: 10.1021/acs.analchem.6c00309. Epub 2026 Jun 10. Trace-Level Detection of a Niacin Metabolite in Human Blood under Phosphonate Pillar[6]arene-Induced Columnar-Like Aggregation Conditions. Chen X(1), Sugiyama H(1), Nishimura T(2), Ueno M(1)(2), Asakawa H(2)(3), Yamashita M(3), Tuo DH(2)(4), Imamura R(5)(6), Masuo Y(5), Maeda K(7), Komatsu R(8), Miyazawa K(2)(9), Takao S(1)(2), Kobayashi M(1), Tadokoro Y(1)(2), Arakawa H(5)(6), Fukuma T(2)(9), Arai S(2), Pu YJ(8), Maeda K(2)(3), Ogoshi T(2)(4), Hirao A(1)(2). Author information: (1)Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan. (2)WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan. (3)Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan. (4)Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan. (5)Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan. (6)Department of Regulatory Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Aichi 467-8603, Japan. (7)College of Science and Engineering, Kanazawa University, Kakuma-machi

A five-year dive in the realm of crystal engineering with water-soluble vitamins in addressing biopharmaceutical bottlenecks.

8. Talanta. 2026 Dec 1;310:130066. doi: 10.1016/j.talanta.2026.130066. Epub 2026 May 30. A five-year dive in the realm of crystal engineering with water-soluble vitamins in addressing biopharmaceutical bottlenecks. Prashar M(1), Chadha R(1), Arora P(2), Dhingra N(3). Author information: (1)University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India. (2)Amity Institute of Pharmacy, Amity University, Mohali, Punjab, 140306, India. Electronic address: poonam0803arora@gmail.com. (3)University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India. Electronic address: neelimad08@gmail.com. Crystal engineering through co-crystallisation offers a robust strategy for modulating the physicochemical properties and bioavailability of poorly soluble active pharmaceutical ingredients. A thoughtful selection of GRAS status co-formers is critical, as their molecular interactions govern the stability and solubility behaviour of the resulting solid-state architecture. Recently, the integration of nutraceuticals as co-formers has emerged as a promising, safe, and cost-effective approach within crystal engineering. Factors such as the type of functional group for hydrogen bonding, pKa, physicochemical compatibility, solubility, and molecular size need to be considered during co-crystal formation. This review provides a comprehensive summarisation of co-crystals synthesised using nicotinic acid, nicotinamide and asc

Vitamin B Intake Is Associated With Lower Incidence of Open-Angle Glaucoma: The Rotterdam Study.

9. Am J Ophthalmol. 2026 Aug;288:120-130. doi: 10.1016/j.ajo.2026.04.020. Epub 2026 Apr 23. Vitamin B Intake Is Associated With Lower Incidence of Open-Angle Glaucoma: The Rotterdam Study. van Haarlem MT(1), van Garderen KA(1), de Vries VA(1), van Rooij FJA(2), Klaver CCW(3), Vergroesen JE(1), Ramdas WD(4). Author information: (1)Department of Ophthalmology (M.T.V.H., K.A.V.G., V.A.D.V., C.C.W.K., J.C.W.K., W.D.R.), Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Epidemiology (M.T.V.H., K.A.V.G., V.A.D.V., F.J.A.V.R., C.C.W.K., J.C.W.K.), Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands. (2)Department of Epidemiology (M.T.V.H., K.A.V.G., V.A.D.V., F.J.A.V.R., C.C.W.K., J.C.W.K.), Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands. (3)Department of Ophthalmology (M.T.V.H., K.A.V.G., V.A.D.V., C.C.W.K., J.C.W.K., W.D.R.), Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Epidemiology (M.T.V.H., K.A.V.G., V.A.D.V., F.J.A.V.R., C.C.W.K., J.C.W.K.), Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Ophthalmology (C.C.W.K.), Radboudumc, Nijmegen, the Netherlands; Institute of Molecular and Clinical Ophthalmology Basel (C.C.W.K.), Basel, Switzerland. (4)Department of Ophthalmology (M.T.V.H., K.A.V.G., V.A.D.V., C.C.W.K., J.C.W.K., W.D.R.), Erasmus MC University Medical Center Rotterdam, Rotterda

Pellagra in Contemporary Clinical Practice (2000-2023): A Systematic Review.

10. Int J Dermatol. 2026 Aug;65(8):1590-1599. doi: 10.1111/ijd.70398. Epub 2026 Mar 24. Pellagra in Contemporary Clinical Practice (2000-2023): A Systematic Review. Litaiem N(1)(2), Sboui K(1)(2), Zeglaoui F(1)(2). Author information: (1)Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia. (2)Department of Dermatology, Charles Nicolle Hospital, Tunis, Tunisia. Pellagra's clinical presentation, etiological factors, and treatment in the early 21st century remain underexplored. This study aimed to update the understanding of pellagra's clinical and etiological aspects with a reappraisal of its treatment and prevention. We searched PubMed and Scopus up to January 9, 2023, to identify relevant studies. The reference lists of all included articles were also carefully screened to identify any additional studies. We included case reports, case series, and case-control studies documenting confirmed cases of pellagra between 2000 and 2023. The review protocol was registered with PROSPERO (CRD42022381416). The search identified 918 studies, of which 133 met the inclusion criteria, comprising 1212 pellagra cases. Cutaneous manifestations were the most common (98.63%), followed by gastrointestinal (59.4%) and neurological (54.2%) signs. Complete symptom resolution occurred on average within 27.42 days of vitamin B3 supplementation. Dietary deficiency remained the predominant cause of pellagra (85%), and it was particularly common in populations af

Niacin alleviates dibutyl phthalate-induced impairment of porcine oocyte quality.

1. Theriogenology. 2026 Sep 22;267:118202. doi: 10.1016/j.theriogenology.2026.118202. Online ahead of print. Niacin alleviates dibutyl phthalate-induced impairment of porcine oocyte quality. Ma J(1), An YJ(1), Liu ZL(1), Fan X(1), Qi MY(2), Jiang WJ(3), Yao YC(4). Author information: (1)College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, China. (2)Institute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Harbin, 150030, China. (3)College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, China. Electronic address: jwj@neau.edu.cn. (4)College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, China. Electronic address: yaoyc@neau.edu.cn. Dibutyl phthalate (DBP) is a common plasticizer widely used in industrial and medical applications. DBP can cause damage to the female reproductive system due to its estrogen-like effects. However, the mechanisms of DBP toxicity on oocytes and the potential for effective intervention have not been investigated. In this study, porcine oocytes were exposed to different concentrations of DBP, and 600 μM DBP exposure in vitro significantly affected cumulus cell expansion, polar body expulsion, and cytoskeleton formation. Further experiments showed that DBP exposure affects embryonic developmental competence. In addition, DBP exposure led to mitochondrial dysfunction, which was reflected by a decrease in

Integrating HPLC-determined vitamins A, E and B-complex (B(1), B(2), B(3), B(6), B(9)) with population intake estimates: insights from Cuba's inaugural Total Diet Study.

2. Eur J Nutr. 2026 Sep 24;65(7):260. doi: 10.1007/s00394-026-04120-6. Integrating HPLC-determined vitamins A, E and B-complex (B(1), B(2), B(3), B(6), B(9)) with population intake estimates: insights from Cuba's inaugural Total Diet Study. Fernández-Guerrero Y(1), Muñoz-Fariña O(2), García O(3), Ravanal MC(4)(5), González L(6). Author information: (1)Doctorado en Ingeniería, Universidad del Bío-Bío, 4051381, Concepción, Chile. (2)Instituto de Ciencia y Tecnología de los Alimentos, Facultad de Ciencias Agrarias y Alimentarias, Universidad Austral de Chile, 5090000, Valdivia, Chile. ocielmunoz@uach.cl. (3)Instituto de Ciencia y Tecnología de los Alimentos, Facultad de Ciencias Agrarias y Alimentarias, Universidad Austral de Chile, 5090000, Valdivia, Chile. (4)Facultad de Agronomía y Sistemas Naturales, Pontificia Universidad Católica de Chile, 7820436, Santiago, Chile. (5)Instituto para el Desarrollo Sustentable, Pontificia Universidad Católica de Chile, 7820436, Santiago, Chile. (6)Instituto de Ciencias Aplicadas, Facultad de Ingeniería, Universidad Autónoma de Chile, 8581151, Santiago, Chile. luisbel.gonzalez@uautonoma.cl. Purpose To quantify seven dietary vitamins and estimate their mean daily intakes and major food sources among Cuban adults through the country's first Total Diet Study.Methods Standardized 24-hour dietary recalls were collected from 450 adults across Western, Central, and Eastern Cuba between October 2020 and March 2021. Foods were classif

Genome-resolved analysis reveals disruption of gut microbial vitamin B and K(2) biosynthesis during Toxoplasma gondii infection in mice.

3. Microbiol Spectr. 2026 Oct 6;14(10):e0156426. doi: 10.1128/spectrum.01564-26. Epub 2026 Sep 8. Genome-resolved analysis reveals disruption of gut microbial vitamin B and K(2) biosynthesis during Toxoplasma gondii infection in mice. Yu H-L(#)(1)(2)(3), Elsheikha HM(#)(4), Wang H-P(5), Gao Y-Q(5), Liu R(5), Ma H(5), Jiang J(1), Li Y(2), Zhang X-X(5). Author information: (1)College of Life Sciences, Changchun Sci-Tech University, Changchun, Jilin, People's Republic of China. (2)College of Food and Pharmaceutical Engineering, Wuzhou University, Wuzhou, Guangxi, People's Republic of China. (3)College of Veterinary Medicine, Jilin Agricultural University, Changchun, Jilin, People's Republic of China. (4)Faculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, United Kingdom. (5)College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong, People's Republic of China. (#)Contributed equally Toxoplasma gondii infection remodels the gut microbiome, yet its impact on microbial vitamin biosynthetic potential and host redox metabolism remains unclear. Here, we integrated mouse gut metagenomes with publicly available metagenome-assembled genomes (MAGs) to construct a genome-resolved atlas of B-vitamin and vitamin K2 biosynthesis. From 45,697 MAGs, we curated 4,771 representative genomes, of which 2,682 met high-quality criteria (completeness ≥90%, contamin

A vitamin B(3)-driven root bacterial metabolite primes systemic immunity in Arabidopsis.

4. Sci Adv. 2026 Aug 28;12(35):eaef8959. doi: 10.1126/sciadv.aef8959. Epub 2026 Aug 26. A vitamin B(3)-driven root bacterial metabolite primes systemic immunity in Arabidopsis. Wang X(1), Jiang P(1)(2), Xu X(1)(2), Zhang J(3), Xia G(4), Qian W(1)(2), Chen Q(1), Wei JW(1), Liu Z(1)(2), Liu L(1), Zhang F(1), Li L(1)(2), Lin S(4)(5), Bai Y(1)(6), Wang G(1)(2). Author information: (1)State Key Laboratory of Seed Innovation, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. (2)College of Advanced Agricultural Sciences, Chinese Academy of Sciences, Beijing 100049, China. (3)School of Pharmacy, Shanxi Medical University, Taiyuan 030001, China. (4)Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dong-zhi-men Hospital, Beijing University of Chinese Medicine, Beijing 100700, China. (5)School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China. (6)State Key Laboratory of Gene Function and Modulation Research, Peking-Tsinghua Center for Life Sciences, Peking-Tsinghua-NIBS Graduate Program, College of Life Sciences, Peking University, Beijing 100871, China. The microbiota is being increasingly recognized for its ability to regulate host physiology through the production of small bioactive molecules. However, how host-derived nutrients are metabolically transformed by root-associated microbes to influence plant immunity remains poorly understood. Here,

Separating extracellular from intracellular fecal metabolites exposes cross-feeding architecture in the gut: exploring metabolite partitioning and ecological associations.

5. Gut Microbes. 2026 Dec 31;18(1):2719062. doi: 10.1080/19490976.2026.2719062. Epub 2026 Aug 24. Separating extracellular from intracellular fecal metabolites exposes cross-feeding architecture in the gut: exploring metabolite partitioning and ecological associations. Hirayama M(1), Takame F(2), Maeda T(3), Kashihara K(4), Ito M(5), Ohno K(6), Ueyama J(7). Author information: (1)Department of Occupational Therapy, Chubu University College of Life and Health Sciences, Kasugai, Japan. (2)Kirin Beverage Co., Ltd., Chubu Regional Headquarters, Nagoya, Japan. (3)Department of Internal Medicine, School of Medicine, Division of Neurology and Gerontology, Iwate Medical University, Iwate, Japan. (4)Okayama Neurology Clinic, Okayama, Japan. (5)Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan. (6)Graduate School of Nutritional Sciences, Nagoya University of Arts and Sciences, Nisshin, Japan. (7)Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan. The gut microbiota forms a complex ecosystem through metabolic interdependence (cross-feeding). However, conventional fecal metabolomics typically quantifies only total metabolite pools, making it difficult to distinguish extracellular-enriched metabolite pools from predominantly cell-associated ones, and thus limiting reconstruction of in situ metabolic networks. Here, we quantifi

Dynamics of blood NAD and glutathione in health, disease, aging, and under NAD(+)-booster treatment.

6. Redox Biol. 2026 Oct;96:104343. doi: 10.1016/j.redox.2026.104343. Epub 2026 Aug 17. Dynamics of blood NAD and glutathione in health, disease, aging, and under NAD(+)-booster treatment. Euro L(1), Haimilahti K(2), Jansson S(3), Forsström S(4), Buzkova J(5), Suomalainen A(6). Author information: (1)Research Programs Unit, Stem Cells and Metabolism Research Program (STEMM), Faculty of Medicine, University of Helsinki, Haartmaninkatu 8, Helsinki, 00014, Finland; NADMED Ltd, Tukholmankatu 8, Biomedicum 2U, Helsinki, 00290, Finland. Electronic address: liliya.euro@helsinki.fi. (2)Research Programs Unit, Stem Cells and Metabolism Research Program (STEMM), Faculty of Medicine, University of Helsinki, Haartmaninkatu 8, Helsinki, 00014, Finland; Research Programs Unit, Clinical and Molecular Metabolism Research Program (CAMM), Faculty of Medicine, University of Helsinki, Haartmaninkatu 8, Helsinki, 00014, Finland. (3)NADMED Ltd, Tukholmankatu 8, Biomedicum 2U, Helsinki, 00290, Finland. (4)Research Programs Unit, Stem Cells and Metabolism Research Program (STEMM), Faculty of Medicine, University of Helsinki, Haartmaninkatu 8, Helsinki, 00014, Finland. (5)Research Programs Unit, Stem Cells and Metabolism Research Program (STEMM), Faculty of Medicine, University of Helsinki, Haartmaninkatu 8, Helsinki, 00014, Finland; NADMED Ltd, Tukholmankatu 8, Biomedicum 2U, Helsinki, 00290, Finland. (6)Research Programs Unit, Stem Cells and Metabolism Research Program (STEMM), Fac

Nicotinamide Supplementation and Primary Open-Angle Glaucoma in Patients With Ocular Hypertension.

7. JAMA Ophthalmol. 2026 Aug 1;144(8):724-730. doi: 10.1001/jamaophthalmol.2026.2472. Nicotinamide Supplementation and Primary Open-Angle Glaucoma in Patients With Ocular Hypertension. Muayad J(1), Sallam AB(2)(3), De Francesco T(4)(5)(6), De Moraes CG(7), Ahmed IIK(6)(8)(9). Author information: (1)College of Medicine, Texas A&M University, Houston. (2)Bernice and Harvey Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock. (3)Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. (4)Clinica de Olhos De Francesco, Fortaleza, Brazil. (5)Hospital de Olhos Leiria de Andrade, Fortaleza, Brazil. (6)John A. Moran Eye Center, University of Utah, Salt Lake City. (7)Department of Ophthalmology, Columbia University Irving Medical Center, New York, New York. (8)Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada. (9)Prism Eye Institute, Mississauga, Ontario, Canada. Comment in JAMA Ophthalmol. 2026 Aug 1;144(8):731-732. doi: 10.1001/jamaophthalmol.2026.2622. IMPORTANCE: Ocular hypertension (OHT) is a primary risk factor for primary open-angle glaucoma (POAG), and systemic nicotinamide has emerged as a potential metabolic prophylactic intervention to prevent conversion; however, real-world evidence is lacking. OBJECTIVE: To determine whether systemic nicotinamide supplementation, with potential neuroprotective properties, is associated with reduced risk of POAG diagn