저분자 피쉬 콜라겐 (모낭 진피 · 모발 굵기)

Addressing hair damage is essential for maintaining overall hair and scalp health. Previous studies have suggested that low-molecular-weight collagen peptides may support hair follicle biology through regulation of extracellular matrix homeostasis and cellular signaling pathways. In addition, recent preclinical studies have demonstrated that low-molecular-weight fish collagen peptides promote hair regrowth through activation of proliferative signaling and suppression of inhibitory pathways. However, their clinical efficacy in improving hair damage has not been clearly established. In this study, the efficacy and safety of low-molecular-weight collagen peptide GT (LMWCP GT) were evaluated in Korean adults with damaged hair. In a randomized,

Bioadhesives in surgery are receiving increasing attention because of their ease of handling and desirable ability to promote wound closure; however, their mechanical mismatch with skin tissue and insufficient multifunctionality hinder clinical application. A mechanically compliant, multifunctional bioadhesive hydrogel (PATF) composed of polyacrylamide (PAM), alginate (Alg), tannic acid (TA), and ferric chloride (FeCl₃) has been developed for rapid wound repair. The covalently crosslinked PAM network provides structural integrity, while multiple noncovalent interactions (Alg/Fe³⁺ ionic bonds, hydrogen bonds, and TA/Fe³⁺ coordination) endows the hydrogel with skin-like modulus (∼25 kPa), improved toughness (328.9 kJ/m³), ultra-stretchability (∼2500% strain), and low hysteresis (<21%). PATF hydrogel exhibits outstanding conformational adhesion with the skin surface, 5.25-fold stronger than that of commercial 3M Tegaderm, and can be readily detached on demand in the presence of FeCl3 solution. Furthermore, multifunction involving antioxidant capacity, photothermal therapy-mediated antibacterial efficacy, comparable conductivity to native skin tissues, and superior hemostatic performance enables PATF hydrogel (with near-infrared irradiation) to suppress inflammation, promote collagen deposition, and enhance angiogenesis, collectively accelerating healing of infected full-thickness skin wounds within 7 days. These integrated mechanically and bio

Collagen peptides have been widely studied for their beneficial effects on skin health; however, their potential role in hair growth remains insufficiently explored. This study aimed to investigate the effects of orally administered low-molecular-weight fish collagen peptide (SH-GT) on hair regrowth and its underlying mechanisms in a hair-removed C57BL/6J mouse model. Mice were administered SH-GT (100, 300, or 600 mg/kg body weight) or a positive control (Pansidil, 400 mg/kg) daily for 28 days. SH-GT significantly enhanced hair regrowth, as evidenced by the increased hair growth area. Histological analysis revealed increased dermal thickness and visible hair follicle structures in SH-GT-treated groups. At the molecular level, SH-GT upregulated proliferation-related proteins, including PCNA and Cyclin D1, and activated Wnt/β-catenin signaling. In addition, SH-GT enhanced PI3K/Akt/mTOR signaling, suggesting improved cellular growth and survival. Conversely, SH-GT suppressed hair growth inhibitory pathways by reducing BMP4 expression and decreasing Smad phosphorylation. Furthermore, SH-GT increased the mRNA expression of growth factors such as IGF-1, HGF, VEGF, EGF, and FGF7. In conclusion, SH-GT promotes hair regrow

Although herbal and bioactive wound dressings are known to promote healing, integrated dressings combining both agents for burn wounds have not been reported. The present study describes the development of a novel herbal biphasic gel (bigel) uniquely combining fish-derived bioactive collagen peptides with phytochemical rich Aloe vera and virgin coconut oil addressing critical limitations of conventional hydrogels and organogels. Among the five formulations, F4 (80:20) hydrogel: organogel (v/v) demonstrated optimal pH, stability and spreadability. It also demonstrated sustained collagen peptide release (97.7%, p < 0.0001) over 18 h following diffusion-controlled kinetics. In vitro studies confirmed its exceptional biocompatibility, demonstrating 100% cell viability, minimal hemolysis (4–6%), excellent antioxidant activity and significant cell migration (91.39% ± 1.95%, p < 0.0001) at 1 mg/ml within 12 h. In vivo studies on male albino Wistar rats with deep partial-thickness burns showed substantial wound healing, with F4-treated wounds reducing to 0.3 cm (p < 0.0001) by day 30, compared to 0.8 cm (p < 0.0001) with Silverex® (positive control) and 1.5 cm in untreated control. Histopathological analysis further supported these findings, revealing enhanced skin regeneration characterized by extensive collagen deposition, new blood vessel formation, and hair follicle development. These findings establish F4 bigel as a paradigm shift towards cost-effective, sus

Introduction: Non-healing diabetic foot ulcers often result in amputation and reduced quality of life. The study objective was to develop and evaluate a novel fish skin-derived acellular dermal matrix (FSADM) for diabetic wound-healing applications, addressing these challenges. Methods: FSADM was fabricated from yellow fin tuna (Thunnus albacares) skin using a decellularization and lyophilization process. The matrix was characterized by Fourier-transform infrared spectroscopy (FTIR). In vitro biocompatibility was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays with L929 fibroblasts and hemocompatibility tests. In vivo, biocompatibility was evaluated through subcutaneous implantation in Sprague-Dawley rats. Wound-healing efficacy was assessed in a streptozotocin-induced diabetic rat model with full-thickness excisional wounds, comparing FSADM with commercial alternatives and untreated controls. Results: FTIR analysis confirmed the preservation of collagen structure in FSADM. In vitro studies demonstrated cytocompatibility with L929 cells and minimal haemolytic activity (0.68 ± 0.034%). Subcutaneous implantation demonstrated good biocompatibility, with a progressive reduction in the inflammator

Hair growth is orchestrated by a complex cycle comprising the anagen, catagen, telogen, and exogen phases that are largely regulated by dermal papilla cells (DPCs). The disruption of oxidative balance and inflammation impairs follicle function and regeneration. Fermented yeast complex extract (FYCE) is a bioactive material derived from enzymatically hydrolyzed yeast and collagen substrates through a two-step fermentation with Lactobacillus brevis and Lactobacillus plantarum, enriched in antioxidant amino acids such as γ-aminobutyric acid (GABA) and L-alanine. In this study, we evaluated the effect of FYCE on hair regrowth, with a focus on its modulation of oxidative stress and inflammatory pathways in hydrogen peroxide (H2O2)-treated DPCs. FYCE treatment significantly enhanced NRF2 expression (3.2-fold compared to H2O2-treated DPCs), a central transcription factor controlling antioxidant defense, and concomitantly suppressed NF-κB activity (0.6-fold compared to H2O2-treated DPCs), a key mediator of inflammation. Importantly, FYCE also attenuated the activation of the NLRP3 inflammasome, as evidenced by the decreased expression levels of its molecular components. Compl

Hair loss is characterized by reduced hair thickness, decreased density, and delayed growth and is associated with factors such as aging, stress, and environmental influences. This study investigated the effects of Gly-Pro-Val-Gly-Pro-Ser low molecular weight fish collagen peptide (FC) on improving hair health and alleviating hair loss. Human dermal papilla cells and C57BL/6 mice were used as experimental models. Mice were administered FC at doses of 200, 400, and 800 mg/kg body weight, followed by protein and RNA analyses and histological evaluations. The results showed that FC significantly increased the expression of vascular endothelial growth factor, PCNA, Hepatocyte growth factor, endothelial growth factor, and insulin-like growth factor 1, which play essential roles in hair follicle growth and regeneration. Additionally, FC administration reduced the expression of specific proteins negatively associated with hair health. Histological and morphological analyses revealed that FC enhanced hair follicle size, density, and overall hair quality. These findings suggest that FC may promote hair growth and regeneration.

BACKGROUND: Hair follicle stem cells (HFSCs) play crucial roles in hair growth and are expected to be potential targets in regenerative medicine and tissue engineering. METHOD: This study aims to investigate the positive effect on hair growth by the recombinant human collagen complex (RHC complex), composed of rhCOL III, rhCOL XVII, and rhCOL XXI, along with nicotinamide, both in vitro and in vivo, by HFSCs and rat models. The survival rate, function, and differentiation of HFSCs were investigated. RESULTS: The CCK-8 experiment showed that the RHC complex was non-toxic to HFSCs, and the cell survival rate exceeded 80% after 8 and 16 h of treatment. The ELISA method showed that the RHC complex significantly increased the intracellular vascular endothelial growth factor (VEGF) levels. In addition, the increase in the content of trichohyalin (a key structural protein of hair) indicates that the structure and function of hair follicles may be enhanced. The expression levels of β-integrin and p63 were significantly upregulated, which are crucial for cell adhesion, migration, and maintenance of HFSCs homeostasis. In the rat model, significant hair growth was observed after a 7-day treatment period. The period of vigorous hair growth in rats was selected for immunofluorescence, enzyme-linked immunosorbent assay (ELISA) and hematoxylin-eosin (HE) staining analysis. The results showed that the RHC complex could promote the expression of I

9. J Drugs Dermatol. 2025 Mar 1;24(3):233-238. doi: 10.36849/JDD.8611. Artificial Intelligence-Based Personalization of Treatment Regimen for Hair Loss: A 6-Month Clinical Trial. Bhardwaj V, Rodgers N, Harth O, Harth Y. Hair loss affects up to 50% of women and 80% of men. The high costs and wait times for professional consultations lead many to seek one-size-fits-all solutions that are frequently ineffective. This study tested an artificial intelligence (AI) model for customizing non-medicated hair loss treatments. In a 24-week trial, 38 women with self-reported hair thinning received personalized product kits based on AI analysis of scalp images and questionnaires. Treatments included various combinations of topical serums, shampoos, oral supplements, and marine collagen peptides. Of the 27 participants who completed the study, significant improvements were observed in hair growth, coverage, and thickness (P&lt;0.001 for all). Hair shedding decreased by 37.3% at 12 weeks and 32.4% at 24 weeks. Scalp transepidermal water loss was reduced by 61.5% at 12 weeks and 69% at 24 weeks. Scanning electron microscopy showed improved hair texture. Participants reported overall hair improvement (88.9%), better scalp health (85.2%), and less hair brittleness (92.6%) (P&lt;0.001 for all). No adverse events were reported. The AI-driven platform effectively delivered personalized hair loss treatments, suggesting a data-driven, customized, and accessible self-served alternative for hair loss management. J Drugs Dermatol. 2025;24(3):233-238. doi:10.36849/JDD.8611.

10. Int J Pharm. 2024 Jan 25;650:123629. doi: 10.1016/j.ijpharm.2023.123629. Epub 2023 Nov 20. An androgenetic alopecia remedy based on marine collagen peptide-incorporated dissolving microneedles. Zheng W(1), Wang F(1), Tao N(2), Wang X(2), Jin X(3), Zhang C(4), Xu C(5). Author information: (1)College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, China; School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai 200240, China; Suzhou Qinpu Biotechnology Pte Ltd, Suzhou, Jiangsu Province 215215, China. (2)College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, China; Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai 201306, China; Laboratory of Quality and Safety Risk Assessment for Aquatic Products on Storage and Preservation, Ministry of Agriculture, Shanghai 201306, China; National R & D Branch Center for Freshwater Aquatic Products Processing Technology, Shanghai 201306, China. (3)School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai 200240, China. Electronic address: jxcindy@sjtu.edu.cn. (4)School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai 200240, China. Electronic address: chuanzhang@sjtu.edu.cn. (5)College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, China; Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai 201306, China; Laboratory of Quality and Safety Risk Assessment for Aquatic Products on Storage and Pres