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멜라토닌 서방형 (5mg)

Melatonin (5mg Extended-Release)

📑 PubMed 30편 🌙 수면·인지 🗓️ 최신 2026
🔬 메타분석 6 📋 체계적 리뷰 2 🧪 RCT 7

📖 핵심 요약

📖 30편 · 15분 읽기

멜라토닌 서방형 (5mg)은(는) 수면·인지 계열 보충제입니다. 주로 수면 분야에서 연구되었으며, PubMed에 30편의 관련 논문이 있습니다.

🔍 연구 분야별 근거

수면 논문 6편

* 제목에 해당 키워드가 포함된 논문 수 (PubMed 근거)

📊 효과 크기 분포 (Forest plot)

각 연구의 효과 추정치와 95% 신뢰구간. 개별 연구를 통합(pooling)하지 않고 그대로 표시합니다.

420230885.29 (3.01–7.57)417272061.87 (0.24–3.5)-1.108.7MD (favours ← / →)

📚 관련 논문 (30편) · 📊 정량 근거 5건

1.
📄 연구
A scoping review of neuroendocrinological biomarkers with potential for use in equine behavioral medicine practice.
BMC veterinary research 2026 PMID:42046067

1. BMC Vet Res. 2026 Apr 27. doi: 10.1186/s12917-026-05509-5. Online ahead of print. A scoping review of neuroendocrinological biomarkers with potential for use in equine behavioral medicine practice. Mendonça T(1)(2)(3), Ribeiro G(4)(5)(6), Casqueiro T(4), Prazeres J(4)(6), Mills DS(7). Autho

2.
🔬 메타분석
Sleep and endocrine effects of acupuncture for insomnia: a systematic review and meta-analysis of randomized controlled trials.
Frontiers in medicine 2026 PMID:42023088
📊 MD 5.29 (95% CI 3.01–7.57)

2. Front Med (Lausanne). 2026 Apr 7;13:1807826. doi: 10.3389/fmed.2026.1807826. eCollection 2026. Sleep and endocrine effects of acupuncture for insomnia: a systematic review and meta-analysis of randomized controlled trials. Hu Y(1), Liu Y(2), Li W(3), Wang Y(4). Author information: (1)Departm

3.
🔬 메타분석
Clinical and endocrine effects of pharmacological therapy in endometriosis: a systematic review and meta-analysis.
Frontiers in endocrinology 2026 PMID:41993993
📊 RR 0.51

3. Front Endocrinol (Lausanne). 2026 Apr 1;17:1792793. doi: 10.3389/fendo.2026.1792793. eCollection 2026. Clinical and endocrine effects of pharmacological therapy in endometriosis: a systematic review and meta-analysis. Sun R(1), Xu H(2), Ma R(3), Xu J(1), Liu Y(4), Mao D(1). Author informatio

4.
📄 연구
Melatonin treatment for neonatal encephalopathy.
The Cochrane database of systematic reviews 2026 PMID:41925053
📊 OR 0.39 (95% CI 0.06–2.37) · n=155

4. Cochrane Database Syst Rev. 2026 Apr 2;4(4):CD013754. doi: 10.1002/14651858.CD013754.pub2. Melatonin treatment for neonatal encephalopathy. Hurley T(1), O'Dea M(1), Aslam S(2), Stewart PA(1), Aly H(3), Cooper C(4)(5), Robertson NJ(6)(7), Molloy E(1)(8)(9)(10). Author information: (1)Discipli

5.
📋 체계적 리뷰
Interventions for Migraine and Sleep: A Systematic Review Exploring Their Bidirectional Association.
European journal of neurology 2026 PMID:41874004

5. Eur J Neurol. 2026 Mar;33(3):e70420. doi: 10.1111/ene.70420. Interventions for Migraine and Sleep: A Systematic Review Exploring Their Bidirectional Association. Sforza M(1)(2), Mariani I(2), Fazzini F(2), Genovese F(1)(3), Salibba A(1)(2), Filippi M(1)(3), Proserpio P(2), Galbiati A(1)(2), M

6.
🔬 메타분석
Do sleep interventions improve sleep in MS? A systematic review and meta-analysis of activity monitor assessed outcomes.
Multiple sclerosis and related disorders 2026 PMID:41861703

6. Mult Scler Relat Disord. 2026 May;109:107136. doi: 10.1016/j.msard.2026.107136. Epub 2026 Mar 11. Do sleep interventions improve sleep in MS? A systematic review and meta-analysis of activity monitor assessed outcomes. Jemere T(1), van der Mei I(2), Honan C(3), Taylor BV(2), Campbell JA(2), B

7.
🔬 메타분석
Timing-dependent effects of melatonin supplementation on exercise performance and exercise-induced muscle damage: a systematic review and meta-analysis.
Frontiers in nutrition 2026 PMID:41769636
📊 SMD 0.29 (95% CI 0.05–0.53) · n=266

7. Front Nutr. 2026 Feb 13;13:1742464. doi: 10.3389/fnut.2026.1742464. eCollection 2026. Timing-dependent effects of melatonin supplementation on exercise performance and exercise-induced muscle damage: a systematic review and meta-analysis. Guo J(#)(1)(2), Zhou L(1), Gu J(#)(3), Sun J(2), Liu G

8.
📄 연구
[The importance of a DLMO-measurement when starting and stopping melatonin in minors].
Tijdschrift voor psychiatrie 2026 PMID:41733025

8. Tijdschr Psychiatr. 2026;68(2):70-74. [The importance of a DLMO-measurement when starting and stopping melatonin in minors]. [Article in Dutch] Baens M, Danckaerts M. BACKGROUND: Melatonin is used as a chronobiotic in the treatment of sleeping disorders to correct disturbances in the circad

9.
🔬 메타분석
The effect of melatonin supplementation on lipid profile, oxidative stress, inflammatory marker, and sleep quality in patients with chronic kidney disease: a GRADE assessed meta-analysis.
Frontiers in nutrition 2026 PMID:41727206
📊 MD 1.87 (95% CI 0.24–3.5)

9. Front Nutr. 2026 Feb 6;13:1772877. doi: 10.3389/fnut.2026.1772877. eCollection 2026. The effect of melatonin supplementation on lipid profile, oxidative stress, inflammatory marker, and sleep quality in patients with chronic kidney disease: a GRADE assessed meta-analysis. Abuhassan Q(1), Ghn

10.
📋 체계적 리뷰
Circadian Dysfunction in Delirium: A Systematic Review.
Journal of the Academy of Consultation-Liaison Psychiatry 2026 PMID:41724386

10. J Acad Consult Liaison Psychiatry. 2026 Mar-Apr;67(2):114-131. doi: 10.1016/j.jaclp.2026.02.002. Epub 2026 Feb 20. Circadian Dysfunction in Delirium: A Systematic Review. Black JR(1), Landrum RE(2), O'Hagan E(3), Fipps DC(4). Author information: (1)Department of Psychiatry and Behavioral Neu

11.
📄 연구
Melatonin effects on the left ventricular function in neonates with persistent pulmonary hypertension.
European journal of pediatrics 2026 PMID:41954764

11. Eur J Pediatr. 2026 Apr 9;185(5):247. doi: 10.1007/s00431-026-06864-z. Melatonin effects on the left ventricular function in neonates with persistent pulmonary hypertension. Nofal SM(1), El-Mashad AM(1), Elmesiry AM(2), Abouelenain AM(3), Awny MM(1). Author information: (1)Pediatric and Neon

12.
🧪 RCT
Role of melatonin for prevention of necrotizing enterocolitis in preterm infants: a randomized controlled trial.
Journal of tropical pediatrics 2026 PMID:41847903

12. J Trop Pediatr. 2026 Feb 9;72(2):fmag020. doi: 10.1093/tropej/fmag020. Role of melatonin for prevention of necrotizing enterocolitis in preterm infants: a randomized controlled trial. Shaaban HA(1), Awad HA(1), El-Farghali OG(1), El-Gammall MM(1), Shaaban MAA(2). Author information: (1)Pedia

13.
🧪 RCT
Low-Dose Melatonin, Climacteric Symptoms and Sleep in Female Shift Workers: A Randomized Controlled Trial.
Journal of pineal research 2026 PMID:41841489

13. J Pineal Res. 2026 Mar;78(2):e70140. doi: 10.1111/jpi.70140. Low-Dose Melatonin, Climacteric Symptoms and Sleep in Female Shift Workers: A Randomized Controlled Trial. Saraiva SP(1), D'Aurea CVR(2), Luz CSS(1), Amaral FG(3), Cipolla-Neto J(3), Marqueze EC(4), Moreno CRC(1). Author informati

14.
📄 연구
Trial of Edaravone for severe hypoxic ischemic encephalopathy in adults: a double-blind placebo-controlled study.
Journal of neurology 2026 PMID:41832246

14. J Neurol. 2026 Mar 14;273(3):207. doi: 10.1007/s00415-026-13723-2. Trial of Edaravone for severe hypoxic ischemic encephalopathy in adults: a double-blind placebo-controlled study. Razmeh S(1), Karimi AA(2), Dashti AM(3), Vafapour F(4), Mousavizadeh A(5). Author information: (1)Neurology Dep

15.
📄 연구
Acute Effects of Different Melatonin Doses on Performance and Psychophysiological Responses During Exhaustive Cycling Exercise: A Double-Blind Crossover Study.
Nutrients 2026 PMID:41829968

15. Nutrients. 2026 Feb 28;18(5):798. doi: 10.3390/nu18050798. Acute Effects of Different Melatonin Doses on Performance and Psychophysiological Responses During Exhaustive Cycling Exercise: A Double-Blind Crossover Study. Pedroso LC(1), Reis MCD(1), Bertolucci V(1), Silva LA(1), Reis IGMD(1), B

16.
🧪 RCT
Effects of bright light and near-infrared light on insomnia symptoms in community-dwelling older adults: a randomized clinical trial.
Photodiagnosis and photodynamic therapy 2026 PMID:41794313

19. Photodiagnosis Photodyn Ther. 2026 Apr;58:105425. doi: 10.1016/j.pdpdt.2026.105425. Epub 2026 Mar 5. Effects of bright light and near-infrared light on insomnia symptoms in community-dwelling older adults: a randomized clinical trial. Chen PY(1), Chen ST(2), Chen YL(1), Yang YC(1), Cheng WJ(

17.
🧪 RCT
Melatonin Supplementation in Adult Patients With Atopic Dermatitis: A Randomized Clinical Trial.
Journal of pineal research 2026 PMID:41787942

22. J Pineal Res. 2026 Mar;78(2):e70130. doi: 10.1111/jpi.70130. Melatonin Supplementation in Adult Patients With Atopic Dermatitis: A Randomized Clinical Trial. Heidari Z(1), Gharibi G(2), Alaeen H(3)(4), Ghadrdan E(2), Shahrestanaki E(5), Sadeghi-Ghadi Z(6)(7), Sahebkar A(8)(9)(10), Daei M(2).

18.
🧪 RCT
The impact of timing on bright light therapy: Alleviating anhedonia and circadian rhythm disturbances in depression patients: a randomized controlled trial.
Journal of affective disorders 2026 PMID:41785919

23. J Affect Disord. 2026 Jul 15;405:121564. doi: 10.1016/j.jad.2026.121564. Epub 2026 Mar 3. The impact of timing on bright light therapy: Alleviating anhedonia and circadian rhythm disturbances in depression patients: a randomized controlled trial. Li X(1), Qin X(2), Fang J(3), Hu Q(3), Yu J(

19.
🧪 RCT
Does melatonin gel improve alveolar preservation? A triple-blind randomized controlled clinical trial.
Journal of applied biomaterials & functional materials 2026 PMID:41721699

32. J Appl Biomater Funct Mater. 2026 Jan-Dec;24:22808000261422958. doi: 10.1177/22808000261422958. Epub 2026 Feb 21. Does melatonin gel improve alveolar preservation? A triple-blind randomized controlled clinical trial. Chaves Cavalcante Kischinhevsky I(1)(2), Alves ATNN(3), Santos CMSFFD(4), B

20.
🧪 RCT
Hepatic Safety of Adjunctive High-Dose Melatonin in Participants Receiving Ocrelizumab for Primary Progressive Multiple Sclerosis: Liver Toxicity Findings from a Phase I/II Randomised Clinical Trial (MELATOMS-1).
CNS drugs 2026 PMID:41706381

1. CNS Drugs. 2026 Apr;40(4):579-596. doi: 10.1007/s40263-025-01261-w. Epub 2026 Feb 18. Hepatic Safety of Adjunctive High-Dose Melatonin in Participants Receiving Ocrelizumab for Primary Progressive Multiple Sclerosis: Liver Toxicity Findings from a Phase I/II Randomised Clinical Trial (MELATOM

21.
📄 연구
Non-Mineral Antioxidant Supplementation in Endometriosis: Biological Rationale, Clinical Evidence, and Therapeutic Implications-A Narrative Review.
Nutrients 2026 PMID:42074994

36. Nutrients. 2026 Apr 9;18(8):1182. doi: 10.3390/nu18081182. Non-Mineral Antioxidant Supplementation in Endometriosis: Biological Rationale, Clinical Evidence, and Therapeutic Implications-A Narrative Review. Pokorska-Niewiada K(1), Janda-Milczarek K(2), Kayumov K(3), Ziętek M(4), Szczuko M(5)

22.
📄 연구
Thermoregulation in Sleep Disorders-Comprehensive Review.
Journal of clinical medicine 2026 PMID:42074731

16. J Clin Med. 2026 Apr 12;15(8):2929. doi: 10.3390/jcm15082929. Thermoregulation in Sleep Disorders-Comprehensive Review. Pierzchała K(1), Bielska W(1), Boczar Z(1), Zawadzka A(1), Okrąglewska A(1), Strzemińska M(1), Białasiewicz P(1), Kuczyński W(1). Author information: (1)Department of Sleep

23.
📄 연구
Melatonergic Receptors Mediate Reduction in Ethanol Consumption in Wistar Rats.
Biomolecules 2026 PMID:42072636

15. Biomolecules. 2026 Mar 31;16(4):514. doi: 10.3390/biom16040514. Melatonergic Receptors Mediate Reduction in Ethanol Consumption in Wistar Rats. Rather ZA(1), Ullal SD(2), Baregundi MY(3), Shenoy AK(2). Author information: (1)Department of Pharmacology, Government Medical College, Handwara 193

24.
📄 연구
Melatonin Attenuates H(2)O(2)-Induced Oxidative Stress by Restoring Redox Balance, Mitochondrial Integrity and Reducing Apoptosis in Buffalo Fibroblasts.
Antioxidants (Basel, Switzerland) 2026 PMID:42072150

10. Antioxidants (Basel). 2026 Apr 20;15(4):508. doi: 10.3390/antiox15040508. Melatonin Attenuates H(2)O(2)-Induced Oxidative Stress by Restoring Redox Balance, Mitochondrial Integrity and Reducing Apoptosis in Buffalo Fibroblasts. Dahiya P(1), Mangal M(1), Bhatia S(1), Sharma N(1), Sindhu A(1),

25.
📄 연구
Melatonin May Improve Post-Thaw Sperm Motility in Epinephelus fuscoguttatus by Potentially Regulating Mitochondrial mPTP via the MT2/PI3K/GSK-3β Pathway: First Evidence in Teleosts.
Antioxidants (Basel, Switzerland) 2026 PMID:42072064

6. Antioxidants (Basel). 2026 Mar 27;15(4):422. doi: 10.3390/antiox15040422. Melatonin May Improve Post-Thaw Sperm Motility in Epinephelus fuscoguttatus by Potentially Regulating Mitochondrial mPTP via the MT2/PI3K/GSK-3β Pathway: First Evidence in Teleosts. Zhang Y(1), Ruan Q(1), Zhang W(1), Wu

26.
📄 연구
The Effects of a Mixture of Monochromatic Green and Blue Light on Growth Performance and Immune Response in Bursa of Fabricius by Morphometry Using Staining and Immunohistochemistry in Broiler Chickens.
Animals : an open access journal from MDPI 2026 PMID:42072004

6. Animals (Basel). 2026 Apr 17;16(8):1238. doi: 10.3390/ani16081238. The Effects of a Mixture of Monochromatic Green and Blue Light on Growth Performance and Immune Response in Bursa of Fabricius by Morphometry Using Staining and Immunohistochemistry in Broiler Chickens. Horodincu L(1), Cotrutz

27.
🔬 메타분석
Melatonin supplementation improves insulin resistance markers but not fasting glucose: a systematic review and meta-analysis of randomized controlled trials.
Diabetes research and clinical practice 2026 PMID:42070664

36. Diabetes Res Clin Pract. 2026 May 1:113290. doi: 10.1016/j.diabres.2026.113290. Online ahead of print. Melatonin supplementation improves insulin resistance markers but not fasting glucose: a systematic review and meta-analysis of randomized controlled trials. Turci Dias GZ(1), Latari Tessar

28.
📄 연구
Design of experiments and bioanalytical LC-MS/MS method for analysis of melatonin and tasimelteon in rat brain homogenate with whiteness assessment.
BMC chemistry 2026 PMID:42069649

34. BMC Chem. 2026 May 2. doi: 10.1186/s13065-026-01808-y. Online ahead of print. Design of experiments and bioanalytical LC-MS/MS method for analysis of melatonin and tasimelteon in rat brain homogenate with whiteness assessment. Levent S(1)(2), Elriş A(3), Avcı H(4)(5)(3), Özcan S(4)(5), Can NÖ

29.
📄 연구
Multi-omics analysis reveals circadian disruption of rumen microbiota and serum metabolites in Tibetan sheep under transport stress.
BMC microbiology 2026 PMID:42069543

23. BMC Microbiol. 2026 May 2. doi: 10.1186/s12866-026-05109-1. Online ahead of print. Multi-omics analysis reveals circadian disruption of rumen microbiota and serum metabolites in Tibetan sheep under transport stress. Tang W(#)(1), Wang P(#)(1), Jiang T(1), Chen N(1), Xue M(1), Chen Y(1), Pang

30.
📄 연구
Seed priming with melatonin enhances salt stress tolerance in triticale through coordinated regulation of antioxidant defense, osmotic homeostasis, and phytohormone signaling.
BMC plant biology 2026 PMID:42067801

21. BMC Plant Biol. 2026 May 1. doi: 10.1186/s12870-026-08867-2. Online ahead of print. Seed priming with melatonin enhances salt stress tolerance in triticale through coordinated regulation of antioxidant defense, osmotic homeostasis, and phytohormone signaling. Lu Y(#)(1), Zhu L(#)(1), Sun H(

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