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아커만시아 무시니필라

Akkermansia muciniphila

📑 PubMed 27편 🦠 프로바이오틱스 🗓️ 최신 2026
🔬 메타분석 6 📋 체계적 리뷰 6 🧪 RCT 8

📖 핵심 요약

📖 27편 · 14분 읽기

아커만시아 무시니필라은(는) 프로바이오틱스 계열 보충제입니다. 주로 항암, 우울 개선, 장 건강, 불안 완화, 면역, 당뇨 분야에서 연구되었으며, PubMed에 27편의 관련 논문이 있습니다.

🔍 연구 분야별 근거

항암 논문 7편
우울 개선 논문 4편
장 건강 논문 11편
불안 완화 논문 1편
면역 논문 1편
당뇨 논문 4편

* 제목에 해당 키워드가 포함된 논문 수 (PubMed 근거)

📚 관련 논문 (27편) · 📊 정량 근거 3건

1.
🔬 메타분석
Effect of probiotic-derived metabolites on hormonal and metabolic profiles in women with polycystic ovary syndrome: a systematic review and meta-analysis.
Frontiers in cellular and infection microbiology 2025 PMID:41346361
📊 SMD -0.46 (95% CI -0.3–-0.08) · n=214

1. Front Cell Infect Microbiol. 2025 Nov 19;15:1680840. doi: 10.3389/fcimb.2025.1680840. eCollection 2025. Effect of probiotic-derived metabolites on hormonal and metabolic profiles in women with polycystic ovary syndrome: a systematic review and meta-analysis. Maddirevula MK(1), Nelson VK(2), S

2.
📄 연구
The impact of gut microbiota modulation on responses to immune checkpoint inhibitors in cancer.
Acta microbiologica et immunologica Hungarica 2026 PMID:41196286
📊 OR 2.91 (95% CI 0.51–0.76) · n=642

2. Acta Microbiol Immunol Hung. 2025 Nov 6;73(1):13-19. doi: 10.1556/030.2025.02719. Print 2026 Mar 5. The impact of gut microbiota modulation on responses to immune checkpoint inhibitors in cancer. Ni Z(1), Ye D(2). Author information: (1)1Department of Gastroenterology, Hangzhou Fuyang Hospit

3.
🔬 메타분석
The Impact of Akkermansia muciniphila on Mouse Models of Depression, Anxiety, and Stress: A Systematic Review and Meta-Analysis.
Current neuropharmacology 2025 PMID:40108902

3. Curr Neuropharmacol. 2025;23(11):1423-1441. doi: 10.2174/011570159X360149250225041829. The Impact of Akkermansia muciniphila on Mouse Models of Depression, Anxiety, and Stress: A Systematic Review and Meta-Analysis. Khalili L(1), Park G(1), Nagpal R(1), Bhide P(2), Salazar G(1). Author infor

4.
🔬 메타분석
Akkermansia muciniphila for the Prevention of Type 2 Diabetes and Obesity: A Meta-Analysis of Animal Studies.
Nutrients 2024 PMID:39458436

4. Nutrients. 2024 Oct 11;16(20):3440. doi: 10.3390/nu16203440. Akkermansia muciniphila for the Prevention of Type 2 Diabetes and Obesity: A Meta-Analysis of Animal Studies. Liu E(1), Ji X(2), Zhou K(1). Author information: (1)Department of Nutrition and Food Science, Wayne State University, Det

5.
📄 연구
Effect of inulin, galacto-oligosaccharides, and polyphenols on the gut microbiota, with a focus on Akkermansia muciniphila.
Food & function 2024 PMID:38590256

5. Food Funct. 2024 May 7;15(9):4763-4772. doi: 10.1039/d4fo00428k. Effect of inulin, galacto-oligosaccharides, and polyphenols on the gut microbiota, with a focus on Akkermansia muciniphila. Tian R(1)(2), Yu L(1)(2), Tian F(1)(2), Zhao J(1)(2), Chen W(1)(2)(3), Zhai Q(1)(2). Author information

6.
🔬 메타분석
Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies.
International journal of molecular sciences 2023 PMID:36834497

6. Int J Mol Sci. 2023 Feb 4;24(4):3084. doi: 10.3390/ijms24043084. Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies. Khalili L(1), Centner AM(1), Salazar G(1)(2). Author information: (1)Department of Nut

7.
🧪 RCT
JK5G postbiotics modulate gut microbiota and metabolome to alleviate cancer-related pain: a randomized controlled trial with multi-omics integration.
Frontiers in immunology 2026 PMID:41859075

7. Front Immunol. 2026 Mar 4;17:1764491. doi: 10.3389/fimmu.2026.1764491. eCollection 2026. JK5G postbiotics modulate gut microbiota and metabolome to alleviate cancer-related pain: a randomized controlled trial with multi-omics integration. Chen M(1), Zhang J(2)(3), Yang H(2)(3), Lei L(2)(3), Y

8.
📄 연구
Efficacy of inulin supplementation in metabolic control and Akkermansia muciniphila levels in subjects with type 1 diabetes: a pilot study.
European review for medical and pharmacological sciences 2026 PMID:41636295

8. Eur Rev Med Pharmacol Sci. 2026 Jan;30(1):15-26. doi: 10.26355/eurrev_202601_37645. Efficacy of inulin supplementation in metabolic control and Akkermansia muciniphila levels in subjects with type 1 diabetes: a pilot study. Ojetti V(1), Saviano A, Rizzi A, Tartaglione L, Di Leo M, Quaranta G,

9.
📄 연구
A Metagenomics Approach to Frailty in Patients With Cirrhosis Undergoing a Multifactorial Intervention.
Liver international : official journal of the International Association for the Study of the Liver 2025 PMID:41174950

9. Liver Int. 2025 Dec;45(12):e70418. doi: 10.1111/liv.70418. A Metagenomics Approach to Frailty in Patients With Cirrhosis Undergoing a Multifactorial Intervention. Vega-Abellaneda S(1), Román E(2)(3)(4)(5), Soler Z(1), Ortiz MÀ(6), Rossi G(7), Biagini L(7), Sánchez E(3)(6), Pons-Tarin M(1), La

10.
🧪 RCT
Effects of home-based exercise training on gut microbiota and possible relations with cognitive function and metabolic health in postmenopausal women with type 2 diabetes mellitus: a randomized control trial.
Diabetes research and clinical practice 2025 PMID:41109629

10. Diabetes Res Clin Pract. 2025 Nov;229:112908. doi: 10.1016/j.diabres.2025.112908. Epub 2025 Oct 17. Effects of home-based exercise training on gut microbiota and possible relations with cognitive function and metabolic health in postmenopausal women with type 2 diabetes mellitus: a randomize

11.
📄 연구
A Low-Gluten Diet Reduces the Abundance of Potentially Beneficial Bacteria in Healthy Adult Gut Microbiota.
Nutrients 2025 PMID:40805974

11. Nutrients. 2025 Jul 22;17(15):2389. doi: 10.3390/nu17152389. A Low-Gluten Diet Reduces the Abundance of Potentially Beneficial Bacteria in Healthy Adult Gut Microbiota. Delmas E(1), Bingula R(2), Del'homme C(1), Meunier N(3), Caille A(3), Lyon-Belgy N(3), Richard R(3), Do Couto MG(1), Wittra

12.
🧪 RCT
Apple Polyphenols and Defecation in Overweight Adults with Constipation - A Randomized Controlled Trial.
Journal of dietary supplements 2025 PMID:40766985

12. J Diet Suppl. 2025;22(5):811-832. doi: 10.1080/19390211.2025.2539878. Epub 2025 Aug 6. Apple Polyphenols and Defecation in Overweight Adults with Constipation - A Randomized Controlled Trial. Sekikawa T(1), Li Y(2), Takara T(3). Author information: (1)BGG Japan Co., Ltd, Chuo-ku, Japan. (2)

13.
🧪 RCT
Comparing the effects of yogurt containing Akkermansia muciniphilia postbiotic with yogurt containing Lactobacillus rhamnosus postbiotic on body composition, biochemical indices, appetite, and depression scores in overweight or obese adults: A randomized, double-blind, controlled clinical trial.
Clinical nutrition ESPEN 2025 PMID:40451504

13. Clin Nutr ESPEN. 2025 Aug;68:438-446. doi: 10.1016/j.clnesp.2025.05.045. Epub 2025 May 30. Comparing the effects of yogurt containing Akkermansia muciniphilia postbiotic with yogurt containing Lactobacillus rhamnosus postbiotic on body composition, biochemical indices, appetite, and depressi

14.
🧪 RCT
Muscadine Grape Skin Extract in Biochemically Recurrent Prostate Cancer: A Randomized, Placebo-Controlled, Biomarker-Enriched Trial in Patients With the SOD2 Ala/Ala Variant.
The Prostate 2025 PMID:40325900

14. Prostate. 2025 Jul;85(10):966-976. doi: 10.1002/pros.24903. Epub 2025 May 5. Muscadine Grape Skin Extract in Biochemically Recurrent Prostate Cancer: A Randomized, Placebo-Controlled, Biomarker-Enriched Trial in Patients With the SOD2 Ala/Ala Variant. Mandl A(1), Zahurak ML(1), Metri NA(1),

15.
🧪 RCT
Multi-species probiotic supplement enhances vagal nerve function - results of a randomized controlled trial in patients with depression and healthy controls.
Gut microbes 2025 PMID:40298641

15. Gut Microbes. 2025 Dec;17(1):2492377. doi: 10.1080/19490976.2025.2492377. Epub 2025 Apr 29. Multi-species probiotic supplement enhances vagal nerve function - results of a randomized controlled trial in patients with depression and healthy controls. Mörkl S(1), Narrath M(1), Schlotmann D(1),

16.
🧪 RCT
Effects of Kefir Consumption on Gut Microbiota and Athletic Performance in Professional Female Soccer Players: A Randomized Controlled Trial.
Nutrients 2025 PMID:39940370

4. Nutrients. 2025 Jan 30;17(3):512. doi: 10.3390/nu17030512. Effects of Kefir Consumption on Gut Microbiota and Athletic Performance in Professional Female Soccer Players: A Randomized Controlled Trial. Öneş E(1), Zavotçu M(2), Nisan N(3), Baş M(4), Sağlam D(4). Author information: (1)Departmen

17.
📄 연구
Huang-Lian-Jie-Du decoction enhances Capecitabine-Oxaliplatin efficacy via Akkermansia muciniphila and CD8(+) T cells in colorectal cancer.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 PMID:40972261

27. Phytomedicine. 2025 Nov 25;148:157233. doi: 10.1016/j.phymed.2025.157233. Epub 2025 Sep 4. Huang-Lian-Jie-Du decoction enhances Capecitabine-Oxaliplatin efficacy via Akkermansia muciniphila and CD8(+) T cells in colorectal cancer. Chen Y(1), Lai X(2), Zhang Y(2), Qiu C(3), Qin Y(4), Fan T(5)

18.
📄 연구
Akkermansia muciniphila Enhances the Antitumor Effect of Cisplatin in Lewis Lung Cancer Mice.
Journal of immunology research 2020 PMID:32832569

32. J Immunol Res. 2020 Aug 7;2020:2969287. doi: 10.1155/2020/2969287. eCollection 2020. Akkermansia muciniphila Enhances the Antitumor Effect of Cisplatin in Lewis Lung Cancer Mice. Chen Z(1), Qian X(1), Chen S(2), Fu X(1), Ma G(3), Zhang A(1). Author information: (1)Institute of Cancer and Ba

19.
🧪 RCT
Pasteurized Akkermansia muciniphila HB05 (HB05P) Improves Muscle Strength and Function: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Nutrients 2024 PMID:39683431

38. Nutrients. 2024 Nov 26;16(23):4037. doi: 10.3390/nu16234037. Pasteurized Akkermansia muciniphila HB05 (HB05P) Improves Muscle Strength and Function: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Kang CH(1), Jung ES(2)(3), Jung SJ(2)(3), Han YH(3)(4)(5), Chae SW(2)(3

20.
📋 체계적 리뷰
Faecalibacterium prausnitzii and Akkermansia muciniphila: driving the multiple sclerosis-a systematic review.
Antonie van Leeuwenhoek 2026 PMID:42020638

19. Antonie Van Leeuwenhoek. 2026 Apr 22;119(5):100. doi: 10.1007/s10482-026-02304-y. Faecalibacterium prausnitzii and Akkermansia muciniphila: driving the multiple sclerosis-a systematic review. Ahmadi S(1)(2), Sedaghat FR(1)(2)(3), Asl YM(3), Khabbaz A(4)(5), Hosseinzadeh N(4), Poortahmasbe V

21.
📋 체계적 리뷰
The Emerging Role of Gut Microbiota in Inflammatory Skin Diseases: A Systematic Review.
Experimental dermatology 2026 PMID:41795861

41. Exp Dermatol. 2026 Mar;35(3):e70234. doi: 10.1111/exd.70234. The Emerging Role of Gut Microbiota in Inflammatory Skin Diseases: A Systematic Review. Malgesini A(1)(2), Marsiglia MD(3), Borghi E(3), Marzano AV(1)(2), Nazzaro G(1)(2). Author information: (1)Department of Pathophysiology and T

22.
🔬 메타분석
Mediterranean diet, gut microbiota, and type 2 diabetes: A systematic review and meta-analysis of intervention trials.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2026 PMID:41381307
📊 MD -0.18 (95% CI -0.35–-0.01) · n=1337

35. Nutr Metab Cardiovasc Dis. 2026 May;36(5):104433. doi: 10.1016/j.numecd.2025.104433. Epub 2025 Nov 3. Mediterranean diet, gut microbiota, and type 2 diabetes: A systematic review and meta-analysis of intervention trials. Lauria F(1), Formisano A(1), Dello Russo M(1), Quaglia C(2), Giacco R(1

23.
📋 체계적 리뷰
Therapeutic potential of Akkermansia muciniphila in non-alcoholic fatty liver disease: a systematic review.
BMC gastroenterology 2025 PMID:41257640

5. BMC Gastroenterol. 2025 Nov 19;25(1):822. doi: 10.1186/s12876-025-04436-3. Therapeutic potential of Akkermansia muciniphila in non-alcoholic fatty liver disease: a systematic review. Asghari P(1)(2), Ahmadi-Khorram M(1)(2), Hatami A(1)(2), Talebi S(3), Afshari A(4). Author information: (1)De

24.
🔬 메타분석
Gut Microbiota and Central Nervous System Tumors: A Comprehensive Systematic Review and Meta-Analysis of Microbiome-CNS Interactions.
International journal of molecular sciences 2025 PMID:41226760

10. Int J Mol Sci. 2025 Nov 4;26(21):10721. doi: 10.3390/ijms262110721. Gut Microbiota and Central Nervous System Tumors: A Comprehensive Systematic Review and Meta-Analysis of Microbiome-CNS Interactions. Nowacka A(1), Śniegocki M(1), Bożiłow D(2), Ziółkowska E(3). Author information: (1)Depart

25.
📋 체계적 리뷰
The pathobiont role of Akkermansia muciniphila in colorectal cancer: a systematic review.
BMC gastroenterology 2025 PMID:41062951

26. BMC Gastroenterol. 2025 Oct 8;25(1):702. doi: 10.1186/s12876-025-04293-0. The pathobiont role of Akkermansia muciniphila in colorectal cancer: a systematic review. Soheilipour M(#)(1), Noursina A(#)(2), Nekookhoo M(3), Malekpour E(4), Mirzaei SA(3), Shafieyoun MH(3), Rouzbahani H(3), Chitsaz

26.
📋 체계적 리뷰
Psychobiotics in Depression: Sources, Metabolites, and Treatment-A Systematic Review.
Nutrients 2025 PMID:40647242

43. Nutrients. 2025 Jun 27;17(13):2139. doi: 10.3390/nu17132139. Psychobiotics in Depression: Sources, Metabolites, and Treatment-A Systematic Review. Śliwka A(1), Polak-Berecka M(1), Zdybel K(1), Zelek-Molik A(2), Waśko A(1). Author information: (1)Department of Biotechnology, Microbiology and

27.
📋 체계적 리뷰
Gut microbiome changes and cancer immunotherapy outcomes associated with dietary interventions: a systematic review of preclinical and clinical evidence.
Journal of translational medicine 2025 PMID:40629403

21. J Transl Med. 2025 Jul 8;23(1):756. doi: 10.1186/s12967-025-06586-0. Gut microbiome changes and cancer immunotherapy outcomes associated with dietary interventions: a systematic review of preclinical and clinical evidence. Somodi C(1), Dora D(2), Horváth M(1), Szegvari G(1), Lohinai Z(3). Au

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