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칼슘+비타민D

Calcium + Vitamin D

📑 PubMed 30편 🦴 관절·뼈 🗓️ 최신 2026
🔬 메타분석 10 📋 체계적 리뷰 1 🧪 RCT 6

📖 핵심 요약

📖 30편 · 15분 읽기

칼슘+비타민D은(는) 관절·뼈 계열 보충제입니다. 주로 항암, 뼈 건강 분야에서 연구되었으며, PubMed에 30편의 관련 논문이 있습니다.

🔍 연구 분야별 근거

항암 논문 4편
뼈 건강 논문 7편

* 제목에 해당 키워드가 포함된 논문 수 (PubMed 근거)

💊⚠️ 약물 상호작용 (1)

아래 약을 복용 중이라면 이 보충제 병용 전 반드시 의사·약사와 상의하세요.

Levothyroxine ⚠️ 보통

영향: 갑상선약 흡수율 감소 → TSH 상승

대처: 4시간 이상 간격으로 복용

📊 효과 크기 분포 (Forest plot)

각 연구의 효과 추정치와 95% 신뢰구간. 개별 연구를 통합(pooling)하지 않고 그대로 표시합니다.

376025800.95 (0.65–1.06)370272860.63 (0.43–0.92)318780191.07 (0.46–2.52)0.215RR (favours ← / →)

📚 관련 논문 (30편) · 📊 정량 근거 6건

1.
🔬 메타분석
Effects of Combined Exercise and Calcium/Vitamin D Supplementation on Bone Mineral Density in Postmenopausal Women: A Systematic Review and Meta-Analysis.
Nutrients 2025 PMID:41470812
📊 SMD 0.31 (95% CI 0.06–0.55)

1. Nutrients. 2025 Dec 11;17(24):3866. doi: 10.3390/nu17243866. Effects of Combined Exercise and Calcium/Vitamin D Supplementation on Bone Mineral Density in Postmenopausal Women: A Systematic Review and Meta-Analysis. Bai J(1), Huang W(2), Yan R(3), Du X(2). Author information: (1)School of Nur

2.
🔬 메타분석
Risk factors for osteoporosis in rheumatoid arthritis patients: a meta-analysis.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2026 PMID:41188646
📊 OR 2.1

2. Osteoporos Int. 2026 Feb;37(2):305-318. doi: 10.1007/s00198-025-07700-0. Epub 2025 Nov 4. Risk factors for osteoporosis in rheumatoid arthritis patients: a meta-analysis. Fu T(1), Zhang R(1), Yue L(2), Yi X(2), Cai Y(3). Author information: (1)First Clinical Academy, Shandong University of Tr

3.
🔬 메타분석
Clinical presentation, risk factors and management of pregnancy-associated osteoporosis: a systematic review and meta-analysis.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2025 PMID:40205203

3. Osteoporos Int. 2025 Jun;36(6):981-993. doi: 10.1007/s00198-025-07479-0. Epub 2025 Apr 9. Clinical presentation, risk factors and management of pregnancy-associated osteoporosis: a systematic review and meta-analysis. Orhadje E(1), Makaram N(1), Berg K(1), Hauser B(1)(2), Ralston SH(3)(4). A

4.
🔬 메타분석
Role of calcium &/or vitamin D supplementation in preventing osteoporotic fracture in the elderly: A systematic review & meta-analysis.
The Indian journal of medical research 2023 PMID:37602580
📊 RR 0.95 (95% CI 0.65–1.06)

4. Indian J Med Res. 2023 Jan;158(1):5-16. doi: 10.4103/ijmr.ijmr_1946_21. Role of calcium &/or vitamin D supplementation in preventing osteoporotic fracture in the elderly: A systematic review & meta-analysis. Khatri K(1), Kaur M(2), Dhir T(3), Kankaria A(4), Arora H(5). Author information: (1)

5.
🔬 메타분석
Chemoprevention of colorectal cancer in general population and high-risk population: a systematic review and network meta-analysis.
Chinese medical journal 2023 PMID:37027286
📊 RR 0.63 (95% CI 0.43–0.92) · n=694

5. Chin Med J (Engl). 2023 Apr 5;136(7):788-798. doi: 10.1097/CM9.0000000000002514. Chemoprevention of colorectal cancer in general population and high-risk population: a systematic review and network meta-analysis. Ma Y(1)(2), You W(1)(2), Cao Y(1)(2), He X(1)(2), Wang J(1)(2), Zhang Y(3), Li J

6.
🔬 메타분석
The Effects of Milk Supplementation on Bone Health Indices in Adults: A Meta-Analysis of Randomized Controlled Trials.
Advances in nutrition (Bethesda, Md.) 2022 PMID:34792092

6. Adv Nutr. 2022 Aug 1;13(4):1186-1199. doi: 10.1093/advances/nmab136. The Effects of Milk Supplementation on Bone Health Indices in Adults: A Meta-Analysis of Randomized Controlled Trials. Hidayat K(1), Chen JS(1), Wang TC(1), Liu YJ(1), Shi YJ(2), Su HW(2), Liu B(2), Qin LQ(1). Author inform

7.
🔬 메타분석
Impact of magnesium on bone health in older adults: A systematic review and meta-analysis.
Bone 2022 PMID:34666201

7. Bone. 2022 Jan;154:116233. doi: 10.1016/j.bone.2021.116233. Epub 2021 Oct 16. Impact of magnesium on bone health in older adults: A systematic review and meta-analysis. Groenendijk I(1), van Delft M(2), Versloot P(2), van Loon LJC(3), de Groot LCPGM(2). Author information: (1)Division of Hum

8.
🔬 메타분석
Effects of Preventive Nutrition Interventions among Adolescents on Health and Nutritional Status in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis.
Nutrients 2019 PMID:31878019
📊 RR 1.07 (95% CI 0.46–2.52) · n=802

8. Nutrients. 2019 Dec 23;12(1):49. doi: 10.3390/nu12010049. Effects of Preventive Nutrition Interventions among Adolescents on Health and Nutritional Status in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis. Salam RA(1), Das JK(1), Ahmed W(1), Irfan O(2), Sheikh SS(1),

9.
🔬 메타분석
Comparison of fracture risk using different supplemental doses of vitamin D, calcium or their combination: a network meta-analysis of randomised controlled trials.
BMJ open 2019 PMID:31619412

9. BMJ Open. 2019 Oct 16;9(10):e024595. doi: 10.1136/bmjopen-2018-024595. Comparison of fracture risk using different supplemental doses of vitamin D, calcium or their combination: a network meta-analysis of randomised controlled trials. Hu ZC(1)(2)(3), Tang Q(4)(2)(3), Sang CM(5), Tang L(4)(2)(

10.
🔬 메타분석
Effect of Calcium‑Vitamin D Co‑Supplementation on Insulin, Insulin Sensitivity, and Glycemia: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2019 PMID:31071733

10. Horm Metab Res. 2019 May;51(5):288-295. doi: 10.1055/a-0887-0205. Epub 2019 May 9. Effect of Calcium‑Vitamin D Co‑Supplementation on Insulin, Insulin Sensitivity, and Glycemia: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Asbaghi O(1), Khosroshahi MZ(1), Kashkooli S(

11.
🧪 RCT
Weighted Vest Use or Resistance Exercise to Offset Weight Loss-Associated Bone Loss in Older Adults: A Randomized Clinical Trial.
JAMA network open 2025 PMID:40540267

11. JAMA Netw Open. 2025 Jun 2;8(6):e2516772. doi: 10.1001/jamanetworkopen.2025.16772. Weighted Vest Use or Resistance Exercise to Offset Weight Loss-Associated Bone Loss in Older Adults: A Randomized Clinical Trial. Beavers KM(1)(2), Lynch SD(3), Fanning J(2), Howard M(4), Lawrence E(1), Lenchi

12.
🧪 RCT
Obesity and Metabolic Disease Impair the Anabolic Response to Protein Supplementation and Resistance Exercise: A Retrospective Analysis of a Randomized Clinical Trial with Implications for Aging, Sarcopenic Obesity, and Weight Management.
Nutrients 2024 PMID:39771028

12. Nutrients. 2024 Dec 23;16(24):4407. doi: 10.3390/nu16244407. Obesity and Metabolic Disease Impair the Anabolic Response to Protein Supplementation and Resistance Exercise: A Retrospective Analysis of a Randomized Clinical Trial with Implications for Aging, Sarcopenic Obesity, and Weight Mana

13.
📄 연구
Association of standardized serum 25-hydroxyvitamin D with falls in post-menopausal women.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2025 PMID:39585370
📊 OR 1.99

13. Osteoporos Int. 2025 Feb;36(2):255-264. doi: 10.1007/s00198-024-07310-2. Epub 2024 Nov 25. Association of standardized serum 25-hydroxyvitamin D with falls in post-menopausal women. Binkley N(1), Sempos CT(2), Borchardt G(3), Larsen J(4), Stacey ML(4), Mosiman S(5), Lappe JM(4). Author inf

14.
📄 연구
One versus 2 years of alendronate following denosumab: the CARD extension.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2024 PMID:39112628

14. Osteoporos Int. 2024 Dec;35(12):2225-2230. doi: 10.1007/s00198-024-07213-2. Epub 2024 Aug 7. One versus 2 years of alendronate following denosumab: the CARD extension. Tsai JN(1), Jordan M(2), Lee H(3), Leder BZ(2). Author information: (1)Department of Medicine, Endocrine Unit, Massachusetts

15.
🧪 RCT
Beneficial effects of exercise, testosterone, vitamin D, calcium and protein in older men-A randomized clinical trial.
Journal of cachexia, sarcopenia and muscle 2024 PMID:38890228

15. J Cachexia Sarcopenia Muscle. 2024 Aug;15(4):1451-1462. doi: 10.1002/jcsm.13498. Epub 2024 Jun 18. Beneficial effects of exercise, testosterone, vitamin D, calcium and protein in older men-A randomized clinical trial. Midttun M(1), Overgaard K(2), Zerahn B(3), Pedersen M(3), Rashid A(3), Øst

16.
📄 연구
Genistein supplementation has no effects on vitamin D levels in healthy Spanish postmenopausal women.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 2024 PMID:36919425

41. Int J Vitam Nutr Res. 2024 Jun;94(3-4):171-176. doi: 10.1024/0300-9831/a000781. Epub 2023 Mar 15. Genistein supplementation has no effects on vitamin D levels in healthy Spanish postmenopausal women. Pérez-Alonso M(1), Calero-Paniagua I(2), Usategui-Martin R(3), Briongos LS(4), Ruiz-Mambril

17.
📄 연구
Association of calcium and vitamin D supplementation with cancer incidence and cause-specific mortality in Black women: Extended follow-up of the Women's Health Initiative calcium-vitamin D trial.
International journal of cancer 2023 PMID:36650676

11. Int J Cancer. 2023 Sep 1;153(5):1035-1042. doi: 10.1002/ijc.34436. Epub 2023 Feb 3. Association of calcium and vitamin D supplementation with cancer incidence and cause-specific mortality in Black women: Extended follow-up of the Women's Health Initiative calcium-vitamin D trial. Kato I(1)(

18.
📄 연구
A smartphone application to improve adherence to vitamin and mineral supplementation after bariatric surgery.
Obesity (Silver Spring, Md.) 2022 PMID:36050801

30. Obesity (Silver Spring). 2022 Oct;30(10):1973-1982. doi: 10.1002/oby.23536. Epub 2022 Sep 1. A smartphone application to improve adherence to vitamin and mineral supplementation after bariatric surgery. Spetz K(1), Hult M(2), Olbers T(1), Bonn S(3), Svedjeholm S(1), Lagerros YT(4), Andersso

19.
🧪 RCT
RadBone: bone toxicity following pelvic radiotherapy - a prospective randomised controlled feasibility study evaluating a musculoskeletal health package in women with gynaecological cancers undergoing pelvic radiotherapy.
BMJ open 2022 PMID:35701060

33. BMJ Open. 2022 Jun 14;12(6):e056600. doi: 10.1136/bmjopen-2021-056600. RadBone: bone toxicity following pelvic radiotherapy - a prospective randomised controlled feasibility study evaluating a musculoskeletal health package in women with gynaecological cancers undergoing pelvic radiotherapy.

20.
📄 연구
The effect of calcium and vitamin D supplements on blood pressure in postmenopausal women: myth or reality?
Hypertension research : official journal of the Japanese Society of Hypertension 2022 PMID:35562420

27. Hypertens Res. 2022 Jul;45(7):1203-1209. doi: 10.1038/s41440-022-00930-3. Epub 2022 May 13. The effect of calcium and vitamin D supplements on blood pressure in postmenopausal women: myth or reality? Sharifi F(1), Heydarzadeh R(2), Vafa RG(2), Rahmani M(2), Parizi MM(2), Ahmadi A(2), Zamiri

21.
📋 체계적 리뷰
[Systematic Review of Case Reports on the Adverse Events Due to Health Food Intake by Cancer Patients].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2019 PMID:31582619

32. Yakugaku Zasshi. 2019;139(10):1333-1347. doi: 10.1248/yakushi.19-00116. [Systematic Review of Case Reports on the Adverse Events Due to Health Food Intake by Cancer Patients]. [Article in Japanese] Kojima A(1), Sato Y(1), Nishijima C(1), Umegaki K(2), Chiba T(1). Author information: (1)Nati

22.
🧪 RCT
Effects of Calcium, Vitamin D, and Hormone Therapy on Cardiovascular Disease Risk Factors in the Women's Health Initiative: A Randomized Controlled Trial.
Obstetrics and gynecology 2017 PMID:27926633

9. Obstet Gynecol. 2017 Jan;129(1):121-129. doi: 10.1097/AOG.0000000000001774. Effects of Calcium, Vitamin D, and Hormone Therapy on Cardiovascular Disease Risk Factors in the Women's Health Initiative: A Randomized Controlled Trial. Schnatz PF(1), Jiang X, Aragaki AK, Nudy M, O'Sullivan DM, Will

23.
📄 연구
Drug-related problems identification in general internal medicine: The impact and role of the clinical pharmacist and pharmacologist.
European journal of internal medicine 2015 PMID:26066400

48. Eur J Intern Med. 2015 Jul;26(6):399-406. doi: 10.1016/j.ejim.2015.05.012. Epub 2015 Jun 9. Drug-related problems identification in general internal medicine: The impact and role of the clinical pharmacist and pharmacologist. Guignard B(1), Bonnabry P(2), Perrier A(3), Dayer P(4), Desmeules

24.
📄 연구
The effect of calcium and vitamin D supplementation on osteoporotic rabbit bones studied by vibrational spectroscopy.
Journal of biological physics 2014 PMID:25005753

27. J Biol Phys. 2014 Sep;40(4):401-12. doi: 10.1007/s10867-014-9358-8. Epub 2014 Jul 9. The effect of calcium and vitamin D supplementation on osteoporotic rabbit bones studied by vibrational spectroscopy. Lani A(1), Kourkoumelis N, Baliouskas G, Tzaphlidou M. Author information: (1)Department

25.
🧪 RCT
Independent and combined effects of calcium-vitamin D3 and exercise on bone structure and strength in older men: an 18-month factorial design randomized controlled trial.
The Journal of clinical endocrinology and metabolism 2011 PMID:21209030

18. J Clin Endocrinol Metab. 2011 Apr;96(4):955-63. doi: 10.1210/jc.2010-2284. Epub 2011 Jan 5. Independent and combined effects of calcium-vitamin D3 and exercise on bone structure and strength in older men: an 18-month factorial design randomized controlled trial. Kukuljan S(1), Nowson CA, Sa

26.
📄 연구
Ask the doctor. Since having a heart attack, I have been taking lisinopril, Zocor, Plavix, aspirin, a multivitamin, fish oil, calcium, vitamin D, coenzyme Q(10), chia oil, B-50 complex, grape seed extract, Nu-Zymes, Natural Energy supplement, Super C22 and astragalus. I am thinking of taking a brain booster called Procera AVH. Will it interfere with my heart medications?
Harvard heart letter : from Harvard Medical School 2009 PMID:19685568

47. Harv Heart Lett. 2009 Jun;19(10):8. Ask the doctor. Since having a heart attack, I have been taking lisinopril, Zocor, Plavix, aspirin, a multivitamin, fish oil, calcium, vitamin D, coenzyme Q(10), chia oil, B-50 complex, grape seed extract, Nu-Zymes, Natural Energy supplement, Super C22 and

27.
📄 연구
Supplementation with calcium + vitamin D enhances the beneficial effect of weight loss on plasma lipid and lipoprotein concentrations.
The American journal of clinical nutrition 2007 PMID:17209177

27. Am J Clin Nutr. 2007 Jan;85(1):54-9. doi: 10.1093/ajcn/85.1.54. Supplementation with calcium + vitamin D enhances the beneficial effect of weight loss on plasma lipid and lipoprotein concentrations. Major GC(1), Alarie F, Doré J, Phouttama S, Tremblay A. Author information: (1)Division of Ki

28.
📄 연구
[Osteoporosis--treatment with Calcium/Vitamin D].
Zeitschrift fur Orthopadie und ihre Grenzgebiete 2005 PMID:15977113

12. Z Orthop Ihre Grenzgeb. 2005 May-Jun;143(3):278. doi: 10.1055/s-2005-871821. [Osteoporosis--treatment with Calcium/Vitamin D]. [Article in German] [No authors listed] DOI: 10.1055/s-2005-871821 PMID: 15977113 [Indexed for MEDLINE]

29.
📄 연구
Hazards of treating osteoporosis and hypertension concurrently with calcium, vitamin D, and distal diuretics.
Journal of the American Geriatrics Society 1984 PMID:6715769

40. J Am Geriatr Soc. 1984 May;32(5):405-7. doi: 10.1111/j.1532-5415.1984.tb02050.x. Hazards of treating osteoporosis and hypertension concurrently with calcium, vitamin D, and distal diuretics. Drinka PJ, Nolten WE. DOI: 10.1111/j.1532-5415.1984.tb02050.x PMID: 6715769 [Indexed for MEDLINE]

30.
📄 연구
[Studies on calcium absorption out of a calcium-vitamin-D-preparation using calcium-47 (author's transl)].
Medizinische Klinik 1976 PMID:958108

11. Med Klin. 1976 Sep 3;71(36):1439-43. [Studies on calcium absorption out of a calcium-vitamin-D-preparation using calcium-47 (author's transl)]. [Article in German] Seim KE, Sattler EL. Calcium absorption in man was studied by means of labelling an ampoule of Frubiase Calcium forte with cal

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