비타민A (레티놀)

Association between vitamin A, retinol intake and blood retinol level and gastric cancer risk: A meta-analysis.

1. Clin Nutr. 2015 Aug;34(4):620-6. doi: 10.1016/j.clnu.2014.06.007. Epub 2014 Jun 23. Association between vitamin A, retinol intake and blood retinol level and gastric cancer risk: A meta-analysis. Wu Y(1), Ye Y(1), Shi Y(2), Li P(1), Xu J(1), Chen K(1), Xu E(3), Yang J(4). Author information:

Assessment of vitamin A, vitamin B(2), vitamin B(12), vitamin K, folate, and choline status following 4 months of multinutrient supplementation in healthy vegans: a randomised, double-blind, placebo-controlled trial.

2. Eur J Nutr. 2025 Dec 19;65(1):9. doi: 10.1007/s00394-025-03814-7. Assessment of vitamin A, vitamin B(2), vitamin B(12), vitamin K, folate, and choline status following 4 months of multinutrient supplementation in healthy vegans: a randomised, double-blind, placebo-controlled trial. Zerback T(

Protein intake counteracts alcohol intake in the regulation of postprandial FGF21 secretion in humans.

3. Am J Physiol Endocrinol Metab. 2025 Nov 1;329(5):E719-E727. doi: 10.1152/ajpendo.00265.2025. Epub 2025 Sep 10. Protein intake counteracts alcohol intake in the regulation of postprandial FGF21 secretion in humans. Ramne S(1), Duarte da Costa Seco T(2), Kuentzel KB(3), Grevengoed TJ(3), Hjerr

Maternal vitamin A and D status in second and third trimester of pregnancy and bone mineral content in offspring at nine years of age.

4. Front Endocrinol (Lausanne). 2024 Jun 28;15:1417656. doi: 10.3389/fendo.2024.1417656. eCollection 2024. Maternal vitamin A and D status in second and third trimester of pregnancy and bone mineral content in offspring at nine years of age. Stunes AK(1)(2), Mosti MP(1)(3), Gustafsson MK(4), Bør

Evaluation of synergistic antimicrobial effect of vitamins (A, B1, B2, B6, B12, C, D, E and K) with antibiotics against resistant bacterial strains.

5. J Glob Antimicrob Resist. 2018 Jun;13:231-236. doi: 10.1016/j.jgar.2018.01.005. Epub 2018 Feb 3. Evaluation of synergistic antimicrobial effect of vitamins (A, B1, B2, B6, B12, C, D, E and K) with antibiotics against resistant bacterial strains. Shahzad S(1), Ashraf MA(2), Sajid M(2), Shahzad

Retinoic acid combined with vitamin A synergizes to increase retinyl ester storage in the lungs of newborn and dexamethasone-treated neonatal rats.

6. Neonatology. 2007;92(1):26-32. doi: 10.1159/000100083. Epub 2007 Feb 23. Retinoic acid combined with vitamin A synergizes to increase retinyl ester storage in the lungs of newborn and dexamethasone-treated neonatal rats. Ross AC(1), Ambalavanan N. Author information: (1)Department of Nutritio

Reactive oxygen species in the progression of CCl4-induced liver injury.

7. Adv Exp Med Biol. 1991;283:489-97. doi: 10.1007/978-1-4684-5877-0_65. Reactive oxygen species in the progression of CCl4-induced liver injury. Sipes IG(1), el Sisi AE, Sim WW, Mobley SA, Earnest DL. Author information: (1)Department of Pharmacology, College of Pharmacy, University of Arizona,

Specificity in the synergism between retinoic acid and EGF on the growth of adult human skin fibroblasts.

8. Exp Cell Res. 1988 Oct;178(2):254-63. doi: 10.1016/0014-4827(88)90396-5. Specificity in the synergism between retinoic acid and EGF on the growth of adult human skin fibroblasts. Harper RA(1). Author information: (1)Connective Tissue Research Institute, University City Science Center, Philad

Retinol (vitamin A) as a modifier of 2-aminofluorene and 2-acetyl-aminofluorene mutagenesis in the Salmonella/microsome assay.

9. Arch Toxicol. 1982 Jan;49(2):169-74. doi: 10.1007/BF00332364. Retinol (vitamin A) as a modifier of 2-aminofluorene and 2-acetyl-aminofluorene mutagenesis in the Salmonella/microsome assay. Busk L, Ahlborg UG. Vitamin A (retinol)has been demonstrated to modify the mutagenic activity of the ar

Association of serum retinoic acid with hepatic steatosis and liver injury in nonalcoholic fatty liver disease.

10. Am J Clin Nutr. 2015 Jul;102(1):130-7. doi: 10.3945/ajcn.114.105155. Epub 2015 May 6. Association of serum retinoic acid with hepatic steatosis and liver injury in nonalcoholic fatty liver disease. Liu Y(1), Chen H(1), Wang J(1), Zhou W(1), Sun R(1), Xia M(2). Author information: (1)Guangdo

Vitamin A and risk of cervical cancer: a meta-analysis.

11. Gynecol Oncol. 2012 Feb;124(2):366-73. doi: 10.1016/j.ygyno.2011.10.012. Epub 2011 Oct 15. Vitamin A and risk of cervical cancer: a meta-analysis. Zhang X(1), Dai B, Zhang B, Wang Z. Author information: (1)Department of Epidemiology and Health Statistics, School of Public Health, Shandong U

Liver endothelial zonation orchestrates hepatic steatosis onset through retinoic acid-regulated FGF1.

1. Sci Adv. 2026 Jun 19;12(25):eaed4384. doi: 10.1126/sciadv.aed4384. Epub 2026 Jun 19. Liver endothelial zonation orchestrates hepatic steatosis onset through retinoic acid-regulated FGF1. Fang Z(1), Che B(1), Ling Y(1), Liu P(1), Liu J(1), Song P(1), Yue Z(1)(2), Ruan B(1)(3)(4), Lin Z(1), Xu H(1), Du W(1), Kou Z(5), He F(1), Duan J(1), Wang L(1). Author information: (1)Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China. (2)Department of Ophthalmology, XiJing Hospital, Fourth Military Medical University, Xi'an, China. (3)State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medica University, Xi'an, China. (4)Center of Clinical Aerospace Medicine and Department of Aviation Medicine, Fourth Military Medical University, Xi'an, China. (5)Department of Gastroenterology, TangDu Hospital, Fourth Military Medical University, Xi'an, China. The contribution of liver sinusoidal endothelial cell (LSEC) zonation to metabolic dysfunction-associated steatotic liver disease (MASLD) pathogenesis remains undefined. We identified selective lipid deposition in the pericentral zone during early MASLD. Multiomics analyses confirmed enhanced pericentral lipid metabolism in both hepatocytes and LSECs. Mechanistically, pericentral LSEC marker c-Kit transcriptionally activated FGF1 via nuclear receptor RXRG, which suppressed hepatocellular lipid accumulation through FGFR4 signa

The gut microbiota directs vitamin A flux to regulate intestinal T cell development.

2. Cell Host Microbe. 2026 Jun 17:S1931-3128(26)00212-X. doi: 10.1016/j.chom.2026.05.019. Online ahead of print. The gut microbiota directs vitamin A flux to regulate intestinal T cell development. Srinivasan T(1), Dende C(2), Ruhn KA(2), Moye SL(3), Johnson A(4), Behrendt CL(2), Hassell B(2), Vale G(5), Kim J(6), Lichterman JN(7), Liang C(2), Arana C(2), Raj P(2), Zhan X(6), McDonald JG(8), Koh AY(9), Hooper LV(10). Author information: (1)Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Medical Scientist Training Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. (2)Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. (3)Medical Scientist Training Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. (4)Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. (5)Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. (6)Department of Public Health, O'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. (7)Department of Internal Medicine, University of Texas Southwestern Medical

Synergistic Interaction Between HPV-16 E7 Oncoprotein and Severe Vitamin A Deficiency in Regulating Adaptive Immunity in a Preclinical Cervical Cancer Model.

3. J Med Virol. 2026 Jun;98(6):e70992. doi: 10.1002/jmv.70992. Synergistic Interaction Between HPV-16 E7 Oncoprotein and Severe Vitamin A Deficiency in Regulating Adaptive Immunity in a Preclinical Cervical Cancer Model. Chávez-Ríos A(1), López-Ruiz C(2), García-Aguirre IA(3), Ocadiz-Delgado R(1), Garcia-Sierra F(4), Hernández-Pando R(5), Lizcano-Meneses S(4), Gariglio P(1). Author information: (1)Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), Mexico City, Mexico. (2)Departamento de Ingeniería en Biotecnología, División de Ciencias de Salud, Biológicas y Ambientales, Universidad Abierta y a Distancia de México, Mexico City, Mexico. (3)Departamento de Bioingeniería, Escuela de Ingeniería y Ciencias, Tecnologico de Monterrey, Ciudad de México, Mexico. (4)Department of Cell Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), Mexico City, Mexico. (5)Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Mexico City, Mexico. Persistent infection with High-Risk Human Papillomavirus (HR-HPV), particularly HPV-16, is the main driver of cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). However, HR-HPV infection alone is insufficient for malignant progression and nutritional cofactors such as Vitamin A deficiency, may influence cervical neoplasia progression

Early Identification of Differentiation Syndrome During ATRA and Arsenic Therapy in Pediatric NHR-APL: Insights From a 14-Year Multicenter Cohort.

4. Pharmacoepidemiol Drug Saf. 2026 Jun;35(6):e70390. doi: 10.1002/pds.70390. Early Identification of Differentiation Syndrome During ATRA and Arsenic Therapy in Pediatric NHR-APL: Insights From a 14-Year Multicenter Cohort. Fan Z(1), Yang LC(2), Chen YQ(3), Wan WQ(4), Mai HR(5), Yang LH(6), Lan HK(6), Zhou DH(7), Li WL(8), Guo BY(9), He F(10), Liao LH(11), Chen HQ(12), Zhen ZJ(13), He XL(14), Feng XQ(15), Chen GH(16), Ji XQ(17), Chen M(18), Li QR(19), Long XJ(20), Tian C(21), Fu Y(22), Huang XY(1), Luo JS(1), Huang DP(1), Wang LN(1), Li Y(1), Li B(23), Luo XQ(1), Huang LB(1), Tang YL(1), Zhang XL(1). Author information: (1)The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. (2)Xiangya Hospital, Central South University, Changsha, China. (3)Fujian Medical University Union Hospital, Fuzhou, China. (4)Second Xiangya Hospital, Central South University, Changsha, China. (5)Shenzhen Children's Hospital, Shenzhen, China. (6)Zhujiang Hospital, Southern Medical University, Guangzhou, China. (7)Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. (8)Hunan Children's Hospital, Changsha, China. (9)First Affiliated Hospital of Xiamen University, Xiamen, China. (10)Jiangxi Children's Hospital, Nanchang, China. (11)Huizhou Central People's Hospital, Huizhou, China. (12)Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. (13)Sun Yat-sen University Cancer Center, Guangzhou, China. (14)Hunan Provincial People's Hospital, Changs

Retinol-guided liposomal platform for targeted pirfenidone delivery in hepatic fibrosis.

5. J Nanobiotechnology. 2026 Jun 8. doi: 10.1186/s12951-026-04453-8. Online ahead of print. Retinol-guided liposomal platform for targeted pirfenidone delivery in hepatic fibrosis. Chen J(#)(1)(2), Tao Z(#)(3), Qiu C(#)(2)(3), Wu R(3), Huang Z(3), Jiang X(3), Zhu P(4), Wang Y(5)(6), Kou L(7), Cai X(8)(9). Author information: (1)Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China. (2)National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments, Hangzhou, 310016, China. (3)Wenzhou Municipal Key Laboratory of Pediatric Pharmacy, Department of Pharmacy, The Second Affiliated Hospital, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China. (4)Department of Radiology, Shanghai Medical College, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, China. zpy0915@126.com. (5)Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China. anwyf@zju.edu.cn. (6)National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments, Hangzhou, 310016, China. anwyf@zju.edu.cn. (7)Wenzhou Municipal Key Laboratory of Pediatric Pharmacy, Department of Pharmacy, The Second Affiliated Hospital, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China. klfpharm@163.com. (8)Department of General Surgery, Sir Run

Anti-asthma drug montelukast induces autistic behaviors via disrupting neuronal retinoic acid signaling.

6. Signal Transduct Target Ther. 2026 Jun 2;11(1):208. doi: 10.1038/s41392-026-02665-w. Anti-asthma drug montelukast induces autistic behaviors via disrupting neuronal retinoic acid signaling. Hao ZJ(#)(1)(2)(3), Wu QH(#)(4)(5), Li YL(#)(3), Guo ZM(#)(6), Li ZW(#)(3), Wang G(6), Meng M(7), Yuan SL(3), Wufuer Y(3), Zhang MH(6), Chen J(4), Yang T(4), Chen MX(6), Zhu J(4), Qi-Hang W(3)(8), Li Q(4), Yu SH(3)(8), Lu M(4), Xiong HY(9)(10), Feng YR(4), Dong MQ(11), Xu JH(12), Xu JL(13), Chen L(4)(5), Yang HT(14), Miao JK(9)(10), Zhu H(15), Yang B(15)(16), Zhao HY(17)(18), Shi XM(19), Bian S(20)(21)(22)(23)(24), Li TY(25)(26), Hu RG(27)(28)(29)(30)(31)(32). Author information: (1)Department of Colorectal Surgery and Oncology and School of Brain Science and Brain Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. (2)Institute of Science and Technology for Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China. (3)Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China. (4)Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China. (5)Growth, D

Upregulation of GnT-IVa and Its Critical Roles in ATRA-Induced Differentiation of Acute Promyelocytic Leukemia Cells.

7. Biomolecules. 2026 May 21;16(5):756. doi: 10.3390/biom16050756. Upregulation of GnT-IVa and Its Critical Roles in ATRA-Induced Differentiation of Acute Promyelocytic Leukemia Cells. Zhang S(1)(2), Isaji T(1)(3), Zheng M(1), Wang Y(1), Wu T(1), Saito T(1), Zhou Y(1), Fukuda T(1)(3), Takahashi S(3)(4), Gu J(1)(3). Author information: (1)Division of Regulatory Glycobiology, Graduate School of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan. (2)Department of Cancer Research Center, Nantong Tumor Hospital, The Affiliated Tumor Hospital of Nantong University, Nantong 226006, China. (3)Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai 981-8558, Japan. (4)Division of Laboratory Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, 1-15-1 Fukumuro, Miyagino-ku, Sendai 983-8536, Japan. Glycosylation is essential for hematopoietic cell homeostasis and malignant transformation. Dysregulated expression of glycosylation genes in leukemia cells accelerates disease progression and fosters drug resistance. Therefore, targeting these genes offers a promising avenue for anti-leukemic therapy. In this study, we explore the roles of N-glycans in acute promyelocytic leukemia (APL) differentiation using the ATRA-induced wild-type NB4 (WT/ATRA) or HL-60 cell model. We found that expression of N-acetylglucosaminyltransferase IVa

Comparison of mediterranean and healthy eating guideline interventions on the dietary inflammatory index in rheumatoid arthritis: results from a dietary randomised controlled intervention trial.

8. Eur J Nutr. 2026 May 26;65(4):144. doi: 10.1007/s00394-026-03987-9. Comparison of mediterranean and healthy eating guideline interventions on the dietary inflammatory index in rheumatoid arthritis: results from a dietary randomised controlled intervention trial. Curran M(1)(2)(3), Canning N(1), Wrenne A(1), Raad T(1), Herbert JR(4)(5), Shivappa N(4)(5), Tierney A(6)(7)(8). Author information: (1)School of Allied Health, University of Limerick, V94 T9PX, Limerick, Ireland. (2)Health Research Institute, University of Limerick, V94 T9PX, Limerick, Ireland. (3)Centre for Implementation Research at UL, University of Limerick, V94 T9PX, Limerick, Ireland. (4)Cancer Prevention and Control Program and Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. (5)Department of Nutrition, Connecting Health Innovations, LLC, Columbia, SC, USA. (6)School of Allied Health, University of Limerick, V94 T9PX, Limerick, Ireland. audrey.tierney@ul.ie. (7)Health Research Institute, University of Limerick, V94 T9PX, Limerick, Ireland. audrey.tierney@ul.ie. (8)Centre for Implementation Research at UL, University of Limerick, V94 T9PX, Limerick, Ireland. audrey.tierney@ul.ie. PURPOSE: Anti-inflammatory diets, such as the Mediterranean Diet (MedDiet) have shown positive effects on disease activity in Rheumatoid Arthritis (RA). The Dietary Inflammatory Index (DII) has been associated with RA risk. However, the e

Imbalance in WNT: retinoic acid signaling dysregulates HOX gene expression: implications for cancer stem cell heterogeneity and CRC patient survival.

9. Stem Cells Transl Med. 2026 May 18;15(6):szag043. doi: 10.1093/stcltm/szag043. Imbalance in WNT: retinoic acid signaling dysregulates HOX gene expression: implications for cancer stem cell heterogeneity and CRC patient survival. Osmond B(1)(2), Zhang C(1)(2), Kataboh PK(3), Facey COB(1), Opdenaker LM(1), Boman BM(1)(2)(3)(4). Author information: (1)Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center & Research Institute, Newark, DE 19713, United States. (2)Department of Biological Sciences, University of Delaware, Newark, DE 19716, United States. (3)Department of Mathematical Sciences, University of Delaware, Newark, DE 19716, United States. (4)Department of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, United States. How HOX transcription factors play a role in the stem cell (SC) origin of cancer is unclear. Our goal is to determine how dysregulation of HOX gene expression promotes colorectal cancer (CRC) development through aberrant SC regulatory mechanisms. We investigated retinoic acid (RA) and WNT signaling because they regulate HOX expression and both pathways are dysregulated in cancer. Previously, we reported WNT and RA pathways are functionally linked, and in CRC, APC mutation generates a WNT:RA imbalance leading to incomplete differentiation and SC overpopulation. We hypothesize that aberrant WNT- and RA-signaling dysregulates HOX expression that contributes to the SC or

Role of micronutrients, phytochemicals, and lipid metabolism in mammary gland development, lactation efficiency, and breast cancer risk.

10. Front Nutr. 2026 May 5;13:1811082. doi: 10.3389/fnut.2026.1811082. eCollection 2026. Role of micronutrients, phytochemicals, and lipid metabolism in mammary gland development, lactation efficiency, and breast cancer risk. Qi J(#)(1), Liang X(#)(2), Li X(3), Zhu J(3), Li X(3), Kong Y(3), Huang K(3), Lai J(4), Hu K(1), Fan X(3). Author information: (1)Department of Breast and Thyroid Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. (2)Department of Breast Surgery, Aviation General Hospital, Beijing, China. (3)Department of Breast Medicine, The Affiliated Foshan Women and Children Hospital, Guangdong Medical University, Foshan, China. (4)Department of Cardiology, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China. (#)Contributed equally BACKGROUND: Micronutrients, dietary phytochemicals, and lipid metabolism influence mammary gland growth, lactation efficiency, and breast cancer incidence. The present retrospective investigation evaluated these aspects using clinical, dietary, and biochemical data from women with established lactation and breast cancer outcomes. METHODS: This retrospective analysis involved 800 women found through hospital electronic medical data. Dietary consumption of micronutrients and phytochemicals was evaluated via food frequency questionnaires and dietary recalls. Lipid metabolism was assessed via serum lipid parameters and fatty acid indicators. Outcom

All-trans retinoic acid and lansoprazole potentiated NKG2D-CAR T for breast cancer treatment.

11. Int Immunopharmacol. 2026 Aug 15;183:116889. doi: 10.1016/j.intimp.2026.116889. Epub 2026 May 20. All-trans retinoic acid and lansoprazole potentiated NKG2D-CAR T for breast cancer treatment. Lu T(1), Yu J(1), Zhou R(1), Zhu J(2), Dai H(3), Lv H(4). Author information: (1)Department of Pharmaceutics, China Pharmaceutical University, Nanjing 211198, China. (2)Nanjing KAEDI Biotherapeutics Co. Ltd., Nanjing 210043, China. (3)Nanjing KAEDI Biotherapeutics Co. Ltd., Nanjing 210043, China. Electronic address: paul.dai@kaedibio.com. (4)Department of Pharmaceutics, China Pharmaceutical University, Nanjing 211198, China. Electronic address: lvhuixia@163.com. In solid cancer, the tumor microenvironment (TME) poses significant challenges to chimeric antigen receptor (CAR) T cell therapy due to its dense physical barrier, abnormal metabolism, and immunosuppressive factors. This study addresses these limitations using a synergistic approach involving all-trans retinoic acid (ATRA) and lansoprazole (LPZ) to target fibrosis and acidity, respectively. In vitro, ATRA reversed activated cancer-associated fibroblasts to a quiescent state, reducing α-SMA production, while LPZ increased tumor-site pH (Δ pH = 0.54) by inhibiting V-ATPase expression. In a triple-negative breast cancer (TNBC) model, a temperature-sensitive hydrogel delivering ATRA and LPZ was administered prior to drug-loaded NKG2D-CAR T (N-CAR T) cell injection, achieving a tumor inhibition rate of 72.08%. N

Plasma Levels of Retinoids and Carotenoids in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation Given Extracorporeal Photopheresis to Prevent Graft-Versus-Host Disease-Analyses From a Randomized Trial.

12. EJHaem. 2026 May 13;7:e70296. doi: 10.1002/jha2.70296. eCollection 2026 Jun. Plasma Levels of Retinoids and Carotenoids in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation Given Extracorporeal Photopheresis to Prevent Graft-Versus-Host Disease-Analyses From a Randomized Trial. Iversen PO(1)(2), Ali MM(3), Bastani NE(1), Blomhoff R(1)(4), Tjønnfjord GE(2)(5), Gedde-Dahl T(2)(5). Author information: (1)Department of Nutrition Institute of Basic Medical Sciences University of Oslo Oslo Norway. (2)Department of Haematology Oslo University Hospital Oslo Norway. (3)Department of Medicine Bærum Hospital Vestre Viken Hospital Trust Gjettum Norway. (4)Division of Cancer Medicine Department of Clinical Service Oslo University Hospital Oslo Norway. (5)Institute of Clinical Medicine University of Oslo Oslo Norway. INTRODUCTION: Whether retinoids and carotenoids impact on graft-versus-host disease (GVHD) following allogeneic stem cell transplantation (ASCT) is unknown. METHODS: We conducted a 1:1 randomized controlled trial with extracorporeal photopheresis for GVHD-prophylaxis as the intervention. The plasma levels of retinoids and carotenoids were determined at randomization and 3 months after ASCT. RESULTS: We found no significant difference in GVHD occurrence and levels of retinoids between the intervention and control groups at either of the two time points. CONCLUSION: Whether routine vitamin A supplementation is warranted for GVHD prevention, ne

mTOR inhibition promotes ATRA-induced cancer cell differentiation by overcoming a metabolic hyperactive state.

13. J Transl Med. 2026 May 11;24(1):662. doi: 10.1186/s12967-026-08218-7. mTOR inhibition promotes ATRA-induced cancer cell differentiation by overcoming a metabolic hyperactive state. Zhang L(#)(1), Xiang G(#)(1), Zhu P(#)(1), Yu S(1), Jiang F(1), Wang S(1), Wang J(1), Dai Y(1), Wang S(1), Tan Y(1), Liu H(2), Liu F(3). Author information: (1)Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine (Shanghai), Ruijin Hospital, Shanghai Jiao Tong University School of Life Sciences and Biotechnology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. (2)Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine (Shanghai), Ruijin Hospital, Shanghai Jiao Tong University School of Life Sciences and Biotechnology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. liuhan68@sjtu.edu.cn. (3)Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine (Shanghai), Ruijin Hospital, Shanghai Jiao Tong University School of Life Sciences and Biotechnology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. lf12034@rjh.com.cn. (#)Contributed equally BACKGROUND: All-trans retinoic acid (ATRA), a derivative of vitamin A, potently induces cell maturation in acute promyelocytic leukemia (APL). However, this therapeutic effec

Transcription factor zinc fingers and homeoboxes protein 2 (ZHX2) drives CRABP1 targeting to strengthen retinoic acid sensitivity and potentiate therapeutic response in neuroblastoma.

14. Biomed Pharmacother. 2026 Jun;199:119324. doi: 10.1016/j.biopha.2026.119324. Epub 2026 May 2. Transcription factor zinc fingers and homeoboxes protein 2 (ZHX2) drives CRABP1 targeting to strengthen retinoic acid sensitivity and potentiate therapeutic response in neuroblastoma. Wang Y(1), Liu W(1), Li D(2), Ma H(2), Liu L(2), Zhang A(3), Ju X(4). Author information: (1)Department of Pediatrics, Qilu hospital of Shandong University, Jinan 250012, China. (2)Cryomedicine Laboratory, Qilu Hospital of Shandong University, Jinan 250012, China. (3)Department of Pediatrics, Qilu hospital of Shandong University, Jinan 250012, China. Electronic address: zhangaijun@sdu.edu.cn. (4)Department of Pediatrics, Qilu hospital of Shandong University, Jinan 250012, China; Cryomedicine Laboratory, Qilu Hospital of Shandong University, Jinan 250012, China. Electronic address: jxlqlyy@163.com. BACKGROUND: Neuroblastoma (NB) is the most common malignant extracranial solid tumor in children, with poor prognosis, inadequate therapeutic responses, and high recurrence rates. Zinc fingers and homeoboxes protein 2 (ZHX2) functions in various cancers, but its role in NB remains unclear. Retinoic acid (RA) has been used as a pro-differentiation agent in NB, but its limited response rate necessitates novel combinations. This study aims to explore key transcription factors (TFs) in improving RA efficacy and NB prognosis. METHODS: ZHX2 was identified as the key TF related to RA efficacy vi

Mechanism-Driven Repurposing of All-Trans Retinoic Acid (ATRA) for AML1-MTG16⁺ Acute Myeloid Leukemia: A First-in-Human Case Report and Translational Roadmap to Overcome the "Long-Tail" Barrier.

15. Clin Ther. 2026 Jun;48(6):539-543. doi: 10.1016/j.clinthera.2026.03.015. Epub 2026 Apr 14. Mechanism-Driven Repurposing of All-Trans Retinoic Acid (ATRA) for AML1-MTG16⁺ Acute Myeloid Leukemia: A First-in-Human Case Report and Translational Roadmap to Overcome the "Long-Tail" Barrier. Zhou K(1), Wang Z(1), Xiong J(1), Huang W(2). Author information: (1)Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. (2)Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address: 2896607051@qq.com. BACKGROUND: Acute myeloid leukemia (AML) with rare aberrations like AML1-MTG16 fusion encounters precision oncology challenges, exacerbated by the "Long-Tail" dilemma. Preclinical data show all-trans retinoic acid (ATRA) restores myeloid differentiation in MTG16-deficient AML models, but its clinical translation remains unexplored. CASE PRESENTATION: We treated a 73-year-old unfit AML patient with early molecular progression (AML1-MTG16 burden elevated to 0.2%) using ATRA plus azacitidine/venetoclax. Sustained measurable residual disease-negative remission (21 months) and undetectable fusion transcripts were achieved with only grade 2 neutropenia. CONCLUSIONS: This case may preliminarily suggest ATRA's potential in AML1-MTG16⁺ AML, offering translational clues for ultra-rare leukemia subtypes, pendi

Licensed delivery: The microbiota authorizes vitamin A transport.

1. Cell Host Microbe. 2026 Aug 12;34(8):1586-1588. doi: 10.1016/j.chom.2026.07.013. Licensed delivery: The microbiota authorizes vitamin A transport. Kim SV(1). Author information: (1)Department of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA; Sidney Kimmel Comprehensive Cancer Center at Jefferson, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address: svkim@jefferson.edu. Vitamin A derivatives imprint adaptive immune cells for small-intestinal homing, yet the microbiota's role remains unclear. In this issue, Srinivasan et al. demonstrate that the microbiota help load vitamin A derivatives onto CD11c+ myeloid cells, thereby enabling their migration to mesenteric lymph nodes, where T cells are conditioned for small-intestinal homing. Copyright © 2026 Elsevier Inc. All rights reserved. DOI: 10.1016/j.chom.2026.07.013 PMID: 42586043 [Indexed for MEDLINE] Conflict of interest statement: Declaration of interests The author declares no competing interests.

Systemic administration of all-trans retinoic acid modulated circulating immune cells but failed to improve healing in a preclinical model of musculoskeletal trauma.

2. Front Immunol. 2026 Jul 28;17:1683993. doi: 10.3389/fimmu.2026.1683993. eCollection 2026. Systemic administration of all-trans retinoic acid modulated circulating immune cells but failed to improve healing in a preclinical model of musculoskeletal trauma. Guyer T(1), Gill D(1), Leguineche KE(1), Link K(1), Jones KA(1), Williams KE(1), Strait LK(1), O'Neill KL(1), Hastings MA(1), Lin A(1), Maniar D(2)(3), Roy K(2)(3)(4)(5)(6), Guldberg RE(1). Author information: (1)University of Oregon, Eugene, OR, United States. (2)Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States. (3)Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, United States. (4)Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States. (5)Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States. (6)Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, United States. Musculoskeletal trauma is exceedingly common and experiences a high incidence of complications, including bone non-union. Previous studies have implicated a dysregulated systemic immune response after injury as an important factor contributing to complications. We have previously identified a negative correlation between circulating myeloid-derived suppressor cel

DECIDER-2: Prospective randomized multicenter phase III trial of decitabine and venetoclax administered in combination with all-trans retinoic acid or placebo in patients with acute myeloid leukemia who are ineligible for induction chemotherapy.

3. BMC Cancer. 2026 Aug 5;26(1):941. doi: 10.1186/s12885-026-16617-8. DECIDER-2: Prospective randomized multicenter phase III trial of decitabine and venetoclax administered in combination with all-trans retinoic acid or placebo in patients with acute myeloid leukemia who are ineligible for induction chemotherapy. Grishina O(1), Schmoor C(1), Sellner C(1), Hackanson B(2), Mikesch JH(3), Deligiannis I(4), Thol F(5), Crysandt M(6), Junghanss C(7), Runde V(8), Rosée P(9), Teichmann LL(10), Al-Ali HK(11), Sauer T(12), Germing U(13), Griesinger F(14), Lukic S(15), Krauter J(16), Janjetovic S(17), Koch J(18), Staib P(19), Topaly J(20), de Wit M(21), Kraemer DM(22), Oelschläger L(23), Schnetzke U(24), Schmah O(25), Wessendorf S(26), Khandanpour C(27), Kündgen L(28), Schwalenberg M(29), Heuser M(30), Ganser A(5), Döhner H(31), Wäsch R(32), Lübbert M(33). Author information: (1)Clinical Trials Unit, Medical Center - University of Freiburg, Faculty of Medicine - University of Freiburg, Elsaesser Str. 2, Freiburg, 79110, Germany. (2)Department of Hematology/Oncology, Comprehensive Cancer Center Augsburg as Part of the CCC-WERA Consortium, University Medical Center Augsburg, Stenglinstraße 2, Augsburg, 86156, Germany. (3)Department of Medicine A, University Hospital Münster, Albert-Schweitzer-Campus 1, Münster, 48149, Germany. (4)Internal Medicine I, Brothers Hospital Trier, Nordallee 1, Trier, 54292, Germany. (5)Department of Hematology, Hemostasis, Oncology, and Cell T

An Efficient Method for Neuron-Like Differentiation of SH-SY5Y Neuroblastoma Cells Using Retinoic Acid and Laminin-Rich Extracellular Matrix.

4. Genesis. 2026 Aug;64(4):e70066. doi: 10.1002/dvg.70066. An Efficient Method for Neuron-Like Differentiation of SH-SY5Y Neuroblastoma Cells Using Retinoic Acid and Laminin-Rich Extracellular Matrix. Grigoli MM(1), Pachane BC(2)(3), Fuzer AM(1), de Oliveira SD(1), Targas ABA(1), Alexandre-Silva V(1), Selistre-de-Araujo HS(2), Manzine PR(1)(4), Cominetti MR(1). Author information: (1)Department of Gerontology, Federal University of São Carlos - UFSCar, São Carlos, Brazil. (2)Department of Physiological Sciences, Federal University of São Carlos - UFSCar, São Carlos, São Paulo, Brazil. (3)Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil. (4)Department of Public Health, Mental Health and Maternal-Child Health, Faculty of Nursing, University of Barcelona, Barcelona, Catalonia, Spain. The human neuroblastoma cell line SH-SY5Y is widely used in vitro as a model due to its ability to acquire neuron-like properties. Conventional differentiation protocols often rely on retinoic acid (RA), which can lead to limited stability of neuronal-like phenotypes over time. In this study, we evaluated a differentiation approach combining RA with a laminin-rich extracellular matrix (LrECM). This approach accelerated differentiation, with neuron-like morphology and neurite outgrowth observed as early as 4 days and sustained features for up to 10 days. Immunofluorescence analysis indicated increased NeuN expression, and Western blot confir

Folic acid prevention of neural tube defects requires retinoic acid produced by ALDH1L1.

5. Proc Natl Acad Sci U S A. 2026 Aug 4;123(31):e2616501123. doi: 10.1073/pnas.2616501123. Epub 2026 Jul 30. Folic acid prevention of neural tube defects requires retinoic acid produced by ALDH1L1. Edri T(#)(1), Abbou-Levy T(#)(1), Cohen D(1), Inácio JM(2), Shabtai Y(1), Pillemer G(1), Belo JA(2), Fainsod A(1). Author information: (1)Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel. (2)Stem Cells and Development Laboratory, iNOVA4Health, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisboa 1150-082, Portugal. (#)Contributed equally Folic acid (FA) supplementation during pregnancy is the commonly accepted treatment to prevent neural tube defects. The mechanism by which FA prevents neural tube defects (NTDs) remains unclear. FA also prevents other developmental malformations, including alcohol-induced malformations in Fetal Alcohol Syndrome models. We show that FA acts through a metabolic link to retinoic acid (RA) signaling. Using a pax3-knockdown Xenopus model of FA-rescuable NTDs, we show that RA or its precursors equally rescue these defects. Similarly, FA rescues alcohol-induced NTDs in a model previously shown to be rescued by retinoids. We identify the FA-metabolizing enzyme, formyl tetrahydrofolate dehydrogenase (ALDH1L1, FTHFD), encoded by the aldh1l1 gene, as essential for this rescu

CRABP2 Promotes Lung Adenocarcinoma Through Retinoic Acid Pathway-Mediated NF-κB Activation.

6. Front Biosci (Landmark Ed). 2026 Jul 27;31(7):51377. doi: 10.31083/FBL51377. CRABP2 Promotes Lung Adenocarcinoma Through Retinoic Acid Pathway-Mediated NF-κB Activation. Zhu X(1), Fan B(1), Lei Q(1), Xin C(1), Li X(1), Ma Z(1), Xie S(1), Shang J(1), Li Z(1), Liu C(2), Wang W(1). Author information: (1)Department of Thoracic Surgery II, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer Center, 650118 Kunming, Yunnan, China. (2)Department of Nuclear Medicine, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer Center, 650118 Kunming, Yunnan, China. BACKGROUND: Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer and remains a major cause of cancer-related mortality. Despite advances in targeted therapies, tumor heterogeneity and acquired resistance frequently undermine clinical outcomes. This study aimed to identify novel oncogenic drivers and underlying mechanisms in LUAD. METHODS: We examined cellular retinoic acid-binding protein 2 (CRABP2) expression in human LUAD specimens and evaluated its functional role through in vitro assays (cell proliferation, migration, invasion, and apoptosis) and in vivo xenograft tumor growth. Mechanistic exploration involved RNA sequencing, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, and immunoblotting for the nuclear factor kappa B (NF-κB) signaling components, along with r

IL-6 Upregulates CD73 in Human Placental Mesenchymal Stem Cells to Promote ATRA-Induced NB4 Cell Differentiation in Acute Promyelocytic Leukemia.

7. Cancer Med. 2026 Aug;15(8):e72149. doi: 10.1002/cam4.72149. IL-6 Upregulates CD73 in Human Placental Mesenchymal Stem Cells to Promote ATRA-Induced NB4 Cell Differentiation in Acute Promyelocytic Leukemia. Qi R(1)(2), Zhang H(3), Wu Y(1), Ma Y(1), Luan X(1). Author information: (1)Department of Immunology, Shandong Medical and Pharmaceutical University, Yantai, Shandong Province, China. (2)Department of Clinical Lab, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong Province, China. (3)Department of Clinical Lab, Yantaishan Hospital Affiliated to Shandong Medical and Pharmaceutical University, Yantai, Shandong Province, China. PURPOSE: To investigate the expression profile of IL-6 in patients with acute promyelocytic leukemia (APL) and its role in modulating the ability of hPMSCs to regulate the differentiation of NB4 cells. METHODS: Peripheral blood samples were obtained from newly diagnosed APL patients and healthy controls. IL-6 levels were measured using flow cytometry-based (FCM) multiplex immunoassays. A co-culture system of hPMSCs and NB4 cells was established. The effects of hPMSCs on ATRA-induced differentiation, proliferation, and phagocytic activity of NB4 cells were evaluated by Wright-Giemsa staining, FCM, CCK-8 assays, and phagocytosis assays. Western blot analysis was performed to investigate the signaling mechanisms by which IL-6 regulates CD73 expression in hPMSCs. To determine whether the regulatory effects o

Vitamins A- and C-augmented platelet-rich fibrin in periodontal intraosseous defects: A randomized clinical trial.

8. J Periodontol. 2026 Jul 29. doi: 10.1002/jper.70173. Online ahead of print. Vitamins A- and C-augmented platelet-rich fibrin in periodontal intraosseous defects: A randomized clinical trial. Sanaa D(1)(2), Elbattawy W(1), Hassan A(1)(2), Magdeldin S(3)(4), Mokhtar M(3), Abdelmoneim TK(3), Fawzy El-Sayed K(1)(5)(6). Author information: (1)Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt. (2)Periodontology Department, School of Dentistry, Newgiza University, Giza, Egypt. (3)Proteomics and Metabolomics Research Program, Basic Research Unit, Research Department, Children's Cancer Hospital Egypt, Cairo, Egypt. (4)Physiology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt. (5)Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, Kiel, Germany. (6)Stem Cells and Tissue Engineering Unit, Faculty of Dentistry, Cairo University, Cairo, Egypt. BACKGROUND: Vitamins A and C (VitA+C) are pivotal biomolecules, with synergistic effects, especially in conjoint presence, on cellular pluripotency and regenerative capabilities. This randomized trial aimed to evaluate (VitA+C)-augmented injectable platelet-rich fibrin (i-PRF) versus i-PRF alone with a modified minimally invasive surgical technique (M-MIST) in periodontal intraosseous defects in patients with stage III periodontitis. METHODS: This parallel group, two-arm, triple-blinded,

Lycopene, Carotenoids, and Retinoids in Cancer Chemoprevention: Molecular Mechanisms and Clinical Implications.

9. Nutrients. 2026 Jul 15;18(14):2318. doi: 10.3390/nu18142318. Lycopene, Carotenoids, and Retinoids in Cancer Chemoprevention: Molecular Mechanisms and Clinical Implications. Kalemoglu E(1), Sahin K(2), Sahin N(2), Kucuk O(3)(4)(5). Author information: (1)Department of Medicine, Rutgers University-Jersey City Medical Center, Jersey City, NJ 07302, USA. (2)Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, 23119 Elazig, Turkey. (3)Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA. (4)Department of Urology, Emory University School of Medicine, Atlanta, GA 30322, USA. (5)Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA. Cancer development arises from dynamic interactions between inherited susceptibility and modifiable environmental exposures, among which diet plays a central role. Carotenoids, lipophilic plant-derived pigments including lycopene, α-carotene, and β-carotene, and retinoids, the vitamin A derivatives that regulate gene transcription via retinoic acid receptors (RARs) and retinoid X receptors (RXRs), have been extensively investigated for their chemopreventive and therapeutic potential. This review aims to provide an integrated, mechanism-based synthesis of the roles of lycopene, α- and β-carotene, and retinoids in cancer chemoprevention and to clarify the conditions under which they are most likely to be effective. Beyond summarizing establi

Pediatric recurrent intracranial hypertension secondary to All-Trans Retinoic Acid treatment in a patient with acute promyelocytic leukemia: value of retinal nerve fiber layer thickness in management.

10. Turk J Pediatr. 2026 Jun 8;68(3):501-514. doi: 10.24953/turkjpediatr.2026.6693. Pediatric recurrent intracranial hypertension secondary to All-Trans Retinoic Acid treatment in a patient with acute promyelocytic leukemia: value of retinal nerve fiber layer thickness in management. Yavuz P(1), Yavaş GF(2), Aytaç S(3), Yalnızoğlu D(1), Ünal Cangül Ş(3), Haliloğlu G(1). Author information: (1)Division of Pediatric Neurology, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Türkiye. (2)Department of Ophthalmology, Faculty of Medicine, Hacettepe University, Ankara, Türkiye. (3)Division of Pediatric Hematology, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Türkiye. BACKGROUND: All-trans retinoic acid (ATRA) is an essential agent in the treatment of acute promyelocytic leukemia (APL). However, careful monitoring is required due to its potential side effects, particularly intracranial hypertension (IH). CASE PRESENTATION: Here, we report a 15-year-old girl who presented with headache, blurred vision, vomiting, and was found to have left homonymous hemianopsia and an acute cerebral infarct. Etiological investigations revealed acute promyelocytic leukemia and treatment with ATRA was initiated. However, this treatment was complicated by repetitive episodes of IH, which improved with discontinuation of ATRA but recurred whenever reinitiation was attempted. Despite this side effect, the patient was able to co

Immunostimulatory lipogel implant enhances cancer immunotherapy.

11. Nat Nanotechnol. 2026 Aug;21(8):1203-1214. doi: 10.1038/s41565-026-02194-1. Epub 2026 Jul 23. Immunostimulatory lipogel implant enhances cancer immunotherapy. Zhang Y(1), Wang E(1), Li S(1), Yao Y(1), Shao Q(1), Wang Y(2)(3)(4)(5)(6), He Y(1), Liu M(1), Jin X(7), Gu Z(8)(9)(10)(11)(12), Mo R(13)(14). Author information: (1)State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases and Jiangsu Key Laboratory of Drug Design and Optimization, Center of Advanced Pharmaceuticals and Biomaterials, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China. (2)Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, School of Pharmacy, Zhejiang University, Hangzhou, China. (3)Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. (4)Jinhua Research Institute, Zhejiang University, Jinhua, China. (5)Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China. (6)State Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou, China. (7)School of Pharmacy, Zhejiang University of Technology, Hangzhou, China. (8)Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, School of Pharmacy, Zhejiang University, Hangzhou, China. guzhen@zju.edu.cn. (9)Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Diet, Gastrointestinal Symptoms, and Health-Related Quality of Life in Children With Solid Tumors Receiving Chemotherapy.

12. J Pediatr Hematol Oncol Nurs. 2026 Jul 20:27527530261462150. doi: 10.1177/27527530261462150. Online ahead of print. Diet, Gastrointestinal Symptoms, and Health-Related Quality of Life in Children With Solid Tumors Receiving Chemotherapy. Giffen A(1), Webster CI(1), Martin M(2), Sutton KS(2)(3)(4), Olson T(2)(3)(4), Noh HI(1), Bruner DW(1)(4), Bai J(1)(4). Author information: (1)Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA. (2)Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA. (3)School of Medicine, Emory University, Atlanta, GA, USA. (4)Winship Cancer Institute, Emory University, Atlanta, GA, USA. BackgroundChildren undergoing chemotherapy often experience gastrointestinal (GI) symptoms, negatively impacting health-related quality of life (HRQOL). Although macro- and micronutrients have been associated with GI symptoms and HRQOL following cancer diagnosis, more evidence is needed in pediatric oncology populations. This study examines how dietary intake is associated with GI symptoms and HRQOL in children with solid tumors undergoing chemotherapy.MethodThis secondary analysis used the Block Kids Food Screener to assess intake of macro- and micronutrients; the Pediatric Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events to measure GI symptoms; and the PedsQL 4.0 to evaluate HRQOL. Logistic and adjusted linear regression models were used to examine

Diagnostic Performance of Fecal Elastase and Risk Factors for Exocrine Pancreatic Insufficiency in Children with Pancreatitis: An INSPPIRE-2 Study.

13. J Pediatr. 2026 Jul 18;298:115245. doi: 10.1016/j.jpeds.2026.115245. Online ahead of print. Diagnostic Performance of Fecal Elastase and Risk Factors for Exocrine Pancreatic Insufficiency in Children with Pancreatitis: An INSPPIRE-2 Study. Gummadi VV(1), Gonska T(2), Morinville VD(3), Maqbool A(4), Wang F(5), Cress GA(6), Abu-El-Haija M(7), Cohen RZ(8), Downs EM(9), Fishman DS(10), Freeman AJ(11), Giefer MJ(12), Ginzburg G(13), Grover AS(14), Liman AY(15), Lindblad D(16), Liu QY(17), Mark JA(18), McFerron BA(19), Mehta MS(20), Ng K(21), Noel RA(22), Ooi CY(23), Perito ER(24), Wilschanski M(25), Zheng Y(26), Liu S(5), Lowe M(27), Uc A(6); Chronic Pancreatitis Clinical Research Consortium (formerly CPDPC). Author information: (1)Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada. (2)Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada; Translational Medicine Program, SickKids Research Institute, Toronto, Canada. Electronic address: tanja.gonska@sickkids.ca. (3)Division of Pediatric Gastroenterology and Nutrition, Montreal Children's Hospital, McGill University Health Centre, Montreal, Canada. (4)Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA. (5

Independent and combined associations of dietary antioxidant exposure with all-cause and cause-specific mortality in the general population.

14. J Nutr Sci. 2026 Jul 7;15:e53. doi: 10.1017/jns.2026.10117. eCollection 2026. Independent and combined associations of dietary antioxidant exposure with all-cause and cause-specific mortality in the general population. Liu Z(1)(2), He Z(1)(3), Xing Y(1). Author information: (1)Department of Child Health Care, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, China. (2)School of public health, Guangzhou Medical University, China. (3)Department of Clinical Medicine, The First Clinical School, Guangzhou Medical University, China. This study aimed to determine if habitual intake of key dietary antioxidants, both individually and collectively, is associated with all-cause and cause-specific mortality among U.S. adults, given that oxidative stress heightens cardiovascular and cancer mortality risk. This prospective cohort study analysed 34,955 participants from the National Health and Nutrition Examination Survey (NHANES) 2003-2018. Intakes of vitamins A, C, E, zinc, selenium, and carotenoids were assessed, and a composite dietary antioxidant index (CDAI) was calculated. The principal results, from 347,580 person-years of follow-up where 4,456 deaths occurred (1,368 CVD; 1,038 cancer), showed significant associations. Compared with the lowest intake quintile, the highest quintile of vitamin E was associated with lower all-cause mortality (HR: 0.69, 95% CI: 0.58-0.83) and CVD mortality (HR: 0.67, 0.48-0.92). High carotenoid intake wa

Cetyl All-Trans-Retinoate as a Lipidic ATRA Prodrug with Enhanced Anticancer and Chemosensitizing Activity.

15. Int J Mol Sci. 2026 Jul 3;27(13):5982. doi: 10.3390/ijms27135982. Cetyl All-Trans-Retinoate as a Lipidic ATRA Prodrug with Enhanced Anticancer and Chemosensitizing Activity. Moroz P(1), Muciek K(1), Świtalska M(2), Wietrzyk J(2), Lazar Z(3), Gliszczyńska A(1). Author information: (1)Department of Food Chemistry and Biocatalysis, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland. (2)Department of Experimental Oncology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wrocław, Poland. (3)Department of Biotechnology and Food Microbiology, Wrocław University of Environmental and Life Sciences, Chelmonskiego 37, 51-630 Wrocław, Poland. Tretinoin (all-trans-retinoic acid, ATRA) is an established therapy for acute promyelocytic leukemia (APL) and neuroblastoma (NB); however, its broader oncological application is limited by poor bioavailability and rapid resistance development. In this study, we developed lipidic ester derivatives of ATRA as a potential prodrug approach aimed at modulating its physicochemical and biological properties. Three ATRA derivatives were evaluated in vitro in six human cancer cell lines: leukemia (MV4-11), gastric (AGS), colon (HT-29), lung (A549), and breast cancer cells (MCF-7, MDA-MB-468). Cytotoxicity toward normal human breast epithelial cells (MCF-10A) was also assessed. Among the synthesized derivatives, cetyl all-trans-retinoate (A

Context-dependent regulation of cytotoxic T lymphocytes by nuclear receptors.

1. J Immunol. 2026 Oct 1;215(10):vkag261. doi: 10.1093/jimmun/vkag261. Context-dependent regulation of cytotoxic T lymphocytes by nuclear receptors. Kim CH(1)(2)(3)(4). Author information: (1)Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, United States. (2)Mary H. Weiser Food Allergy Center, University of Michigan School of Medicine, Ann Arbor, MI, United States. (3)Immunology Graduate Program, University of Michigan, Ann Arbor, MI, United States. (4)Rogel Cancer Center, University of Michigan School of Medicine, Ann Arbor, MI, United States. Cytotoxic CD8⁺ T lymphocytes eliminate pathogen-infected and malignant cells through migration to affected tissues, cytokine production, and cytotoxic activity. A mounting body of evidence indicates that CD8 T cell differentiation into functionally different subsets, such as effector, memory, tissue-resident memory, and exhausted T cells, is controlled by a group of nuclear receptors (NRs). NRs sense signals from various physiological and environmental cues, such as nutritional, endocrine, stress/circadian, and metabolic signals, and translate them into gene-regulatory decisions. NRs act through direct and indirect DNA binding, corepressor-coactivator exchange, and transrepression of effector-associated transcription factors, thereby reshaping chromatin accessibility and metabolic programs during CD8 T cell differentiation. This review highlights major CD8 T cell-regulating pathways

Cystic Fibrosis.

2. Cystic Fibrosis. Savant A(1), Bojanowski CM(2), Upadia J(1). In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(®) [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. 2001 Mar 26 [updated 2026 Oct 1]. Author information: (1)Tulane University School of Medicine;, Manning Family Children’s Hospital, New Orleans, Louisiana (2)Tulane University School of Medicine, New Orleans, Louisiana CLINICAL CHARACTERISTICS: Cystic fibrosis (CF) is a multisystem disease affecting epithelia of the respiratory tract, pancreas, intestine, hepatobiliary system, and exocrine sweat glands. Morbidities include progressive obstructive pulmonary disease with bronchiectasis, recurrent sinusitis and bronchitis, exocrine pancreatic deficiency and malnutrition, pancreatitis, gastrointestinal manifestations (meconium ileus, rectal prolapse, distal intestinal obstructive syndrome), liver disease, diabetes, osteopenia/osteoporosis, male infertility due to hypoplasia or aplasia of the vas deferens, and reduced fertility or infertility in some women. By 2025, 95% of individuals with CF were eligible for targeted therapies, which has significantly altered the long-term course of the disease with a reduced overall disease burden. The impact is most evident in fewer hospitalizations, reduced clinic visits, and a decreased need for lung transplantation, all of which are associated with improved survival. While the CF disease phenotype has overall b

Rethinking Drug Resistance in Acute Promyelocytic Leukemia: The Regulated Cell Death Network as an Integrative Framework.

3. Biomolecules. 2026 Sep 21;16(9):1375. doi: 10.3390/biom16091375. Rethinking Drug Resistance in Acute Promyelocytic Leukemia: The Regulated Cell Death Network as an Integrative Framework. Lin S(1)(2)(3), Qin B(1)(2)(3), Ye Z(1)(2)(3), Qing J(1)(2)(4), Zhen H(1)(2)(5), Yang S(1)(2)(6), Jiang X(1)(2)(5), Fan Y(1)(2)(5), Zhu L(1)(2)(5), Liu J(1)(2)(5). Author information: (1)Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Changsha Medical University, Changsha 410219, China. (2)Hunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Neurodegenerative Diseases, Changsha Medical University, Changsha 410219, China. (3)School of Traditional Chinese Medicine, Changsha Medical University, Changsha 410219, China. (4)School of First Clinical, Changsha Medical University, Changsha 410219, China. (5)School of Public Health, Changsha Medical University, Changsha 410219, China. (6)School of Dental Medicine, Changsha Medical University, Changsha 410219, China. Drug resistance in acute promyelocytic leukemia (APL) remains clinically challenging despite the success of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) therapy. Existing explanations, including promyelocytic leukemia protein-retinoic acid receptor alpha (PML-RARα) mutations and alterations in individual death pathways, do not fully account for the heterogeneity of resistant phenotypes. This review proposes regulated cell death net

Photodynamic Therapy in Cancer: Mechanisms, Photosensitizer Technology, Vitamin Modulation, and Rational Combination Design.

4. Biomedicines. 2026 Aug 24;14(9):1889. doi: 10.3390/biomedicines14091889. Photodynamic Therapy in Cancer: Mechanisms, Photosensitizer Technology, Vitamin Modulation, and Rational Combination Design. Naser I(1), Bartusik-Aebisher D(2), Smolak B(3), Dynarowicz K(2), Kowalczyk E(4), Guz W(3), Aebisher D(5), Henrykowska G(6). Author information: (1)English Division Science Club, Faculty of Medicine, University of Rzeszów, 35-310 Rzeszów, Poland. (2)Department of Biochemistry and General Chemistry, Faculty of Medicine, University of Rzeszów, 35-310 Rzeszów, Poland. (3)Department of Diagnostic Imaging and Nuclear Medicine, Faculty of Medicine, University of Rzeszów, 35-310 Rzeszów, Poland. (4)Department of Pharmacology and Toxicology, Faculty of Medicine, Medical University of Lodz, T. Kosciuszki 4, 90-419 Lodz, Poland. (5)Department of Photomedicine and Physical Chemistry, Faculty of Medicine, University of Rzeszów, 35-310 Rzeszów, Poland. (6)Department of Epidemiology and Public Health, Faculty of Medicine, Medical University of Lodz, T. Kosciuszki 4, 90-419 Lodz, Poland. Photodynamic therapy (PDT) is a minimally invasive anticancer modality based on the interaction of a photosensitizer, light of an appropriate wavelength, and molecular oxygen, resulting in reactive oxygen species (ROS)-mediated tumor injury. This review discusses PDT as a mechanism-dependent therapeutic platform and evaluates how photosensitizers, vitamin A, vitamin D, nanotechnology, and comb

Secondary Acute T-Lymphoblastic Leukemia Following Pregnancy After Remission of Acute Promyelocytic Leukemia: A Case Report with Literature Review.

5. Ann Clin Lab Sci. 2026 Jul;56(4):482-489. Secondary Acute T-Lymphoblastic Leukemia Following Pregnancy After Remission of Acute Promyelocytic Leukemia: A Case Report with Literature Review. Chen Y(1), Wang Y(2), Yang X(3), Zhang Z(4)(5). Author information: (1)Department of Hematology Laboratory, Affiliated Hospital of Chengde Medical University, Chengde, Hebei Province. (2)Department of Hematology, Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong Province. (3)Department of Pediatric Surgery, Affiliated Hospital of Chengde Medical University, Chengde, Hebei Province. (4)Department of Hematology Laboratory, Affiliated Hospital of Chengde Medical University, Chengde, Hebei Province zzhangzhihua@163.com. (5)Hebei Key Laboratory of Panvascular Diseases, Chengde, Hebei Province, China. Acute promyelocytic leukemia (APL) predominantly affects younger patients with significantly prolonged survival. Therefore, controlling the incidence of secondary hematological malignancies represents a crucial therapeutic goal. Secondary, acute T-lymphoblastic leukemia (T-ALL) following APL is rare and confers a poor prognosis, with only 2 cases reported to date. Herein, we present a case of a young female with APL who attained complete remission (CR) after receiving dual induction therapy with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), followed by standard consolidation and maintenance treatment cycles. After discontinuing chemotherapy for 26

Vitamin intake and colorectal cancer incidence and mortality: evidence from a large prospective cohort.

6. Front Nutr. 2026 Sep 9;13:1877860. doi: 10.3389/fnut.2026.1877860. eCollection 2026. Vitamin intake and colorectal cancer incidence and mortality: evidence from a large prospective cohort. Gong LL(1)(2), Qi-Wu(3), Geng-Xue(2), Huang FC(1)(4), Pu L(1)(2), Ning-Xu(1)(4), Li WL(1)(2). Author information: (1)The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. (2)The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. (3)College of Food Science and Technology, and Yunnan Key Laboratory of Precision Nutrition and Personalized Food Manufacturing, Yunnan Agricultural University, Kunming, Yunnan, China. (4)Department of Oncology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. BACKGROUND: Emerging evidence suggests that vitamin intake may be associated with colorectal cancer (CRC) risk, yet prospective studies on CRC incidence and mortality remain limited. We therefore investigated the associations between vitamin intake and CRC incidence and mortality in a large cohort of US adults. METHODS: We included 101,692 participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Vitamin intake (including dietary and supplement sources) was assessed using the Dietary History Questionnaire based on the USDA 1994-1996 survey and the University of Minnesota Nutrition Data System for Research. Prospective associations with CRC incidence and mortality

Retinoic acid in health and disease.

7. Signal Transduct Target Ther. 2026 Sep 22;11(1):400. doi: 10.1038/s41392-026-03055-y. Retinoic acid in health and disease. De Angelis MT(#)(1), Dattilo V(#)(1), Vono N(1), Lise V(1), Reda M(1), De Marco C(1)(2), Rizzuto A(3), Trapasso F(1)(4), Viglietto G(1)(2)(4), Santamaria G(5)(6). Author information: (1)Department of Experimental and Clinical Medicine, University "Magna Graecia", Catanzaro, Italy. (2)Interdepartmental Center of Services (CIS), Omics Sciences and Biobank, University "Magna Graecia", Catanzaro, Italy. (3)Department of Medical and Surgical Sciences, University "Magna Graecia", Catanzaro, Italy. (4)Medical Genetics Unit, Renato Dulbecco University Hospital, Catanzaro, Italy. (5)Department of Experimental and Clinical Medicine, University "Magna Graecia", Catanzaro, Italy. gsantamaria@unicz.it. (6)Interdepartmental Center of Services (CIS), Omics Sciences and Biobank, University "Magna Graecia", Catanzaro, Italy. gsantamaria@unicz.it. (#)Contributed equally Retinoic acid, the active metabolite of vitamin A, is a pleiotropic signaling molecule that integrates developmental, homeostatic, and pathological processes across multiple organ systems. During embryogenesis, RA gradients regulate tissue patterning and lineage commitment, while in adult tissues, RA contributes to epithelial integrity, stem-cell regulation, immune homeostasis, and metabolic balance. Disruption of retinoic acid synthesis, degradation, receptor signaling, or pathway cros

Dietary carotenoids and vitamin A are associated with lower gastric cancer risk and favorable inflammatory and oxidative stress biomarkers: an incident case- control study.

8. Front Nutr. 2026 Sep 7;13:1953378. doi: 10.3389/fnut.2026.1953378. eCollection 2026. Dietary carotenoids and vitamin A are associated with lower gastric cancer risk and favorable inflammatory and oxidative stress biomarkers: an incident case- control study. Vahid F(1), Bohn T(1). Author information: (1)Nutrition and Health Research Group, Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg. BACKGROUND: Dietary carotenoids and vitamin A may contribute to gastric cancer (GC) prevention through anti-inflammatory and antioxidant mechanisms; however, epidemiological evidence remains limited. We investigated the associations of total and individual carotenoid and vitamin A intakes with GC and their relationships with inflammatory/oxidative stress biomarkers. METHODS: The case-control study included 177 adults (82 GC incidence cases/95 controls). A validated 168-item food frequency questionnaire assessed dietary intakes of individual carotenoids and preformed vitamin A. Metabolic biomarkers, lipid profile, inflammatory/oxidative stress markers [e.g., high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), interleukins (6/1β/10/4), total antioxidant capacity (TAC), and malondialdehyde (MDA)] were measured. Multivariable logistic regression models estimated odds ratios (ORs) for GC risk; linear regression models examined associations between carotenoid intakes and biomarkers. RESULTS: Total carotenoid (

All-Trans Retinoic Acid and Curcumin Exhibit Hormesis or Synergistic Anticancer Effects in U87 Glioblastoma Cells: Defining the Proteome Accompanying Synergism.

9. Int J Mol Sci. 2026 Aug 31;27(17):7795. doi: 10.3390/ijms27177795. All-Trans Retinoic Acid and Curcumin Exhibit Hormesis or Synergistic Anticancer Effects in U87 Glioblastoma Cells: Defining the Proteome Accompanying Synergism. Sönmez C(1), Altinoz MA(1)(2), Baltacıoğlu A(1), Ergün B(1), Özpınar A(1)(3). Author information: (1)Department of Biochemistry and Molecular Biology, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Türkiye. (2)Department of Public Health, Kagithane District Health Directorate, Turkish Ministry of Health, Istanbul 34408, Türkiye. (3)Department of Medical Biochemistry, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Türkiye. Persistently poor glioblastoma (GBM) survival necessitates better elucidation of tumor drug responses. After observing that low curcumin and all-trans retinoic acid (ATRA) doses stimulated cell proliferation and counteracted each other's high-dose antiproliferative effects in U87 GBM cells, drug influences on cell growth, migration, and death and the antiproliferative interaction proteome were further studied. Cell proliferation and migration were assessed by xCELLigence Real-Time Cell Analysis (RTCA). Cell death was defined using flow cytometry. Drug interactions were determined with CompuSyn software (version 1.0). Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS), High-Performance Liquid Chromatography (HPLC), and SequestHT softw

Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF-β Axis Inhibition and Ferroptosis Induction.

10. Adv Healthc Mater. 2026 Sep 11:e71657. doi: 10.1002/adhm.71657. Online ahead of print. Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF-β Axis Inhibition and Ferroptosis Induction. Yang Y(1)(2), Mu M(3), Ren K(3), Liu H(3), Ma P(3), Wang Y(3), Zhang M(3), Xu X(4), Li W(5), Gao W(6), Sun X(3), Zhu Q(1)(2)(7). Author information: (1)Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Ji'nan, Shandong, China. (2)Department of Infectious Disease, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong, China. (3)Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong Cancer Hospital and Institute, Ji'nan, Shandong, China. (4)School of Science, Shandong Jianzhu University, Ji'nan, Shandong, China. (5)Central Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong, China. (6)Rehabilitation Center, Qilu Hospital of Shandong University, Ji'nan, Shandong, China. (7)The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. Liver fibrosis and its terminal stage, cirrhosis, represent a major cause of morbidity and mortality related to hepatic pathologies. Activated hepatic stellate cells (aHSCs) are the principal drivers of fibrogenesis and therefore constitute key therapeutic targets. Lanifibranor, a pan-peroxisome proliferator-activated receptor agon

Selenium in aging and longevity.

11. Biochimie. 2026 Sep 8:S0300-9084(26)00221-X. doi: 10.1016/j.biochi.2026.09.002. Online ahead of print. Selenium in aging and longevity. Pierce WG(1), Mackrill JJ(2). Author information: (1)Scientific Advisor at Eli Lilly and Company, Cork, Ireland. (2)Department of Physiology, School of Medicine, University College Cork, Ireland. Electronic address: j.mackrill@ucc.ie. Selenium is an essential dietary micronutrient, exerting beneficial effects over a limited range of concentrations. Insufficient dietary intake of selenium increases the risk of type 2 diabetes, infertility, immune dysfunction, prostate cancer, cognitive decline, prostate cancer, colorectal cancer in females, skeletal muscle disorders, overall mortality and an endemic cardiomyopathy known as Keshan disease. Excessive intake of selenium is toxic, leading to a condition termed selenosis, that is associated with damage to the nails, dermatitis, alopecia, central nervous system dysfunction and death. Selenium exerts its biological effects through low-molecular weight molecules, through a small family of selenoproteins which contain the 21st amino acid selenocysteine, and via selenium-binding proteins, in which an atom of selenium is covalently bound to a cysteine residue. In addition to being regulated by body selenium status, the abundance and function of these biomolecules can be controlled by other dietary components (including copper, zinc, folic acid, resveratrol, vitamin A and α-linolei

PML-driven sumoylation of PML::RARA-bound repressors drives hematopoietic progenitor immortalization.

12. J Exp Med. 2026 Sep 7;223(9):e20252333. doi: 10.1084/jem.20252333. Epub 2026 Aug 28. PML-driven sumoylation of PML::RARA-bound repressors drives hematopoietic progenitor immortalization. Wu HC(1)(2), Laplantine E(1)(2), Esnault C(1)(2), Niwa-Kawakita M(1)(2), Zhang Y(1)(2), De Almeida Bastos V(3), Geoffroy MC(#)(1)(2), de Thé H(#)(1)(2)(4). Author information: (1)Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, CIRB, Institut National de la Santé et de la Recherche Médicale UMR 1050, Centre National de la Recherche Scientifique UMR 7241 , Equipe Labellisée par la Ligue contre le Cancer, Paris, France. (2)Université Paris-Cité, Institut National de la Santé et de la Recherche Médicale U1342, Centre National de la Recherche Scientifique EMR8000, Institut de Recherche Saint-Louis, Hôpital Saint-Louis , Paris, France. (3)Sorbonne Université, UMS 37 PASS, P3S, Institut National de la Santé et de la Recherche Médicale , Paris, France. (4)Laboratoire d'hématologie Moléculaire, Assistance Publique-Hôpitaux de Paris, Hôpital St. Louis, Paris, France. (#)Contributed equally Erratum in J Exp Med. 2026 Oct 5;223(10):e2025233309092026c. doi: 10.1084/jem.2025233309092026c. While acute promyelocytic leukemia (APL) is always driven by fusions involving one of the three retinoic acid receptors, why PML and RARA are the preferred fusion partners has remained largely unsettled. Here, we demonstrate that corepressor (NCoR) binding onto the RARA m

Retinoic Acid Receptor γ Is a Ligand-Activated Gatekeeper to Stem Cell Developmental Progression.

13. Int J Mol Sci. 2026 Aug 11;27(16):7160. doi: 10.3390/ijms27167160. Retinoic Acid Receptor γ Is a Ligand-Activated Gatekeeper to Stem Cell Developmental Progression. Johnson WEB(1), McQueen C(2), Brown G(3). Author information: (1)Chester Medical School, University of Chester, Chester CH1 4B1, UK. (2)Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TL, UK. (3)Department of Biomedical Sciences, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. RARγ is expressed during embryogenesis by stem/primitive progenitor cells, indicating a role in controlling their development. Supporting this view is that a physiological level of 10 nM of the RARγ agonist AGN205327 blocked stem/progenitor cell differentiation during zebrafish embryogenesis, mouse gastruloid development, and adult chondro- and osteogenesis. Similarly, transgene expression of RARγ or the use of the RARγ agonist CD437 enhanced the generation of induced pluripotent stem cells (iPSCs) from human and mouse somatic cells. RARγ regulates many events that control the behavior of stem/progenitor cells regarding whether they develop to give rise to mature cells. RARγ positively regulates the expressions of NOTCH ligands and their receptors, transforming growth factors (TGFs), and molecules pertaining to cell identity, extracellular matrix communication, and all-trans retinoic acid synthes

All-trans retinoic acid suppresses CD8(+) T-cell terminal exhaustion and potentiates anti-PD-1 therapy in glioblastoma.

14. Signal Transduct Target Ther. 2026 Aug 26;11(1):348. doi: 10.1038/s41392-026-02852-9. All-trans retinoic acid suppresses CD8(+) T-cell terminal exhaustion and potentiates anti-PD-1 therapy in glioblastoma. Kang I(1)(2), Kim Y(1), Kang BH(1)(2), Kim HJ(1), Kim E(3), Kim CW(1), Kim HC(1), Park SH(1)(2), Park WH(1)(2), Im SH(1), Kim NE(1), Chang S(2), La J(2), Hwang I(2), Kim M(2), Ahn S(4), Lee SK(5), Chang JB(3), Lee HK(6)(7). Author information: (1)Laboratory of Host Defenses, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea. (2)Graduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea. (3)Department of Material Science and Engineering, KAIST, Daejeon, Republic of Korea. (4)Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. (5)Department of Obstetrics and Gynecology, College of Medicine, Myunggok Medical Research Center, Konyang University, Daejeon, Republic of Korea. (6)Laboratory of Host Defenses, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea. heungkyu.lee@kaist.ac.kr. (7)Regenerative Medical Research Institute (reMRI) for Aging-related Diseases, KAIST, Daejeon, Republic of Korea. heungkyu.lee@kaist.ac.kr. Terminal exhaustion of CD8⁺ T cells limits the efficacy of immune checkpoint blockade (ICB