← 전체 보충제 목록

포도씨 추출물

Grape Seed Extract

📑 PubMed 30편 🌿 허브 🗓️ 최신 2026
🔬 메타분석 7 📋 체계적 리뷰 1 🧪 RCT 7

📖 핵심 요약

📖 30편 · 15분 읽기

포도씨 추출물은(는) 허브 계열 보충제입니다. 주로 혈압, 항염, 콜레스테롤, 항산화, 심혈관, 당뇨 분야에서 연구되었으며, PubMed에 30편의 관련 논문이 있습니다.

🔍 연구 분야별 근거

혈압 논문 1편
항염 논문 1편
콜레스테롤 논문 2편
항산화 논문 1편
심혈관 논문 1편
당뇨 논문 1편

* 제목에 해당 키워드가 포함된 논문 수 (PubMed 근거)

📊 효과 크기 분포 (Forest plot)

각 연구의 효과 추정치와 95% 신뢰구간. 개별 연구를 통합(pooling)하지 않고 그대로 표시합니다.

41158097-2.28 (-3.01–-1.56)34107109-1.04 (-1.65–-0.42)37352393-2.23 (-4.34–-1.37)-500.65SMD (favours ← / →)

📚 관련 논문 (30편) · 📊 정량 근거 4건

1.
🔬 메타분석
The Impact of Antioxidant Adjuncts on Periodontal Health in Type 2 Diabetes Patients: A Meta-Analysis.
Clinical and experimental dental research 2025 PMID:41158097
📊 SMD -2.28 (95% CI -3.01–-1.56) · n=315

1. Clin Exp Dent Res. 2025 Dec;11(6):e70215. doi: 10.1002/cre2.70215. The Impact of Antioxidant Adjuncts on Periodontal Health in Type 2 Diabetes Patients: A Meta-Analysis. Abdulla SA(1), Abdalla BA(2), Muhammed AA(3), Elawamy HA(4), Hawda SM(1), Mohamed N(4), Abduallah EH(5), Younis MYG(1), Als

2.
🔬 메타분석
The effect of grape (Vitis vinifera) seed extract supplementation on flow-mediated dilation, blood pressure, and heart rate: A systematic review and meta-analysis of controlled trials with duration- and dose-response analysis.
Pharmacological research 2022 PMID:34798267
📊 MD -2.2 (95% CI -3.79–-0.6)

2. Pharmacol Res. 2022 Jan;175:105905. doi: 10.1016/j.phrs.2021.105905. Epub 2021 Nov 17. The effect of grape (Vitis vinifera) seed extract supplementation on flow-mediated dilation, blood pressure, and heart rate: A systematic review and meta-analysis of controlled trials with duration- and dos

3.
🔬 메타분석
The effect of grape seed extract supplementation on oxidative stress and inflammation: A systematic review and meta-analysis of controlled trials.
International journal of clinical practice 2021 PMID:34107109
📊 SMD -1.04 (95% CI -1.65–-0.42)

3. Int J Clin Pract. 2021 Nov;75(11):e14469. doi: 10.1111/ijcp.14469. Epub 2021 Jun 28. The effect of grape seed extract supplementation on oxidative stress and inflammation: A systematic review and meta-analysis of controlled trials. Foshati S(1), Rouhani MH(2), Amani R(1). Author information:

4.
🔬 메타분석
The effect of grape products containing polyphenols on C-reactive protein levels: a systematic review and meta-analysis of randomised controlled trials.
The British journal of nutrition 2021 PMID:32921322

4. Br J Nutr. 2021 Jun 14;125(11):1230-1245. doi: 10.1017/S0007114520003591. Epub 2020 Sep 14. The effect of grape products containing polyphenols on C-reactive protein levels: a systematic review and meta-analysis of randomised controlled trials. Sarkhosh-Khorasani S(1)(2), Hosseinzadeh M(1)(2)

5.
🧪 RCT
Chardonnay grape marc/grape seed extract blends improve postprandial triglycerides and/or HDL cholesterol concentrations in adults with mild dyslipidemia in a randomized double blinded crossover trial.
Nutrition research (New York, N.Y.) 2026 PMID:41894982

5. Nutr Res. 2026 May;149:66-80. doi: 10.1016/j.nutres.2026.02.009. Epub 2026 Mar 4. Chardonnay grape marc/grape seed extract blends improve postprandial triglycerides and/or HDL cholesterol concentrations in adults with mild dyslipidemia in a randomized double blinded crossover trial. Lee F(1)

6.
📄 연구
Overall Survival of Glioblastoma Patients Treated With a Combination of 7 Micronutrients: A Nutraceutical Trial.
Anticancer research 2026 PMID:41760279

6. Anticancer Res. 2026 Mar;46(3):1599-1608. doi: 10.21873/anticanres.18055. Overall Survival of Glioblastoma Patients Treated With a Combination of 7 Micronutrients: A Nutraceutical Trial. Rooprai HK(1), Lawrence P(2), Ashkan K(3), Beaney R(4), Pilkington GJ(5), Gullan RW(1). Author informatio

7.
🧪 RCT
Vitis vinifera seed extract reduces venous reflux time in patients with varicose veins: VICTORY randomized controlled trial.
Journal of vascular surgery. Venous and lymphatic disorders 2026 PMID:41242464

7. J Vasc Surg Venous Lymphat Disord. 2026 Jan;14(1):102355. doi: 10.1016/j.jvsv.2025.102355. Epub 2025 Nov 15. Vitis vinifera seed extract reduces venous reflux time in patients with varicose veins: VICTORY randomized controlled trial. Bae S(1), Kim H(2), Son NH(3), Kim M(1), Park S(2), Jung IH

8.
🧪 RCT
Clinical and radiological assessment of grape seed extract versus mineral trioxide aggregates in primary molar pulpotomy: A randomized controlled clinical trial.
Medicine 2025 PMID:41029033

8. Medicine (Baltimore). 2025 Sep 26;104(39):e44827. doi: 10.1097/MD.0000000000044827. Clinical and radiological assessment of grape seed extract versus mineral trioxide aggregates in primary molar pulpotomy: A randomized controlled clinical trial. Bakr NM(1), Balbola GA(2), Alqadi SF(3), Dar-O

9.
📄 연구
Effect of 7-day dietary supplementation with grape seed extract on cardiac autonomic and hemodynamic responses in elevated and stage 1 hypertension.
Clinical physiology and functional imaging 2025 PMID:40341867

9. Clin Physiol Funct Imaging. 2025 May;45(3):e70010. doi: 10.1111/cpf.70010. Effect of 7-day dietary supplementation with grape seed extract on cardiac autonomic and hemodynamic responses in elevated and stage 1 hypertension. Lira A(1), Boyer W(1), Gillum T(1), Sullivan S(1), Kim JK(1). Author

10.
🧪 RCT
Vitamin E ameliorates blood cholesterol level and alters gut microbiota composition: A randomized controlled trial.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2025 PMID:40087044

10. Nutr Metab Cardiovasc Dis. 2025 Aug;35(8):103964. doi: 10.1016/j.numecd.2025.103964. Epub 2025 Feb 25. Vitamin E ameliorates blood cholesterol level and alters gut microbiota composition: A randomized controlled trial. Chen B(1), Li Y(2), Li Z(3), Hu X(4), Zhen H(3), Chen H(3), Nie C(3), Hou

11.
🧪 RCT
Comparison of the Effects of Dill Seed, Grape Seed and Date Extracts on Postpartum Hemorrhage Rates in the Fourth Stage of Labor: A Randomized Clinical Trial.
Reviews on recent clinical trials 2025 PMID:39410893

11. Rev Recent Clin Trials. 2025;20(1):68-78. doi: 10.2174/0115748871317272240930092220. Comparison of the Effects of Dill Seed, Grape Seed and Date Extracts on Postpartum Hemorrhage Rates in the Fourth Stage of Labor: A Randomized Clinical Trial. Shayan A(1), Refaei M(2), Parsapour H(3), Masou

12.
🧪 RCT
Vitis Vinifera Seed Extract Versus Micronized Purified Flavonoid Fraction for Patients with Chronic Venous Disease: A Randomized Noninferiority Trial.
Annals of vascular surgery 2024 PMID:39009117

12. Ann Vasc Surg. 2024 Dec;109:177-186. doi: 10.1016/j.avsg.2024.06.011. Epub 2024 Jul 14. Vitis Vinifera Seed Extract Versus Micronized Purified Flavonoid Fraction for Patients with Chronic Venous Disease: A Randomized Noninferiority Trial. Kim SM(1), Joh JH(2), Jung IM(3), Kim MJ(4), Lee SS(5

13.
🧪 RCT
The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study.
BMC complementary medicine and therapies 2024 PMID:38755622

13. BMC Complement Med Ther. 2024 May 16;24(1):192. doi: 10.1186/s12906-024-04477-3. The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-contro

14.
📄 연구
Grape seed extract supplementation in non-alcoholic fatty liver disease.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 2024 PMID:38419408

14. Int J Vitam Nutr Res. 2024 Jun;94(5-6):365-376. doi: 10.1024/0300-9831/a000805. Epub 2024 Feb 28. Grape seed extract supplementation in non-alcoholic fatty liver disease. Ghanbari P(1), Alboebadi R(1), Bazyar H(2)(3), Raiesi D(4), ZareJavid A(5), Azadbakht MK(6), Karimi M(1), Razmi H(1). Au

15.
📄 연구
The effect of grape seed and green tea extracts on the pharmacokinetics of imatinib and its main metabolite, N-desmethyl imatinib, in rats.
BMC pharmacology & toxicology 2020 PMID:33198812

15. BMC Pharmacol Toxicol. 2020 Nov 16;21(1):77. doi: 10.1186/s40360-020-00456-9. The effect of grape seed and green tea extracts on the pharmacokinetics of imatinib and its main metabolite, N-desmethyl imatinib, in rats. Darweesh RS(1), El-Elimat T(2), Zayed A(2), Khamis TN(3), Babaresh WM(2), A

16.
📄 연구
Effect of pea protein plus grape seed dry extract on a murine model of Candida albicans induced vaginitis.
Future microbiology 2018 PMID:30256168

45. Future Microbiol. 2018 Sep;13:1375-1382. doi: 10.2217/fmb-2018-0102. Epub 2018 Sep 26. Effect of pea protein plus grape seed dry extract on a murine model of Candida albicans induced vaginitis. Esposito E(1), Campolo M(1), Casili G(1), Lanza M(1), Filippone A(1), Peritore AF(1), Cuzzocrea S

17.
📄 연구
Combinational Proanthocyanidins and Resveratrol Synergistically Inhibit Human Breast Cancer Cells and Impact Epigenetic⁻Mediating Machinery.
International journal of molecular sciences 2018 PMID:30060527

5. Int J Mol Sci. 2018 Jul 27;19(8):2204. doi: 10.3390/ijms19082204. Combinational Proanthocyanidins and Resveratrol Synergistically Inhibit Human Breast Cancer Cells and Impact Epigenetic⁻Mediating Machinery. Gao Y(1), Tollefsbol TO(2)(3)(4)(5)(6). Author information: (1)Department of Biology,

18.
📄 연구
Grape seed proanthocyanidins and metformin combination attenuate hepatic endoplasmic reticulum stress in rats subjected to nutrition excess.
Archives of physiology and biochemistry 2019 PMID:29482356

49. Arch Physiol Biochem. 2019 May;125(2):174-183. doi: 10.1080/13813455.2018.1444058. Epub 2018 Feb 27. Grape seed proanthocyanidins and metformin combination attenuate hepatic endoplasmic reticulum stress in rats subjected to nutrition excess. Yogalakshmi B(1), Sathiya Priya C(1), Anuradha CV(

19.
📄 연구
Synergistic radiation protective effect of purified Auricularia auricular-judae polysaccharide (AAP IV) with grape seed procyanidins.
Molecules (Basel, Switzerland) 2014 PMID:25514216

37. Molecules. 2014 Dec 11;19(12):20675-94. doi: 10.3390/molecules191220675. Synergistic radiation protective effect of purified Auricularia auricular-judae polysaccharide (AAP IV) with grape seed procyanidins. Bai H(1), Wang Z(2), Cui J(3), Yun K(4), Zhang H(5), Liu RH(6), Fan Z(7), Cheng C(8).

20.
📄 연구
Low molecular weight procyanidins from grape seeds enhance the impact of 5-Fluorouracil chemotherapy on Caco-2 human colon cancer cells.
PloS one 2014 PMID:24905821

6. PLoS One. 2014 Jun 6;9(6):e98921. doi: 10.1371/journal.pone.0098921. eCollection 2014. Low molecular weight procyanidins from grape seeds enhance the impact of 5-Fluorouracil chemotherapy on Caco-2 human colon cancer cells. Cheah KY(1), Howarth GS(2), Bindon KA(3), Kennedy JA(4), Bastian SE(5

21.
📄 연구
Grape-seed procyanidins modulate cellular membrane potential and nutrient-induced GLP-1 secretion in STC-1 cells.
American journal of physiology. Cell physiology 2014 PMID:24371039

37. Am J Physiol Cell Physiol. 2014 Mar 1;306(5):C485-92. doi: 10.1152/ajpcell.00355.2013. Epub 2013 Dec 26. Grape-seed procyanidins modulate cellular membrane potential and nutrient-induced GLP-1 secretion in STC-1 cells. González-Abuín N(1), Martínez-Micaelo N, Blay M, Green BD, Pinent M, Ardé

22.
📄 연구
The effect of grape seed extract on the pharmacokinetics of dextromethorphan in healthy volunteers.
European journal of clinical pharmacology 2013 PMID:23881421

16. Eur J Clin Pharmacol. 2013 Nov;69(11):1883-90. doi: 10.1007/s00228-013-1558-9. Epub 2013 Jul 24. The effect of grape seed extract on the pharmacokinetics of dextromethorphan in healthy volunteers. Goey AK(1), Meijerman I, Beijnen JH, Schellens JH. Author information: (1)Department of Pharma

23.
📄 연구
Identification of oligomer proanthocyanidins (F2) isolated from grape seeds as a formyl peptide receptor 1 partial agonist.
International immunopharmacology 2013 PMID:23523627

20. Int Immunopharmacol. 2013 Apr;15(4):756-63. doi: 10.1016/j.intimp.2013.03.007. Epub 2013 Mar 21. Identification of oligomer proanthocyanidins (F2) isolated from grape seeds as a formyl peptide receptor 1 partial agonist. Yang J(1), Wang Q, Zhao R, Sun B, Wang L, Hou Y, Li X, Wu C. Author in

24.
📄 연구
Effect of selenium and grape seed extract on indomethacin-induced gastric ulcers in rats.
Journal of physiology and biochemistry 2013 PMID:23456451

26. J Physiol Biochem. 2013 Sep;69(3):527-37. doi: 10.1007/s13105-013-0241-z. Epub 2013 Mar 1. Effect of selenium and grape seed extract on indomethacin-induced gastric ulcers in rats. Abbas AM(1), Sakr HF. Author information: (1)Medical Physiology Department, Faculty of Medicine, Mansoura Univ

25.
📄 연구
Effect of Dentin Biomodification on the Survival of Resin Composite Restorations: An Umbrella Review.
International dental journal 2026 PMID:41713123

21. Int Dent J. 2026 Apr;76(2):109446. doi: 10.1016/j.identj.2026.109446. Epub 2026 Feb 18. Effect of Dentin Biomodification on the Survival of Resin Composite Restorations: An Umbrella Review. El Alaoui N(1), Chala S(2), Ghoul S(3). Author information: (1)International Faculty of Dental Medici

26.
🔬 메타분석
Effects of cross-linking agents on hydroxyproline release and root caries lesion size: Systematic review and network meta-analysis of in vitro studies.
European journal of oral sciences 2024 PMID:39579122

8. Eur J Oral Sci. 2024 Dec;132(6):e13028. doi: 10.1111/eos.13028. Epub 2024 Nov 23. Effects of cross-linking agents on hydroxyproline release and root caries lesion size: Systematic review and network meta-analysis of in vitro studies. Monici Silva I(1), Barbosa CB(1), Cena JA(1), Ribeiro E(1),

27.
📋 체계적 리뷰
Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus mutans: a systematic review of in vitro studies.
BMC oral health 2024 PMID:38840232

24. BMC Oral Health. 2024 Jun 5;24(1):662. doi: 10.1186/s12903-024-04263-0. Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus mutans: a systematic review of in vitro studies. Castellanos JS(1), Betancourt DE(1), Díaz-Báez D(2), Baldión P

28.
🔬 메타분석
Does the Grape Products Intake has an Effect on Body Weight in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Current drug targets 2024 PMID:38141198

23. Curr Drug Targets. 2024;25(2):121-134. doi: 10.2174/0113894501272740231219072525. Does the Grape Products Intake has an Effect on Body Weight in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Goudarzi MA(1), Sohrabi Z(2), Hashempur MH(3), Nosratabadi S(4), Nam

29.
📄 연구
Anticaries properties of natural berries: systematic literature review.
Nutrition reviews 2024 PMID:37352393
📊 SMD -2.23 (95% CI -4.34–-1.37)

44. Nutr Rev. 2024 Feb 12;82(3):302-317. doi: 10.1093/nutrit/nuad063. Anticaries properties of natural berries: systematic literature review. García-Manríquez N(1), Lozano C(2), Muñoz A(1), Morales MF(1), Giacaman RA(1)(2)(3). Author information: (1)Cariology Unit, Department of Oral Rehabilitat

30.
🔬 메타분석
The effect of grape products on liver enzymes: A systematic review and meta-analysis of randomized controlled trials.
Phytotherapy research : PTR 2022 PMID:36264051

42. Phytother Res. 2022 Dec;36(12):4491-4503. doi: 10.1002/ptr.7653. Epub 2022 Oct 20. The effect of grape products on liver enzymes: A systematic review and meta-analysis of randomized controlled trials. Zamani M(1), Ashtary-Larky D(2), Hafizi N(3), Naeini F(4), Rezaei Kelishadi M(3), Clark CC

🔗 같은 분류의 보충제

⚠️ 면책 고지

이 정보는 일반 교육 목적이며 의료 진단/처방을 대체하지 않습니다.