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종합 유산균

Multi-strain Probiotic

📑 PubMed 20편 🦠 프로바이오틱스 🗓️ 최신 2026
🔬 메타분석 5 📋 체계적 리뷰 2 🧪 RCT 6

📖 핵심 요약

📖 20편 · 10분 읽기

종합 유산균은(는) 프로바이오틱스 계열 보충제입니다. 주로 항암, 뼈 건강 분야에서 연구되었으며, PubMed에 20편의 관련 논문이 있습니다.

🔍 연구 분야별 근거

항암 논문 1편
뼈 건강 논문 1편

* 제목에 해당 키워드가 포함된 논문 수 (PubMed 근거)

💊⚠️ 약물 상호작용 (1)

아래 약을 복용 중이라면 이 보충제 병용 전 반드시 의사·약사와 상의하세요.

항생제 전반 ℹ️ 경미

영향: 효과 감소 가능

대처: 2-3시간 간격으로 복용 (항생제 → 2-3h → 프로바이오틱스)

📊 효과 크기 분포 (Forest plot)

각 연구의 효과 추정치와 95% 신뢰구간. 개별 연구를 통합(pooling)하지 않고 그대로 표시합니다.

41574289-0.35 (3.1–13.7)32190365-0.32 (-0.48–-0.15)-2.6016SMD (favours ← / →)

📚 관련 논문 (20편) · 📊 정량 근거 4건

1.
🔬 메타분석
Meta-analysis of the effects of probiotic supplementation on bone turnover markers in middle-aged and elderly patients with osteoporosis.
Frontiers in cellular and infection microbiology 2025 PMID:41574289
📊 SMD -0.35 (95% CI 3.1–13.7) · n=432

1. Front Cell Infect Microbiol. 2026 Jan 7;15:1738378. doi: 10.3389/fcimb.2025.1738378. eCollection 2025. Meta-analysis of the effects of probiotic supplementation on bone turnover markers in middle-aged and elderly patients with osteoporosis. Yuan Y(1), Li J(1), Wang K(1), Li J(1), Wei H(1). A

2.
🔬 메타분석
Microbiota-based therapies as novel targets for autism spectrum disorder: A systematic review and meta-analysis.
Progress in neuro-psychopharmacology & biological psychiatry 2025 PMID:40348275

2. Prog Neuropsychopharmacol Biol Psychiatry. 2025 Jun 20;139:111385. doi: 10.1016/j.pnpbp.2025.111385. Epub 2025 May 14. Microbiota-based therapies as novel targets for autism spectrum disorder: A systematic review and meta-analysis. Hassib L(1), Kanashiro A(2), Pedrazzi JFC(3), Vercesi BF(4),

3.
📄 연구
The effect of probiotics supplementation on cancer-treatment complications: a critical umbrella review of interventional meta-analyses.
Critical reviews in food science and nutrition 2025 PMID:39002141
📊 OR 0.53 (95% CI 0.44–0.62)

3. Crit Rev Food Sci Nutr. 2025;65(19):3702-3727. doi: 10.1080/10408398.2024.2372880. Epub 2024 Jul 13. The effect of probiotics supplementation on cancer-treatment complications: a critical umbrella review of interventional meta-analyses. Yang Z(1)(2), Zhang S(3)(4), Ying L(1)(2), Zhang W(1), C

4.
🔬 메타분석
Role of probiotic as adjuvant in treating various infections: a systematic review and meta-analysis.
BMC infectious diseases 2024 PMID:38773400
📊 RR 1.09 (95% CI 1.04–1.13)

4. BMC Infect Dis. 2024 May 21;24(1):505. doi: 10.1186/s12879-024-09259-3. Role of probiotic as adjuvant in treating various infections: a systematic review and meta-analysis. Nelwan EJ(1)(2)(3), Herdiman A(4), Kalaij AGI(4), Lauditta RK(5), Yusuf SM(6), Suarthana E(7). Author information: (1)F

5.
🔬 메타분석
Efficacy and Safety of Probiotics, Prebiotics and Synbiotics in the Treatment of Irritable Bowel Syndrome: A systematic review and meta-analysis.
Sultan Qaboos University medical journal 2020 PMID:32190365
📊 SMD -0.32 (95% CI -0.48–-0.15) · n=321

5. Sultan Qaboos Univ Med J. 2020 Feb;20(1):e13-e24. doi: 10.18295/squmj.2020.20.01.003. Epub 2020 Mar 9. Efficacy and Safety of Probiotics, Prebiotics and Synbiotics in the Treatment of Irritable Bowel Syndrome: A systematic review and meta-analysis. Asha MZ(1), Khalil SFH(2). Author informati

6.
🔬 메타분석
The safety profile of probiotic VSL#3®. A meta-analysis of safety data from double-blind, randomized, placebo-controlled clinical trials.
European review for medical and pharmacological sciences 2020 PMID:32017005

6. RETRACTED ARTICLE Eur Rev Med Pharmacol Sci. 2020 Jan;24(2):963-973. doi: 10.26355/eurrev_202001_20082. The safety profile of probiotic VSL#3®. A meta-analysis of safety data from double-blind, randomized, placebo-controlled clinical trials. Panetta V(1), Bacchieri A, Papetti S, De Stefani E

7.
📄 연구
Multi-strain probiotic enhances metformin tolerance by modulating gut microbiome and bile acid pathways: Insight from multi-omics post-hoc analysis (ProGasMet trial).
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2026 PMID:41985330

7. Biomed Pharmacother. 2026 May;198:119370. doi: 10.1016/j.biopha.2026.119370. Epub 2026 Apr 14. Multi-strain probiotic enhances metformin tolerance by modulating gut microbiome and bile acid pathways: Insight from multi-omics post-hoc analysis (ProGasMet trial). Kwiendacz H(1), Cembrowska-Lec

8.
🧪 RCT
Multi-strain probiotic reduces gastrointestinal side effects in women with elevated HOMA-IR index treated with metformin: a 12-week randomised controlled trial.
Frontiers in endocrinology 2026 PMID:41852479

8. Front Endocrinol (Lausanne). 2026 Mar 3;17:1765741. doi: 10.3389/fendo.2026.1765741. eCollection 2026. Multi-strain probiotic reduces gastrointestinal side effects in women with elevated HOMA-IR index treated with metformin: a 12-week randomised controlled trial. Ratajczak M(1), Bilska A(2),

9.
🧪 RCT
A multi-strain probiotic formulation alleviates chronic constipation in middle-aged and older adults: A randomized, double-blind, placebo-controlled trial.
Clinical nutrition (Edinburgh, Scotland) 2026 PMID:41747651

9. Clin Nutr. 2026 Apr;59:106598. doi: 10.1016/j.clnu.2026.106598. Epub 2026 Feb 14. A multi-strain probiotic formulation alleviates chronic constipation in middle-aged and older adults: A randomized, double-blind, placebo-controlled trial. Xiao R(1), He Y(2), Mao X(3), Sun L(1), Ao L(1), Wang

10.
📄 연구
Adjunctive probiotic therapy sustains symptom relief in gastroesophageal reflux disease through gut microbiome-metabolome remodeling.
mSystems 2026 PMID:41609355

10. mSystems. 2026 Feb 17;11(2):e0156825. doi: 10.1128/msystems.01568-25. Epub 2026 Jan 29. Adjunctive probiotic therapy sustains symptom relief in gastroesophageal reflux disease through gut microbiome-metabolome remodeling. Li Y(#)(1)(2)(3)(4)(5)(6), Li Q(#)(5)(7), Quan K(#)(1)(2)(3)(4), Xie Y

11.
🧪 RCT
Multi-Strain Probiotic and Common Infections in Early Childhood Education Settings: A Randomised Controlled Trial.
Journal of paediatrics and child health 2026 PMID:41574644

11. J Paediatr Child Health. 2026 Mar;62(3):463-470. doi: 10.1111/jpc.70295. Epub 2026 Jan 23. Multi-Strain Probiotic and Common Infections in Early Childhood Education Settings: A Randomised Controlled Trial. Ahmad HH(1)(2), Peck B(1), Terry D(1)(3)(4). Author information: (1)Institute of Heal

12.
🧪 RCT
Effects of Probiotic Short-Term Regiment on Oral Health Parameters in Children: A Pilot Randomized Controlled Trial.
Nutrients 2025 PMID:41305654

12. Nutrients. 2025 Nov 18;17(22):3604. doi: 10.3390/nu17223604. Effects of Probiotic Short-Term Regiment on Oral Health Parameters in Children: A Pilot Randomized Controlled Trial. Starck E(1), Machado V(1), Botelho J(1), Proença L(1), Barroso H(1), Ascenso C(1), Rozan C(1). Author information

13.
🧪 RCT
Effects of Two Compound Probiotic Formulations on Gastrointestinal Symptoms and Gut Microbiota: A 4-Week Randomized, Double-Blind Intervention Trial.
Nutrients 2025 PMID:40944274

13. Nutrients. 2025 Sep 6;17(17):2886. doi: 10.3390/nu17172886. Effects of Two Compound Probiotic Formulations on Gastrointestinal Symptoms and Gut Microbiota: A 4-Week Randomized, Double-Blind Intervention Trial. Qu Z(1), Wu Y(1)(2), Jiang Y(1), Fan J(1), Cao L(1)(2), Dong Y(3), Fang S(3), Gu S

14.
🧪 RCT
Diversity and Dosage Determine the Efficacy of the Probiotic SYN-53 in Allergic Rhinoconjunctivitis: A Randomized, Double-Blind, Placebo-Controlled Trial.
Allergy 2025 PMID:40931615

14. Allergy. 2025 Dec;80(12):3310-3318. doi: 10.1111/all.70045. Epub 2025 Sep 10. Diversity and Dosage Determine the Efficacy of the Probiotic SYN-53 in Allergic Rhinoconjunctivitis: A Randomized, Double-Blind, Placebo-Controlled Trial. Bergmann KC(1)(2), Zuberbier T(1)(2). Author information: (

15.
📄 연구
Synergistic Effects of Probiotic and Omega-3 Supplementation with Ultra-Short Race Pace Training on Sprint Swimming Performance.
Nutrients 2025 PMID:40732922

15. Nutrients. 2025 Jul 11;17(14):2296. doi: 10.3390/nu17142296. Synergistic Effects of Probiotic and Omega-3 Supplementation with Ultra-Short Race Pace Training on Sprint Swimming Performance. Maymandinejad I(1), Hemmatinafar M(1), Jäger R(2), Imanian B(1), Koushkie Jahromi M(1), Suzuki K(3).

16.
📄 연구
Effect of the Multi-Strain Probiotic SYN-53 in the Management of Allergic Rhinoconjunctivitis.
Allergy 2025 PMID:40577168

2. Allergy. 2025 Aug;80(8):2158-2166. doi: 10.1111/all.16634. Epub 2025 Jun 27. Effect of the Multi-Strain Probiotic SYN-53 in the Management of Allergic Rhinoconjunctivitis. Bergmann KC(1)(2)(3), Zuberbier T(1)(2)(3). Author information: (1)Institute of Allergology, Charité Universitätsmedizin,

17.
📄 연구
The effects of an orally administered probiotic on sulfasalazine metabolism in individuals with rheumatoid arthritis: a preliminary study.
International journal of rheumatic diseases 2010 PMID:20374384

30. Int J Rheum Dis. 2010 Feb 1;13(1):48-54. doi: 10.1111/j.1756-185X.2009.01449.x. The effects of an orally administered probiotic on sulfasalazine metabolism in individuals with rheumatoid arthritis: a preliminary study. Lee HJ(1), Waller RD, Stebbings S, Highton J, Orlovich DA, Schmierer D, Fa

18.
📋 체계적 리뷰
The health effect of probiotics on high-fat diet-induced cognitive impairment, depression and anxiety: A cross-species systematic review.
Neuroscience and biobehavioral reviews 2022 PMID:35339484

47. Neurosci Biobehav Rev. 2022 May;136:104634. doi: 10.1016/j.neubiorev.2022.104634. Epub 2022 Mar 23. The health effect of probiotics on high-fat diet-induced cognitive impairment, depression and anxiety: A cross-species systematic review. Lof J(1), Smits K(2), Melotte V(1), Kuil LE(3). Autho

19.
📄 연구
Probiotic Supplementation During the Perinatal and Infant Period: Effects on Gut Dysbiosis and Disease.
Nutrients 2020 PMID:32727119

47. Nutrients. 2020 Jul 27;12(8):2243. doi: 10.3390/nu12082243. Probiotic Supplementation During the Perinatal and Infant Period: Effects on Gut Dysbiosis and Disease. Navarro-Tapia E(1)(2), Sebastiani G(3), Sailer S(3), Toledano LA(4)(5), Serra-Delgado M(4)(5), García-Algar Ó(1)(3), Andreu-Fern

20.
📋 체계적 리뷰
Probiotics in Irritable Bowel Syndrome: An Up-to-Date Systematic Review.
Nutrients 2019 PMID:31480656

45. Nutrients. 2019 Sep 2;11(9):2048. doi: 10.3390/nu11092048. Probiotics in Irritable Bowel Syndrome: An Up-to-Date Systematic Review. Dale HF(1)(2)(3), Rasmussen SH(4), Asiller ÖÖ(4)(5), Lied GA(4)(6)(7). Author information: (1)Centre for Nutrition, Department of Clinical Medicine, University o

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