콜라겐 (II형)

Efficacy of combined undenatured type II collagen and hydrolysed collagen supplementation in knee osteoarthritis: a randomised controlled trial.

1. Sci Rep. 2025 Sep 2;15(1):32313. doi: 10.1038/s41598-025-17505-0. Efficacy of combined undenatured type II collagen and hydrolysed collagen supplementation in knee osteoarthritis: a randomised controlled trial. Yuenyongviwat V(1), Anusitviwat C(1), Tuntarattanapong P(1), Hongnaparak T(1), Iam

Oral enzyme combination therapy reduces systemic inflammation, urinary CTXII and pain in knee osteoarthritis: a proof-of-mechanism, randomised, crossover, double-blind, placebo-controlled trial.

2. RMD Open. 2025 Aug 12;11(3):e005433. doi: 10.1136/rmdopen-2025-005433. Oral enzyme combination therapy reduces systemic inflammation, urinary CTXII and pain in knee osteoarthritis: a proof-of-mechanism, randomised, crossover, double-blind, placebo-controlled trial. Henrotin Y(#)(1), Pap T(#)(

Effects of cartilage-supporting nutritional supplementation on knee osteoarthritis symptoms and quality of life in a 12-week randomized double-blind placebo-controlled pilot study.

3. Sci Rep. 2025 Jul 15;15(1):25625. doi: 10.1038/s41598-025-11723-2. Effects of cartilage-supporting nutritional supplementation on knee osteoarthritis symptoms and quality of life in a 12-week randomized double-blind placebo-controlled pilot study. Fladerer-Grollitsch JP(1)(2), Klein T(3), Kom

[Experience with the use of undenatured type II collagen in patients with stage III knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized trial].

4. Ter Arkh. 2025 Feb 21;97(1):54-64. doi: 10.26442/00403660.2025.01.203145. [Experience with the use of undenatured type II collagen in patients with stage III knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized trial]. [Article in Russian; Abstract ava

The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy: a randomized, double-blind, placebo-controlled study.

5. BMC Musculoskelet Disord. 2025 Jan 4;26(1):17. doi: 10.1186/s12891-024-08244-w. The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy: a randomized, double-blind, plac

Effect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study.

6. Jt Dis Relat Surg. 2025 Jan 2;36(1):85-96. doi: 10.52312/jdrs.2025.1965. Epub 2024 Nov 5. Effect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placeb

A Dietary Supplement in the Management of Patients with Lumbar Osteochondrosis: A Randomized, Double-Blinded, Placebo-Controlled Study.

7. Nutrients. 2024 Aug 14;16(16):2695. doi: 10.3390/nu16162695. A Dietary Supplement in the Management of Patients with Lumbar Osteochondrosis: A Randomized, Double-Blinded, Placebo-Controlled Study. Laky B(1)(2)(3)(4)(5), Huemer D(1)(6), Eigenschink M(1)(7), Sagl B(8), Thell R(6)(9), Wagner KH(

Optimizing oral immune tolerance to Type II collagen in patients with rheumatoid arthritis: The importance of dose, interfering medication and genetics.

8. Am J Med Sci. 2024 Oct;368(4):300-310. doi: 10.1016/j.amjms.2024.06.008. Epub 2024 Jun 17. Optimizing oral immune tolerance to Type II collagen in patients with rheumatoid arthritis: The importance of dose, interfering medication and genetics. Postlethwaite AE(1), Jiao Y(2), Yang C(2), Dong W

[Efficacy and safety of undenatured type II collagen in patients with knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized trial].

9. Ter Arkh. 2024 Jun 3;96(5):500-509. doi: 10.26442/00403660.2024.05.202788. [Efficacy and safety of undenatured type II collagen in patients with knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized trial]. [Article in Russian; Abstract available in Rus

[Comparative efficacy of a combination of undenatured type II collagen, Boswellic acids, methylsulfonylmethane, vitamins C and D(3) and a combination of chondroitin sulfate and glucosamine hydrochloride in the treatment of primary osteoarthritis of the knee joint].

10. Ter Arkh. 2023 Dec 28;95(12):1141-1150. doi: 10.26442/00403660.2023.12.202540. [Comparative efficacy of a combination of undenatured type II collagen, Boswellic acids, methylsulfonylmethane, vitamins C and D(3) and a combination of chondroitin sulfate and glucosamine hydrochloride in the trea

Hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site.

11. Eur J Pharm Biopharm. 2024 Jun;199:114308. doi: 10.1016/j.ejpb.2024.114308. Epub 2024 Apr 28. Hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site. Gomes C(1), Gridley K(2), Anastasiou I(1), Sinkó B(1), Mrsny RJ(3). Author information: (1)Pion,

Niacinamide and undenatured type II collagen modulates the inflammatory response in rats with monoiodoacetate-induced osteoarthritis.

12. Sci Rep. 2021 Jul 19;11(1):14724. doi: 10.1038/s41598-021-94142-3. Niacinamide and undenatured type II collagen modulates the inflammatory response in rats with monoiodoacetate-induced osteoarthritis. Sahin K(1), Kucuk O(2), Orhan C(3), Tuzcu M(4), Durmus AS(5), Ozercan IH(6), Sahin N(3), Ju

A Synthetic Cell-Penetrating Heparin-Binding Peptide Derived from BMP4 with Anti-Inflammatory and Chondrogenic Functions for the Treatment of Arthritis.

13. Int J Mol Sci. 2020 Jun 15;21(12):4251. doi: 10.3390/ijms21124251. A Synthetic Cell-Penetrating Heparin-Binding Peptide Derived from BMP4 with Anti-Inflammatory and Chondrogenic Functions for the Treatment of Arthritis. Choi DH(1), Lee D(2), Jo BS(2), Park KS(3), Lee KE(1), Choi JK(1), Park

The influence of probiotic diet and chondroitin sulfate administration on Ptgs2, Tgfb1 and Col2a1 expression in rat knee cartilage during monoiodoacetate-induced osteoarthritis.

14. Minerva Med. 2019 Oct;110(5):419-424. doi: 10.23736/S0026-4806.19.06063-4. Epub 2019 Apr 1. The influence of probiotic diet and chondroitin sulfate administration on Ptgs2, Tgfb1 and Col2a1 expression in rat knee cartilage during monoiodoacetate-induced osteoarthritis. Korotkyi OH(1), Vovk

Allylpyrocatechol attenuates methotrexate-induced hepatotoxicity in a collagen-induced model of arthritis.

15. Free Radic Res. 2018 Jun;52(6):698-711. doi: 10.1080/10715762.2018.1466391. Allylpyrocatechol attenuates methotrexate-induced hepatotoxicity in a collagen-induced model of arthritis. De S(1), Kundu S(1), Chatterjee U(2), Chattopadhyay S(3), Chatterjee M(1). Author information: (1)a Departmen

ASIC2a overexpression enhances the protective effect of PcTx1 and APETx2 against acidosis-induced articular chondrocyte apoptosis and cytotoxicity.

30. Gene. 2018 Feb 5;642:230-240. doi: 10.1016/j.gene.2017.11.034. Epub 2017 Nov 13. ASIC2a overexpression enhances the protective effect of PcTx1 and APETx2 against acidosis-induced articular chondrocyte apoptosis and cytotoxicity. Zhou RP(1), Ni WL(2), Dai BB(1), Wu XS(1), Wang ZS(1), Xie YY(1)

Intra-Articular Injection of Cross-Linked Hyaluronic Acid-Dexamethasone Hydrogel Attenuates Osteoarthritis: An Experimental Study in a Rat Model of Osteoarthritis.

5. Int J Mol Sci. 2016 Apr 15;17(4):411. doi: 10.3390/ijms17040411. Intra-Articular Injection of Cross-Linked Hyaluronic Acid-Dexamethasone Hydrogel Attenuates Osteoarthritis: An Experimental Study in a Rat Model of Osteoarthritis. Zhang Z(1), Wei X(2), Gao J(3), Zhao Y(4), Zhao Y(5), Guo L(6),

TGF-β3 and IGF-1 synergy ameliorates nucleus pulposus mesenchymal stem cell differentiation towards the nucleus pulposus cell type through MAPK/ERK signaling.

42. Growth Factors. 2015;33(5-6):326-36. doi: 10.3109/08977194.2015.1088532. Epub 2015 Oct 2. TGF-β3 and IGF-1 synergy ameliorates nucleus pulposus mesenchymal stem cell differentiation towards the nucleus pulposus cell type through MAPK/ERK signaling. Tao Y(1), Zhou X(1), Liang C(1), Li H(1),

Retinol encapsulated into amorphous Ca(2+) polyphosphate nanospheres acts synergistically in MC3T3-E1 cells.

20. Eur J Pharm Biopharm. 2015 Jun;93:214-23. doi: 10.1016/j.ejpb.2015.04.005. Epub 2015 Apr 18. Retinol encapsulated into amorphous Ca(2+) polyphosphate nanospheres acts synergistically in MC3T3-E1 cells. Müller WE(1), Tolba E(2), Schröder HC(3), Diehl-Seifert B(4), Wang X(5). Author informati

Amelioration of bleomycin-induced pulmonary fibrosis in a mouse model by a combination therapy of bosentan and imatinib.

27. Exp Lung Res. 2015 May;41(4):173-88. doi: 10.3109/01902148.2014.939312. Epub 2015 Apr 6. Amelioration of bleomycin-induced pulmonary fibrosis in a mouse model by a combination therapy of bosentan and imatinib. Chilakapati SR(1), Serasanambati M, Vissavajjhala P, Kanala JR, Chilakapati DR. A

An In Vivo Study to Evaluate the Efficacy of Blue Shark (Prionace glauca) Cartilage Collagen as a Cosmetic.

17. Mar Drugs. 2022 Oct 5;20(10):633. doi: 10.3390/md20100633. An In Vivo Study to Evaluate the Efficacy of Blue Shark (Prionace glauca) Cartilage Collagen as a Cosmetic. Lu WC(1), Chiu CS(2), Chan YJ(3), Guo TP(4), Lin CC(5), Wang PC(4), Lin PY(4), Mulio AT(6), Li PH(6). Author information: (1

Inhalation therapy of calcitonin relieves osteoarthritis of the knee.

42. J Korean Med Sci. 2012 Nov;27(11):1405-10. doi: 10.3346/jkms.2012.27.11.1405. Epub 2012 Oct 30. Inhalation therapy of calcitonin relieves osteoarthritis of the knee. Armagan O(1), Serin DK, Calisir C, Dokumacioglu A, Ozgen M, Oner S, Alatas O. Author information: (1)Department of Physical Th

Ethnic differences in levels of bone and cartilage biomarkers and hormonal responsiveness in nine groups of postmenopausal Asian women: the Pan-Asia Menopause (PAM) study.

41. Climacteric. 2008 Feb;11(1):44-54. doi: 10.1080/13697130701744886. Ethnic differences in levels of bone and cartilage biomarkers and hormonal responsiveness in nine groups of postmenopausal Asian women: the Pan-Asia Menopause (PAM) study. Holinka CF(1), Christiansen C, Tian XW, Ausmanas MK.

The Role of Exosome-Loaded Hydrogels in Improving Intervertebral Disc Degeneration: A Systematic Review and Meta-Analysis of Preclinical Animal Studies.

35. Front Biosci (Landmark Ed). 2025 Jun 25;30(6):38302. doi: 10.31083/FBL38302. The Role of Exosome-Loaded Hydrogels in Improving Intervertebral Disc Degeneration: A Systematic Review and Meta-Analysis of Preclinical Animal Studies. Wang B(1), Xie D(1), Huang J(1), Huang Z(1), Weng W(1), Huang

Advance in candidate genes in mandibular retrognathism: A systematic review.

35. Arch Oral Biol. 2025 Jun;174:106234. doi: 10.1016/j.archoralbio.2025.106234. Epub 2025 Mar 13. Advance in candidate genes in mandibular retrognathism: A systematic review. Yang L(1), Yang W(2), Shen Y(1), Zhou Y(3). Author information: (1)School and Hospital of Stomatology, Wenzhou Medical U

Uncovering the "riddle of femininity" in osteoarthritis: a systematic review and meta-analysis of menopausal animal models and mathematical modeling of estrogen treatment.

6. Osteoarthritis Cartilage. 2023 Apr;31(4):447-457. doi: 10.1016/j.joca.2022.12.009. Epub 2023 Jan 6. Uncovering the "riddle of femininity" in osteoarthritis: a systematic review and meta-analysis of menopausal animal models and mathematical modeling of estrogen treatment. Gilmer G(1), Bean AC

Preclinical Use of FGF-18 Augmentation for Improving Cartilage Healing Following Surgical Repair: A Systematic Review.

18. Cartilage. 2023 Mar;14(1):59-66. doi: 10.1177/19476035221142010. Epub 2022 Dec 21. Preclinical Use of FGF-18 Augmentation for Improving Cartilage Healing Following Surgical Repair: A Systematic Review. DePhillipo NN(1)(2), Hendesi H(3), Aman ZS(4), Lind DRG(1), Smith J(5), Dodge GR(1)(2).

Is collagen supplementation friend or foe in rheumatoid arthritis and osteoarthritis? A comprehensive systematic review.

42. Int J Rheum Dis. 2022 Sep;25(9):973-981. doi: 10.1111/1756-185X.14382. Epub 2022 Jul 5. Is collagen supplementation friend or foe in rheumatoid arthritis and osteoarthritis? A comprehensive systematic review. Jabbari M(1), Barati M(2), Khodaei M(3), Babashahi M(4), Kalhori A(5), Tahmassian

Three-Dimensional Bioprinting Scaffolding for Nasal Cartilage Defects: A Systematic Review.

6. Tissue Eng Regen Med. 2021 Jun;18(3):343-353. doi: 10.1007/s13770-021-00331-6. Epub 2021 Apr 17. Three-Dimensional Bioprinting Scaffolding for Nasal Cartilage Defects: A Systematic Review. Chiesa-Estomba CM(1)(2), Aiastui A(3)(4), González-Fernández I(5), Hernáez-Moya R(3), Rodiño C(4), Delg

Clinically Relevant Molecular Biomarkers for Use in Human Knee Osteoarthritis: A Systematic Review.

46. Cartilage. 2021 Dec;13(1_suppl):1511S-1531S. doi: 10.1177/1947603520941239. Epub 2020 Jul 17. Clinically Relevant Molecular Biomarkers for Use in Human Knee Osteoarthritis: A Systematic Review. Convill JG(1), Tawy GF(1), Freemont AJ(1), Biant LC(1). Author information: (1)Faculty of Biology