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사프란

Saffron (Crocus sativus)

📑 PubMed 26편 🌿 허브 🗓️ 최신 2025
🔬 메타분석 8 📋 체계적 리뷰 5 🧪 RCT 9

📖 핵심 요약

📖 26편 · 13분 읽기

사프란은(는) 허브 계열 보충제입니다. 주로 간 건강, 체중 관리 분야에서 연구되었으며, PubMed에 26편의 관련 논문이 있습니다.

🔍 연구 분야별 근거

간 건강 논문 1편
체중 관리 논문 1편

* 제목에 해당 키워드가 포함된 논문 수 (PubMed 근거)

📊 효과 크기 분포 (Forest plot)

각 연구의 효과 추정치와 95% 신뢰구간. 개별 연구를 통합(pooling)하지 않고 그대로 표시합니다.

36105788-0.69 (-0.01–0.09)32525606-1.29 (-4.13–1.55)31987241-4.86 (-6.58–-3.14)-7.802.8MD (favours ← / →)

📚 관련 논문 (26편) · 📊 정량 근거 5건

1.
🔬 메타분석
The Effect of Saffron (Crocus sativus L.) Supplementation on Renal Function: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.
International journal of clinical practice 2022 PMID:36105788
📊 MD -0.69 (95% CI -0.01–0.09)

1. Int J Clin Pract. 2022 Aug 29;2022:9622546. doi: 10.1155/2022/9622546. eCollection 2022. The Effect of Saffron (Crocus sativus L.) Supplementation on Renal Function: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials. Karimi E(1)(2), Shahdadian F(2), Hadi A(3), Tar

2.
🔬 메타분석
Effects of saffron (Crocus sativus L.) on anthropometric and cardiometabolic indices in overweight and obese patients: A systematic review and meta-analysis of randomized controlled trials.
Phytotherapy research : PTR 2022 PMID:35866520
📊 SMD -0.41 (95% CI -0.63–0.03)

2. Phytother Res. 2022 Sep;36(9):3394-3414. doi: 10.1002/ptr.7530. Epub 2022 Jul 22. Effects of saffron (Crocus sativus L.) on anthropometric and cardiometabolic indices in overweight and obese patients: A systematic review and meta-analysis of randomized controlled trials. Tahmasbi F(1)(2), Ar

3.
🔬 메타분석
The effects of saffron supplementation on the measures of renal function indicators: a systematic review and meta-analysis.
International urology and nephrology 2022 PMID:35103929

3. Int Urol Nephrol. 2022 Sep;54(9):2215-2226. doi: 10.1007/s11255-022-03127-2. Epub 2022 Feb 1. The effects of saffron supplementation on the measures of renal function indicators: a systematic review and meta-analysis. Norouzy A(1), Ghodrat S(1), Bahrami LS(1), Feizy Z(2), Arabi SM(3). Author

4.
🔬 메타분석
Effect of saffron supplementation on liver enzymes: A systematic review and meta-analysis of randomized controlled trials.
Diabetes & metabolic syndrome 2021 PMID:34678576
📊 SMD -0.18 (95% CI -0.34–-0.02) · n=463

4. Diabetes Metab Syndr. 2021 Nov-Dec;15(6):102311. doi: 10.1016/j.dsx.2021.102311. Epub 2021 Oct 12. Effect of saffron supplementation on liver enzymes: A systematic review and meta-analysis of randomized controlled trials. Hasani M(1), Malekahmadi M(2), Rezamand G(3), Estêvão MD(4), Pizarro AB

5.
🔬 메타분석
Effects of saffron (Crocus sativus L.) supplementation on inflammatory biomarkers: A systematic review and meta-analysis.
Phytotherapy research : PTR 2021 PMID:32525606
📊 MD -1.29 (95% CI -4.13–1.55)

5. Phytother Res. 2021 Jan;35(1):20-32. doi: 10.1002/ptr.6748. Epub 2020 Jun 11. Effects of saffron (Crocus sativus L.) supplementation on inflammatory biomarkers: A systematic review and meta-analysis. Asbaghi O(1), Sadeghian M(2), Sadeghi O(3), Rigi S(3), Tan SC(4), Shokri A(5)(6), Mousavi SM(

6.
🔬 메타분석
The effects of saffron (Crocus sativus L.) on mental health parameters and C-reactive protein: A meta-analysis of randomized clinical trials.
Complementary therapies in medicine 2020 PMID:31987241
📊 MD -4.86 (95% CI -6.58–-3.14)

6. Complement Ther Med. 2020 Jan;48:102250. doi: 10.1016/j.ctim.2019.102250. Epub 2019 Nov 21. The effects of saffron (Crocus sativus L.) on mental health parameters and C-reactive protein: A meta-analysis of randomized clinical trials. Ghaderi A(1), Asbaghi O(2), Reiner Ž(3), Kolahdooz F(4), Am

7.
🔬 메타분석
Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials.
Journal of integrative medicine 2013 PMID:24299602

7. J Integr Med. 2013 Nov;11(6):377-83. doi: 10.3736/jintegrmed2013056. Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials. Hausenblas HA(1), Saha D, Dubyak PJ, Anton SD. Author information: (1)Department of Sport and Exercise Sciences, Jacks

8.
🧪 RCT
A standardised saffron extract improves subjective and objective sleep quality in healthy older adults with sleep complaints: results from the gut-sleep-brain axis randomised, double-blind, placebo-controlled pilot study.
Food & function 2025 PMID:40762630

8. Food Funct. 2025 Aug 26;16(17):6817-6832. doi: 10.1039/d5fo00917k. A standardised saffron extract improves subjective and objective sleep quality in healthy older adults with sleep complaints: results from the gut-sleep-brain axis randomised, double-blind, placebo-controlled pilot study. Lang

9.
🧪 RCT
Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Concurrent Use of Crocin During Chemoradiation for Esophageal Squamous Cell Carcinoma.
Cancer investigation 2024 PMID:38385429

9. Cancer Invest. 2024 Feb;42(2):155-164. doi: 10.1080/07357907.2024.2319754. Epub 2024 Feb 22. Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Concurrent Use of Crocin During Chemoradiation for Esophageal Squamous Cell Carcinoma. Ebrahimi N(1), Javadinia SA(2), Salek R(3), Fanipa

10.
🧪 RCT
The effect of Crocus sativus L. (saffron) herbal tea on happiness in postmenopausal women: a randomized controlled trial.
BMC complementary medicine and therapies 2023 PMID:37264347

10. BMC Complement Med Ther. 2023 Jun 1;23(1):176. doi: 10.1186/s12906-023-04014-8. The effect of Crocus sativus L. (saffron) herbal tea on happiness in postmenopausal women: a randomized controlled trial. Delam H(1)(2), Keshtkaran Z(3), Shokrpour N(4), Eidi A(1), Bazrafshan MR(5). Author inform

11.
🧪 RCT
The effect of saffron (Crocus sativus L.) on glycemia, lipid profile, and antioxidant status in patients with type-2 diabetes mellitus: A randomized placebo-controlled trial.
Phytotherapy research : PTR 2023 PMID:36580575

11. Phytother Res. 2023 Feb;37(2):388-398. doi: 10.1002/ptr.7600. Epub 2022 Dec 29. The effect of saffron (Crocus sativus L.) on glycemia, lipid profile, and antioxidant status in patients with type-2 diabetes mellitus: A randomized placebo-controlled trial. Tajaddini A(1), Roshanravan N(2), Mob

12.
🧪 RCT
Improvement of inflammatory status following saffron (Crocus sativus L.) and resistance training in elderly hypertensive men: A randomized controlled trial.
Experimental gerontology 2022 PMID:35235859

12. Exp Gerontol. 2022 Jun 1;162:111756. doi: 10.1016/j.exger.2022.111756. Epub 2022 Feb 27. Improvement of inflammatory status following saffron (Crocus sativus L.) and resistance training in elderly hypertensive men: A randomized controlled trial. Mojtahedi S(1), Hooshmand-Moghadam B(2), Rosen

13.
🧪 RCT
The effects of saffron (Crocus sativus L.) in conjunction with concurrent training on body composition, glycaemic status, and inflammatory markers in obese men with type 2 diabetes mellitus: A randomized double-blind clinical trial.
British journal of clinical pharmacology 2022 PMID:35001410

13. Br J Clin Pharmacol. 2022 Jul;88(7):3256-3271. doi: 10.1111/bcp.15222. Epub 2022 Feb 18. The effects of saffron (Crocus sativus L.) in conjunction with concurrent training on body composition, glycaemic status, and inflammatory markers in obese men with type 2 diabetes mellitus: A randomized

14.
🧪 RCT
Amelioration of anxiety, depression, and chemotherapy related toxicity after crocin administration during chemotherapy of breast cancer: A double blind, randomized clinical trial.
Phytotherapy research : PTR 2021 PMID:34164855

14. Phytother Res. 2021 Sep;35(9):5143-5153. doi: 10.1002/ptr.7180. Epub 2021 Jun 24. Amelioration of anxiety, depression, and chemotherapy related toxicity after crocin administration during chemotherapy of breast cancer: A double blind, randomized clinical trial. Salek R(1), Dehghani M(2), Mo

15.
🧪 RCT
Saffron (Crocus sativus L.) in combination with resistance training reduced blood pressure in the elderly hypertensive men: A randomized controlled trial.
British journal of clinical pharmacology 2021 PMID:33496985

15. Br J Clin Pharmacol. 2021 Aug;87(8):3255-3267. doi: 10.1111/bcp.14746. Epub 2021 Feb 21. Saffron (Crocus sativus L.) in combination with resistance training reduced blood pressure in the elderly hypertensive men: A randomized controlled trial. Hooshmand-Moghadam B(1), Eskandari M(2), Shabkhi

16.
🧪 RCT
Evaluation of modulatory effects of saffron (Crocus sativus L.) aqueous extract on oxidative stress in ischemic stroke patients: a randomized clinical trial.
Nutritional neuroscience 2022 PMID:33151132

28. Nutr Neurosci. 2022 Jun;25(6):1137-1146. doi: 10.1080/1028415X.2020.1840118. Epub 2020 Nov 5. Evaluation of modulatory effects of saffron (Crocus sativus L.) aqueous extract on oxidative stress in ischemic stroke patients: a randomized clinical trial. Gudarzi S(1), Jafari M(1)(2), Pirzad Jah

17.
📄 연구
Effects of short-term saffron (Crocus sativus L.) intake on the in vivo activities of xenobiotic metabolizing enzymes in healthy volunteers.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2019 PMID:31082462

6. Food Chem Toxicol. 2019 Aug;130:32-43. doi: 10.1016/j.fct.2019.05.013. Epub 2019 May 10. Effects of short-term saffron (Crocus sativus L.) intake on the in vivo activities of xenobiotic metabolizing enzymes in healthy volunteers. Begas E(1), Bounitsi M(2), Kilindris T(3), Kouvaras E(4), Makar

18.
📄 연구
Use of in vitro assays to assess the potential antigenotoxic and cytotoxic effects of saffron (Crocus sativus L.).
Toxicology in vitro : an international journal published in association with BIBRA 2003 PMID:14599470

26. Toxicol In Vitro. 2003 Oct-Dec;17(5-6):731-6. doi: 10.1016/s0887-2333(03)00098-5. Use of in vitro assays to assess the potential antigenotoxic and cytotoxic effects of saffron (Crocus sativus L.). Abdullaev FI(1), Riverón-Negrete L, Caballero-Ortega H, Manuel Hernández J, Pérez-López I, Per

19.
📄 연구
Inhibition of colony formation of Hela cells by naturally occurring and synthetic agents.
BioFactors (Oxford, England) 1995 PMID:8922269

47. Biofactors. 1995-1996;5(3):133-8. Inhibition of colony formation of Hela cells by naturally occurring and synthetic agents. Abdullaev FI(1), Gonzalez de Mejia E. Author information: (1)Department of Food Research and Postgraduate Studies, Autonomous University of Queretaro, Mexico. The pre

20.
📄 연구
Psychological and neuroendocrinological effects of odor of saffron (Crocus sativus).
Phytomedicine : international journal of phytotherapy and phytopharmacology 2011 PMID:21242071

24. Phytomedicine. 2011 Jun 15;18(8-9):726-30. doi: 10.1016/j.phymed.2010.11.013. Epub 2011 Jan 15. Psychological and neuroendocrinological effects of odor of saffron (Crocus sativus). Fukui H(1), Toyoshima K, Komaki R. Author information: (1)Department of Education, Nara University of Educatio

21.
📋 체계적 리뷰
Efficacy of Saffron (Crocus sativus L.) and Its Constituents on Breast Cancer, a Systematic Review of Preclinical Studies and Potential Therapeutic Mechanisms.
Integrative cancer therapies 2025 PMID:40819247

15. Integr Cancer Ther. 2025 Jan-Dec;24:15347354251361450. doi: 10.1177/15347354251361450. Epub 2025 Aug 17. Efficacy of Saffron (Crocus sativus L.) and Its Constituents on Breast Cancer, a Systematic Review of Preclinical Studies and Potential Therapeutic Mechanisms. Hasheminasab FS(1)(2), Azim

22.
📋 체계적 리뷰
Therapeutic effects of saffron (Crocus sativus L) on female reproductive system disorders: A systematic review.
Phytotherapy research : PTR 2024 PMID:38558480

50. Phytother Res. 2024 Jun;38(6):2832-2846. doi: 10.1002/ptr.8186. Epub 2024 Apr 1. Therapeutic effects of saffron (Crocus sativus L) on female reproductive system disorders: A systematic review. Hasheminasab FS(1), Azimi M(2), Raeiszadeh M(3). Author information: (1)Pharmacology Research Cente

23.
📋 체계적 리뷰
New horizons for the study of saffron (Crocus sativus L.) and its active ingredients in the management of neurological and psychiatric disorders: A systematic review of clinical evidence and mechanisms.
Phytotherapy research : PTR 2024 PMID:38424688

49. Phytother Res. 2024 May;38(5):2276-2302. doi: 10.1002/ptr.8110. Epub 2024 Feb 29. New horizons for the study of saffron (Crocus sativus L.) and its active ingredients in the management of neurological and psychiatric disorders: A systematic review of clinical evidence and mechanisms. Han S(

24.
📋 체계적 리뷰
The potential role of saffron (Crocus Sativus L.) and its components in oxidative stress in diabetes mellitus: A systematic review.
Clinical nutrition ESPEN 2022 PMID:35331485

37. Clin Nutr ESPEN. 2022 Apr;48:148-157. doi: 10.1016/j.clnesp.2022.01.022. Epub 2022 Jan 26. The potential role of saffron (Crocus Sativus L.) and its components in oxidative stress in diabetes mellitus: A systematic review. Moini Jazani A(1), Karimi A(2), Nasimi Doost Azgomi R(3). Author inf

25.
📋 체계적 리뷰
The mechanisms of saffron (Crocus sativus') on the inflammatory pathways of diabetes mellitus: A systematic review.
Diabetes & metabolic syndrome 2022 PMID:34923214

32. Diabetes Metab Syndr. 2022 Jan;16(1):102365. doi: 10.1016/j.dsx.2021.102365. Epub 2021 Dec 14. The mechanisms of saffron (Crocus sativus') on the inflammatory pathways of diabetes mellitus: A systematic review. Nasimi Doost Azgomi R(1), Karimi A(2), Zarshenas MM(3), Moini Jazani A(4). Autho

26.
🔬 메타분석
Saffron, as an adjunct therapy, contributes to relieve depression symptoms: An umbrella meta-analysis.
Pharmacological research 2022 PMID:34757208

41. Pharmacol Res. 2022 Jan;175:105963. doi: 10.1016/j.phrs.2021.105963. Epub 2021 Oct 29. Saffron, as an adjunct therapy, contributes to relieve depression symptoms: An umbrella meta-analysis. Musazadeh V(1), Zarezadeh M(2), Faghfouri AH(3), Keramati M(3), Ghoreishi Z(4), Farnam A(5). Author

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