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붉은토끼풀

Red Clover

📑 PubMed 30편 🌿 허브 🗓️ 최신 2026
🔬 메타분석 7 📋 체계적 리뷰 1 🧪 RCT 4

📖 핵심 요약

📖 30편 · 15분 읽기

붉은토끼풀은(는) 허브 계열 보충제입니다. PubMed에 30편의 관련 논문이 있습니다.

📊 효과 크기 분포 (Forest plot)

각 연구의 효과 추정치와 95% 신뢰구간. 개별 연구를 통합(pooling)하지 않고 그대로 표시합니다.

35745197-0.19 (-0.3–-0.08)2432391420.15 (-12.08–52.38)20511398-1.1 (-3.22–1.03)17943751-0.6 (-1.8–0.6)17239573-1.5 (-2.94–0.03)-22062MD (favours ← / →)

📚 관련 논문 (30편) · 📊 정량 근거 6건

1.
🔬 메타분석
Efficacy of plant-derived dietary supplements in improving overall menopausal symptoms in women: An updated systematic review and meta-analysis.
Phytotherapy research : PTR 2024 PMID:38189863

1. Phytother Res. 2024 Mar;38(3):1294-1309. doi: 10.1002/ptr.8112. Epub 2024 Jan 8. Efficacy of plant-derived dietary supplements in improving overall menopausal symptoms in women: An updated systematic review and meta-analysis. Oh MR(1), Park JH(2), Park SK(2), Park SH(2). Author information: (

2.
🔬 메타분석
Role of Phytoestrogen-Rich Bioactive Substances (Linum usitatissimum L., Glycine max L., Trifolium pratense L.) in Cardiovascular Disease Prevention in Postmenopausal Women: A Systematic Review and Meta-Analysis.
Nutrients 2022 PMID:35745197
📊 MD -0.19 (95% CI -0.3–-0.08)

2. Nutrients. 2022 Jun 14;14(12):2467. doi: 10.3390/nu14122467. Role of Phytoestrogen-Rich Bioactive Substances (Linum usitatissimum L., Glycine max L., Trifolium pratense L.) in Cardiovascular Disease Prevention in Postmenopausal Women: A Systematic Review and Meta-Analysis. Błaszczuk A(1), Bar

3.
🔬 메타분석
Neither soy nor isoflavone intake affects male reproductive hormones: An expanded and updated meta-analysis of clinical studies.
Reproductive toxicology (Elmsford, N.Y.) 2021 PMID:33383165

3. Reprod Toxicol. 2021 Mar;100:60-67. doi: 10.1016/j.reprotox.2020.12.019. Epub 2020 Dec 28. Neither soy nor isoflavone intake affects male reproductive hormones: An expanded and updated meta-analysis of clinical studies. Reed KE(1), Camargo J(2), Hamilton-Reeves J(3), Kurzer M(4), Messina M(5)

4.
📄 연구
Phytoestrogens for menopausal vasomotor symptoms.
The Cochrane database of systematic reviews 2013 PMID:24323914
📊 MD 20.15 (95% CI -12.08–52.38) · n=364

4. Cochrane Database Syst Rev. 2013 Dec 10;2013(12):CD001395. doi: 10.1002/14651858.CD001395.pub4. Phytoestrogens for menopausal vasomotor symptoms. Lethaby A(1), Marjoribanks J, Kronenberg F, Roberts H, Eden J, Brown J. Author information: (1)Department of Obstetrics and Gynaecology, University

5.
🔬 메타분석
Effects of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis of randomized controlled trials.
Human reproduction update 2010 PMID:20511398
📊 MD -1.1 (95% CI -3.22–1.03) · n=1287

5. Hum Reprod Update. 2010 Nov-Dec;16(6):745-60. doi: 10.1093/humupd/dmq011. Epub 2010 May 28. Effects of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis of randomized controlled trials. Hooper L(1), Madhavan G, Tice JA, Leinster SJ, Cassidy

6.
🔬 메타분석
Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis.
Fertility and sterility 2010 PMID:19524224

6. Fertil Steril. 2010 Aug;94(3):997-1007. doi: 10.1016/j.fertnstert.2009.04.038. Epub 2009 Jun 12. Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis. Hamilton-Reeves JM(1), Vazquez G, Duval SJ, Phipps WR, Kurzer MS, Messin

7.
📄 연구
Phytoestrogens for vasomotor menopausal symptoms.
The Cochrane database of systematic reviews 2007 PMID:17943751
📊 MD -0.6 (95% CI -1.8–0.6)

7. Cochrane Database Syst Rev. 2007 Oct 17;(4):CD001395. doi: 10.1002/14651858.CD001395.pub3. Phytoestrogens for vasomotor menopausal symptoms. Lethaby AE(1), Brown J, Marjoribanks J, Kronenberg F, Roberts H, Eden J. Author information: (1)University of Auckland, O&G FMHS, Grafton Rd, Private Ba

8.
🔬 메타분석
Trifolium pratense isoflavones in the treatment of menopausal hot flushes: a systematic review and meta-analysis.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2007 PMID:17239573
📊 MD -1.5 (95% CI -2.94–0.03)

8. Phytomedicine. 2007 Feb;14(2-3):153-9. doi: 10.1016/j.phymed.2006.12.009. Epub 2007 Jan 18. Trifolium pratense isoflavones in the treatment of menopausal hot flushes: a systematic review and meta-analysis. Coon JT(1), Pittler MH, Ernst E. Author information: (1)Complementary Medicine, Penins

9.
📄 연구
Critical review of health effects of soyabean phyto-oestrogens in post-menopausal women.
The Proceedings of the Nutrition Society 2006 PMID:16441947

9. Proc Nutr Soc. 2006 Feb;65(1):76-92. doi: 10.1079/pns2005476. Critical review of health effects of soyabean phyto-oestrogens in post-menopausal women. Cassidy A(1), Albertazzi P, Lise Nielsen I, Hall W, Williamson G, Tetens I, Atkins S, Cross H, Manios Y, Wolk A, Steiner C, Branca F. Author

10.
📄 연구
Overall Survival of Glioblastoma Patients Treated With a Combination of 7 Micronutrients: A Nutraceutical Trial.
Anticancer research 2026 PMID:41760279

10. Anticancer Res. 2026 Mar;46(3):1599-1608. doi: 10.21873/anticanres.18055. Overall Survival of Glioblastoma Patients Treated With a Combination of 7 Micronutrients: A Nutraceutical Trial. Rooprai HK(1), Lawrence P(2), Ashkan K(3), Beaney R(4), Pilkington GJ(5), Gullan RW(1). Author informati

11.
🧪 RCT
Precision health targeting TMAO in postmenopausal women: polyphenol effects modulated by urolithin A and equol metabotypes in a randomised, placebo-controlled crossover trial.
Food & function 2026 PMID:41642121

11. Food Funct. 2026 Feb 23;17(4):2037-2049. doi: 10.1039/d5fo05461c. Precision health targeting TMAO in postmenopausal women: polyphenol effects modulated by urolithin A and equol metabotypes in a randomised, placebo-controlled crossover trial. Jarrín-Orozco MP(1), García-Nicolás M(1), Romo-Vaq

12.
🧪 RCT
Polyphenol-Related Gut Metabotype Signatures Linked to Quality of Life in Postmenopausal Women: A Randomized, Placebo-Controlled Crossover Trial.
Nutrients 2025 PMID:41305622

12. Nutrients. 2025 Nov 15;17(22):3572. doi: 10.3390/nu17223572. Polyphenol-Related Gut Metabotype Signatures Linked to Quality of Life in Postmenopausal Women: A Randomized, Placebo-Controlled Crossover Trial. Jarrín-Orozco MP(1), Romo-Vaquero M(1), Carrascosa C(2), Pertegal M(2), Berná J(3), P

13.
📄 연구
Connecting plant, animal, and human health using untargeted metabolomics.
Journal of animal science 2025 PMID:40831047

13. J Anim Sci. 2025 Jan 4;103:skaf254. doi: 10.1093/jas/skaf254. Connecting plant, animal, and human health using untargeted metabolomics. Fleming A(1), Provenza FD(2), Leroy F(3), van Vliet S(4), Elliot C(1), Hamlin M(1), Garrett K(1), Marshall CJ(1), Gregorini P(1). Author information: (1)Dep

14.
🧪 RCT
Isoflavones obtained from red clover improve both dyslipidemia and menopausal symptoms in menopausal women: a prospective randomized placebo-controlled trial.
Climacteric : the journal of the International Menopause Society 2024 PMID:39254422

14. Climacteric. 2024 Dec;27(6):548-554. doi: 10.1080/13697137.2024.2393121. Epub 2024 Sep 10. Isoflavones obtained from red clover improve both dyslipidemia and menopausal symptoms in menopausal women: a prospective randomized placebo-controlled trial. Yigit E(1), Unsal S(2). Author informatio

15.
🧪 RCT
Use of Fermented Red Clover Isoflavones in the Treatment of Overactive Bladder in Postmenopausal Women: A Randomized, Double-Blinded, Placebo-Controlled Trial.
Nutrients 2023 PMID:37836449

15. Nutrients. 2023 Sep 27;15(19):4165. doi: 10.3390/nu15194165. Use of Fermented Red Clover Isoflavones in the Treatment of Overactive Bladder in Postmenopausal Women: A Randomized, Double-Blinded, Placebo-Controlled Trial. Villadsen AB(1)(2), Holm-Jacobsen JN(1), Prabhala BK(3), Bundgaard-Niels

16.
📄 연구
Disposition of Dietary Polyphenols in Breast Cancer Patients' Tumors, and Their Associated Anticancer Activity: The Particular Case of Curcumin.
Molecular nutrition & food research 2021 PMID:33939887

9. Mol Nutr Food Res. 2021 Jun;65(12):e2100163. doi: 10.1002/mnfr.202100163. Epub 2021 May 10. Disposition of Dietary Polyphenols in Breast Cancer Patients' Tumors, and Their Associated Anticancer Activity: The Particular Case of Curcumin. Ávila-Gálvez MÁ(1), González-Sarrías A(1), Martínez-Díaz

17.
📄 연구
The natural isoflavone Biochanin-A synergizes 5-fluorouracil anticancer activity in vitro and in vivo in Ehrlich solid-phase carcinoma model.
Phytotherapy research : PTR 2022 PMID:35112408

38. Phytother Res. 2022 Mar;36(3):1310-1325. doi: 10.1002/ptr.7388. Epub 2022 Feb 2. The natural isoflavone Biochanin-A synergizes 5-fluorouracil anticancer activity in vitro and in vivo in Ehrlich solid-phase carcinoma model. Mahmoud M(1), Abdollah MRA(2)(3), Elsesy ME(4)(5), Abou El Ella DA(6),

18.
📄 연구
Irilone from Red Clover ( Trifolium pratense) Potentiates Progesterone Signaling.
Journal of natural products 2018 PMID:30199256

12. J Nat Prod. 2018 Sep 28;81(9):1962-1967. doi: 10.1021/acs.jnatprod.8b00131. Epub 2018 Sep 10. Irilone from Red Clover ( Trifolium pratense) Potentiates Progesterone Signaling. Lee JH(1), Dean M(1), Austin JR(1), Burdette JE(1), Murphy BT(1). Author information: (1)Department of Medicinal Ch

19.
📄 연구
Development of a highly reproducible system to evaluate inhibition of cytochrome P450 3A4 activity by natural medicines.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2015 PMID:26626238

45. J Pharm Pharm Sci. 2015;18(4):316-27. doi: 10.18433/j3vk5g. Development of a highly reproducible system to evaluate inhibition of cytochrome P450 3A4 activity by natural medicines. Sato Y(1), Sasaki T, Takahashi S, Kumagai T, Nagata K. Author information: (1)Tohoku Pharmaceutical University.

20.
📄 연구
In vivo prediction of CYP-mediated metabolic interaction potential of formononetin and biochanin A using in vitro human and rat CYP450 inhibition data.
Toxicology letters 2015 PMID:26278343

32. Toxicol Lett. 2015 Nov 19;239(1):1-8. doi: 10.1016/j.toxlet.2015.08.202. Epub 2015 Aug 13. In vivo prediction of CYP-mediated metabolic interaction potential of formononetin and biochanin A using in vitro human and rat CYP450 inhibition data. Arora S(1), Taneja I(2), Challagundla M(3), Raju

21.
📄 연구
Biochanin a: understanding the complexities in the paradoxical drug-drug interaction potential.
European journal of drug metabolism and pharmacokinetics 2015 PMID:25903969

15. Eur J Drug Metab Pharmacokinet. 2015 Jun;40(2):119-25. doi: 10.1007/s13318-015-0279-0. Biochanin a: understanding the complexities in the paradoxical drug-drug interaction potential. Srinivas NR(1). Author information: (1)Department of Pharmacokinetics and Biopharmaceutics, Dr. Reddy's Inst

22.
📄 연구
Red clover causing symptoms suggestive of methotrexate toxicity in a patient on high-dose methotrexate.
Menopause international 2013 PMID:24072635

43. Menopause Int. 2013 Sep;19(3):133-4. doi: 10.1177/1754045313502473. Red clover causing symptoms suggestive of methotrexate toxicity in a patient on high-dose methotrexate. Orr A(1), Parker R. Author information: (1)Foyleside Family Practice, Bridge Street Medical Center, Londonderry, UK. Th

23.
📄 연구
Evaluating the evidence for over-the-counter alternatives for relief of hot flashes in menopausal women.
Journal of the American Pharmacists Association : JAPhA 2010 PMID:20833608

16. J Am Pharm Assoc (2003). 2010 Sep-Oct;50(5):e106-15. doi: 10.1331/JAPhA.2010.09243. Evaluating the evidence for over-the-counter alternatives for relief of hot flashes in menopausal women. Kelley KW(1), Carroll DG. Author information: (1)School of Pharmacy, Auburn University, Alabama, USA.

24.
📄 연구
Drug-herb interactions with herbal medicines for menopause.
The journal of the British Menopause Society 2004 PMID:15667753

7. J Br Menopause Soc. 2004 Dec;10(4):162-5. doi: 10.1258/1362180042721067. Drug-herb interactions with herbal medicines for menopause. Huntley A(1). Author information: (1)Peninsula Medical School, Universities of Exeter and Plymouth, 25 Victoria Park Road, Exeter EX2 4NT, UK. Herbal medicine

25.
📄 연구
Herbal medication: potential for adverse interactions with analgesic drugs.
Journal of clinical pharmacy and therapeutics 2002 PMID:12472978

48. J Clin Pharm Ther. 2002 Dec;27(6):391-401. doi: 10.1046/j.1365-2710.2002.00444.x. Herbal medication: potential for adverse interactions with analgesic drugs. Abebe W(1). Author information: (1)Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Ge

26.
📄 연구
Potential interactions between alternative therapies and warfarin.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 2000 PMID:10902065

43. Am J Health Syst Pharm. 2000 Jul 1;57(13):1221-7; quiz 1228-30. Potential interactions between alternative therapies and warfarin. Heck AM(1), DeWitt BA, Lukes AL. Author information: (1)School of Pharmacy and Pharmacal Sciences, Purdue University, Indianapolis, IN, USA. amheck@iupui.edu Po

27.
🔬 메타분석
Effect of phytoestrogens on sexual function in menopausal women: a systematic review and meta-analysis.
Climacteric : the journal of the International Menopause Society 2018 PMID:30156931
📊 SMD -0.087 (95% CI -3.033–0.835)

5. Climacteric. 2018 Oct;21(5):437-445. doi: 10.1080/13697137.2018.1472566. Epub 2018 Aug 29. Effect of phytoestrogens on sexual function in menopausal women: a systematic review and meta-analysis. Najaf Najafi M(1), Ghazanfarpour M(2). Author information: (1)a Clinical Research Unit , Mashhad

28.
📄 연구
Induction of apoptosis in low to moderate-grade human prostate carcinoma by red clover-derived dietary isoflavones.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002 PMID:12496063

16. Cancer Epidemiol Biomarkers Prev. 2002 Dec;11(12):1689-96. Induction of apoptosis in low to moderate-grade human prostate carcinoma by red clover-derived dietary isoflavones. Jarred RA(1), Keikha M, Dowling C, McPherson SJ, Clare AM, Husband AJ, Pedersen JS, Frydenberg M, Risbridger GP. Aut

29.
📄 연구
Pharmacological and therapeutic properties of the Red Clover (Trifolium pratense L.): an overview of the new finding.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2021 PMID:34392659

46. J Tradit Chin Med. 2021 Aug;41(4):642-649. doi: 10.19852/j.cnki.jtcm.20210324.001. Pharmacological and therapeutic properties of the Red Clover (Trifolium pratense L.): an overview of the new finding. Mohsen A(1), Fatemeh K(1), Leila N(1), Mona P(2), Mohammad Z(3), Mozafar K(2). Author info

30.
📋 체계적 리뷰
Impact of phytoestrogens on treatment of urogenital menopause symptoms: A systematic review of randomized clinical trials.
European journal of obstetrics, gynecology, and reproductive biology 2021 PMID:33962824

15. Eur J Obstet Gynecol Reprod Biol. 2021 Jun;261:222-235. doi: 10.1016/j.ejogrb.2021.03.039. Epub 2021 Apr 20. Impact of phytoestrogens on treatment of urogenital menopause symptoms: A systematic review of randomized clinical trials. Abdi F(1), Rahnemaei FA(2), Roozbeh N(3), Pakzad R(4). Auth

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