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클로스트리디움 부티리쿰

Clostridium butyricum

📑 PubMed 20편 🦠 프로바이오틱스 🗓️ 최신 2026
🔬 메타분석 4 📋 체계적 리뷰 1 🧪 RCT 6

📖 핵심 요약

📖 20편 · 10분 읽기

클로스트리디움 부티리쿰은(는) 프로바이오틱스 계열 보충제입니다. PubMed에 20편의 관련 논문이 있습니다.

📊 효과 크기 분포 (Forest plot)

각 연구의 효과 추정치와 95% 신뢰구간. 개별 연구를 통합(pooling)하지 않고 그대로 표시합니다.

317851732.68 (1.13–6.35)310392870.45 (0.36–0.56)286811770.49 (1.13–1.25)266950800.46 (0.35–0.61)4158056323.54 (7.58–73.08)0.215RR (favours ← / →)

📚 관련 논문 (20편) · 📊 정량 근거 5건

1.
🔬 메타분석
Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable bowel syndrome: a systematic review and network meta-analysis.
European journal of gastroenterology & hepatology 2026 PMID:40929652

1. Eur J Gastroenterol Hepatol. 2026 Jan 1;38(1):27-35. doi: 10.1097/MEG.0000000000003062. Epub 2025 Aug 25. Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable bowel syndrome: a systematic review and network meta-analysis. Rokka

2.
🔬 메타분석
The effectiveness of probiotics as an adjunct therapy in patients under mechanical ventilation: an umbrella systematic review and meta-analysis.
Food & function 2024 PMID:38771159

2. Food Funct. 2024 Jun 4;15(11):5737-5751. doi: 10.1039/d3fo04653b. The effectiveness of probiotics as an adjunct therapy in patients under mechanical ventilation: an umbrella systematic review and meta-analysis. Anvarifard P(1), Anbari M(1), Ghalichi F(2), Ghoreishi Z(3)(4), Zarezadeh M(1)(3).

3.
🔬 메타분석
Effects of probiotics in children with acute gastroenteritis: A systematic review and meta-analysis focusing on probiotics utilized in Japan.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2024 PMID:37956795

3. J Infect Chemother. 2024 Apr;30(4):337-342. doi: 10.1016/j.jiac.2023.11.005. Epub 2023 Nov 11. Effects of probiotics in children with acute gastroenteritis: A systematic review and meta-analysis focusing on probiotics utilized in Japan. Higuchi T(1), Furuichi M(2), Maeda N(3), Tsugawa T(4), I

4.
📄 연구
Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis.
The Cochrane database of systematic reviews 2019 PMID:31785173
📊 RR 2.68 (95% CI 1.13–6.35) · n=547

4. Cochrane Database Syst Rev. 2019 Nov 30;11(11):CD001176. doi: 10.1002/14651858.CD001176.pub5. Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis. Nguyen N(1), Zhang B(2), Holubar SD(3), Pardi DS(4), Singh S(1). Author information: (1)Unive

5.
📄 연구
Probiotics for the prevention of pediatric antibiotic-associated diarrhea.
The Cochrane database of systematic reviews 2019 PMID:31039287
📊 RR 0.45 (95% CI 0.36–0.56) · n=6352

5. Cochrane Database Syst Rev. 2019 Apr 30;4(4):CD004827. doi: 10.1002/14651858.CD004827.pub5. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Guo Q(1), Goldenberg JZ, Humphrey C, El Dib R, Johnston BC. Author information: (1)Department of Pediatrics, West China Second

6.
🔬 메타분석
Efficacy and safety of probiotic-supplemented triple therapy for eradication of Helicobacter pylori in children: a systematic review and network meta-analysis.
European journal of clinical pharmacology 2017 PMID:28681177
📊 RR 0.49 (95% CI 1.13–1.25) · n=3122

6. Eur J Clin Pharmacol. 2017 Oct;73(10):1199-1208. doi: 10.1007/s00228-017-2291-6. Epub 2017 Jul 5. Efficacy and safety of probiotic-supplemented triple therapy for eradication of Helicobacter pylori in children: a systematic review and network meta-analysis. Feng JR(1)(2), Wang F(1)(2), Qiu X(

7.
📄 연구
Probiotics for the prevention of pediatric antibiotic-associated diarrhea.
The Cochrane database of systematic reviews 2015 PMID:26695080
📊 RR 0.46 (95% CI 0.35–0.61) · n=2455

7. Cochrane Database Syst Rev. 2015 Dec 22;(12):CD004827. doi: 10.1002/14651858.CD004827.pub4. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Goldenberg JZ(1), Lytvyn L, Steurich J, Parkin P, Mahant S, Johnston BC. Author information: (1)Bastyr University Research Ins

8.
🧪 RCT
Effects of a spore-forming probiotic blend on bowel habits and physical well-being in adults with functional constipation: A randomized, double-blind, placebo-controlled trial.
PloS one 2026 PMID:42030329

8. PLoS One. 2026 Apr 24;21(4):e0337019. doi: 10.1371/journal.pone.0337019. eCollection 2026. Effects of a spore-forming probiotic blend on bowel habits and physical well-being in adults with functional constipation: A randomized, double-blind, placebo-controlled trial. Park HG(1)(2), Lee HB(3)

9.
🧪 RCT
Randomized, Double-Blind, Placebo-Controlled Trial of ID-CBT5101, a Tyndallized Clostridium butyricum Postbiotic, in Adults with Mild-to-Moderate Knee Osteoarthritis.
Journal of microbiology and biotechnology 2026 PMID:41581926

9. J Microbiol Biotechnol. 2026 Jan 22;36:e2512024. doi: 10.4014/jmb.2512.12024. Randomized, Double-Blind, Placebo-Controlled Trial of ID-CBT5101, a Tyndallized Clostridium butyricum Postbiotic, in Adults with Mild-to-Moderate Knee Osteoarthritis. Lee HB(1), Lee J(1), Jeong K(2), Yang J(3), Jung

10.
📄 연구
Oxygen-driven nebulization of Clostridium butyricum prevents drug-resistant bacterial pneumonia.
Applied microbiology and biotechnology 2026 PMID:41580563
📊 RR 23.54 (95% CI 7.58–73.08) · n=310

10. Appl Microbiol Biotechnol. 2026 Jan 24;110(1):39. doi: 10.1007/s00253-026-13716-1. Oxygen-driven nebulization of Clostridium butyricum prevents drug-resistant bacterial pneumonia. Zhan MH(1), Zhan SH(2), Han HQ(3), Kang LN(4), Yang XG(5), Chai AX(6). Author information: (1)Intensive Care Un

11.
🧪 RCT
Clostridium butyricum MIYAIRI 588 Reduces Colorectal Adenomatous Polyp Recurrence: A Randomized Crossover Trial.
Oncology research 2025 PMID:41425719

11. Oncol Res. 2025 Nov 27;33(12):3907-3922. doi: 10.32604/or.2025.070432. eCollection 2025. Clostridium butyricum MIYAIRI 588 Reduces Colorectal Adenomatous Polyp Recurrence: A Randomized Crossover Trial. Wang JW(1)(2)(3), Hsu WH(2)(3)(4), Yu FJ(2)(3), Kuo FC(5), Liu CJ(3)(6), Kuo CH(1)(2)(3),

12.
🧪 RCT
Efficacy and safety of N-acetylcysteine vs. probiotics in in-vivo biofilm prevention on ureteral stents: a prospective randomized controlled pilot in vivo study.
International urology and nephrology 2026 PMID:40788469

12. Int Urol Nephrol. 2026 Mar;58(3):811-820. doi: 10.1007/s11255-025-04713-w. Epub 2025 Aug 11. Efficacy and safety of N-acetylcysteine vs. probiotics in in-vivo biofilm prevention on ureteral stents: a prospective randomized controlled pilot in vivo study. Singh I(1), Agrawal H(2), Maurya S(2

13.
🧪 RCT
Perioperative administration of CBM588 in colorectal cancer radical surgery: A single-center, randomized controlled trial.
Cell reports. Medicine 2025 PMID:40633539

13. Cell Rep Med. 2025 Jul 15;6(7):102234. doi: 10.1016/j.xcrm.2025.102234. Epub 2025 Jul 8. Perioperative administration of CBM588 in colorectal cancer radical surgery: A single-center, randomized controlled trial. Yang Y(1), Guo Y(1), Ding Y(1), Li J(1), Liang L(1), Shi D(1), Li X(1), Ma Y(2).

14.
🧪 RCT
Impact of supplementing Limosilactobacillus fermentum MN-LF23 on the eradication of Helicobacter pylori with 14-day standard quadruple therapy: a randomized, double-blind, placebo-controlled trial.
Nutrition journal 2025 PMID:40624535

14. Nutr J. 2025 Jul 7;24(1):106. doi: 10.1186/s12937-025-01124-6. Impact of supplementing Limosilactobacillus fermentum MN-LF23 on the eradication of Helicobacter pylori with 14-day standard quadruple therapy: a randomized, double-blind, placebo-controlled trial. Zhao Y(1), Niu X(2), Zhang Y(3)

15.
📄 연구
Innovative strategies for the rapid restoration of intestinal function in patients undergoing abdominal surgery: use of probiotics. Pilot study of 15 patients.
Minerva gastroenterology 2025 PMID:39639791

15. Minerva Gastroenterol (Torino). 2025 Mar;71(1):7-14. doi: 10.23736/S2724-5985.24.03701-X. Epub 2024 Dec 6. Innovative strategies for the rapid restoration of intestinal function in patients undergoing abdominal surgery: use of probiotics. Pilot study of 15 patients. Radice E, Potapov O, Sha

16.
📄 연구
Clostridium butyricum Potentially Improves Immunity and Nutrition through Alteration of the Microbiota and Metabolism of Elderly People with Malnutrition in Long-Term Care.
Nutrients 2022 PMID:36079806

3. Nutrients. 2022 Aug 28;14(17):3546. doi: 10.3390/nu14173546. Clostridium butyricum Potentially Improves Immunity and Nutrition through Alteration of the Microbiota and Metabolism of Elderly People with Malnutrition in Long-Term Care. Liu L(1), Chen X(2), Liu L(3), Qin H(1). Author informatio

17.
📄 연구
Effects of Clostridium butyricum Capsules Combined with Rosuvastatin on Intestinal Flora, Lipid Metabolism, Liver Function and Inflammation in NAFLD Patients.
Cellular and molecular biology (Noisy-le-Grand, France) 2022 PMID:35869734

30. Cell Mol Biol (Noisy-le-grand). 2022 Feb 28;68(2):64-69. doi: 10.14715/cmb/2022.68.2.10. Effects of Clostridium butyricum Capsules Combined with Rosuvastatin on Intestinal Flora, Lipid Metabolism, Liver Function and Inflammation in NAFLD Patients. Zhu W(1), Yan M(2), Cao H(3), Zhou J(1), Xu

18.
📄 연구
[Combination use of kampo-medicines and drugs affecting intestinal bacterial flora].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2002 PMID:12235860

6. Yakugaku Zasshi. 2002 Sep;122(9):695-701. doi: 10.1248/yakushi.122.695. [Combination use of kampo-medicines and drugs affecting intestinal bacterial flora]. [Article in Japanese] Ishihara M(1), Homma M, Kuno E, Watanabe M, Kohda Y. Author information: (1)Department of Pharmacy, Tsukuba Unive

19.
📄 연구
The Microbiota-gut-brain axis in vascular cognitive impairment: unraveling the mysterious link and therapeutic prospects.
Frontiers in immunology 2025 PMID:41126840

21. Front Immunol. 2025 Oct 7;16:1648800. doi: 10.3389/fimmu.2025.1648800. eCollection 2025. The Microbiota-gut-brain axis in vascular cognitive impairment: unraveling the mysterious link and therapeutic prospects. Liu T(1)(2), Li Y(1)(2), Xiong X(3)(4)(5), Lai X(3)(4), Xu X(1). Author informat

20.
📋 체계적 리뷰
The Metabolome and the Gut Microbiota for the Prediction of Necrotizing Enterocolitis and Spontaneous Intestinal Perforation: A Systematic Review.
Nutrients 2022 PMID:36145235

22. Nutrients. 2022 Sep 18;14(18):3859. doi: 10.3390/nu14183859. The Metabolome and the Gut Microbiota for the Prediction of Necrotizing Enterocolitis and Spontaneous Intestinal Perforation: A Systematic Review. Moschino L(1)(2), Verlato G(1), Duci M(3), Cavicchiolo ME(1), Guiducci S(1), Stocche

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