← 전체 보충제 목록

신바이오틱스 (유산균 + 프리)

Synbiotic (Pro + Pre)

📑 PubMed 21편 🦠 프로바이오틱스 🗓️ 최신 2026
🔬 메타분석 10 📋 체계적 리뷰 4 🧪 RCT 4

📖 핵심 요약

📖 21편 · 11분 읽기

신바이오틱스 (유산균 + 프리)은(는) 프로바이오틱스 계열 보충제입니다. 주로 체중 관리, 장 건강 분야에서 연구되었으며, PubMed에 21편의 관련 논문이 있습니다.

🔍 연구 분야별 근거

체중 관리 논문 1편
장 건강 논문 4편

* 제목에 해당 키워드가 포함된 논문 수 (PubMed 근거)

📊 효과 크기 분포 (Forest plot)

각 연구의 효과 추정치와 95% 신뢰구간. 개별 연구를 통합(pooling)하지 않고 그대로 표시합니다.

40987620-0.25 (-1.96–1.47)400118390.33 (0.11–0.55)403119220.04 (-0.31–0.4)-2.502MD (favours ← / →)

📚 관련 논문 (21편) · 📊 정량 근거 5건

1.
🔬 메타분석
Effect of host and gut microbiota-altering interventions on sarcopenia or its defining parameters: a systematic review and meta-analysis of nutrition-based intervention studies.
Aging clinical and experimental research 2025 PMID:41269489

1. Aging Clin Exp Res. 2025 Nov 21;38(1):17. doi: 10.1007/s40520-025-03216-z. Effect of host and gut microbiota-altering interventions on sarcopenia or its defining parameters: a systematic review and meta-analysis of nutrition-based intervention studies. Lapauw L(1), Amini N(2), Switsers E(3),

2.
🔬 메타분석
Can pre-/pro and synbiotics affect cardiovascular risk factors in children and adolescence with overweight and obesity? A grade-assessed systematic review and meta-analysis of randomized controlled trials.
Obesity research & clinical practice 2025 PMID:40987620
📊 MD -0.25 (95% CI -1.96–1.47)

2. Obes Res Clin Pract. 2025 Sep-Oct;19(5):367-379. doi: 10.1016/j.orcp.2025.08.010. Epub 2025 Sep 23. Can pre-/pro and synbiotics affect cardiovascular risk factors in children and adolescence with overweight and obesity? A grade-assessed systematic review and meta-analysis of randomized contro

3.
🔬 메타분석
Systematic review and meta-analysis of randomized controlled trials on pre-, pro-, post- and synbiotic supplementation in follow-on formula.
Clinical nutrition (Edinburgh, Scotland) 2025 PMID:40541131

3. Clin Nutr. 2025 Aug;51:101-114. doi: 10.1016/j.clnu.2025.05.022. Epub 2025 Jun 6. Systematic review and meta-analysis of randomized controlled trials on pre-, pro-, post- and synbiotic supplementation in follow-on formula. Delcourt H(1), Verbrugghe L(1), Vandenplas Y(1), Huysentruyt K(2). Au

4.
🔬 메타분석
Efficacy of prebiotic, probiotic and synbiotic administration in improving growth in children aged 0-59 months living in low- and middle-income countries: a systematic review and meta-analysis.
BMC pediatrics 2025 PMID:40011839
📊 MD 0.33 (95% CI 0.11–0.55) · n=991

4. BMC Pediatr. 2025 Feb 27;25(1):149. doi: 10.1186/s12887-025-05503-0. Efficacy of prebiotic, probiotic and synbiotic administration in improving growth in children aged 0-59 months living in low- and middle-income countries: a systematic review and meta-analysis. Khouma M(1), Diallo M(#)(2), S

5.
🔬 메타분석
Effect of Pro-, Pre- and Synbiotic Supplementation on the Growth of Infants and Children: An Umbrella Systematic Review and Meta-Analysis.
Journal of paediatrics and child health 2025 PMID:39949153
📊 SMD 0.17 (95% CI 0.09–0.25) · n=285

5. J Paediatr Child Health. 2025 Mar;61(3):354-368. doi: 10.1111/jpc.16789. Epub 2025 Feb 13. Effect of Pro-, Pre- and Synbiotic Supplementation on the Growth of Infants and Children: An Umbrella Systematic Review and Meta-Analysis. An S(1), Kong J(1), Ghorbani A(2), Dehghani A(3), Alizadeh S(4)

6.
🔬 메타분석
Microbiome-modulating nutraceuticals ameliorate dyslipidemia in type 2 diabetes: A systematic review, meta-analysis, and meta-regression of clinical trials.
Diabetes/metabolism research and reviews 2024 PMID:37381688

6. Diabetes Metab Res Rev. 2024 Feb;40(2):e3675. doi: 10.1002/dmrr.3675. Epub 2023 Jun 28. Microbiome-modulating nutraceuticals ameliorate dyslipidemia in type 2 diabetes: A systematic review, meta-analysis, and meta-regression of clinical trials. Kaul R(1), Paul P(1), Harfouche M(2)(3), Saliba

7.
🔬 메타분석
The effect of microbiome-modulating probiotics, prebiotics and synbiotics on glucose homeostasis in type 2 diabetes: A systematic review, meta-analysis, and meta-regression of clinical trials.
Pharmacological research 2022 PMID:36272640

7. Pharmacol Res. 2022 Nov;185:106520. doi: 10.1016/j.phrs.2022.106520. Epub 2022 Oct 20. The effect of microbiome-modulating probiotics, prebiotics and synbiotics on glucose homeostasis in type 2 diabetes: A systematic review, meta-analysis, and meta-regression of clinical trials. Paul P(1), K

8.
🔬 메타분석
Pro-, pre- and synbiotics for the prevention of incidental ventilator-associated pneumonia among critically ill patients: a systematic review and meta-analysis of randomized controlled trials.
Expert review of anti-infective therapy 2022 PMID:35695312

8. Expert Rev Anti Infect Ther. 2022 Sep;20(9):1205-1215. doi: 10.1080/14787210.2022.2089652. Epub 2022 Jun 16. Pro-, pre- and synbiotics for the prevention of incidental ventilator-associated pneumonia among critically ill patients: a systematic review and meta-analysis of randomized controlled

9.
🔬 메타분석
Postnatal probiotics administration does not prevent asthma in children, but using prebiotics or synbiotics may be the effective potential strategies to decrease the frequency of asthma in high-risk children - a meta-analysis of clinical trials.
Allergologia et immunopathologia 2021 PMID:34224213

9. Allergol Immunopathol (Madr). 2021 Jul 1;49(4):4-14. doi: 10.15586/aei.v49i4.69. eCollection 2021. Postnatal probiotics administration does not prevent asthma in children, but using prebiotics or synbiotics may be the effective potential strategies to decrease the frequency of asthma in high-

10.
🔬 메타분석
The effect of pro/synbiotics on postoperative infections in colorectal cancer patients: A systematic review and meta-analysis.
Complementary therapies in clinical practice 2021 PMID:33894576
📊 OR 0.28 · n=1975

10. Complement Ther Clin Pract. 2021 May;43:101370. doi: 10.1016/j.ctcp.2021.101370. Epub 2021 Apr 1. The effect of pro/synbiotics on postoperative infections in colorectal cancer patients: A systematic review and meta-analysis. Zeng J(1), Ji Y(2), Liang B(3), Zhang G(4), Chen D(5), Zhu M(6), Wu

11.
📄 연구
Synergistic Effects of Probiotic and Omega-3 Supplementation with Ultra-Short Race Pace Training on Sprint Swimming Performance.
Nutrients 2025 PMID:40732922

11. Nutrients. 2025 Jul 11;17(14):2296. doi: 10.3390/nu17142296. Synergistic Effects of Probiotic and Omega-3 Supplementation with Ultra-Short Race Pace Training on Sprint Swimming Performance. Maymandinejad I(1), Hemmatinafar M(1), Jäger R(2), Imanian B(1), Koushkie Jahromi M(1), Suzuki K(3).

12.
🧪 RCT
Ameliorating effects of L-carnitine and synbiotic co-supplementation on anthropometric measures and cardiometabolic traits in women with obesity: a randomized controlled clinical trial.
Frontiers in endocrinology 2023 PMID:37929031

12. Front Endocrinol (Lausanne). 2023 Oct 18;14:1237882. doi: 10.3389/fendo.2023.1237882. eCollection 2023. Ameliorating effects of L-carnitine and synbiotic co-supplementation on anthropometric measures and cardiometabolic traits in women with obesity: a randomized controlled clinical trial. F

13.
🧪 RCT
Effect of synbiotic supplementation on immune parameters and gut microbiota in healthy adults: a double-blind randomized controlled trial.
Gut microbes 2023 PMID:37614109

13. Gut Microbes. 2023 Dec;15(2):2247025. doi: 10.1080/19490976.2023.2247025. Effect of synbiotic supplementation on immune parameters and gut microbiota in healthy adults: a double-blind randomized controlled trial. Li X(1)(2), Hu S(1)(2), Yin J(1)(2), Peng X(1)(2), King L(1)(2), Li L(1)(2), Xu

14.
🧪 RCT
Effects of a Synbiotic on Plasma Immune Activity Markers and Short-Chain Fatty Acids in Children and Adults with ADHD-A Randomized Controlled Trial.
Nutrients 2023 PMID:36904292

14. Nutrients. 2023 Mar 6;15(5):1293. doi: 10.3390/nu15051293. Effects of a Synbiotic on Plasma Immune Activity Markers and Short-Chain Fatty Acids in Children and Adults with ADHD-A Randomized Controlled Trial. Yang LL(1)(2)(3), Stiernborg M(1)(2), Skott E(1)(2)(4), Xu J(1)(2), Wu Y(5), Landber

15.
🧪 RCT
L-Carnitine and synbiotic co-supplementation: beneficial effects on metabolic-endotoxemia, meta-inflammation, and oxidative-stress biomarkers in obese patients: a double blind, randomized, controlled clinical trial.
Food & function 2023 PMID:36752775

15. Food Funct. 2023 Feb 21;14(4):2172-2187. doi: 10.1039/d2fo03348h. L-Carnitine and synbiotic co-supplementation: beneficial effects on metabolic-endotoxemia, meta-inflammation, and oxidative-stress biomarkers in obese patients: a double blind, randomized, controlled clinical trial. Fallah F(1

16.
📄 연구
Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats.
Carcinogenesis 2002 PMID:12419846

42. Carcinogenesis. 2002 Nov;23(11):1953-60. doi: 10.1093/carcin/23.11.1953. Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats. Fe

17.
📋 체계적 리뷰
From gut to glee: Is butyrate a promising antidepressant? A systematic review and mechanistic insights.
Brain, behavior, and immunity 2026 PMID:41429215

19. Brain Behav Immun. 2026 Feb;132:106237. doi: 10.1016/j.bbi.2025.106237. Epub 2025 Dec 20. From gut to glee: Is butyrate a promising antidepressant? A systematic review and mechanistic insights. Korenblik V(1), Schilder NKM(2), de Lange IGS(3), Daams JG(4), Bockting CLH(5), Brul S(6), Nieuwd

18.
📋 체계적 리뷰
The efficacy of probiotics, prebiotics or synbiotics in scleroderma: A systematic review.
Clinical nutrition ESPEN 2025 PMID:40311922
📊 MD 0.04 (95% CI -0.31–0.4) · n=56

30. Clin Nutr ESPEN. 2025 Aug;68:206-215. doi: 10.1016/j.clnesp.2025.04.004. Epub 2025 Apr 29. The efficacy of probiotics, prebiotics or synbiotics in scleroderma: A systematic review. Wach AA(1), Storman D(2), Więckowski K(1), Wojtaszek-Główka M(1), Żabicka W(1), Krupka K(1), Abadi AK(3), Celi

19.
📋 체계적 리뷰
"Do probiotics mitigate GI-induced inflammation and perceived fatigue in athletes? A systematic review".
Journal of the International Society of Sports Nutrition 2024 PMID:39193818

41. J Int Soc Sports Nutr. 2024 Dec;21(1):2388085. doi: 10.1080/15502783.2024.2388085. Epub 2024 Aug 28. "Do probiotics mitigate GI-induced inflammation and perceived fatigue in athletes? A systematic review". Kearns RP(1), Dooley JSG(1), Matthews M(1), McNeilly AM(1). Author information: (1)Ul

20.
📄 연구
Effects of probiotics, prebiotics and synbiotics on anthropometric, cardiometabolic and inflammatory markers: An umbrella review of meta-analyses.
Clinical nutrition (Edinburgh, Scotland) 2024 PMID:38754308

24. Clin Nutr. 2024 Jun;43(6):1563-1583. doi: 10.1016/j.clnu.2024.05.019. Epub 2024 May 10. Effects of probiotics, prebiotics and synbiotics on anthropometric, cardiometabolic and inflammatory markers: An umbrella review of meta-analyses. Teo YQJ(1), Chong B(2), Soong RY(2), Yong CL(2), Chew NW(

21.
📋 체계적 리뷰
Effects of prebiotics, probiotics, and synbiotics on the infant gut microbiota and other health outcomes: A systematic review.
Critical reviews in food science and nutrition 2023 PMID:37667870

40. Crit Rev Food Sci Nutr. 2023;63(22):5620-5642. doi: 10.1080/10408398.2021.2022595. Epub 2022 Jan 4. Effects of prebiotics, probiotics, and synbiotics on the infant gut microbiota and other health outcomes: A systematic review. Ferro LE(1), Crowley LN(1), Bittinger K(2), Friedman ES(3), Decke

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