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세인트존스워트

St. John's Wort (Hypericum)

📑 PubMed 20편 🌿 허브 🗓️ 최신 2025
🔬 메타분석 1 📋 체계적 리뷰 2 🧪 RCT 1

📖 핵심 요약

📖 20편 · 10분 읽기

세인트존스워트은(는) 허브 계열 보충제입니다. PubMed에 20편의 관련 논문이 있습니다.

💊⚠️ 약물 상호작용 (4)

아래 약을 복용 중이라면 이 보충제 병용 전 반드시 의사·약사와 상의하세요.

Warfarin 🛑 주의

영향: INR 감소 → 혈전 위험

대처: 병용 금기

SSRI (fluoxetine 등) 🛑 주의

영향: 세로토닌 증후군 (고열, 경련, 사망 가능)

대처: 절대 병용 금기

Cyclosporine 🛑 주의

영향: 면역억제 효과 감소 → 이식 거부 반응

대처: 절대 병용 금기

경구 피임약 🛑 주의

영향: 피임 실패 (부정 출혈, 임신 가능)

대처: 병용 금기 — 대체 피임법 사용

📚 관련 논문 (20편) · 📊 정량 근거 1건

1.
📄 연구
A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies.
Phytotherapy research : PTR 2016 PMID:26887532

1. Phytother Res. 2016 May;30(5):691-700. doi: 10.1002/ptr.5591. Epub 2016 Feb 17. A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies. Izzo AA(1), Hoon-Kim S(2), Radhakrishnan R(3), Williamson EM(4). Author information: (1)Department of P

2.
📄 연구
Antidepressants for smoking cessation.
The Cochrane database of systematic reviews 2014 PMID:24402784
📊 RR 2.03 (95% CI 1.48–2.78) · n=13

2. Cochrane Database Syst Rev. 2014 Jan 8;2014(1):CD000031. doi: 10.1002/14651858.CD000031.pub4. Antidepressants for smoking cessation. Hughes JR(1), Stead LF, Hartmann-Boyce J, Cahill K, Lancaster T. Author information: (1)Dept of Psychiatry, University of Vermont, UHC Campus, OH3 Stop # 482, 1

3.
🧪 RCT
The Effects of St. John's Wort on Healing of Stages 1 and 2 Pressure Injuries: A Randomized Controlled Trial.
Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society 2025 PMID:40717256

3. J Wound Ostomy Continence Nurs. 2025 Jul-Aug 01;52(4):285-291. doi: 10.1097/WON.0000000000001200. Epub 2025 Jul 24. The Effects of St. John's Wort on Healing of Stages 1 and 2 Pressure Injuries: A Randomized Controlled Trial. Yıldırım S(1)(2)(3), Kaya H(1)(2)(3), Süzer Ö(1)(2)(3). Author inf

4.
📄 연구
Integrative Medicine: Herbal Supplements.
FP essentials 2021 PMID:34128628

4. FP Essent. 2021 Jun;505:23-27. Integrative Medicine: Herbal Supplements. Hawks MK(1), Crawford PF 3rd(1), Moss DA(2), Snyder MJ(2). Author information: (1)F. Edward Hébert School of Medicine at the Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 2081

5.
📄 연구
Antiproliferative Effects of St. John's Wort, Its Derivatives, and Other Hypericum Species in Hematologic Malignancies.
International journal of molecular sciences 2020 PMID:33375664

5. Int J Mol Sci. 2020 Dec 25;22(1):146. doi: 10.3390/ijms22010146. Antiproliferative Effects of St. John's Wort, Its Derivatives, and Other Hypericum Species in Hematologic Malignancies. Allegra A(1), Tonacci A(2), Spagnolo EV(3), Musolino C(1), Gangemi S(4). Author information: (1)Division of

6.
📄 연구
Understanding drug interactions with St John's wort (Hypericum perforatum L.): impact of hyperforin content.
The Journal of pharmacy and pharmacology 2019 PMID:29411879

6. J Pharm Pharmacol. 2019 Jan;71(1):129-138. doi: 10.1111/jphp.12858. Epub 2018 Feb 7. Understanding drug interactions with St John's wort (Hypericum perforatum L.): impact of hyperforin content. Chrubasik-Hausmann S(1), Vlachojannis J(1), McLachlan AJ(2)(3). Author information: (1)Institute o

7.
📄 연구
Clinical risks of St John's Wort (Hypericum perforatum) co-administration.
Expert opinion on drug metabolism & toxicology 2017 PMID:28885074

7. Expert Opin Drug Metab Toxicol. 2017 Oct;13(10):1047-1062. doi: 10.1080/17425255.2017.1378342. Epub 2017 Sep 13. Clinical risks of St John's Wort (Hypericum perforatum) co-administration. Soleymani S(1), Bahramsoltani R(1)(2), Rahimi R(1)(3), Abdollahi M(4)(5). Author information: (1)a Depart

8.
📄 연구
Kidney toxicity related to herbs and dietary supplements: Online table of case reports. Part 3 of 5 series.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 PMID:28755953

8. Food Chem Toxicol. 2017 Sep;107(Pt A):502-519. doi: 10.1016/j.fct.2016.07.024. Kidney toxicity related to herbs and dietary supplements: Online table of case reports. Part 3 of 5 series. Brown AC(1). Author information: (1)Department of Complementary and Alternative Medicine, John A. Burns Sc

9.
📄 연구
[Decreased everolimus blood concentration associated with consumption of St. John's wort (Hypericum perforatum) extract sweets].
Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 2017 PMID:28683711

9. Farm Hosp. 2017 Jul 1;41(4):565-566. doi: 10.7399/fh.2017.41.4.10777. [Decreased everolimus blood concentration associated with consumption of St. John's wort (Hypericum perforatum) extract sweets]. [Article in Spanish] Cristóbal Gutiérrez H(1), Martínez Callejo V(2), García de la Paz AM(3),

10.
📄 연구
Clinically Relevant Pharmacokinetic Herb-drug Interactions in Antiretroviral Therapy.
Current drug metabolism 2015 PMID:26526838

10. Curr Drug Metab. 2015;17(1):52-64. doi: 10.2174/1389200216666151103115053. Clinically Relevant Pharmacokinetic Herb-drug Interactions in Antiretroviral Therapy. Fasinu PS(1), Gurley BJ, Walker LA. Author information: (1)National Center for Natural products Research, School of Pharmacy, Unive

11.
📄 연구
Pharmacokinetic Interactions between Drugs and Botanical Dietary Supplements.
Drug metabolism and disposition: the biological fate of chemicals 2016 PMID:26438626

11. Drug Metab Dispos. 2016 Feb;44(2):162-71. doi: 10.1124/dmd.115.066902. Epub 2015 Oct 5. Pharmacokinetic Interactions between Drugs and Botanical Dietary Supplements. Sprouse AA(1), van Breemen RB(2). Author information: (1)University of Illinois at Chicago/National Institutes of Health Cente

12.
📄 연구
St. John's wort for the treatment of psychiatric disorders.
The Psychiatric clinics of North America 2013 PMID:23538077

12. Psychiatr Clin North Am. 2013 Mar;36(1):65-72. doi: 10.1016/j.psc.2013.01.004. St. John's wort for the treatment of psychiatric disorders. Sarris J(1). Author information: (1)Department of Psychiatry, The Melbourne Clinic, The University of Melbourne, 2 Salisbury Street, Richmond, Victoria 3

13.
🔬 메타분석
Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms - an update on the evidence.
Climacteric : the journal of the International Menopause Society 2021 PMID:33021111

13. Climacteric. 2021 Apr;24(2):109-119. doi: 10.1080/13697137.2020.1820477. Epub 2020 Oct 6. Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms - an update on the evidence. Castelo-Branco C(1), Gambacciani M(2), Cano A(3), Minkin MJ(4), Rachoń D(5), Ruan X(6

14.
📄 연구
Benefit-risk profile of black cohosh (isopropanolic Cimicifuga racemosa extract) with and without St John's wort in breast cancer patients.
Climacteric : the journal of the International Menopause Society 2019 PMID:30626212

14. Climacteric. 2019 Aug;22(4):339-347. doi: 10.1080/13697137.2018.1551346. Epub 2019 Jan 10. Benefit-risk profile of black cohosh (isopropanolic Cimicifuga racemosa extract) with and without St John's wort in breast cancer patients. Ruan X(1)(2), Mueck AO(1)(2), Beer AM(3), Naser B(4), Pickart

15.
📋 체계적 리뷰
Systematic review of breastfeeding and herbs.
Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine 2012 PMID:22686865

15. Breastfeed Med. 2012 Dec;7(6):489-503. doi: 10.1089/bfm.2011.0122. Epub 2012 Jun 11. Systematic review of breastfeeding and herbs. Budzynska K(1), Gardner ZE, Dugoua JJ, Low Dog T, Gardiner P. Author information: (1)Section of General Internal Medicine, Department of Medicine, Boston Univer

16.
📄 연구
Depression in children and adolescents.
BMJ clinical evidence 2011 PMID:22018419

7. BMJ Clin Evid. 2011 Oct 21;2011:1008. Depression in children and adolescents. Hazell P(1). Author information: (1)Discipline of Psychiatry, Sydney Medical School, Sydney, Australia. INTRODUCTION: Depression may affect 2% to 8% of children and adolescents, with a peak incidence around puberty

17.
📋 체계적 리뷰
Interactions between herbal medicines and prescribed drugs: an updated systematic review.
Drugs 2009 PMID:19719333

1. Drugs. 2009;69(13):1777-98. doi: 10.2165/11317010-000000000-00000. Interactions between herbal medicines and prescribed drugs: an updated systematic review. Izzo AA(1), Ernst E. Author information: (1)Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano

18.
📄 연구
Kava and St. John's Wort: current evidence for use in mood and anxiety disorders.
Journal of alternative and complementary medicine (New York, N.Y.) 2009 PMID:19614563

27. J Altern Complement Med. 2009 Aug;15(8):827-36. doi: 10.1089/acm.2009.0066. Kava and St. John's Wort: current evidence for use in mood and anxiety disorders. Sarris J(1), Kavanagh DJ. Author information: (1)School of Medicine, The University of Queensland, Royal Brisbane and Women's Hospita

19.
📄 연구
Depression in children and adolescents.
BMJ clinical evidence 2009 PMID:19445770

39. BMJ Clin Evid. 2009 Jan 7;2009:1008. Depression in children and adolescents. Hazell P(1). Author information: (1)Concord Clinical School, University of Sydney, Sydney, Australia. INTRODUCTION: Depression may affect 2-8% of children and adolescents, with a peak incidence around puberty. It m

20.
📄 연구
An update on clinical drug interactions with the herbal antidepressant St. John's wort.
Current drug metabolism 2008 PMID:18537576

50. Curr Drug Metab. 2008 Jun;9(5):394-409. doi: 10.2174/138920008784746391. An update on clinical drug interactions with the herbal antidepressant St. John's wort. Zhou SF(1), Lai X. Author information: (1)School of Health Sciences, World Health Organization Collaborating Centre for Traditiona

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