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비피도박테리움 브레베

Bifidobacterium breve

📑 PubMed 25편 🦠 프로바이오틱스 🗓️ 최신 2026
🔬 메타분석 3 📋 체계적 리뷰 8 🧪 RCT 10

📖 핵심 요약

📖 25편 · 13분 읽기

비피도박테리움 브레베은(는) 프로바이오틱스 계열 보충제입니다. 주로 간 건강, 우울 개선, 당뇨 분야에서 연구되었으며, PubMed에 25편의 관련 논문이 있습니다.

🔍 연구 분야별 근거

간 건강 논문 1편
우울 개선 논문 2편
당뇨 논문 1편

* 제목에 해당 키워드가 포함된 논문 수 (PubMed 근거)

📊 효과 크기 분포 (Forest plot)

각 연구의 효과 추정치와 95% 신뢰구간. 개별 연구를 통합(pooling)하지 않고 그대로 표시합니다.

286811770.49 (1.13–1.25)266892240.99 (0.97–1.01)0.215RR (favours ← / →)

📚 관련 논문 (25편) · 📊 정량 근거 4건

1.
📋 체계적 리뷰
An updated systematic review and appraisal of the pathophysiologic mechanisms of probiotics in alleviating depression.
Nutritional neuroscience 2025 PMID:40669008

1. Nutr Neurosci. 2025 Dec;28(12):1564-1584. doi: 10.1080/1028415X.2025.2531357. Epub 2025 Jul 16. An updated systematic review and appraisal of the pathophysiologic mechanisms of probiotics in alleviating depression. Sulaiman NNY(1)(2), Mohamad Nizam NB(1), Mohd Noor NA(1)(2), Lim SM(2), Ramasa

2.
🔬 메타분석
Impact of bacterial probiotics on obesity, diabetes and non-alcoholic fatty liver disease related variables: a systematic review and meta-analysis of randomised controlled trials.
BMJ open 2019 PMID:30928918

2. BMJ Open. 2019 Mar 30;9(3):e017995. doi: 10.1136/bmjopen-2017-017995. Impact of bacterial probiotics on obesity, diabetes and non-alcoholic fatty liver disease related variables: a systematic review and meta-analysis of randomised controlled trials. Koutnikova H(#)(1), Genser B(#)(2)(3), Mont

3.
📋 체계적 리뷰
Bifidobacterium breve M-16V as a Probiotic for Preterm Infants: A Strain-Specific Systematic Review.
JPEN. Journal of parenteral and enteral nutrition 2018 PMID:28796951
📊 OR 0.56 · n=482

3. JPEN J Parenter Enteral Nutr. 2018 May;42(4):677-688. doi: 10.1177/0148607117722749. Epub 2017 Dec 19. Bifidobacterium breve M-16V as a Probiotic for Preterm Infants: A Strain-Specific Systematic Review. Athalye-Jape G(1)(2)(3), Rao S(1)(2)(3), Simmer K(1)(3), Patole S(1)(3). Author informat

4.
🔬 메타분석
Efficacy and safety of probiotic-supplemented triple therapy for eradication of Helicobacter pylori in children: a systematic review and network meta-analysis.
European journal of clinical pharmacology 2017 PMID:28681177
📊 RR 0.49 (95% CI 1.13–1.25) · n=3122

4. Eur J Clin Pharmacol. 2017 Oct;73(10):1199-1208. doi: 10.1007/s00228-017-2291-6. Epub 2017 Jul 5. Efficacy and safety of probiotic-supplemented triple therapy for eradication of Helicobacter pylori in children: a systematic review and network meta-analysis. Feng JR(1)(2), Wang F(1)(2), Qiu X(

5.
🧪 RCT
Absence of adverse events in healthy individuals using probiotics--analysis of six randomised studies by one study group.
Beneficial microbes 2016 PMID:26689224
📊 RR 0.99 (95% CI 0.97–1.01) · n=909

5. Benef Microbes. 2016;7(2):161-9. doi: 10.3920/BM2015.0096. Epub 2015 Dec 21. Absence of adverse events in healthy individuals using probiotics--analysis of six randomised studies by one study group. Tapiovaara L(1), Lehtoranta L(2), Poussa T(3), Mäkivuokko H(4), Korpela R(2), Pitkäranta A(1).

6.
🔬 메타분석
Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis.
Revista espanola de enfermedades digestivas 2013 PMID:23548007

6. Rev Esp Enferm Dig. 2013 Jan;105(1):19-36. doi: 10.4321/s1130-01082013000100005. Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis. Ortiz-Lucas M, Tobías A, Saz P, Sebastián JJ. Comment in Rev Esp Enferm Dig. 2013 Jan;105(1):1-2. doi: 10.4

7.
📄 연구
Therapeutical efficacy of immunobiotics in patients with newly diagnosed rheumatoid arthritis.
Journal of infection in developing countries 2025 PMID:41529011
📊 HR 2.703 · n=100

7. J Infect Dev Ctries. 2025 Dec 31;19(12):1861-1868. doi: 10.3855/jidc.21182. Therapeutical efficacy of immunobiotics in patients with newly diagnosed rheumatoid arthritis. Barac B(1), Lukovic S(1), Kojic T(1), Radnic TZ(1), Bibic A(2). Author information: (1)Institute of Rheumatology, Belgrade

8.
🧪 RCT
School-Age Neurodevelopmental and Atopy Outcomes in Extremely Preterm Infants: Follow-Up from the Single Versus Triple-Strain Bifidobacterium Randomized Controlled Trial.
Nutrients 2026 PMID:41515257

8. Nutrients. 2026 Jan 1;18(1):141. doi: 10.3390/nu18010141. School-Age Neurodevelopmental and Atopy Outcomes in Extremely Preterm Infants: Follow-Up from the Single Versus Triple-Strain Bifidobacterium Randomized Controlled Trial. Athalye-Jape G(1)(2), Rath C(1)(2)(3), Esvaran M(4), Jacques A(5

9.
🧪 RCT
Imaging and Microorganism Analyses of the Effects of Oral Bifidobacterium breve Intake on Facial Skin in Females: A Randomized, Double-Blind, Placebo-Controlled Study.
Nutrients 2025 PMID:41010502

9. Nutrients. 2025 Sep 17;17(18):2976. doi: 10.3390/nu17182976. Imaging and Microorganism Analyses of the Effects of Oral Bifidobacterium breve Intake on Facial Skin in Females: A Randomized, Double-Blind, Placebo-Controlled Study. Nishikawa Y(1), Xu C(1)(2), Yoshimoto S(1)(2), Katsumata N(1)(2)

10.
🧪 RCT
The impact of Bifidobacterium breve BBr60 (BBr60) on metabolic and gastrointestinal health in healthy adults: A combined in vitro metabolomic and randomized, double-blind, placebo-controlled study.
Clinical nutrition (Edinburgh, Scotland) 2025 PMID:40652782

10. Clin Nutr. 2025 Aug;51:349-361. doi: 10.1016/j.clnu.2025.07.004. Epub 2025 Jul 7. The impact of Bifidobacterium breve BBr60 (BBr60) on metabolic and gastrointestinal health in healthy adults: A combined in vitro metabolomic and randomized, double-blind, placebo-controlled study. Dong Y(1),

11.
🧪 RCT
Impact of an Integrated Intervention Package During Preconception, Pregnancy, and Early Childhood on the Gut Microbiome at Six Months of Age: Findings from the Women and Infants Integrated Growth Study (WINGS) Randomized Controlled Trial.
The Journal of nutrition 2025 PMID:40615170

11. J Nutr. 2025 Jul;155(7):2355-2366. doi: 10.1016/j.tjnut.2025.04.016. Impact of an Integrated Intervention Package During Preconception, Pregnancy, and Early Childhood on the Gut Microbiome at Six Months of Age: Findings from the Women and Infants Integrated Growth Study (WINGS) Randomized Con

12.
📄 연구
Pre-sleep casein ingestion with probiotic strains improves anaerobic power and lower-body-specific strength and power performance in soccer players.
Journal of the International Society of Sports Nutrition 2025 PMID:40353739

12. J Int Soc Sports Nutr. 2025 Dec;22(1):2505184. doi: 10.1080/15502783.2025.2505184. Epub 2025 May 12. Pre-sleep casein ingestion with probiotic strains improves anaerobic power and lower-body-specific strength and power performance in soccer players. Sadeghi R(1), Hemmatinafar M(1), Eftekhari

13.
🧪 RCT
Probiotics and Fever Duration in Children With Upper Respiratory Tract Infections: A Randomized Clinical Trial.
JAMA network open 2025 PMID:40085083

13. JAMA Netw Open. 2025 Mar 3;8(3):e250669. doi: 10.1001/jamanetworkopen.2025.0669. Probiotics and Fever Duration in Children With Upper Respiratory Tract Infections: A Randomized Clinical Trial. Bettocchi S(1), Comotti A(2), Elli M(3), De Cosmi V(4)(5), Berti C(1), Alberti I(1), Mazzocchi A(5)

14.
📄 연구
Restoration of gut microbiota with a specific synbiotic-containing infant formula in healthy Chinese infants born by cesarean section.
European journal of clinical nutrition 2025 PMID:39915586

14. Eur J Clin Nutr. 2025 Jun;79(6):567-575. doi: 10.1038/s41430-025-01571-8. Epub 2025 Feb 6. Restoration of gut microbiota with a specific synbiotic-containing infant formula in healthy Chinese infants born by cesarean section. Wang Y(#)(1), Wopereis H(#)(2), Kakourou A(3), Liu M(4), Wu J(5),

15.
📄 연구
Exploring the Fecal Metabolome in Infants With Cow's Milk Allergy: The Distinct Impacts of Cow's Milk Protein Tolerance Acquisition and of Synbiotic Supplementation.
Molecular nutrition & food research 2025 PMID:39665335

15. Mol Nutr Food Res. 2025 Jan;69(1):e202400583. doi: 10.1002/mnfr.202400583. Epub 2024 Dec 12. Exploring the Fecal Metabolome in Infants With Cow's Milk Allergy: The Distinct Impacts of Cow's Milk Protein Tolerance Acquisition and of Synbiotic Supplementation. Zhu P(1), Savova MV(1), Kindt A(

16.
🧪 RCT
Gut Microbiome and Metabolome Alterations in Overweight or Obese Adult Population after Weight-Loss Bifidobacterium breve BBr60 Intervention: A Randomized Controlled Trial.
International journal of molecular sciences 2024 PMID:39456659

9. Int J Mol Sci. 2024 Oct 10;25(20):10871. doi: 10.3390/ijms252010871. Gut Microbiome and Metabolome Alterations in Overweight or Obese Adult Population after Weight-Loss Bifidobacterium breve BBr60 Intervention: A Randomized Controlled Trial. Bai Z(1), Wu Y(1)(2), Gao D(1), Dong Y(3), Pan Y(1)

17.
🧪 RCT
Reply to Lee, S.Y. Comment on "Sung et al. Body Fat Reduction Effect of Bifidobacterium breve B-3: A Randomized, Double-Blind, Placebo Comparative Clinical Trial. Nutrients 2023, 15, 28".
Nutrients 2023 PMID:36904095

25. Nutrients. 2023 Feb 22;15(5):1094. doi: 10.3390/nu15051094. Reply to Lee, S.Y. Comment on "Sung et al. Body Fat Reduction Effect of Bifidobacterium breve B-3: A Randomized, Double-Blind, Placebo Comparative Clinical Trial. Nutrients 2023, 15, 28". Sung HK(1), Youn SJ(2), Choi Y(2), Eun SW(3)

18.
🧪 RCT
Body Fat Reduction Effect of Bifidobacterium breve B-3: A Randomized, Double-Blind, Placebo Comparative Clinical Trial.
Nutrients 2022 PMID:36615686

37. Nutrients. 2022 Dec 21;15(1):28. doi: 10.3390/nu15010028. Body Fat Reduction Effect of Bifidobacterium breve B-3: A Randomized, Double-Blind, Placebo Comparative Clinical Trial. Sung HK(1), Youn SJ(2), Choi Y(2), Eun SW(3), Shin SM(4). Author information: (1)Department of Pediatrics, College

19.
🧪 RCT
Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: A Post Hoc Analysis of a Randomized Clinical Trial.
Journal of neurogastroenterology and motility 2022 PMID:36250371

37. J Neurogastroenterol Motil. 2022 Oct 30;28(4):642-654. doi: 10.5056/jnm21202. Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: A Post Hoc Analysis of a Randomized Clinical Tri

20.
📋 체계적 리뷰
Psychobiotics in Depression: Sources, Metabolites, and Treatment-A Systematic Review.
Nutrients 2025 PMID:40647242

43. Nutrients. 2025 Jun 27;17(13):2139. doi: 10.3390/nu17132139. Psychobiotics in Depression: Sources, Metabolites, and Treatment-A Systematic Review. Śliwka A(1), Polak-Berecka M(1), Zdybel K(1), Zelek-Molik A(2), Waśko A(1). Author information: (1)Department of Biotechnology, Microbiology and

21.
📋 체계적 리뷰
Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic Review.
Nutrients 2025 PMID:39940249

17. Nutrients. 2025 Jan 22;17(3):391. doi: 10.3390/nu17030391. Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic Review. Reiriz M(1), Beltrán-Velasco AI(1), Echeverry-Alzate V(1), Martínez-Miguel E(1), Gómez-S

22.
📋 체계적 리뷰
Infant Formulas With Postbiotics: An Updated Systematic Review.
Journal of pediatric gastroenterology and nutrition 2022 PMID:35258495

41. J Pediatr Gastroenterol Nutr. 2022 Jun 1;74(6):823-829. doi: 10.1097/MPG.0000000000003441. Epub 2022 Mar 4. Infant Formulas With Postbiotics: An Updated Systematic Review. Szajewska H(1), Kołodziej M, Skórka A, Pieścik-Lech M. Author information: (1)Department of Paediatrics, Medical Univers

23.
📋 체계적 리뷰
The role of probiotics in the immune response and intestinal microbiota of children with celiac disease: a systematic review.
Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo 2021 PMID:34495279

1. Rev Paul Pediatr. 2021 Sep 1;40:e2020447. doi: 10.1590/1984-0462/2022/40/2020447. eCollection 2021. The role of probiotics in the immune response and intestinal microbiota of children with celiac disease: a systematic review. Jedwab CF(1), Roston BCMB(1), Toge ABFS(1), Echeverria IF(1), Tavar

24.
📋 체계적 리뷰
Search and Selection of Probiotics That Improve Mucositis Symptoms in Oncologic Patients. A Systematic Review.
Nutrients 2019 PMID:31581434

43. Nutrients. 2019 Oct 1;11(10):2322. doi: 10.3390/nu11102322. Search and Selection of Probiotics That Improve Mucositis Symptoms in Oncologic Patients. A Systematic Review. Picó-Monllor JA(1)(2), Mingot-Ascencao JM(3). Author information: (1)Universidad Miguel Hernández, 03202 Elche, Spain. ja

25.
📋 체계적 리뷰
Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review.
Journal of clinical gastroenterology 2018 PMID:29782469

24. J Clin Gastroenterol. 2018 Nov/Dec;52 Suppl 1, Proceedings from the 9th Probiotics, Prebiotics and New Foods, Nutraceuticals and Botanicals for Nutrition & Human and Microbiota Health Meeting, held in Rome, Italy from September 10 to 12, 2017:S10-S26. doi: 10.1097/MCG.0000000000001054. Effec

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